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All Journal Jurnal Kedokteran Syiah Kuala Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Nusantara Medical Science Journal Jurnal Keperawatan Padjadjaran Jurnal Kesehatan Prima Oceana Biomedicina Journal Jurnal Ilmu Kefarmasian Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Medical and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology International Islamic Medical Journal journal of Basic Medical Veterinary Oceana Biomedicina Journal Cerdika: Jurnal Ilmiah Indonesia Jurnal Kedokteran Meditek
Yuani Setiawati
Departemen Farmakologi, Fakultas Kedokteran, Universitas Airlangga, Surabaya, Indonesia
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Molecular Docking Human Plasma Kallikrein to Prevent Acute Respiratory Distress Syndrome(ARDS) in COVID-19 Patient Feriawan Tan; Cindy ApriliaEkaPrasanty; Anna Surgean Veterini; YuaniSetiawati; Rizki Awaluddin; Fadilah Fadilah; Siti Khaerunnisa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16860

Abstract

SARS CoV-2 infection causes various clinical manifestations ranging from mild to severe. Acute RespiratoryDistress Syndrome (ARDS) is a severe complication of COVID-19 caused by activation of the kallikreinkininsystem which produces bradykinin which is a potent proinflammatory mediator. This research is anin silico study which aims to determine the potential of active medicinal plant compounds in inhibiting thekallikrein-kinin system.Molecular docking in this study using Autodock 4.2 with Lamarckian GA criteria.Human plasma kallikrein (PDB ID: 5TJX) was docked with 70 compounds and one native ligandand analyzedusing Autodock 4.2.The smallest binding energy obtained from docking 5TJX with several compoundsin sequence, namely, xanthohumol, nafamostat, demethoxycurcumin, epicatechingallate, beta mangostin,alpha mangostin (-9.52, -9.35, -9.33, -9.28, -9.19, -9.06 kcal/mol). Therefore, the compound shows the bestpotential as a plasma kallikrein inhibitor. However, further research is still needed to determine the potentialof drugs and medicinal plant active compounds for medical treatment.
In Vitro Antibacterial Activity of Waste Palm Cooking Oil Against Staphylococcus Aureus Fiqih Faizara Ustadi; Agung Dwi Wahyu Widodo; Yuani Setiawati
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17499

Abstract

Background: Staphylococcus aureus is a Gram-positive coccus which acts as a pathogen causing awide range of infectious diseases. In recent years, several strains of S. aureus have been found to showresistance to several antibiotics. Waste cooking oil may be considered as an alternative antibacterialproduct, as it contains long-chain fatty acids whose antibacterial effectiveness against S. aureus hasbeen known for years. In addition, oxidative biocides produced during the frying process have manytargets for antibacterial activity in the cell and affect almost every biomolecule. Nonetheless, there isno literature that is able to prove the antimicrobial effects of the waste palm cooking oil. Objective: Toexamine the in vitro antibacterial effect of waste palm cooking oil against S. aureus. Method: a twofoldserial dilution method to set the minimum level of both inhibitory and bactericidal concentrations.Conclusion: This study showed that waste palm cooking oil did not show antibacterial effects againstS. aureus, indicating that waste palm cooking oil is not possibly to be applied as an antibacterial agentagainst S. aureus.
Antibacterial Activity of Methanol Extract of Red Dragon Fruit Peel ( Hylocereus polyrhizus) against MethicillinSusceptible Staphylococcus aureus ( MSSA) ATCC 25923 and Methicillin Resistant Staphylococcus aureus (MRSA) In Vitro Shazia Hafazhah Aulia; Yuani Setiawati; Eko Budi Koendhori
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15963

