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Acta Chimica Asiana
Published by Universitas Mataram
ISSN : 2550049x     EISSN : 25500503     DOI : -
Core Subject : Science,
Chemistry
Acta Chimica Asiana (online ISSN 2550-0503, print ISSN 2550-049x) is a peer-reviewed, open access journal that publishes high-quality original research articles as well as review articles in all areas of Chemistry and Chemical Engineering. Significant finding that is insufficient to be presented as comprehensive paper but needs to reach the reader immediately may also be submitted as a short communication. The editors welcome original contributions that have not been published and are not under consideration elsewhere. This journal published by the Indonesian Chemical Society, Chapter Nusa Tenggara and the University of Mataram. All papers published free of charge. Upon request, language assistance may also be provided to ensure valuable works in chemistry meet their readers. Acta Chimica Asiana is a peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry, including applied chemistry, and chemical engineering. Subject areas include (but are by no means limited to): 1. Analytical chemistry, including new techniques and instrumentation 2. Biochemistry and medicinal chemistry 3. Inorganic chemistry, including main group, transition metal, and f-block compounds, as well as coordination, organometallic, and solid state chemistry 4. Materials chemistry of hard and soft matter, from the nanoscale upwards 5. Nuclear chemistry and radioactivity 6. Organic chemistry, including synthesis, characterization, and properties of organic compounds, as well as study of organic reactions and their mechanisms 7. Physical chemistry and chemical physics 8. Sustainable, green, and environmental chemistry 9. Theoretical and computational chemistry
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 12 Documents
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Search results for , issue "Vol. 8 No. 1 (2025)" : 12 Documents clear
Uji Efektivitas Mikrofilter Masker Berbasis Biopolimer Serat Selulosa Limbah Jerami Rofiqoh, Hazi; Ummah, Baiq Hizanatul; Hanafi, Imam Galih; Budhiartini, Baiq Nely; Murniati, Murniati; Chen, Chang-Nan
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.172

Abstract

Straw waste, which is often underutilized, contains abundant cellulose that holds potential as a raw material for environmentally friendly filtration technologies. The conversion of agricultural waste into value-added products, such as mask microfilters, aligns with the increasing demand for sustainable materials, particularly in the context of public health protection. Harnessing cellulose from straw offers a promising alternative to synthetic fibers commonly used in mask production, while simultaneously addressing waste management challenges. This study aims to determine the characterization of microfilter masks from straw waste and the effectiveness of straw microfilters used in cloth masks. Cellulose from straw waste can be used as a mask microfilter by going through several stages, such as: preparation, extraction, delignification, bleaching, characterization, and making mask microfilters and effectiveness tests. The characterization of structure, morphology and topology from the straw waste cellulose has not been fully degraded from lignin as shown from the aromatic C = C stretching vibrations on lignin at wave numbers 1638.34 cm-1, 1648 cm-1, and 1583.56 cm-1 of FTIR also SEM tools at 3600 times magnification. The effectiveness of the microfilter mask is 94% and 91%  as evidenced by each bacterial filtration test and the decreasing data of the dust filtration test.
Synthesis and characterization of 2,4,6-trihydroxy benzophenone and its activity as sunscreen Yuanita, Emmy; Rohmana, Ainni; Ulfa, Maria; Ningsih, Baiq Nila Sari; Sudirman, Sudirman; Dharmayani, Ni Komang Tri; Lestarini, Ima Arum; Septiyana, Maulida; Ratnasari, Baiq Desy
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.175

