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All Journal Folia Medica Indonesiana Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Indonesian Journal of Cardiology Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Cardiovascular and Cardiometabolic Journal (CCJ) Journal of Global Pharma Technology
Budi Susetyo Pikir
Departemen Kardiologi Dan Kedokteran Vaskuler, Fakultas Kedokteran –RSUD Dr. Soetomo. Kelompok Peneliti Sel Punca – Institut Penyakit Tropik, Universitas Airlangga, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Correlations between Total Antioxidant Capacity and 8-Hydroxydeoxyguanosine with Carotid-Femoral Pulse Wave Velocity in Chronic Kidney Disease Mochammad Yusuf Alsagaff; Budi Susetyo Pikir; Mochammad Thaha; Hendri Susilo
The Indonesian Biomedical Journal Vol 12, No 3 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i3.1241

Abstract

BACKGROUND: Chronic kidney disease (CKD) is often associated with an increased risk of cardiovascular disease. Cardiovascular disease in CKD can be affected by oxidative stress and inflammation. The oxidative stress can affect arterial stiffness, especially in patients with CKD, which will increase the risk of cardiovascular disease. This study aimed to explain the correlation between total antioxidant capacity (TAC) and 8-hydroxydeoxyguanosine (8-OHdG) with carotid-femoral pulse wave velocity (cf-PWV) in patients with CKD.METHODS: Forty-three CKD patients was included in this cross-sectional study. TAC was measured from serum samples by colorimetric method and 8-OHDG was measured from urine by enzyme-linked immunoassay method. cf-PWV was measured by Doppler ultrasound as a diagnostic tool for arterial stiffness.RESULTS: Significant correlations were found between age, estimated glomerular filtration rate (e-GFR), Hemoglobin A1C (HbA1C), serum creatinine, cystatin-C, and severity of CKD with urinary 8-OHdG levels. Serum creatinine, cystatin-C, severity of CKD, age, high-density lipoprotein (HDL), e-GFR, and HbA1C also had significant correlations with serum TAC levels. Other significant correlations between e-GFR, HbA1C, serum creatinine, cystatin-C, and severity of CKD with cf-PWV were also obtained. A significant negative correlation was obtained between serum TAC and cf-PWV with moderate levels of correlation coefficient (r=-0.504).CONCLUSION: There was a negative correlation between TAC and cf-PWV, but there was no significant correlation between 8-OHdG and cf-PWV in patients with CKD.KEYWORDS: chronic kidney disease, total antioxidant capacity, 8-hydroxydeoxyguanosine, carotid-femoral pulse wave velocity
Estimasi Tekanan Atrium Budi Susetyo Pikir
Jurnal Kardiologi Indonesia Vol. 31, No. 1 Januari - April 2010
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v31i1.152

Abstract

Ekokardiografi alat yang serbaguna dengan ketersedia-an dan mobililitas yang tinggi dapat digunakan pada penderita dengan keadaan gawat dengan nilai diagnosis yang cukup tinggi. Pada penelitian Hanifah dkk dibandingkan penilaian parameter diastolik (E/Ea, E/E’ atau E/e) secara non-invasif dan pemeriksaan CVP secara invasif. Pada penelitian seperti ini cara pengambilan sampel yang mudah ialah dengan purposive sampling yang dapat secara judgementatau quota. Cara terakhir yang sering digunakan dibidang kedokteran, setelah memenuhi kuota tertentu yang cukup secara statistik dengan memperhatikan kriteria inklusi dan eksklusi, penelitian diakhiri biasanya dengan pernyataan misalnya penelitian dilakukan antara periode September – November 2009 seperti pada penelitian ini.
Hipertensi Pulmonalis Resisten Pasca Peniupan Balon pada Stenosis Mitral Budi Susetyo Pikir
Jurnal Kardiologi Indonesia Vol. 29, No. 3 September - Desember 2008
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v29i3.183

Abstract

Hipertensi Pulmonalis (Arterial) yang terjadi pada Stenosis Mitral termasuk kelompok Hipertensi Pulmonalis Arterial Sekunder akibat adanya Hipertensi Pulmonalis Venous Pasif yang dapat disebabkan berbagai penyakit yaitu antara lain trombosis vena pulmonalis dan bermacam kelainan Jantung Kiri termasuk Penyakit Katub Mitral dan katub Aorta.Dengan koreksi Stenosis Mitral (dengan peniupan balon atau pembedahan) diharapkan terjadi pe-nurunan Hipertensi Pulmonalis Arterial tersebut. Tetapi kenyataannya tidak semua penderita mengalami penurunan tekanan darah arteri pulmonalis. Pada Penelitian Irwan dkk. sekitar 21.1 % penderita masih terdapat Hipertensi Pulmonalis berat. Hal ini mudah dipahami bahwa Hipertensi Pulmonalis apapun sebabnya akhirnya akan terjadi perubahan patologi arteria pulmonalis.Pada Penyakit Jantung Bawaan (PDA, VSD besar, ASD Besar) dapat terjadi pada dekade 1 sampai ke-3 yang akhirnya menjadi Sindroma Eisenmenger. Heath dan Edwards membuat klasifikasi perubahan patologi menjadi 6 derajat. Pada Hipertensi Pulmonalis Arterial karena penyakit Mitral pun dapat mengalami perubahan patologi.
Gene Expression of SOX2, OCT4, and Nanog by Small Molecule Compound VC6TFZ on Peripheral Blood Mononuclear Cell Rizka Amalia; Budi Susetyo Pikir; Andrianto Andrianto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1759

