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Yudi Her Oktaviono
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Jl. Mayjen. Prof. Dr. Moestopo No. 6-8, Surabaya
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Cardiovascular and Cardiometabolic Journal (CCJ)
Published by Universitas Airlangga
ISSN : 27466930     EISSN : 27223582     DOI : 10.20473/ccj.v1i2.2020.31-37
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
- Adult cardiac surgery - Atherosclerosis - Cardiac imaging - Cardiac prevention - Cardiac rehabilitation - Cardiomyopathy - Cardiovascular immunology and infection - Congenital heart disease - Diabetes mellitus - Dyslipidaemia - Electrophysiological heart disease and arrhythmias - Extracorporeal circulation and cardiac perfusion - Heart failure - Hypertension and hypertensive heart disease - Ischaemic heart disease and coronary artery disease - Metabolic disorders and its linked to cardiovascular diseases - Pediatric cardiac surgery - Pericarditis and pericardial disease - Reactive oxygen species - Rheumatic valvular disease - Vascular disease
Arjuna Subject : Kedokteran - Cardiology and Cardiovascular Medicine
Articles 82 Documents
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Potential Biomarkers as Early Detection of Diabetic Cardiomyopathy Hariadi Hariadi; Maia Thalia Giani; Silvia Handika Anggraeni
Cardiovascular and Cardiometabolic Journal Vol. 2 No. 2 (2021): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v2i2.2021.95-109

Abstract

Diabetes mellitus (DM) is one of the most prevalent and burdensome among chronic disease worldwide. Its complications accelerate mortality rate within population. Diabetic cardiomyopathy (DCM) is one of diabetes macrovascular complications, which symptoms are frequently unforeseen. Advances in pathogenesis understanding DCM underlying mechanisms remain not fully perceived. Current diagnostic approach of DCM can hardly determine diabetic patients with asymptomatic cardiomyopathy. Previous studies suggested biomarkers might detect early stage DCM. There are numerous selective biomarkers representing several pathophysiological pathways, such as myocardial fibrosis, inflammatory response, cardiomyocyte apoptosis, and metabolic dysregulation in the development of diabetic heart anomaly  It was also reported those biomarkers are useful for the prognostic assessment of the disease. However, not all biomarkers are cardiac specific and can be an auspicious diagnostic tool candidate. Recent studies show that there are certain biomarkers, such as microRNA, H-FABP, IGFBP7, and some other novel cardiac biomarkers were more specifically associated with the pathological mechanism of DCM. In this review, we aimed to discuss the role of several potential cardiac biomarkers as early detection in DCM that may predict future incident of DCM, and contribute to improving mortality prediction in patients with subclinical DCM.   Keywords: Biomarker, Cardiomyocyte, Diabetic Cardiomyopathy, Diastolic
Profile of Major Risk Factors in Acute Coronary Syndrome (ACS) at Pusat Pelayanan Jantung Terpadu (PPJT) Dr. Soetomo Public Hospital Surabaya Between the Period of January-December 2019 Ikhsanuddin Qothi; Muhamad Robi’ul Fuadi; Agus Subagjo
Cardiovascular and Cardiometabolic Journal Vol. 2 No. 2 (2021): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v2i2.2021.59-72

Abstract

Background: Coronary heart disease (CHD) is a leading cause of death worldwide. One type of CHD that most often causes clinical manifestations and death is Acute Coronary Syndrome (ACS). In 2013 the prevalence of SKA in Indonesia reached 1.5% and it is estimated that it will continue to increase every year. Objective: This study aims to determine the profile of major risk factors for ACS sufferers in the Pusat Pelayanan Jantung Terpadu (PPJT) Dr. Soetomo Public Hospital Surabaya in the period January-December 2019. Methods: This study used a retrospective descriptive method to analyze the patient's electronic medical record (e-MR). Results: Out of 623 patients diagnosed with ACS, 429 were excluded from the research. 194 patients who met the inclusion criteria were studied with the following details: 19 APTS patients, 43 N-STEMI patients, and 132 STEMI patients. It was found that 73% of ACS patients were male, with the 55-64 years’ age group dominating by 46%. Based on blood pressure and serum cholesterol examination data, it was found that 51% of patients had hypertension and 77% of patients had dyslipidemia (40% hypercholesterolemia, 42% hypertriglyceridemia, 40% low HDL-C levels, and 34% high LDL-C levels). 60% patients had type-2 diabetes mellitus and 52% of patients had a history of smoking. Conclusion: 73% of ACS patients in this study were men. Most common age groups were 55-64 years old (46%), had hypertension by 51%, had dyslipidemia by 77% (40% hypercholesterolemia, 42% hypertriglyceridemia, 40% low HDL-C levels, 34% high LDL-C), had type-2 diabetes mellitus by 60%, and had a smoking history by 52%.
Correlation Between Bioelectrical Impedance Analysis-Measured Body Fat, Body Mass Index and Waist Circumference with Cardiovascular Risk Factors in Acute Coronary Syndrome Patients Imam Mahbub Zam Zami; Budi Susetyo Pikir
Cardiovascular and Cardiometabolic Journal Vol. 2 No. 2 (2021): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v2i2.2021.50-58

