International Journal of Nasopharyngeal Carcinoma
The International Journal of Nasopharyngeal Carcinoma (IJNPC) is an open access journal that publishes research findings from disciplines related to nasopharyngeal carcinoma. This journal was published by the Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara, collaborated with TALENTA Publisher Universitas Sumatera Utara. The publication of papers is quarter yearly, published in March, June, September, and December within 10 articles per issue. The journal is purposed to provide international sources of information to doctors and other health professionals who are interested in nasopharyngeal carcinoma. This journal is expected to improve communication between researchers so that it has an impact on the development of knowledge regarding nasopharyngeal carcinoma and stimulates further research related to head and neck surgical oncology, diagnosis, and clinical management.
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94 Documents
<![CDATA[THE EFFECT OF GINKGO BILOBA AGAINST OTOTOXIC HEARING LOSS ON ADVANCED STAGE UNDIFFERENTIATED NASOPHARYNGEAL CARCINOMA RECEIVING CISPLATIN CHEMOTHERAPY ]]>
<![CDATA[Donny Hendriyanto]]>;
<![CDATA[Made Setiamika]]>;
<![CDATA[Novi Primadewi]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3910
<![CDATA[Abstract Introduction: Undifferentiated nasopharyngeal carcinoma is the most common malignant tumor in nasopharynx, in which most patients come to a hospital in advanced stage. Cisplatin is one of the most effective widely used chemotherapy drugs for advanced stage undifferentiated nasopharyngeal carcinoma. Although it provides a successful outcome against cancer, there is serious side effect namely ototoxic hearing loss. Ginkgo biloba is a powerful antioxidant which may prevent ototoxic hearing loss. Objective: The study aims to determine the effect of ginkgo biloba against ototoxic hearing loss on advanced stage undifferentiated nasopharyngeal carcinoma receiving cisplatin chemotherapy. Methods: This study was double blind Randomized Control Trial with pre-post test design, was conducted in 22 patients with advanced stage undifferentiated nasopharyngeal carcinoma receiving cisplatin chemotherapy at the Department of Otorhinolaryngology Head and Neck Surgery dr. Moewardi Hospital Surakarta between June 1st and October 1st 2019. The subjects were allocated into control (plasebo) and treatment (80 mg Ginkgo biloba extract) groups. Hearing function was examined with pure tone audiometry, tympanometry and Distortion Product Otoacoustic Emission before and after the first, the second and the third cisplatin chemotherapy. The results of the examination of the two groups were tested using Friedman and Chi Square test. P value of <0.05 was considered significant. Results: The study subjects were mostly male (63.6%), with the age range of 40-59 years (90.9%). The baseline characteristics of the study subjects were homogeneous (p>0.05). There was a significant difference in the incidence of ototoxic hearing loss between control and treatment group after getting the second and the third chemotherapy (p=0.043 and p=0.033, respectively). Conclusion: There is a significant effect of ginkgo biloba in term of preventing ototoxic hearing loss on advanced stage undifferentiated nasopharyngeal carcinoma patients receiving cisplatin chemotherapy.]]>
<![CDATA[THE EFFECT OF GINKGO BILOBA AGAINST OTOTOXIC HEARING LOSS ON ADVANCED STAGE UNDIFFERENTIATED NASOPHARYNGEAL CARCINOMA RECEIVING CISPLATIN CHEMOTHERAPY ]]>
<![CDATA[Hendriyanto, Donny]]>;
<![CDATA[Setiamika, Made]]>;
<![CDATA[Primadewi, Novi]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3910
<![CDATA[Abstract Introduction: Undifferentiated nasopharyngeal carcinoma is the most common malignant tumor in nasopharynx, in which most patients come to a hospital in advanced stage. Cisplatin is one of the most effective widely used chemotherapy drugs for advanced stage undifferentiated nasopharyngeal carcinoma. Although it provides a successful outcome against cancer, there is serious side effect namely ototoxic hearing loss. Ginkgo biloba is a powerful antioxidant which may prevent ototoxic hearing loss. Objective: The study aims to determine the effect of ginkgo biloba against ototoxic hearing loss on advanced stage undifferentiated nasopharyngeal carcinoma receiving cisplatin chemotherapy. Methods: This study was double blind Randomized Control Trial with pre-post test design, was conducted in 22 