Abstract

Background: Staphylococcus aureus is one of the most virulent Staphylococcus which could cause systemic broad-spectrum infections and developed resistant strains. Red dragon fruit (Hylocereus polyrhizus) peel has a broad antibacterial activity against both gram-negative and positive bacteria, including Staphylococcus aureus. Objective: To determine and compare the antibacterial activity of methanol extract of red dragon fruit peel against Methicillin-Susceptible Staphylococcus aureus ATCC 25923 and Methicillin-Resistant Staphylococcus aureus. Method: Well diffusion test method was performed on 5 concentrations: 100%, 75%, 50%, 25%, and 0%, dissolved in DMSO 10% where at a concentration of 100% contains 1g/mL extract. The inhibition zone elicited as clear zone around the well then measured and analyzed with SPSS using One-Way ANOVA and Post Hoc LSD, to determine the significance of each concentration. Results: The mean diameter of the inhibition zone observed towards Methicillin-Susceptible Staphylococcus aureuswas 9.5333 ± 0.26822 - 15.4167 ± 0.22048, while bigger zone was found in Mueller-Hinton plate with Methicillin-Resistant Staphylococcus aureus which is 12.30 ± 0.20817 - 17.80 ± 0.25166 mm. Conclusion: This study showed that methanol extract of red dragon fruit peel has antibacterial activity against S. aureus, and shows higher antibacterial activity against Methicillin-Resistant Staphylococcus aureus than MethicillinSusceptible Staphylococcus aureus.
The Response Time of Trauma and non Trauma Patients Handling in Emergency Room Surabaya Yuani Setiawati; Maya Hapsari Kusumaningtyas; Annete d’Arqom
Jurnal Ilmu Kesehatan dan Kesehatan Vol 6 No 1 (2022): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v6i1.2154

Abstract

Background: Emergency room is one of the unit services in hospitals that provide first services in patients with threat of disability or even death. Emergency room is a service unit in hospital with 24 service hours for 7 days in a week. The high risk and working hours in the emergency room requires the medical personnel that have a good response times in triage room. Objective: To compare response time of medical personnel when handling trauma and non trauma patients in the emergency room. Method: A non-experimental, quantitative research methods using analytic observational. The population of this study was patient in emergency room Soetomo hospital Surabaya. The amount of the sample was 244 which divided into 41 trauma case and 203 non trauma case. Result: Response time of patients with trauma injuries that include quick category (< 5 minutes) amounted to 35 patients and 6 patients in slow category (> 5 minutes) with average response times of trauma patients is 6.244 minutes. Response time of patients with non trauma injuries that include quick category (< 5 minutes) amounted to 161 patients and 42 patients in slow category (>5 minutes) with average response times of non trauma patients is 3.722 minutes. The p value response times of medical personnel in dealing with trauma and non-trauma patients is 0.374 (> 0.05) which means there is no difference in response times from medical personnel in handling trauma and non-trauma patients. Conclusion: There was no difference in the response time of medical personnel in trauma and non-traumatic patients handling (p>0,05). Overall, it was found that the average emergency room’s response time at Soetomo hospital was 4.15 minutes, still meeting the applicable standards.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL LIDAH BUAYA (Aloe vera) TERHADAP BAKTERI Staphylococcus aureus Mia Rahardjo; Eko Budi Koendhori; Yuani Setiawati
Jurnal Kedokteran Syiah Kuala Vol 17, No 2 (2017): Volume 17 Nomor 2 Agustus 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v17i2.8975

