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Hotimah Masdan Salim, dr., Ph.D
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iimj@unusa.ac.id
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Faculty of Medicine, University of Nahdlatul Ulama Surabaya
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Kota surabaya,
Jawa timur
INDONESIA
International Islamic Medical Journal
Published by Universitas Nahdlatul Ulama Surabaya
ISSN : 27162370     EISSN : 27162389     DOI : https://doi.org/10.33086/iimj
Core Subject : Religion, Humanities, Health,
Religion Humanities Health Professions Medicine & Pharmacology Public Health
The International Islamic Medical Journal (IIMJ) is the official journal of Faculty of Medicine, University of Nahdlatul Ulama Surabaya, Indonesia. It serves primarily as a forum for education and intellectual discourse for health professionals namely in clinical medicine but covers diverse issues relating to medical ethics, professionalism as well as medical developments and research in basic medical sciences (Anatomy, Histology, Physiology, Biochemistry and etc) . It also serves the unique purpose of highlighting issues and research pertaining to the Islamic medical in the world. IIMJ is an online journal published twice a year (June and December). This article should be written in academic English.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
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Search results for , issue "Vol 1 No 1 (2019): December" : 6 Documents clear
Antibacterial Effect of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 ON Klebsiella pneumoniae Producting Extended-Spectrum β-Lactamase (ESBL) Setiawati, Yuani; Retnowati, Wiwin; Basori, Achmad
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1326

Abstract

Klebsiella pneumoniae as an opportunistic pathogen can cause nosocomial infection. The main concern on this bacterium is directed on the extended-spectrum β-Lactamase (ESBL)-producing Klebsiella pneumoniae. The therapy of ESBL-producing Klebsiella pneumoniae infections is very limited because of its multidrug resistance. It had been found new local isolates Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 in mangrove East Coast of Surabaya. These isolates have potential to produce antibiotics (Retnowati, 2008). This study was aimed to prove these isolates may inhibit the growth of ESBL-producing Klebsiella pneumonia. The test of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 using the modification Agar print method against clinical isolates of ESBL-producing Klebsiella pneumoniae. The diameter of inhibition zone (mm) formed shows activity of these isolates. The profiles of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 were different in terms of periode required to reach peak activity, duration of activity and inhibition zone diameter produced during 10 days of observation. Streptomyces sp-MWS3 reached the peak activity most rapidly on day 3 with the largest inhibition zone diameter of 9 mm in ESBL-producing Klebsiella pneumoniae. There were significant differences in inhibition zone diameter between Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 against ESBL-producing Klebsiella pneumoniae.
Hypoglycemic Effects of Extract Nigella Sativa in Diabetic mice model Awwaliya, Evi; Salim, Hotimah Masdan; Muhammad, David Sajid; Romadhani, Deny Febriwijaya; Nisaussholihah, Nadia
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1327

Abstract

Background; Adiponectin is an important adipokine with anti-inflammatory and insulin-sensitizing effects, the circulating levels of which are reduced in individuals with type 2 diabetes and obesity. Indeed, there is evidence that adiponectin released from perivascular adipose tissue (PVAT), that may play a key role in vascular physiology, as bioactive molecules released from it could have direct paracrine effects on the underlying vessel. The present study investigated the effects of extract Nigella sativa (N. sativa) on blood glucose levels of diabetic mice. Materials; Eight-week-old male musmusculus were treated with alloxan (150 mg/ kg) by a single intraperitoneal injection to induce diabetes mellitus. At 3 days of injection, N. sativa extract (150 and 300 mg/kg) was administered via gavage for 2 weeks. Results: The extract of N.Sativa administration significantly reduced blood glucose level (P < 0.05). However, N.Sativa did not alter a body weight Conclusion: Extract of Nigella Sativa improved blood glucose level in diabetic mice model.
Dengue Vaccine Development at the Dengue virus serotypes Desi Irawati, Adinda; Salim, Hotimah Masdan
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1360

Abstract

Dengue hemorrhagic fever (DHF) is a disease caused by dengue virus (DENV1-4) and is transmitted by the Aedes aegypti mosquito. However, in 2015, official data from the member countries, WHO reported more than 3.2 million cases, including 10,200 severe dengue cases and 1181 deaths. The protein encoded by the genome of dengue virus. Major structural and non structural proteins making up the genome of dengue. From genomic data several studies found that mechanism of vaccine that can use in dengue virus. Several vaccines was establish in the world for example Live attenuated Vaccine, Chimera Vaccine, Subunit Vaccine, DNA vaccines DENV, Activated DENV Vaccine - Whole Virus Particles, Activated DENV Vaccine - Recombinant Subunit DENV, and DENV Vaccine 5.
A Promising Effect of Pravastatin For Reducing Preeclamsia Incidence In High Risk Pregnant Women Zata, Fariska; Nasir, Mohammad
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1385

