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Hotimah Masdan Salim, dr., Ph.D
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Faculty of Medicine, University of Nahdlatul Ulama Surabaya
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INDONESIA
International Islamic Medical Journal
Published by Universitas Nahdlatul Ulama Surabaya
ISSN : 27162370     EISSN : 27162389     DOI : https://doi.org/10.33086/iimj
Core Subject : Religion, Humanities, Health,
Religion Humanities Health Professions Medicine & Pharmacology Public Health
The International Islamic Medical Journal (IIMJ) is the official journal of Faculty of Medicine, University of Nahdlatul Ulama Surabaya, Indonesia. It serves primarily as a forum for education and intellectual discourse for health professionals namely in clinical medicine but covers diverse issues relating to medical ethics, professionalism as well as medical developments and research in basic medical sciences (Anatomy, Histology, Physiology, Biochemistry and etc) . It also serves the unique purpose of highlighting issues and research pertaining to the Islamic medical in the world. IIMJ is an online journal published twice a year (June and December). This article should be written in academic English.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 98 Documents
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Antibacterial Effect of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 ON Klebsiella pneumoniae Producting Extended-Spectrum β-Lactamase (ESBL) Setiawati, Yuani; Retnowati, Wiwin; Basori, Achmad
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1326

Abstract

Klebsiella pneumoniae as an opportunistic pathogen can cause nosocomial infection. The main concern on this bacterium is directed on the extended-spectrum β-Lactamase (ESBL)-producing Klebsiella pneumoniae. The therapy of ESBL-producing Klebsiella pneumoniae infections is very limited because of its multidrug resistance. It had been found new local isolates Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 in mangrove East Coast of Surabaya. These isolates have potential to produce antibiotics (Retnowati, 2008). This study was aimed to prove these isolates may inhibit the growth of ESBL-producing Klebsiella pneumonia. The test of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 using the modification Agar print method against clinical isolates of ESBL-producing Klebsiella pneumoniae. The diameter of inhibition zone (mm) formed shows activity of these isolates. The profiles of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 were different in terms of periode required to reach peak activity, duration of activity and inhibition zone diameter produced during 10 days of observation. Streptomyces sp-MWS3 reached the peak activity most rapidly on day 3 with the largest inhibition zone diameter of 9 mm in ESBL-producing Klebsiella pneumoniae. There were significant differences in inhibition zone diameter between Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 against ESBL-producing Klebsiella pneumoniae.
Hypoglycemic Effects of Extract Nigella Sativa in Diabetic mice model Awwaliya, Evi; Salim, Hotimah Masdan; Muhammad, David Sajid; Romadhani, Deny Febriwijaya; Nisaussholihah, Nadia
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1327

Abstract

Background; Adiponectin is an important adipokine with anti-inflammatory and insulin-sensitizing effects, the circulating levels of which are reduced in individuals with type 2 diabetes and obesity. Indeed, there is evidence that adiponectin released from perivascular adipose tissue (PVAT), that may play a key role in vascular physiology, as bioactive molecules released from it could have direct paracrine effects on the underlying vessel. The present study investigated the effects of extract Nigella sativa (N. sativa) on blood glucose levels of diabetic mice. Materials; Eight-week-old male musmusculus were treated with alloxan (150 mg/ kg) by a single intraperitoneal injection to induce diabetes mellitus. At 3 days of injection, N. sativa extract (150 and 300 mg/kg) was administered via gavage for 2 weeks. Results: The extract of N.Sativa administration significantly reduced blood glucose level (P < 0.05). However, N.Sativa did not alter a body weight Conclusion: Extract of Nigella Sativa improved blood glucose level in diabetic mice model.
Dengue Vaccine Development at the Dengue virus serotypes Desi Irawati, Adinda; Salim, Hotimah Masdan
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1360

Abstract

Dengue hemorrhagic fever (DHF) is a disease caused by dengue virus (DENV1-4) and is transmitted by the Aedes aegypti mosquito. However, in 2015, official data from the member countries, WHO reported more than 3.2 million cases, including 10,200 severe dengue cases and 1181 deaths. The protein encoded by the genome of dengue virus. Major structural and non structural proteins making up the genome of dengue. From genomic data several studies found that mechanism of vaccine that can use in dengue virus. Several vaccines was establish in the world for example Live attenuated Vaccine, Chimera Vaccine, Subunit Vaccine, DNA vaccines DENV, Activated DENV Vaccine - Whole Virus Particles, Activated DENV Vaccine - Recombinant Subunit DENV, and DENV Vaccine 5.
A Promising Effect of Pravastatin For Reducing Preeclamsia Incidence In High Risk Pregnant Women Zata, Fariska; Nasir, Mohammad
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1385