patients with advanced stage undifferentiated nasopharyngeal carcinoma receiving cisplatin chemotherapy at the Department of Otorhinolaryngology Head and Neck Surgery dr. Moewardi Hospital Surakarta between June 1st and October 1st 2019. The subjects were allocated into control (plasebo) and treatment (80 mg Ginkgo biloba extract) groups. Hearing function was examined with pure tone audiometry, tympanometry and Distortion Product Otoacoustic Emission before and after the first, the second and the third cisplatin chemotherapy. The results of the examination of the two groups were tested using Friedman and Chi Square test. P value of <0.05 was considered significant. Results: The study subjects were mostly male (63.6%), with the age range of 40-59 years (90.9%). The baseline characteristics of the study subjects were homogeneous (p>0.05). There was a significant difference in the incidence of ototoxic hearing loss between control and treatment group after getting the second and the third chemotherapy (p=0.043 and p=0.033, respectively). Conclusion: There is a significant effect of ginkgo biloba in term of preventing ototoxic hearing loss on advanced stage undifferentiated nasopharyngeal carcinoma patients receiving cisplatin chemotherapy.]]>
<![CDATA[CORRELATION BETWEEN NUCLEUS FACTOR KAPPA B AND MICROVESSEL DENSITY IN NASOPHARYNGEAL CARCINOMA ]]>
<![CDATA[Farrel]]>;
<![CDATA[Izry Naomi Tobing]]>;
<![CDATA[Fahat]]>;
<![CDATA[Rizalina A Asnir]]>;
<![CDATA[Adlin Adnan]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3924
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer, mostly associated with EBV infection. Nuclear factor kappa B (NF-κB) is transcription factors that act as a tumor promoter, especially in inflammation-associated cancer. It also attracts angiogenesis. Microvessel Density (MVD) is widely used as an index for tumor angiogenesis. There have been no studies found about the correlation of NF-κB and MVD expression in NPC. Objective: The aim of this study is to investigate the correlation of NF-κB and MVD expression that may affect targeted therapies in NPC patients Methods: A total of 30 paraffin blocks of NPC patients biopsies were assessed immunohistochemically for NF-κB expression and MVD. Data were analyzed using the Spearman's nonparametric test to assess the correlation between NF-κB expression and MVD. Results: Positive NF-κB expression was found in 22 (73.33%) patients and negative in 8 (26.67%) patients. High MVD expression in 17 (56.67%) patients and low MVD expression in 13 (43.33%) patients. There was no significant correlation found between NF-κB and MVD. Conclusion: This study has not confirmed any correlation between NF-κB and MVD. Further research needs to be done to get a better assessment on nuclear proliferation rates and tumor-related angiogenesis in NPC.]]>
<![CDATA[CORRELATION BETWEEN NUCLEUS FACTOR KAPPA B AND MICROVESSEL DENSITY IN NASOPHARYNGEAL CARCINOMA ]]>
<![CDATA[Farrel]]>;
<![CDATA[Tobing, Izry Naomi]]>;
<![CDATA[Fahat]]>;
<![CDATA[Asnir, Rizalina A]]>;
<![CDATA[Adnan, Adlin]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3924
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer, mostly associated with EBV infection. Nuclear factor kappa B (NF-κB) is transcription factors that act as a tumor promoter, especially in inflammation-associated cancer. It also attracts angiogenesis. Microvessel Density (MVD) is widely used as an index for tumor angiogenesis. There have been no studies found about the correlation of NF-κB and MVD expression in NPC. Objective: The aim of this study is to investigate the correlation of NF-κB and MVD expression that may affect targeted therapies in NPC patients Methods: A total of 30 paraffin blocks of NPC patients biopsies were assessed immunohistochemically for NF-κB expression and MVD. Data were analyzed using the Spearman's nonparametric test to assess the correlation between NF-κB expression and MVD. Results: Positive NF-κB expression was found in 22 (73.33%) patients and negative in 8 (26.67%) patients. High MVD expression in 17 (56.67%) patients and low MVD expression in 13 (43.33%) patients. There was no significant correlation found between NF-κB and MVD. Conclusion: This study has not confirmed any correlation between NF-κB and MVD. Further research needs to be done to get a better assessment on nuclear proliferation rates and tumor-related angiogenesis in NPC.]]>
<![CDATA[NASOPHARYNGEAL CARCINOMA IN PANYABUNGAN DISTRICT HOSPITAL ]]>