Abstract

Estimation of fat using bioelectrical impedance analysis (BIA) is thought to be a more predictive measure of cardiovascular (CV) risk assessment than body mass index (BMI) or waist circumference (WC). Percent body fat as measured using BIA (BIA-BF%) is independently associated with future cardiovascular events namely acute myocardial infarction, ischemic heart disease. This study is conducted to determine the correlation between body fat which consists of BIA-BF%, percentage of subcutaneous adipose tissue (SAT) and visceral fat level (Visceral Adipose Tissue/VAT) measured using BIA device, BMI and WC with CV risk factors (blood pressure, blood glucose level, LDL, HDL, TG, total cholesterol, HbA1c and serum fibrinogen) in patients with acute coronary syndrome (ACS). Material and Methods : This study used a cross-sectional correlation analysis. Sample was 70 ACS patients that match with inclusion criteria. Results : We found significant correlations between BIA-BF% with diastolic blood pressure, TG, and total cholesterol (r = 0.246, r = 0.250, r = 0.348 respectively; p <0.05). There was a significant correlation between VAT with diastolic blood pressure, LDL, TG, total cholesterol, HbA1c, and fibrinogen (r = 0.299, r = 0.306, r = 0.278, r = 0.265, r = 0.292, r = 0.330 respectively, p <0.05). There was a significant correlation between the percentage SAT and HDL levels (r = 0.318; p <0.05). We found no correlation between BMI and WC with blood pressure, LDL, HDL, TG, blood glucose, HbA1c and fibrinogen levels in ACS patients. Conclusion: VAT and BIA-BF% correlate with several cardiovascular risk factors better than BMI and WC. Body fat examination using BIA may be done to manage risk factors in ACS patients.
A Case of Malignant Course of Right Coronary Artery: Frequent Angina in Young Person Sidhi Laksono Purwowiyoto; Steven Philip Surya
Cardiovascular and Cardiometabolic Journal Vol. 2 No. 2 (2021): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v2i2.2021.90-94

Abstract

Congenital anomalous coronary artery is a rare condition, but it might be the biggest pitfall for cardiologist. It might be silent until the patient reach young adult and has high intensity activity. Symptomatic anomalous course of coronary artery has wide spectrum from asymptomatic until the lethal one. We present a case of young adult with activity-triggered atypical chest pain and diagnose with anomalous origin of right coronary artery (RCA) from the left coronary sinus with inter-arterial course between the aorta and the main pulmonary artery that was detected by CT coronary angiography. This anomaly has been called malignant course RCA. Coronary artery anomaly is a congenital condition. Most of the cases are remain asymptomatic. This condition also one of the most cause for sudden cardiac death because the coronary artery examination is not regularly done. Nevertheless, during high intense activity, it will be symptomatic and might be lethal. Diagnose coronary artery anomalies might be tricky and cardiologist must be aware with this. More devastating, no firm guideline in treatment of right anomalous coronary artery from opposite sinus. Keywords: Chest Pain, CT Coronary Angiography, Malignant RCA
Infective Endocarditis: A Case with Prolonged Fever Maulia Prismadani; Agus Subagjo
Cardiovascular and Cardiometabolic Journal Vol. 2 No. 2 (2021): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v2i2.2021.84-89