Abstract

Peripheral blood mononuclear cells are a potential source of cells to be induced into pluripotent stem cells because the collection procedure is easy, minimally invasive, and can be stored in a frozen form. Small molecule compound VC6TFZ consisting of valproic acid (VPA), CHIR990210 (CHIR), 616452, Tranylcypromine, Farsokline, 3-deazaneplanocin (DZnep) and TTNPB has been shown to induce pluripotency in mouse fibroblasts, but this has not been proven in peripheral blood cells. This chemical reprogramming strategy has the potential to be used in producing the desired functional cell types for clinical applications. This study aims to determine whether the small molecule compound VC6TFZ can induce pluripotency of peripheral blood mononuclear cells to become induced pluripotent stem cells. Mononuclear cells were isolated from peripheral venous blood by density gradient centrifugation method. The cells are grouped into 4 groups. Group 1 was the control group, which was not exposed to the small molecule. Groups 2-4 were experimental groups exposed to different doses of the small molecule VC6TFZ. Identification of induced pluripotent stem cells was carried out by identifying colony morphology and pluripotent gene expression of Octamer-binding transcription factor-4 (OCT4), Sex-determining region Y-box 2 (SOX2), and Nanog using Real-Time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). Colonies with a round shape, large, cobble stone like, and clear boundaries resembling pluripotent stem cell colonies appeared on the 9th day of the induction process. OCT4 and Nanog gene expression were significantly increased in the treatment group compared to the control.
Correlation Between Bioelectrical Impedance Analysis-Measured Body Fat, Body Mass Index and Waist Circumference with Cardiovascular Risk Factors in Acute Coronary Syndrome Patients Imam Mahbub Zam Zami; Budi Susetyo Pikir
Cardiovascular and Cardiometabolic Journal Vol. 2 No. 2 (2021): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v2i2.2021.50-58

Abstract

Estimation of fat using bioelectrical impedance analysis (BIA) is thought to be a more predictive measure of cardiovascular (CV) risk assessment than body mass index (BMI) or waist circumference (WC). Percent body fat as measured using BIA (BIA-BF%) is independently associated with future cardiovascular events namely acute myocardial infarction, ischemic heart disease. This study is conducted to determine the correlation between body fat which consists of BIA-BF%, percentage of subcutaneous adipose tissue (SAT) and visceral fat level (Visceral Adipose Tissue/VAT) measured using BIA device, BMI and WC with CV risk factors (blood pressure, blood glucose level, LDL, HDL, TG, total cholesterol, HbA1c and serum fibrinogen) in patients with acute coronary syndrome (ACS). Material and Methods : This study used a cross-sectional correlation analysis. Sample was 70 ACS patients that match with inclusion criteria. Results : We found significant correlations between BIA-BF% with diastolic blood pressure, TG, and total cholesterol (r = 0.246, r = 0.250, r = 0.348 respectively; p <0.05). There was a significant correlation between VAT with diastolic blood pressure, LDL, TG, total cholesterol, HbA1c, and fibrinogen (r = 0.299, r = 0.306, r = 0.278, r = 0.265, r = 0.292, r = 0.330 respectively, p <0.05). There was a significant correlation between the percentage SAT and HDL levels (r = 0.318; p <0.05). We found no correlation between BMI and WC with blood pressure, LDL, HDL, TG, blood glucose, HbA1c and fibrinogen levels in ACS patients. Conclusion: VAT and BIA-BF% correlate with several cardiovascular risk factors better than BMI and WC. Body fat examination using BIA may be done to manage risk factors in ACS patients.
Dapagliflozin Use in Heart Failure with Reduced Ejection Fraction Accompanied by Type 2 Diabetes Mellitus: A Systematic Review Sinta Dwi Juniar; Mochamad Yusuf Alsagaff; Budi Susetyo Pikir; Pudji Lestari
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 1 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i1.2022.60-74