Abstract

Abstrak. Staphylococcus aureus merupakan salah satu flora normal pada kulit, membran mukosa, orofaring, saluran pencernaan dan vagina yang berpotensi menjadi patogen. Pertumbuhan S. aureus yang berlebihan dapat menimbulkan infeksi yang serius baik di manusia atau hewan. Dan sekarang, beberapa S. aureus dikabarkan telah resisten terhadap antibiotik karena proses mutasi. Berdasarkan hal tersebut, penulis mencoba memberi alternatif pengobatan dengan memanfaatkan ekstrak etanol gel Aloe vera yang menurut beberapa penulis lain, gel Aloe vera mengandung antraquinone, tannin, polysaccharide, flavonoid, and saponin yang bersifat sebagai antibakteri. Jenis penelitian ini adalah eksperimental laboratorium dengan metode difusi dan dilusi. Penelitian ini menggunakan konsentrasi 100%, 75%, 50%, 25%, dan 0% pada metode difusi. Sementara itu metode dilusi menggunakan konsentrasi 100%, 50%, 25%, 12,5%, 6,25%, 3,125%, 1,5625% kontrol positif (+), dan kontrol negatif (-).Dari pengamatan hasil penelitian, tidak didapatkan zona inhibisi pada metode difusi serta tidak dapat ditentukan konsentrasi hambat minimum (KHM) dan konsentrasi bunuh minimum (KBM) terhadap pertumbuhan Staphylococcus aureus. Hal ini terkait dengan rendahnya senyawa aktif yang digunakan di sampel gel Aloe vera dalam penelitian ini akibat pengaruh dari faktor lingkungan, perbedaan usia tanaman dengan literatur awal, proses degradasi dan reaksi enzimatik, adanya perbedaan metode ekstraksi, serta proses oksidasi saat terpapar oleh udara. Berdasarkan hal tersebut, dapat disimpulkan bahwa aktivitas antibakteri dari ekstrak etanol gel Aloe vera terhadap Staphylococcus aureus tidak dapat ditentukandengan metode difusi dan metode dilusi. (JKS 2017; 2: 65-71) Kata Kunci : Gel lidah buaya (Aloe vera), Staphylococcus aureus, antibakteri, metode difusi dan dilusi.  Abstract. Staphylococcus aureus is one of the normal flora in human skin, mucous membrane, oropharynx, gastrointestinal tract, and vagina which potentially becomes a pathogen. The excessive growth of S. aureus can cause many serious infection whether in human or animal. And nowadays, some of S.aureus have become resistant to antibiotic caused by its mutation. According to that case, researcher try to find an alternative solution by using Aloe vera gel ethanol extract that some other researchers say it contains antraquinone, tannin, polysaccharide, flavonoid, and saponin as anti bacterial compound. This research aimed to find out the effectiveness of Aloe vera gel ethanol extract in inhibiting Staphylococcus aureus.This research is designed as an laboratorium experimental with difusion and dilusion method. Test performed with using 100%, 75%, 50%, 25%, and 0% concentration in difusion method and using 100%, 50%, 25%, 12,5%, 6,25%, 3,125%, 1,5625% concentration , positive control (+) and negative control (-) in dilution method. There is no inhibition zone in difusion method, also no minimum inhibitory concentration and no bactericidal concentration can be seen in dilution method that inhibit the growth of Staphylococcus aureus. This result might be related to the minimal amount of active compound in this sample, that is taken from Aloe vera gel. The amount of active compound can be influenced by the environment, difference in Aloe’s age, degradation process and enzymatic reaction, difference in extraction method and also influenced by oxidation process when it’s exposed to air. Based on the results, anti bacterial activity of Aloe vera gel ethanol extract towards Staphylococcus aureus can not be determined in difusion and dilution method.  (JKS 2017; 2: 65-71) Key words : Aloe vera gel, Staphylococcus aureus, antibacterial, difusion and dilusion method
Uji aktivitas antibakteri ekstrak biji petai cina (Leucaena leucocephala) terhadap Staphylococcus aureus Vivi Permata Sari; Wiwin Retnowati; Yuani Setiawati
Jurnal Kedokteran Syiah Kuala Vol 20, No 2 (2020): Volume 20 Nomor 2 Agustus 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i2.18501