Abstract

Benzophenone was synthesized through a condensation reaction of benzoic acid and phloroglucinol with an Eaton reagent as a catalyst. The percentage of the product was 60%, and it was characterized using FTIR and 1H-NMR. The sunscreen activity was carried out using a UV-Vis spectrophotometer to calculate the SPF value. The synthesis result was made in several concentration variations: 100, 150, 200, 250, and 300 ppm to measure the SPF values. The results showed that the SPF values were 9.89, 13.39, 17.83, 23.77, and 28.26, respectively. Based on this, it can be concluded that these compounds have biological activity as sunscreen and samples of 200-300 ppm are included in the ultra-category as sunscreen.
Bentonite-chitosan bionanocomposite for adsorption of used lubricant oil: Bentonit-kitosan Siregar, Sri Hilma; Nurhaliza, Dwi; Ramadhanti, Aulia Rizki
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.220

Abstract

The growth of the transportation industry has led to the expansion of the automotive sector. Automotive business activities have the potential to cause several environmental problems, one of which is environmental pollution caused by used lubricating oil waste. One alternative effort to process lubricating oil waste is the adsorption method. This research aims to determine the ability or effectiveness of bentonite-chitosan composites in adsorbing waste lubricating oil. This research began by synthesizing Bentonite-Chitosan composites. The successfully synthesized material was then characterized using X-ray diffraction (XRD) and Fourier Transform Infra Red (FTIR) instruments. After that, it will be applied to used lubricating oil waste with variations in time and mass variations. The ability of the Bentonite-Chitosan composite to adsorb waste lubricating oil will be seen through the viscosity test results. The viscosity test results show a significant influence on the viscosity of the used lubricating oil. Meanwhile, the results of viscosity testing for mass variations show that the more bentonite-chitosan composite used, the greater the viscosity increase value. The highest viscosity value was obtained in the bentonite-chitosan composite of 15 g with a time of 5 hours at 7,75 cSt.
Screening, molecular docking and dynamic simulations of bioactive compounds from Prunus africana’s stem bark for potential prostate cancer inhibitors Odozi , Nnenna Winifred; Osi, Valentine
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.224

Abstract

Prostate cancer is a major health problem for men, with few effective treatment choices. The growing interest in plant-based medicines needs more research into their safety and efficacy. In this study, twenty-seven (27) phytochemicals found in Prunus africana stem bark are evaluated using in silico methodologies such as toxicological and virtual screening, molecular docking, and molecular dynamics simulations. The PASS server projected that twenty (20) of these chemicals had anticancer properties. Molecular docking studies revealed that four bioactive compounds—β-Sitosterol (-8.9 kcal/mol), Campesterol (-8.7 kcal/mol), Prunetrin (-8.7 kcal/mol), and Stigmastan-3,5-diene (-8.7 kcal/mol)—have higher binding affinities than Flutamide (-8.6 kcal/mol), a commonly androgen receptor inhibitor. Further molecular dynamics simulations indicated that these compounds have comparable or greater stability than Flutamide. These data indicate that Prunus africana-derived phytochemicals could be viable candidates for prostate cancer treatment, necessitating further experimental validation.
Biological degradation of aflatoxin by microbe and enzyme: a review Nasution, Musyirna; Suryono, Suryono; Awaluddin, Amir; Haryani, Yuli
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.230

Abstract

Aflatoxins, produced by fungi like Aspergillus flavus and Aspergillus parasiticus, pose significant threats to food safety, impacting human and animal health while causing economic losses. Detoxifying aflatoxins is crucial to reducing contamination in food and feed. Enzymes and microorganisms present an eco-friendly and efficient solution for this purpose. This review highlights their roles in detoxification, focusing on bacteria, yeasts, and fungi that can degrade or bind aflatoxins, thereby lowering toxicity. Enzymes such as laccase, peroxidase, and reductase facilitate detoxification through oxidative and hydrolytic degradation. The efficiency of these methods depends on factors like pH, substrate availability, and temperature. Understanding the interactions between enzymes, microorganisms, and aflatoxins is essential for optimizing detoxification strategies. While promising, further research is needed to enhance their application in food safety.
Exploration of secondary metabolite profile in the n-hexane fraction of Rhizophora mucronata, Avicennia marina, and Sonneratia alba Maziya, Raehanul; Permatasari, Lina; Deccati, Rizqa Fersiyana; Muliasari, Handa; Rahman, Fania; Annas, Zulfiana Fatianingrum; Sammanta, Rahula Vijja
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.231