Abstract

Abstract: Heart failure patients with reduced ejection fraction (HFrEF) respond well to pharmacological therapy and show a better prognosis. Heart failure patients with reduced ejection fraction and type 2 diabetes who were given SGLT-2 inhibitor therapy showed a strong and consistent reduction in the risk of death and hospitalization. The therapy that has recently begun to be investigated for its benefits for heart failure from the SGLT-2 inhibitor class is Dapagliflozin. The systematic review aims to analyze the effect of Dapagliflozin on the prognosis of HFrEF patients with type 2 diabetes mellitus. Material and Methods: The literature was searched from e-database PubMed, ScienceDirect, and ClinicalTrial.gov. Quality assessment was done using the Critical Appraisal Skills Program (CASP) Randomized Controlled Trial Standard Checklist. Results: A total of 22,167 patients from 4 RCTs eligible studies were included. The analysis results of all of the included studies indicate that Dapagliflozin affected the patient's prognosis. Two studies discuss mortality and hospitalization, and two studies discuss symptoms, functional status, and Quality of Life (QoL). Conclusion: Dapagliflozin can improve the prognosis of HFrEF patients with type 2 DM. The improved prognosis includes reduced mortality, reduced hospitalizations by minimizing disease worsening, reducing symptoms, improving functional status and QoL. Keyword: Cardiovascular disease, Dapagliflozin, Diabetes, Prognosis, SGLT 2 inhibitor
The Role of Klotho G395A Gene Polymorphism in Atherosclerotic Cardiovascular Disease and Mortality Risk Scores in Non-dialysis Chronic Kidney Disease Hendri Susilo; Budi Susetyo Pikir; Mochammad Thaha; Mochamad Yusuf Alsagaff; Satriyo Dwi Suryantoro; Citrawati Dyah Kencono Wungu; David Setyo Budi; Laurentius Andre; Cennikon Pakpahan
The Indonesian Biomedical Journal Vol 14, No 3 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i3.1975

Abstract

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Klotho expression was reduced in patients with CKD, leading to vascular calcification, endothelial dysfunction, and atherosclerosis. We investigated the role of the klotho G395A gene polymorphism and plasma klotho level in the ten-year risk of atherosclerotic cardiovascular disease (ASCVD) and CVD mortality in CKD patients.METHODS: We used the PCR-CTPP assay method to genotype klotho G395A single nucleotide polymorphism (SNP) in 72 non-dialysis CKD patients. The klotho level was determined using the enzyme-linked immunoassay (ELISA) method. Path analysis was used to determine the relationship between the klotho G395A SNP, plasma klotho level, ASCVD risk score, and CVD mortality risk score.RESULTS: Our results showed that the GA genotype had lower plasma klotho levels than the GG genotype (path coefficient=-0.185, p=0.000). There was a significant negative correlation between plasma klotho level and the ASCVD risk score (r=-0.243, p=0.040), but no significant correlation was found between plasma klotho level and the CVD mortality risk score (r=-0.145, p=0.225). Path analysis showed that plasma klotho level had a significant negative direct effect on ASCVD risk score (path coefficient=-0.272, p=0.000) and an indirect effect on CVD mortality risk score (path coefficient=0.187, p=0.005).CONCLUSION: Klotho G395A SNP might reduce lower plasma klotho levels, which increased ASCVD and CVD mortality risk scores in non-dialysis CKD patients. However, other risk factors such as age, CKD stages, hypertension, and smoking should be taken into consideration. Therefore, large-scale genetic association studies with adjusted variables could be conducted in various ethnic groups for a more robust result.KEYWORDS: klotho, single nucleotide polymorphism, cardiovascular disease, chronic kidney disease
Association Between Dietary Patterns of Salty Foods, Sweet Drinks, Fruit and Vegetables and The Prevalence of Hypertension in East Java: Multivariate Analysis of Indonesian Basic Health Surveys Data 2018 Andrianto; Mohammad Satya Bhisma; Fita Triastuti; Budi Susetyo Pikir; Annisa Trissatharra
Media Gizi Indonesia Vol. 18 No. 1 (2023): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypertension remains the main cause of mortality globally, including in Indonesia, with a prevalence rate of 34.1%. Various studies have reported an association between dietary patterns and the prevalence of hypertension. Therefore, further analysis is needed to determine preventive intervention strategies in each region. This study aimed to analyze the effect of dietary patterns on the prevalence of hypertension in East Java Province. The sample is the result of multistage random sampling from the census block of Basic Health Research (Riskesdas) report in the East Java Province collected from 2013 – 2018. The classical assumption test was carried out using the Kolmogorov-Smirnov method, bivariate test using the Pearson method, and multivariate test using the multiple linear regression method. There are three variables tested that have a p-value below the value of α <0.05, including eating salty foods once a day (p=0.021), drinking sweet drinks three times per month (p=0.008), and non-routine of fruits and vegetables consumption (p=0.003). Based on the r-value, the association between predictor variables and prevalence in order from the largest to the smallest of the habit of not consuming fruits and vegetables (r=-0.469), the habit of drinking sugary drinks three times per month (r=-0.425), and salty eating habits one time per day (r=-0.372). Multivariate multiple linear regression analysis showed that daily intake of salty foods (p=0.013) was associated with the prevalence of hypertension.
The Association Between Brachial Ankle Pulse Wave Velocity and Left Ventric Mass Index In Patients With Hypertension Budi Susetyo Pikir
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Arterial stiffness has been considered as a modest method in detecting the arterial burden that can trigger left ventricular hypertrophy in the heart. Increased left ventricle hypertrophy in hypertension patients is a predictor which has impact in the increase of morbidity and mortality. Objectives: We aimed to investigate the association between brachial ankle pulse wave velocity (BaPWV) and left ventricle mass index (LVMI) in patients with hypertension. Material and Methods: This study was conducted by collecting secondary data of 40 hypertension patients aged >40 years old, suffered from hypertension >1 year and have encountered brachial ankle pulse wave velocity test and echocardiography test. Results: There was a significant positive correlation between brachial ankle pulse wave velocity and left ventricle mass index in hypertension patients with r = 0.493 dan p = 0.001. Also, there was a significant correlation between BaPWV and Relative Wall Thickness with r = 0.404 and p = 0.01. There was a significant difference of LVMI value in males and females with the result of (117.78+22.70 and 100.15+16.82, p = 0.008). In contrast, there was no significant difference in BaPWV value in males and females (1865.63+322.29 and 1811.08+350.28). It was also obtained a significant correlation between age factor and systolic blood pressure with LVMI and BaPWV (r = 0.493, p = 0.001). Conclusions: There was significant positive correlation between BaPWV and LVMI in hypertension patients. The arterial stiffness was an indicator of increased left ventricle mass index in hypertension patients.Keywords: Brachial ankle pulse wave velocity, Left ventricle mass index, Hypertension, Heart.
Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation Rendra Mahardhika Putra; Budi Bakti Dharmadjati; Budi Susetyo Pikir; Irma Maghfirah; Ilma Alfia Isaridha; Jannatin Nisa Arnindita
Folia Medica Indonesiana Vol. 59 No. 1 (2023): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (508.934 KB) | DOI: 10.20473/fmi.v59i1.37126