Abstract

Infective endocarditis (IE) is associated with a high rate of mortality and morbidity in patients with anomalies of heart valves. We present a case of a 23-year-old male known to have severe mitral regurgitation (MR) with a history of prolonged fever for 5 months. According to The Modified Duke Criteria, clinical sign and symptoms fulfilled one major criterion (echocardiography finding of vegetation on mitral valve) and three minor (fever of at least 380 Celsius, valvular heart disease as a predisposing heart condition, and positive blood culture for Lactococcus sp. and Pediococcus sp.) considered as definite IE. Fever is one of the most common symptoms of IE (>90% of cases). Patient with prolonged fever and structural abnormality of heart valve should be considered for acute or subacute of IE. Establishing an diagnosis of IE and appropriate antibiotic therapy will improve the patient's clinical condition, and reduce morbidity and mortality. Keywords: Infective endocarditis (IE), Prolonged fever
Case Presentation - Biventricular Hypertrophy and Valvular Pulmonary Stenosis in Adult Patient with Noonan Syndrome: A Rare Case Tinton Pristianto; Rosi Amrilla Fagi
Cardiovascular and Cardiometabolic Journal Vol. 2 No. 2 (2021): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v2i2.2021.77-83

Abstract

Introduction: Noonan syndrome (NS) is a genetic disorder often accompanied by multiple congenital abnormalities. The prevalence of NS at live birth has been reported as one in 1000-2500 individuals. About 80% of patients with Noonan syndrome have abnormalities in the cardiovascular system. Case presentation:41-year-old Javanese male presented with chief complaint shortness of breath.  His Body Mass Index (BMI) was 18,3. He had an oval-shaped face with a short neck, thin hair, and prominent nasolabial fold. Echocardiography showed biventricular hypertrophy alongside pulmonary valve stenosis, pulmonary regurgitation and minimal pericardial effusion. Discussion: In 1962, Jacqueline Noonan, a pediatric cardiologist, identified 9 patients whose faces were very similar, had short stature, significant chest deformities, and with pulmonary stenosis. Noonan syndrome is a relatively common non-chromosomal syndrome that is similar to the phenotype of Turner's syndrome and presents with cardiovascular malformations. Adult with NS has distinctive facial features such as ptosis, wide eyes, low posterior rotation of ears and helical thickening, and a wide neck.Pulmonary stenosis is the most common heartdefect found in NS, besides HCM isalsoquitecommon inabout20% of patients. We reported a case of a patient with typical characteristics of NS such as pulmonary valve stenosis accompanied by biventricular ventricular hypertrophyand its typical face who survived through adulthood. Conclusion: Syndrome Noonan in the adult is quite rare and difficult to diagnose. We reported a case of an adult man with facial appearance and echocardiographic findings identical with Noonan Syndrome. Keywords: Adult, Biventricular hypertrophy, Noonan Syndrome, Pulmonary valve stenosis
The Exacerbation of Lutembatcher Syndrome in The Setting of COVID-19 infection: A Rare Case Report Adriyawan Widya Nugraha; Yusuf Azmi; Terrence T. E. Lusida; Lisca Namretta; Nida A. Suyani; Fitriyani S. Laitupa
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 1 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i1.2022.22-31

Abstract

Lutembatcher syndrome is a rare cardiac condition characterized by a combination of the atrial septal defect (ASD; congenital or iatrogenic) and mitral stenosis (MS; congenital or acquired). Patients with Lutembatcher syndrome and adults with congenital heart disease (ACHD) in general may be at high risk when accompanied by coronavirus disease 2019 (COVID-19). Since there is no published study on the impact of COVID-19 on ACHD, little is known about management strategies in this subset of patients. Herein, we report a young adult female presented with abdominal discomfort, swollen legs, fever, cough, and dyspnea. The patient had developed palpitation and exercise intolerance five years ago but paid it no attention. Echocardiography revealed large secundum type ASD with severe MS (Wilkins score of eight) and a nasopharyngeal swab confirmed SARS-COV-2 infection. The patient was diagnosed with Lutembacher syndrome and COVID-19. Intensive treatment was given to relieve symptoms due to heart failure and to treat COVID-19 pneumonia. Patients with Lutembatcher syndrome are at a higher risk of being infected with COVID-19 and manifest into severe infections. Therefore, determining the risk of infection and the severity of COVID-19 in ACHD patients are required during the pandemic. Keywords: Adults with congenital heart disease, Coronavirus disease 2019, Lutembacher
Simultaneous Transcatheter Pulmonary Balloon Valvuloplasty and Atrial Septal Defect Closure in Adult Patient Deasy Eka Wardhani; Eka Prasetya Budi Mulia; Dita Aulia Rachmi
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 1 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i1.2022.32-39