Abstract

 Abstract. Staphylococcus aureus merupakan flora normal kulit manusia yang bisa menyebabkan infeksi ketika sistem imun tubuh manusia sedang lemah. Pengobatan Staphylococcus aureus tergolong sulit karena Staphylococcus aureus mudah resisten terhadap beberapa antibiotik sehingga dikenal istilah Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-intermediate Staphylococcus aureus (VISA), dan Vancomycin-resistant Staphylococcus aureus (VRSA) yang menunjukkan resistensi tersebut. Pertumbuhan Staphylococcus aureus dapat dihambat ekstrak daun petai cina (Leucaena leucocephala). Tanaman petai cina (Leucaena leucocephala) digunakan masyarakat Indonesia sebagai obat tradisional untuk menyembuhkan luka, mengobati cacingan, dan mengobati jerawat. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak biji petai cina (Leucaena leucocephala) dalam menghambat pertumbuhan Staphylococcus aureus.Penelitian ini merupakan eksperimental laboratorium dengan metode dilusi sebanyak 6 replikasi. Setiap replikasi menggunakan konsentrasi ekstrak biji petai cina (Leucaena leucocephala) sebesar 3,125%, 6,25%, 12,5%, 25%, 50%, dan 100% untuk mencari konsentrasi hambat minimal dan konsentrasi bunuh minimal terhadap Staphylococcus aureus.Hasil penelitian tidak dapat menentukan konsentrasi hambat minimal (KHM) ekstrak biji petai cina (Leucaena leucocephala) terhadap Staphylococcus aureus karena warna ekstrak yang gelap. Sedangkan konsentrasi bunuh minimal (KBM) ekstrak biji petai cina (Leucaena leucocephala) terhadap Staphylococcus aureus ditemukan pada konsentrasi 50%, yang menunjukkan bahwa konsentrasi 50% adalah konsentrasi terkecil dimana tidak terdapat pertumbuhan bakteri Staphylococcus aureus.Sebagai simpulan, ekstrak biji petai cina (Leucaena leucocephala) memiliki aktivitas antibakteri terhadap Staphylococcus aureus. Kata kunci: Staphylococcus aureus, Leucaena leucocephala, metode dilusi  Abstract. Staphylococcus aureus is a normal human skin flora that can cause infection when human immune system is weak. Staphylococcus aureus treatment is difficult because Staphylococcus aureus is easily resistant to some antibiotics so several terms such as Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-intermediate Staphylococcus aureus (VISA), and Vancomycin-resistant Staphylococcus aureus (VRSA) are known to indicate the resistance. The growth of Staphylococcus aureus can be inhibited by Leucaena leucocephala leaf extract. Leucaena leucocephala is used by Indonesian people as traditional medicine to heal wounds, treat worm infection, and treat acne. The objective of this study was to identify the antibacterial activity of Leucaena leucocephala seed extract against Staphylococcus aureus.This was a laboratory experimental study using dilution method as many as five replications. Each replication used Leucaena leucocephala seed extract in concentrations of 3.125%, 6.25%, 12.5%, 25%, 50%, and 100% to determine the minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) against Staphylococcus aureus. The results were not able to determine the minimal inhibitory concentration (MIC) of Leucaena leucocephala seed extract against Staphylococcus aureus due to dark color of the extract. While the minimal bactericidal concentration (MBC) of Leucaena leucocephala seed extract against Staphylococcus aureus was 50%. This showed that the concentration of 50% was the lowest concentration where there was no growth of the bacteria Staphylococcus aureus.In conclusion, the extract of Leucaena leucocephala seed has antibacterial activity against Staphylococcus aureus. Keywords: Staphylococcus aureus, Leucaena leucocephala, dilution method
Comparison of Aloe vera leaves ethanol extract effect against Escherichia coli ESBL and Klebsiella pneumoniae ESBL Dewinta Enggar Pramesthi; Yuani Setiawati; Eko Budi Koendhori
Jurnal Kedokteran Syiah Kuala Vol 20, No 2 (2020): Volume 20 Nomor 2 Agustus 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i2.18502

Abstract

Abstrak. Aloe vera merupakan tanaman herbal yang mengandung beberapa zat aktif yang telah terbukti mempunyai efek antibakteri untuk berbagai macam bakteri. Dapat ditemukan banyak infeksi yang disebabkan oleh bakteri gram negatif. Beberapa bakteri gram negatif ini memproduksi enzim β lactamase mutan, yang diketahui sebagai Extended Spectrum Beta Lactamase (ESBL). Bakteri ESBL resisten terhadap beberapa macam antibiotik dalam golongan beta laktam, hal ini menjadi salah satu permasalahan utama di rumah sakit. Berdasarkan latar belakang yang ada, tujuan dari studi ini adalah untuk membandingkan efek antibakteri dari ekstrak etanol daun lidah buaya terhadap Escherichia coli ESBL dan Klebsiella pneumoniae ESBL. Studi ini merupakan eksperimental laboratorium. Konsentrasi Hambat Minimal (KHM) dan Konsentrasi Bunuh Minimal (KBM) ditentukan dengan metode dilusi. Konsentrasi yang digunakan pada penentuan KHM untuk kedua bakteri adalah 90%; 80%; 70%; 60%; 50%; 40%; 30%; dan 20%. Penentuan KBM dilakukan dengan cara penanaman suspensi dari muller hinton broth pada nutrient agar plate. Hasil yang didapatkan dianalisis menggunakan metode deskripsi. KHM untuk kedua bakteri ditemukan pada konsentrasi yang sama yaitu 80% (8 g ml-1). KBM untuk kedua bakteri juga ditemukan pada konsentrasi yang sama yaitu 80% (8 g ml-1). Penentuan KHM dan KBM dilakukan sebanyak 10 kali replikasi. Dapat disimpulkan bahwa ektrak etanol daun lidah buaya tidak mempunyai efektivitas yang berbeda terhadap Escherichia coli ESBL dan Klebsiella pneumoniae ESBL. Kata kunci: Escherichia coli ESBL - Klebsiella pneumoniae ESBL - Ekstrak etanol daun lidah buaya- antibakteri - dilusi Abstract. Aloe vera is a herbal which has some active substances that have been proven for its antibacterial effect for some bacterias. There are many infections caused by gram negative bacterias. Some of gram negative bacterias produce mutant β lactamase enzyme, that known as Extended Spectrum Beta Lactamase (ESBL). ESBL bacteria are resistant to some antibiotics in beta lactam class and become one of main problem in hospital. Based on this background, the aim of this study was to compare the antibacterial activity of aloe vera leaves ethanol extract between Escherichia coli ESBL and Klebsiella pneumoniae ESBL. This study was a lab experimental. Minimum Inhibitory Concentration (MIC) values and Minimum Bactericidal Concentration (MBC) values were determined by dilution method. The concentration used in MIC determination for both bacteria is 90%; 80%; 70%; 60%; 50%; 40%; 30%; and 20%. The MBC values were determined by suspension streaking from muller hinton broth on nutrient agar plate. The result is analyzed with description method. The MIC value for Escherichia coli ESBL and Klebsiella pneumoniae ESBL is found in the same concentration which is 80% (8 g ml-1). The MBC values for Escherichia coli ESBL and Klebsiella pneumoniae ESBL also found in the same concentration 80% (8 g ml-1).  MIC and MBC values have been proved in the first until tenth replications. Thus, aloe vera leaves ethanol extract has no different effectiveness against Escherichia coli ESBL and Klebsiella pneumoniae ESBL. Keywords: Escherichia coli ESBL - Klebsiella pneumoniae ESBL - Aloe vera leaves - antibacterial - dilution method
UJI EFEKTIVITAS EKSTRAK BUNGA KAMBOJA (Plumeria alba) SEBAGAI ANTIBAKTERI TERHADAP Streptococcus pyogenes Felicia Jiwantono; Marijam Purwanta; Yuani Setiawati
Jurnal Kedokteran Syiah Kuala Vol 17, No 3 (2017): Volume 17 Nomor 3 Desember 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v17i3.9066