Abstract

Indonesia is a maritime and archipelagic country with an ocean area of almost two-thirds of its total area, with a coastline stretching 99.123 km from Sabang to Merauke. According to Indonesian Law Number 1 of 2014, it is mentioned that one of the most important biological resources of the coast is mangroves. Some mangrove species commonly found on Lombok Island are Rhizophora mucronata, Sonneratia alba, and Avicennia marina. However, there has not been much exploration of the compound content in these mangroves. Therefore, this study aimed to identify the secondary metabolites of the n-hexane fraction of the three mangrove species using Gas Chromatography-Mass Spectrometry (GC-MS). The leaves of each mangrove species were extracted by sonication method using 96% ethanol solvent, followed by multistage fractionation using n-hexane and water. GC-MS analyzed the n-hexane fraction of each mangrove species. The GC-MS analysis revealed that in the n-hexane fraction of mangrove leaves Rhizophora mucronata and Avicennia marina there were 10 compounds, while Sonneratia alba obtained five compounds. The compounds with the highest intensity in the n-hexane fraction of mangrove leaves of Rhizophora mucronata, Sonneratia alba, and Avicennia marina were squalene (41.71%), ethyl oleate (87.53%), and ethyl oleate (44.02%), respectively. Squalene was reported to have antioxidant and anticancer activities. The ethyl oleate was reported to have bactericidal activity on gram-positive and negative bacteria. The three types of mangrove leaves can be an alternative source of medicine
NM-polynomial and neighborhood degree-based indices in graph theory: a study on non-kekulean benzenoid graphs Asghar, Adnan
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.232

Abstract

In this study, we explore the neighborhood degree sum-based topological indices of Non-Kekulean Benzenoid graphs Kn using graph theory and computational tools. The novelty of this work lies in the application of the neighborhood M-polynomial (NM-polynomial) to derive various topological indices, which provide deep insights into the structural properties of Non-Kekulean Benzenoid systems. We compute several indices, including the third version of the Zagreb index, neighborhood second Zagreb index, neighborhood forgotten topological index, and others, using edge partitioning and combinatorial methods. The results are graphically represented and compared using MATLAB and Maple, revealing significant relationships between the molecular topology and the computed indices. Our findings demonstrate that the ND3 index is the most dominant, while the  index increases more slowly compared to other indices. This study not only advances the understanding of Non-Kekulean Benzenoid graphs but also highlights the effectiveness of combining mathematical methodologies with computational tools for molecular structure analysis. The results contribute to the fields of graph theory and computational chemistry, offering a foundation for future research on diverse molecular structures.
Eco-friendly designing of zinc oxide nanoparticle as a potential semiconducting device for H2O-capture: a density functional theory study Mollaamin, Fatemeh
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.233

Abstract

We employ first-principles calculations to investigate the structural stability and electronic properties of zinc oxide (ZnO) nanocluster adsorbed with H2O molecule. A comprehensive investigation on H2O grabbing by ZnO nanocluster was carried out using DFT computations at the CAM–B3LYP–D3/6–311+G (d, p) level of theory. The hypothesis of the energy adsorption phenomenon was confirmed by density distributions of CDD, TDOS/PDOS/OPDOS, and ELF for ZnO and ZnO–H2O. A vaster jointed area engaged by an isosurface map for H/OH adsorption on ZnO surface towards formation of ZnO–H2O complex due to labeling atoms of O1, Zn15, O27, H29, H30. Therefore, it can be considered that zinc in the functionalized ZnO might have more impressive sensitivity for accepting the electrons in the process of H/OH adsorption. It is considerable that when all surface atoms of ZnO are coated by OH and H groups, the semiconducting behavior is recovered. Our results open up the possibility of tailoring the electronic properties by controlling the surface adsorption sites. The nanoclusters of bare ZnO and ZnO–H2O can be defined by ELF graphs owing to exploring their delocalization/localization characterizations of electrons and chemical bonds. The results indicate that the stability and the optical gap are related to the sizes and symmetries of the clusters. Further, it is shown that the structures have much greater impact on the optical gap, there is the dipole-forbidden transition in the optical gap for high symmetric structures.
Molecular docking study of catharanthus roseus compounds as potential ABL1 inhibitors for leukemia treatment Farid, Muhammad; Al Madury, Shalahuddin; Muslim, Ahmad Suriyadi; ‘Aini, Zakiyyah Qurrotul
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.235