Abstract

Highlights: A genetic variable has been identified as an atrial fibrillation risk factor. Rs2200733 is a type of SNP that increases atrial fibrillation risk, whereas rs3853445, rs6838973, and rs17570669 have the reverse effect. Abstract: Atrial fibrillation (AF) is a highly prevalent arrhythmia. The involvement of molecular mechanisms in increased AF risk remains uncertain. However, the paired-like homeodomain transcription factor 2 or pituitary homeobox 2 (PITX2) gene has been linked to AF development. A comprehensive search was carried out to identify all eligible case-control studies in order to assess the association between five single-nucleotide polymorphisms (SNPs) in the PITX2 gene and the risk of AF. This meta-analysis employed the Review Manager (RevMan) software version 5.3 (Cochrane). There were 13 clinical studies, with a total of 11,961 subjects, that met the inclusion criteria. These subjects consisted of 4,440 patients with AF and 7,521 controls. The meta-analysis of five SNP types in the PITX2 gene was done using crude odds ratios (ORs). This revealed that rs2200733 increased the risk of AF (OR=1.80; 95% CI=1.53-2.11; p=0.0005; I2=80%). On the other hand, the other three SNPs decreased the risk of AF, namely, rs385344 (OR=0.75; 95% CI=0.59-0.95; p=0.002; I2=85%), rs6838973 (OR=0.64; 95% CI=0.51-0.81; p=0.0001; I2=73%), and rs17570669 (OR=0.80; 95% CI=0.65-0.98; p=0.03; I2=70%). However, there was no significant association between rs10033464 and AF (OR=1.21; 95% CI=0.97-1.50; p=0.13; I2=83%). In conclusion, depending on the type, SNPs in the PITX2 gene correlate with AF risk factors, either by alleviating or reducing the risk.
Co-Authors Andrianto Annisa Trissatharra Bambang Purwanto Budi Bakti Dharmadjati David Setyo Budi Fita Triastuti Hendri Susilo Ilma Alfia Isaridha Imam Mahbub Zam Zami Irma Maghfirah Jannatin Nisa Arnindita Laurentius Andre Mochamad Yusuf Alsagaff MOCHAMMAD THAHA Mochammad Yusuf Alsagaff Mohammad Satya Bhisma Pakpahan, Cennikon Pudji Lestari Rendra Mahardhika Putra Rizka Amalia Setiabudi, Narendra Arya Sinta Dwi Juniar Suryantoro, Satriyo Dwi Wungu, Citrawati Dyah Kencono