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3BIO: Journal of Biological Science, Technology and Management
Published by Institut Teknologi Bandung
ISSN : -     EISSN : 26558777     DOI : http://dx.doi.org/10.5614%2F3bio.2020.2.1
Core Subject : Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Neuroscience
3Bio: Journal of Biological Science, Technology and Management is an interdisciplinary peer-reviewed journal in a wide aspect related to the field of life sciences and other related fields of study. The journal aims to promote scientific discourse and disseminate research on various branches and applications of bio-science, biotechnology and bio-based management. This journal invites original empirical research, literature reviews, theoretical or methodological contributions, or short communications on, but not limited to, the following topics: - Ecology and Biosystematics - Microbiology - Genetics and Molecular Biology - Animal Development and Physiology - Plant Development and Physiology - Entomology - Biomedical science - Biochemistry - Agronomy - Forestry - Bioengineering - Bioethics - Management of Biological Resources The journal also invites contributions from other associated disciplines. This journal is an open-access journal. Readers may read, download, copy, distribute, print, search, or link to the full texts of these articles without any charge, provided that readers acknowledge the Creative Commons attached to the articles. All submitted papers are reviewed by at least two referees before being accepted for publication, following a double-blind review process. This journal is delivered in an academic English and rigorously edited to provide a quality standard of a scientific journal. This journal is managed by the School of Life Sciences and Technology, Institut Teknologi Bandung, Indonesia.
Arjuna Subject : Ilmu Pertanian dan Biologi (Semua) - Ilmu Pertanian dan Biologi (Lain-Lain)
Articles 7 Documents
 1 
Search results for , issue "Vol. 4 No. 1 (2022)" : 7 Documents clear
Wheatgrass microgreen with high antioxidants content in an urban indoor farming system Myrea Chalil; Karlia Meitha; Ramadhani Eka Putra; Fathia Aulia Rahmah; Ridho R Sinatra; Anindha Ajeng Putri Winanta
3BIO: Journal of Biological Science, Technology and Management Vol. 4 No. 1 (2022)
Publisher : School of Life Sciences and Technology, Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/3bio.2022.4.1.4

Abstract

Urban lifestyle is identical to stressful life and sedentary habit, leading to the increase of chronic conditions such as diabetes and cardiovascular-related diseases. Antioxidants are renowned for maintaining cellular function by quenching radicals produced in stressful conditions or infection. Fresh fruits and vegetables are the primary sources of antioxidants, but the long postharvest and transport system may reduce the benefits for the urban population. Hence, we designed a cultivation method to produce wheatgrass microgreens with high antioxidants in an urban indoor farming system. Generally, plants require light at the wavelength of 663 and 642 nm (red) and 430 nm and 453 nm (blue) to allow photosynthesis and production of secondary metabolites, such as antioxidants. We applied the LED lights with an RGB ratio of 91R/9B, 83R/17B, 47R/53B, 35R/65B, and white florescent as the control. Our results showed that 91R/9B reduced fresh mass and chlorophyll content, which might be due to the suppression of photosynthesis capacity. Interestingly, we found a significant (p<0.05) increase in carotenoids and flavonoid contents due to light combinations of 35R/65B and 83R/17B, respectively. However, the total antioxidants capacity was similar among all treatments. Carotenoids and flavonoids are among the antioxidants with a significant role in decreasing the risks of chronic diseases and their potential as antiviral agents. This cultivation system of wheat microgreen could be a promising solution to routinely supply carotenoids and flavonoids to the urban population. Further, it is also considered more environmentally friendly as it could be performed in a limited amount of land (vertically) and potentially use less energy for distribution.
Autosterilization Effect of Gamma Radiation in Non-sterile Radiopharmaceuticals Widyastuti Widjaksana; Enny Lestari; Maskur Maskur; Sudarsih Sudarsih
3BIO: Journal of Biological Science, Technology and Management Vol. 4 No. 1 (2022)
Publisher : School of Life Sciences and Technology, Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/3bio.2022.4.1.3