Abstract

Abstract. infeksi adalah salah satu dari isu kesehatan yang disebabkan oleh mikroorganisme patogen dan salah satu mikroorganisme yang tersering adalah Streptococcus. Terdapat 616 kasus faringitis di dunia yang disebabkan oleh Streptococcus. Penyakit tersebut dapat menimbulkan berbgai komplikasi lain bila tidak diterapi dengan baik. Pengobatan menggunakan antibiotik memiliki risiko terjadinya resistensi. Oleh sebab itu, diperlukan pengembangan penelitian pada herbal sebagai pengobatan. Bunga kamboja putih (Plumeria alba) diketahui memiliki aktivitas antibakteri melawan berbagai macam mikroorganisme. Dengan latar belakang tersebut, tujuan dari penelitian ini adalah untuk menentukan adanya aktivitas antimikroba dari Plumeria alba terhadap Streptococcus pyogenes yang dapat diamati dari Konsentrasi Hambat Minimum (KHM) dan Konsentrasi Bunuh Minimum (KBM). Penelitian ini dikerjakan menggunakan metode eksperimental. Metode dilusi agar digunakan untuk menentukan KHM dan KBM. Konentrasi yang digunakan pada penelitian ini adalah 250 mg/ml, 125 mg/ml, 62,50 mg/ml, 31.25 mg/ml, 15,63 mg/m, 7,81 mg/ml, 3,91 mg/ml, 1,95 mg/ml, 0,98 mg/ml, kontrol positif (+) dan kontrol negatif (-).Melalui observasi dari penelitian ini, KHM tidak dapat ditentukan. Nilai dari KBM adalah 7,81 mg/ml yang menunjukkan konsentrasi dimana tidak didapatkan pertumbuhan koloni bakteri. Ekstrak etanol dari bunga kamboja putih (Plumeria alba) memiliki aktivitas antimikroba terhadapt Streptococcus pyogenes. Dalam studi in vitro ini menggunakan metode dilusi agar, KBM untuk Streptococcus pyogenes adalah 7,81 mg/ml.
MIC and MBC Levels of Combination Camellia Sinensis and Mentha Piperita Extract Mouthwash Against Streptococcus Mutans Yuani Setiawati; Muflikhah Ramadhani; Jihan Bobsaid; Dennia Oktavia Zahidah Hulwah
Nusantara Medical Science Journal Volume 7 Issue 1, January - June 2022
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v7i1.19203