Abstract

Background: Percutaneous pulmonary balloon valvuloplasty (PBV) has become the first choice of management in patients with valvular pulmonary stenosis, while transcatheter closure in secundum atrial septal defect (ASD) is an alternative therapy besides surgical closure. The combination of PBV and transcatheter ASD closure is an action that is possible to do, but rarely done. Case Illustration: We present a case of 26-year-old woman with severe pulmonary stenosis and secundum ASD.  Echocardiographic examination revealed the presence of severe pulmonary stenosis (mean gradient 99.19 mmHg) and defects in the intra atrial septum (with a size of 1.3 cm). Cardiac catheterization revealed right ventricular pressure of 160 mmHg. This patient then successfully corrected with both procedures ASD closure and PBV simultaneously.  Discussion: These procedures have high feasibility, good safety, and shows good effectiveness. There were no complications during the procedures, and a satisfying immediate outcome was obtained. Conclusion: Pulmonary stenosis and atrial septal defects are rare forms of congenital heart disease. Transcatheter pulmonary balloon valvuloplasty and atrial septal defect closure performed simultaneously are promising alternatives, apart from surgical correction. Keywords: Atrial septal defect closure, Percutaneous pulmonary balloon valvuloplasty, Pulmonary stenosis
Doubly Committed Subarterial Ventricular Septal Defect Coexisted with Ruptured Aneurysm of The Right Sinus Valsava Irma Maghfirah; Rochmad Romdoni
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 1 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i1.2022.40-45

Abstract

Sinus of Valsalva aneurysms (SVAs) are uncommon cardiac abnormalities and most of them are in congenital origin. Some patients may have SVAs that concomitant with ventricular septal defect (VSD). Here, we reported case of a 37-year-old male presented with worsening exertional dyspnoea. Thrills and loud continuous murmur along the left sternal border were discovered during physical examination. Echocardiogram displayed ruptured sinus of valsalva aneurysm to the right ventricle along with supracristal ventricular septal defect (VSD). The patient underwent surgical correction with patch repair and aortic valve replacement. Most cases of SVAs were originated from right coronary sinus. They usually ruptured into right ventricle. Ventricular septal defects often coexisted with this condition. Echocardiography provided a complete evaluation of such cases and prohibited missed diagnosis of other coexistent congenital heart defects. Keywords: Aneurysm of sinus Valsalva, Ventricular septal defect
Clinical Characteristics and Profile of Heart Failure Patients at dr. Ramelan Navy Hospital in 2020 I Kadek Herry Hermawan; Ken Christian Kawilarang; Febriyanti Hartono
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 1 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i1.2022.9-14

Abstract

Background: Heart failure (HF) is a global pandemic affecting at least 26 million people worldwide and is increasing in prevalence. It has been associated with a high rate of readmissions and prolonged hospitalizations. There were few publications in Indonesia that described the characteristics and length of hospital stay of heart failure patients. Aims: To obtain data and describe the clinical characteristics and profile of heart failure patients hospitalized at dr. Ramelan Navy Hospital in 2020. Methods and Results: A cross sectional study was done using secondary data from patients’ medical records in dr. Ramelan Navy Hospital admitted during 2020. Data were then calculated and presented further. Based on the medical records, 121 heart failure patients were included in the study. Median age was 56 years old, 58,7% were men. Median length of stay was 6 days for all patients. 51.2% patients admitted to hospital with NYHA FC III. When patients were admitted to hospital, median systolic blood pressure was 124 mmHg and pulse was 91 beats per minute. Peripheral edema was shown in 67,8% of patients, hypertension in 49,6%, diabetes mellitus in 24,8%, ischemic heart disease in 52,9%. 6.6% of total patients treated in hospital died. Conclusion: Median length of stay for heart failure patients at dr. Ramelan Navy Hospital was 6 days. Most patients were men with median age of 56 years old. Keywords: Clinical characteristic, Demographic, Heart failure

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