<![CDATA[Muhammad Rusli Pulungan]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3932
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma is the most common malignancy found in the head and neck area. Non-specific initial symptoms and hidden locations often make it difficult to diagnose early nasopharyngeal carcinoma. The limitations of tools and human resources in the district are a problem in enforcing and finding patients with nasopharyngeal carcinoma in this situation. Objective: The purpose of this study is to observe the prevalence of nasopharyngeal carcinoma in Departement of Otorhinolaryngology-Head and Neck Surgery Panyabungan District Hospital. Method: This study collecting data from medical record of Nasopharyngeal carcinoma (NPC) at Panyabungan District Hospital. Result: The distribution of NPC patients during January-December 2018 there were 10 patients. NPC base on gender male 50% and female 50%. NPC based on age groups in 46-55 years is 40%, 56-65 years old is 20% and 16-25 years, 26-35 years, 36-45 years, and 66-75 years each of 10%. NPC patients based of clinical appearance is limadenophaty colli is 100%, epistaxis 80%, Nasal congesty 70%.ear fulness 40% and diplopia 30%. NPC based on histophatologycal types is WHO type I 10%, WHO type II 50% and WHO type III 40%. Conclusion: Nasopharyngeal carcinoma is a malignant tumor originating from the nasopharyngeal epithelium. The patient NPC were diagnosed at an advanced stage. All of patients showed enlargement of neck limph nodes and some showed diplopia.]]>
<![CDATA[NASOPHARYNGEAL CARCINOMA IN PANYABUNGAN DISTRICT HOSPITAL ]]>
<![CDATA[Pulungan, Muhammad Rusli]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3932
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma is the most common malignancy found in the head and neck area. Non-specific initial symptoms and hidden locations often make it difficult to diagnose early nasopharyngeal carcinoma. The limitations of tools and human resources in the district are a problem in enforcing and finding patients with nasopharyngeal carcinoma in this situation. Objective: The purpose of this study is to observe the prevalence of nasopharyngeal carcinoma in Departement of Otorhinolaryngology-Head and Neck Surgery Panyabungan District Hospital. Method: This study collecting data from medical record of Nasopharyngeal carcinoma (NPC) at Panyabungan District Hospital. Result: The distribution of NPC patients during January-December 2018 there were 10 patients. NPC base on gender male 50% and female 50%. NPC based on age groups in 46-55 years is 40%, 56-65 years old is 20% and 16-25 years, 26-35 years, 36-45 years, and 66-75 years each of 10%. NPC patients based of clinical appearance is limadenophaty colli is 100%, epistaxis 80%, Nasal congesty 70%.ear fulness 40% and diplopia 30%. NPC based on histophatologycal types is WHO type I 10%, WHO type II 50% and WHO type III 40%. Conclusion: Nasopharyngeal carcinoma is a malignant tumor originating from the nasopharyngeal epithelium. The patient NPC were diagnosed at an advanced stage. All of patients showed enlargement of neck limph nodes and some showed diplopia.]]>
<![CDATA[CASE REPORT: NASOPHARYNGEAL CARCINOMA IN PREGNANCY ]]>
<![CDATA[Sugeng Santoso]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3934
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma in pregnancy is a rare case, a dilemma in its management. This condition has a significant negative effect on pregnancy, given risk of premature birth, fetal defects and abortion. Case Report: 23-year-old woman with 13 weeks gestation age comes with swelling in both necks accompanied by nosebleeds. On nasoendoscopic examination, there was a mass at nasopharynx. Histopathological examination results a nasopharyngeal squamous cell carcinoma. Conclusion: The management of nasopharyngeal carcinoma in pregnancy is very complex, need for extensive multidisciplinary approach with experienced doctors in their respective fields]]>
<![CDATA[CASE REPORT: NASOPHARYNGEAL CARCINOMA IN PREGNANCY ]]>
<![CDATA[Santoso, Sugeng]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i02.3934
<![CDATA[Abstract Introduction: Nasopharyngeal carcinoma in pregnancy is a rare case, a dilemma in its management. This condition has a significant negative effect on pregnancy, given risk of premature birth, fetal defects and abortion. Case Report: 23-year-old woman with 13 weeks gestation age comes with swelling in both necks accompanied by nosebleeds. On nasoendoscopic examination, there was a mass at nasopharynx. Histopathological examination results a nasopharyngeal squamous cell carcinoma. Conclusion: The management of nasopharyngeal carcinoma in pregnancy is very complex, need for extensive multidisciplinary approach with experienced doctors in their respective fields]]>