Abstract

Leukemia is one type of cancer with a high mortality rate, caused by the proliferation of abnormal white blood cells that disrupt hematopoiesis function. Conventional therapies, such as chemotherapy and targeted therapy, often face challenges in the form of side effects and drug resistance. This study aims to evaluate the potential of Catharanthus roseus as a leukemia therapeutic agent through in silico. The docking process uses autodock, and ADMET prediction uses SwissADME and PKCMS. The study used the ABL1 protein (PDB ID: 4TWP) as a target with active compounds of Catharanthus roseus. The validation process of the docking method showed an RMSD value of 0.705 Å, indicating that the method used was valid. The results of the docking simulation showed that vindoline had the best affinity after native ligands with a binding energy of -8.64 kcal/mol, followed by catharanthine -6.16 kcal/mol and tryptophan -3.87 kcal/mol. ADMET prediction analysis showed that vindoline and catharanthine had promising pharmacokinetic and toxicity profiles, such as good blood-brain barrier (BBB) permeability and did not inhibit the CYP3A4 enzyme. These results indicate that vindoline and catharanthine are potential alternative leukemia treatments with high efficacy and low risk of side effects. This study provides a basis for further exploration of Catharanthus roseus in the development of effective and safe leukemia therapies.
Network pharmacology and molecular docking simulation uncovered the potential of hexacyclinic acid as anti-osteoarthritis by regulating IL-17 signaling pathway Setiawansyah, Arif
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.238

Abstract

Hexacyclinic acid has shown promising pharmacological activities, yet its molecular mechanisms and therapeutic potential remain largely unexplored. This study aimed to identify potential disease targets and elucidate the mechanism of action of hexacyclinic acid using an integrated computational approach. We employed network pharmacology analysis to predict potential targets and pathways of hexacyclinic acid using SuperPred and Swiss Target server, followed by protein-protein interaction network construction via STRING database. Pathway enrichment analysis was performed using ShyniGO and DAVID databases. Molecular docking studies were conducted using AutoDock Vina to evaluate binding affinities between hexacyclinic acid and identified target proteins. Binding poses and interactions were visualized using Biovia Discovery Studio Visualizer. Disease prediction analysis identified osteoarthritis as the most promising target, with the IL-17 signaling pathway emerging as the most significant KEGG pathway. TNF-α and IL-1β were identified as key molecular targets within this pathway. Molecular docking simulations corroborated these findings, revealing favorable binding energies between hexacyclinic acid and TNF-α (-8.62 kcal/mol) and IL-1β (-8.76 kcal/mol). These results suggest that hexacyclinic acid may exert its anti-osteoarthritis effects by modulating the IL-17 signaling pathway, particularly through interactions with TNF-α and IL-1β. The strong binding affinities observed indicate a potentially high efficacy of hexacyclinic acid in targeting these inflammatory mediators. These results have significant clinical implications, potentially leading to the development of new therapeutic strategies for osteoarthritis management with reduced side effects compared to current treatments. Future research should focus on experimental validation through in vitro and in vivo models to confirm these computational predictions and establish hexacyclinic acid as a viable candidate for clinical development

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