Abstract

Preeclamsia is still a threat in obstetrics because it is the leading cause of maternal death (15-20% in developing countries). Globally, preeclampsia causes 70,000-80,000 pregnant women to die and 500,000 babies die annually1, with increased morbidity such as prematurity and fetal growth disturbance2. The exact cause of preeclampsia is still not clearly known (also called "The disease of theory"), but recent studies shows that the imbalance of pro-angiogenic (VEGF, PlGF) and anti-angiogenic factors (sFlt-1, s-Eng) plays an important role in the pathogenesis preeclampsia. The presence of general maternal endothelial dysfunction induced by an imbalance of these factors is a major phenomenon in preeclampsia, which results in placental hypoxia / ischemia, resulting in vasoconstriction resulting in hypertension1. Termination of pregnancy is still as a definitive therapy for preeclamsia. Therefore, early prevention is necessary in the management of preeclampsia. In 2013, ACOG recommended the administration of low-dose aspirin and calcium 1 gram / day to patients in pregnant women with high risk of preeclamsia3. However, low-dose aspirin is less useful in preventing preeclampsia in patients with a history of previous chronic hypertension4 and not reduce the incidence of term preeclampsia (the incidence of preeclampsia at gestational age above 37 weeks)5,6. This weakness of low-dose aspirin has led to recent research focusing on the prevention of preeclampsia. The similarity between the pathogenesis mechanism of preeclampsia and cardiovascular disease makes pravastatin (a protective therapy in cardiovascular disease before) as a potential agent for preventing preeclampsia7. Therefore, the role of pravastatin for reducing preeclampsia incidence in high risk pregnant women will be discussed in this article.
Low Birth Weight Infants Outcome In Single Tertiary Referral Hospital Putra, Dimas Abdi; I, Cininta N.; P, Wardhana M.; A, Aryananda R.; E, Gumilar K.; I, Aldika M.; B, Wicaksono; Ernawati, Ernawati; A, Sulistyono; Aditiawarman, Aditiawarman; J, Hermanto T.; N, Abdullah; G, Dachlan E.
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1386

Abstract

Background: Low birth weight (LBW) is defined by infants with birth weight less than 2500 gram, commonly caused by prematurity. Preterm infants are prone to problems such as organ immaturity, neurodevelopmental impairment until behavior disorder. Hypertension on pregnancy and preeclampsia is the most case referred and treated in dr. Soetomo General Hospital as a single tertiary teaching hospital in Surabaya, Indonesia which require early delivery and possess consequences to maternal and perinatal side. Objective: This study aims to determine the incidence and outcome of LBW infants born in dr. Soetomo General Hospital. Methods: Retrospective cross-sectional by using medical record data of dr. Soetomo General Hospital on January 2014 – December 2017. Results: There were 2350 infants with birth weight of 500-2499 gram, in which majority was on the range of 2001-2499 gram (38%.) Hypertension on pregnancy and the complications were the most indication for pregnancy termination that resulted in LBW infants. This study also found that the LBW outcome was linear with birth weight. In addition, the gestational age and five minutes APGAR score also had important role to the LBW outcome. Conclusion: The major cause of LBW infants in dr. Soetomo General Hospital was hypertension on pregnancy. There was a positive trend of survival in infants with birth weight range of 1501-2000 gram.
Clinical Forensic Examination on Mass Violence’s Victim With Head and Ocular Injury (A Case Report) Syarifah, Mustika Chasanatusy; Yudianto, Ahmad
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1389

Abstract

Introduction: Clinical forensic medicine is a branch of medicine that applies medicine to uphold justice in the case of living victims. In accordance with this understanding, the handling of cases of living victims, especially victims of crime, must involve doctors in the field of forensics, in addition to doctors in other fields according to their competence. With so many cases of violent crime, a doctor must be able to provide a report on the results of the examination to the legal apparatus to assist in the judicial process. Case: A man, aged 44 years, found bruises on right eyelid, left eye, left cheek, left and right scalp; blisters on the left and right eye membranes; a cut wound on the right eye membrane and the left eyelid; bleeding under the thick membrane of the brain and swelling of the brain. Discussion: Injuries can occur as a result of violence perpetrated by criminal offenses, such as cases of theft by violence, murder, traffic accidents or ill-treatment. The doctor must be able to mention that the wound examined is caused by sharp violence, blunt force, electrical trauma, thermal trauma, chemical trauma, or other causes of trauma. Determination of the magnitude of the effect of injury to the victim, related to criminal sanctions that will be imposed on the perpetrators of criminal acts. The head is an organ that is often the target of violent blunt crimes. The brain and the surrounding layers are easily susceptible to trauma, resulting in death compared to other body parts. The wound is in accordance with Criminal Code article 90 concerning serious injuries, which results in injuries that do not give any hope of healing at all.

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