Abstract

Gamma radiation is commonly used in sterilizing various products because of its microbial-killing property. Several radiopharmaceuticals are processed aseptically, which requires a well-managed GMP-based facility. This study aims to ensure that radiopharmaceutical can behave as an auto sterilizing agent since it contains radionuclide that emits gamma radiation. Sm-153-ethylenediaminetetramethylenephosphonate (Sm-153-EDTMP) and I-131-Hippuran were used as models in this study, in which various radioactivities of these products were added into non-sterile vials in the non-aseptic working area and tested for sterility using direct inoculation method. The result showed that samples containing 7 mCi of Sm-153-EDTMP and less than 2 mCi of I-131-orthoiodohippurate (I-131-Hippuran) changed the clarity of the media, but not for those containing higher radioactivity. The results showed that Sm-153-EDTMP and I-131-Hippuran at certain radioactivity can auto sterilize themselves, whereas the positive control sample and the products diluted with non-sterile water remained unsterile. This study showed that radiopharmaceuticals have auto sterilizing properties at relatively low radioactivity, depending on the products’ bioburden. Therefore, the usual aseptic preparation of some radiopharmaceuticals can be considered terminal sterilization.
Heterologous Production of Human Papillomavirus L1 Capsid Protein: Systematic Review and Meta-analysis Andre Hendrawan; Azzania Fibriani
3BIO: Journal of Biological Science, Technology and Management Vol. 4 No. 1 (2022)
Publisher : School of Life Sciences and Technology, Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/3bio.2022.4.1.5

Abstract

The coverage of HPV vaccination in Indonesia remains low due to the high-cost vaccination. The vaccine prices were affected by the production rate of L1, the active substance of HPV vaccines. L1 has been produced using various organisms with varying L1 production rates and immunogenicity. A systematic review and meta-analysis were conducted to determine the organism producing L1 with the highest production, treatments affecting the L1 expression rate, and immunogenicity (represented by anti-L1 IgG titer in mice). The data of L1 titer, induction period, and IgG titer were extracted from 19 articles that have passed the articles screening. The L1 titer and induction period data were used to calculate the L1 production rate, while the IgG titer was used in the immunogenicity analysis. On a 95% confidence level, the meta-analysis revealed weak evidence that E. coli produced L1 at the highest rate. The highest IgG titer was induced using L1 expressed in Saccharomyces cerevisiae, albeit insufficient evidence on 95% confidence level. Pearson’s correlation analysis showed that the concentration of glucose, IPTG, NH4+, K+, Ca2+, Mn2+, Fe2+, Zn2+, B4O72−, H2PO4−, HPO42−, Mo7O246−, and citric acid had a positive correlation with L1 production rate in E. coli. The treatment injection doses positively correlated with IgG titer in S. cerevisiae. This study reveals the mineral salts as the potential treatments to increase L1 production rates.
Estimation of Minimum Viable Population of Long-tailed Macaques (Macaca fascicularis Raffles 1821) in Support of Wildlife Management in Ir. H. Djuanda Grand Forest Park Hatta Vrazila; Elham Sumarga; Hikmat Ramdan
3BIO: Journal of Biological Science, Technology and Management Vol. 4 No. 1 (2022)
Publisher : School of Life Sciences and Technology, Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/3bio.2022.4.1.2

Abstract

Most long-tailed macaques (LTMs) in Southeast Asia are commensal animals, which means they can coexist and benefit from humans. This interaction potentially triggers disturbance and disease transmission caused by LTMs, for instance, in Ir. Djuanda Grand Forest Park (GFP). A previous study indicates an overpopulation of LTMs in this area. The need for population control of this macaque requires appropriate ecological considerations, including determining the minimum viable population (MVP). This study aims to estimate the MVP of LTMs in Ir. Djuanda GFP area is the key input for its population control scheme. The MVP is determined based on population growth simulation using the Lefkovitch matrix. In combination with the estimate of population growth, the MVP was used to formulate the population control scheme of LTMs, by considering the current wildlife management regulations and the perception of Ir. Djuanda GFP area manager obtained through interviews. This study found six groups of LTMs in Ir. Djuanda GFP with a total population of 229 individuals, a sex ratio of 1:1.05, an age class ratio of infants, juveniles, sub-adults, and adults of 16.6%:25.7%:32,3%:25.3%, and a population growth rate of 19.7%/year. The estimate of MVP of this primate is 230 individuals, with an average group size of 38 individuals and an age class ratio of infants, juveniles, sub-adults, and adults 30%:9.1%:27.4%:23.5%. Based on wildlife management regulations and area manager perceptions, population control schemes can be implemented for relocation and captive purposes. The population control scheme consists of an age-class control scheme and a group control scheme. The age-class control scheme controls the population by 334 individuals, while the colony control scheme controls 406 individuals.
Preliminary Economic Potential Evaluation of Seaweed Gracilaria sp. Biomass Waste as Bioindustry Feedstock Through a Biorefinery Approach: A Case Study in Karawang, Indonesia Muhammad Fadhlullah; Sukma Budi Prasetyati; Imam Pudoli; Calvin Lo
3BIO: Journal of Biological Science, Technology and Management Vol. 4 No. 1 (2022)
Publisher : School of Life Sciences and Technology, Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/3bio.2022.4.1.6