<![CDATA[CORRELATION OF KI67 LEVEL TO METASTATIC EVENTS IN NASOPHARYNGEAL CARCINOMA ]]>
<![CDATA[Eriza]]>;
<![CDATA[Kurnia, Ermalinda]]>;
<![CDATA[Utama, Denny Satria]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i2.4276
<![CDATA[Introduction Nasopharyngeal carcinoma (KNF) is a malignant squamous cell tumor occurring in the nasopharyngeal epithelial region where the cuboid epithelium is transformed into squamous cells. One of the typical signs of malignancy is uncontrolled cell proliferation. K67 is an immunohistochemical (IHC) test to assess cell proliferation activity. Increased Ki67 expression is associated with increased mitotic activity in cell proliferation. Objective To determine the correlation of ki67 expression to regional and distant metastases events of nasopharyngeal carcinoma at KNF in Dr. Mohammad Hoesin Palembang. Methods This cross-sectional study was conducted on 31 subjects of KNF patients who had been diagnosed in Oncology Division of Department of Ear Nose and Throat Head Neck Surgery, then performed immunohistochemistry inspection of KI67 in Department of Anatomical Pathology of Dr. Mohammad Hoesin Palembang. The subjects were collected consecutive sampling from October to December 2017 and performed other tests for staging such as computer tomography, chest x ray and abdominal ultrasound. Results In the Ki67 level correlation analysis of the incidence of metastasis in nasopharyngeal carcinoma, the correlation coefficient was 0.98 with very strong correlation strength and the positive correlation was not statistically significant (p=0.599). However, in Ki67 level correlation analysis of histopathology result of nasopharyngeal carcinoma was found correlation coefficient of 0.385 and positive correlation which was statistically significant (p=0.032). Conclusion Ki67 levels of metastatic occurrence in nasopharyngeal carcinoma have no statistically significant correlation. However, Ki67 level on histopathological results of nasopharyngeal carcinoma and Ki67 immunoreactivity with primary tumor has a statistically significant correlation.]]>
<![CDATA[Current Outcome of Adjuvant Platinum-Based Chemotherapy for Nasopharyngeal Carcinoma: A Systematic Review ]]>
<![CDATA[Namira Kesuma Jelita]]>;
<![CDATA[Marlinda Adham]]>;
<![CDATA[Saffanah Zahra]]>
<![CDATA[ INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 03 (2020): International Journal of Nasopharyngeal Carcinoma ]]>
Publisher : <![CDATA[TALENTA PUBLISHER ]]>
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DOI: 10.32734/ijnpc.v2i03.4301
<![CDATA[Introduction: Indonesia are among the top 5 countries with highest prevalence of NPC with a meta-analysis from 2018 stating prevalence as high as 13.084 cases. According to the latest guideline published by National Comprehensive Cancer Network (NCCN) in 2018. The main treatment for NPC remain radiotherapy, chemotherapy, and surgery. Induction or adjuvant chemotherapy place in treatment are still uncertain because variety of results from multiple clinical trial. Discussion: This review evaluates the current outcome of patient undergoing chemoradiotherapy with or without adjuvant chemotherapy and its usage in nasopharyngeal carcinoma patient. Search on online databases are performed with keywords including “nasopharyngeal carcinoma”, “chemotherapy”, “adjuvant” and “outcome” along with their synonyms. Studies in English from 2014-2019 are included. Quality assessment were done with Newcastle Ottawa Scale for Cohort studies and with CEBM for Randomized Controlled Trial Studies. Risk of bias assessed using Cochrane Method. A total of 7 studies were included in the final review with 1 RCT and 6 Cohort study. Most study have no significance in overall survival, progressive disease or distant metastasis free time, but differ in high stage and high risk patient. Three studies included toxicity as an outcome with adjuvant toxicity outweigh the need to add another round of chemotherapy. Conclusion: Adjuvant chemotherapy is believed to be necessary in eliminating residual cancer cells but current studies shows little improvement in overall survival and sometimes unbearable toxicities.]]>