Abstract

Introduction: Awareness of Indonesian people in maintaining dental and oral health is low, proved by an increase in the percentage of dental and oral health problems by 2.7%. Caries is a dental and oral health problem that occurs in many children. The main cause of dental caries is Streptococcus mutans. To solve this problem, it is necessary to use herbal mouthwash made from a combination of Camellia sinensis and Mentha piperita extract as an antibacterial against Streptococcus mutans. Methods:  Mouthwash is made through several processes namely plant determination, extraction, and mouthwash making. Minimal Inhibitory Concentration (MIC) is determined by diluted methods, Minimal Bactericidal Concentration (MBC) is determined by the agar streaking method, and colony tests are calculated using colony counters. Results: The result of plant determination showed the plants in this study were Camellia sinensis and Mentha piperita. At a concentration of 6.25%, no growth of bacteria in each repetition with the number of colonies 0 CFU / ml. While at a concentration of 3.125% found the average number of colonies 13 CFU / ml. Conclusions: Based on good MIC and MBC results, mouthwash containing Camellia sinensis and Mentha piperita has been shown to kill and inhibit the growth of Streptococcus mutans bacteria
Skrining Pendahuluan Toksisitas Beberapa Tumbuhan Benalu terhadap Larva Udang Artemia Salina Leach DANTI NUR INDIASTUTI; SRI PURWANINGSIH; YUANI SETIAWATI; NOOR CHOLIES
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1138.28 KB)

Abstract

The brine shrimp lethality test (BSLT) is considered as a useful tool for preliminary assessment of toxicity. It has also been suggested for screening of pharmacological activities of plant extracts. The bioactivity of eight methanol extracts of four parasite plants and two host plants were evaluated using the brine shrimp lethality assay. The results showed that all methanol extracts of the host plants did not have any indication of toxicity The LC50 of methanol extract of Moringa pterygosperma stem was 1085.44±84.32 µg/ml, and of Ficus refusal stem was 1240.86±50.71 µg/ml. But methanol extracts of whole parts of parasite plants showed toxicity to Artemia Salina Leach. The LC50 of methanol extract of Loranthus peretandrus herb parasite was 175.66±29,24 µg/ml while that of Elytranthe evenia leaf parasite was 327.15±38.66 µg/ml; of Elytranthe evenia stem parasite was 320.39±39.57 µg/ml; of Elytranthe evenia flower parasite was 456.79±15.69 µg/ml; of Scurulla atropurpurea herb parasite was 176.44±28.46 µg/ml; and of Viscum articulatum parasite was 53.79±10.83 µg/ml.
Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Achmad Basori, Achmad ACHMAD RIFAI Agung Dwi Wahyu Widodo Akbar Kurniawan, Mohammad Anna Surgean Veterini Annete d’Arqom Annette d’Arqom, Annette Arifa Mustika Asrianti, Nur Ilma Baitul Fatimah Benny Iswanto Pantoro Cindy ApriliaEkaPrasanty Citagami, Salsabila Dennia Oktavia Zahidah Hulwah Dennia Oktavia Zahidah Hulwah Dewangga Sakti Satria Kinasih Dewinta Enggar Pramesthi Djoko Marsudi D’Arqom, Annette Eko Budi Koendhori, Eko Budi Fadilah Fadilah Farhadi, Azmi Farhan Nurdiansyah Fatimah, Nurmawati Felicia Jiwantono Feriawan Tan Fiqih Faizara Ustadi Firda Fitra Qolbina Fitriati, Mariza Gatot Soegiarto Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Isyroqiyyah, Nur Moya Izzatul Fithriyah Jihan Bobsaid Jihan Bobsaid Khaerunnisa, Siti Kusuma Eko Purwantari Maftuchah Maftuchah Manaf, Syifa Az Zahrah Maya Hapsari Kusumaningtyas Mhd Zamal Nasution Mia Rahardjo Muflikhah Ramadhani Muflikhah Ramadhani Muhammad Khafidin Al Alim NOOR CHOLIES Nurina Hasanatuludhhiyah Nurul Wiqoyah, Nurul Pepy Dwi Endraswari, Pepy Dwi Purwanta, Marijam Rehatta, Nancy Margarita Rizki Awaluddin Rochmah Kurnijasanti Shazia Hafazhah Aulia Siti Khaerunnisa Siti Khaerunnisa Sri Purwaningsih Sri Purwaningsih Trisniartami Setyaningrum Vivi Permata Sari Wiwin Retnowati Wiyogo, Illona Okvita Yuri Widia, Yuri