Abstract

Seaweed processing usually produces biomass waste from unused and rejected materials, which have economic potential due to their bioactive components. This preliminary study aims to evaluate the economic potential of seaweed biomass waste through a biorefinery approach. Seaweed Gracilaria sp. biomass waste samples were collected from a representative seaweed production unit in Karawang, Indonesia, and their biochemical composition was analyzed. Relevant information related to seaweed biomass waste was gathered. The preliminary economic evaluation was assessed from the gross revenue of the proposed products, based on the assumed annual seaweed biomass waste productivity, biochemical composition, and estimated market price of the products. The present study revealed that the dry weight of Gracilaria sp. biomass waste contains 63.2% carbohydrates, 13.6% proteins, 1.6% lipids, and 21.5% ashes. Heavy metals were detected in the biomass waste, although no pigments were detected. This study estimates that 52 metric tons/year of Gracilaria sp. biomass waste could generate amino acids, fatty acids, lipids, carbohydrates, and minerals with potential gross revenue of ± USD 222,924.6/year. This study suggests that Gracilaria sp. biomass waste could be potentially used as feedstock to improve its economic value for bioindustry purposes.  
Effects of Leaf Storage and Distillation Time on the Quality of Eucalyptus (Eucalyptus grandis) Essential Oil Setiawan Setiawan; Annisa Nadhilah; Rita P Ilhamsari
3BIO: Journal of Biological Science, Technology and Management Vol. 4 No. 1 (2022)
Publisher : School of Life Sciences and Technology, Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/3bio.2022.4.1.1

Abstract

Essential oils such as eucalyptus oil are widely used as antioxidants, antimicrobial, anti-inflammatory, fragrance, and other medical needs. This oil is extracted from eucalyptus terpenoid compounds, e.g., cineole. This study aims to evaluate the effect of the leaf storage time and distillation time (DT) on Eucalyptus grandis essential oil yield and quality. Three DT treatments (i.e., 2 h, 3 h, and 4 h) and storage time of eucalyptus leaf in warehouse (i.e., 2 h, 3 h, and 4 h) were applied on eucalyptus leaf samples. The quality of the eucalyptus essential oil was determined using cineole content, solubility in alcohol, and optical rotation. The essential oil yield ranges between 0.165-0.220%, with the maximum yield of 0.220% on 3 days of storage and 4-hour distillation time. The cineole content ranged between 10-30% and the highest at 3 h DT with a storage time of 2 days. The optical rotation on the tested specimen showed that the index of refraction produced in oil projections was positive. The samples in all treatments showed high solubility in alcohol. This study showed that storage time of 3 days and 3-hour distillation time resulted in the most optimal eucalyptus essential oil yield, and the excellent quality of oil produced has a high potential for health product applications.
Correlation of Microclimate of West Java on Caffeine and Chlorogenic acid in Coffea canephora var. robusta Suci Awaliyah; Sri Nanan B. Widiyanto; Rijanti R. Maulani; Asep Hidayat; Ujang Dinar Husyari; Tati Suryati Syamsudin; Erly Marwani
3BIO: Journal of Biological Science, Technology and Management Vol. 4 No. 1 (2022)
Publisher : School of Life Sciences and Technology, Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/3bio.2022.4.1.7

Abstract

Caffeine and chlorogenic acid (CGA) are two compounds that play a role in determining the quality of coffee. The amount of the two compounds may vary depending on the environment where they are grown. This study aimed to determine the correlation between the local microclimatic condition and the concentration of caffeine and CGA in green and roasted beans of Robusta coffee from six different cultivation areas in West Java, Indonesia (i.e., Ciamis, Tasikmalaya, Sumedang, Kuningan, Cianjur, and Bogor). Samples of green beans and roasted beans were extracted with 70% methanol for caffeine analysis and ethyl acetate for CGA analysis. Caffeine and CGA were analyzed by UV-HPLC using a C18 shimpack gist shimadzu column, with an isocratic elution of methanol:water (1:1) at a 1 mL/min flow rate. Detection was performed at  λ272 nm and λ324 nm for caffeine and chlorogenic acid, respectively. Principal component analysis (PCA) was used to evaluate the correlation between microclimate with caffeine and chlorogenic acid. Results indicated that the concentration of caffeine ranged from 7.67 to 16.52% and 10.79 to 15.56% in the green and roasted bean coffee, respectively. The concentration of CGA ranged from 0.74 to 3.03% and 0.25 to 0.77% in the green and roasted bean coffee, respectively. Based on PCA analysis, the most influential microclimate on the caffeine concentration were the humidity, temperature, and altitude, with the total variance of PC1 and PC2 of  76.3%. However, there was no positive correlation between the measured microclimate and the CGA concentration. In conclusion, Robusta coffee's caffeine content is positively affected by the microclimatic condition (i.e., humidity, temperature, and altitude).

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