Abstract

Preeclamsia is still a threat in obstetrics because it is the leading cause of maternal death (15-20% in developing countries). Globally, preeclampsia causes 70,000-80,000 pregnant women to die and 500,000 babies die annually1, with increased morbidity such as prematurity and fetal growth disturbance2. The exact cause of preeclampsia is still not clearly known (also called "The disease of theory"), but recent studies shows that the imbalance of pro-angiogenic (VEGF, PlGF) and anti-angiogenic factors (sFlt-1, s-Eng) plays an important role in the pathogenesis preeclampsia. The presence of general maternal endothelial dysfunction induced by an imbalance of these factors is a major phenomenon in preeclampsia, which results in placental hypoxia / ischemia, resulting in vasoconstriction resulting in hypertension1. Termination of pregnancy is still as a definitive therapy for preeclamsia. Therefore, early prevention is necessary in the management of preeclampsia. In 2013, ACOG recommended the administration of low-dose aspirin and calcium 1 gram / day to patients in pregnant women with high risk of preeclamsia3. However, low-dose aspirin is less useful in preventing preeclampsia in patients with a history of previous chronic hypertension4 and not reduce the incidence of term preeclampsia (the incidence of preeclampsia at gestational age above 37 weeks)5,6. This weakness of low-dose aspirin has led to recent research focusing on the prevention of preeclampsia. The similarity between the pathogenesis mechanism of preeclampsia and cardiovascular disease makes pravastatin (a protective therapy in cardiovascular disease before) as a potential agent for preventing preeclampsia7. Therefore, the role of pravastatin for reducing preeclampsia incidence in high risk pregnant women will be discussed in this article.
Low Birth Weight Infants Outcome In Single Tertiary Referral Hospital Putra, Dimas Abdi; I, Cininta N.; P, Wardhana M.; A, Aryananda R.; E, Gumilar K.; I, Aldika M.; B, Wicaksono; Ernawati, Ernawati; A, Sulistyono; Aditiawarman, Aditiawarman; J, Hermanto T.; N, Abdullah; G, Dachlan E.
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1386

Abstract

Background: Low birth weight (LBW) is defined by infants with birth weight less than 2500 gram, commonly caused by prematurity. Preterm infants are prone to problems such as organ immaturity, neurodevelopmental impairment until behavior disorder. Hypertension on pregnancy and preeclampsia is the most case referred and treated in dr. Soetomo General Hospital as a single tertiary teaching hospital in Surabaya, Indonesia which require early delivery and possess consequences to maternal and perinatal side. Objective: This study aims to determine the incidence and outcome of LBW infants born in dr. Soetomo General Hospital. Methods: Retrospective cross-sectional by using medical record data of dr. Soetomo General Hospital on January 2014 – December 2017. Results: There were 2350 infants with birth weight of 500-2499 gram, in which majority was on the range of 2001-2499 gram (38%.) Hypertension on pregnancy and the complications were the most indication for pregnancy termination that resulted in LBW infants. This study also found that the LBW outcome was linear with birth weight. In addition, the gestational age and five minutes APGAR score also had important role to the LBW outcome. Conclusion: The major cause of LBW infants in dr. Soetomo General Hospital was hypertension on pregnancy. There was a positive trend of survival in infants with birth weight range of 1501-2000 gram.
Clinical Forensic Examination on Mass Violence’s Victim With Head and Ocular Injury (A Case Report) Syarifah, Mustika Chasanatusy; Yudianto, Ahmad
Jurnal Medis Islam Internasional Vol 1 No 1 (2019): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i1.1389

Abstract

Introduction: Clinical forensic medicine is a branch of medicine that applies medicine to uphold justice in the case of living victims. In accordance with this understanding, the handling of cases of living victims, especially victims of crime, must involve doctors in the field of forensics, in addition to doctors in other fields according to their competence. With so many cases of violent crime, a doctor must be able to provide a report on the results of the examination to the legal apparatus to assist in the judicial process. Case: A man, aged 44 years, found bruises on right eyelid, left eye, left cheek, left and right scalp; blisters on the left and right eye membranes; a cut wound on the right eye membrane and the left eyelid; bleeding under the thick membrane of the brain and swelling of the brain. Discussion: Injuries can occur as a result of violence perpetrated by criminal offenses, such as cases of theft by violence, murder, traffic accidents or ill-treatment. The doctor must be able to mention that the wound examined is caused by sharp violence, blunt force, electrical trauma, thermal trauma, chemical trauma, or other causes of trauma. Determination of the magnitude of the effect of injury to the victim, related to criminal sanctions that will be imposed on the perpetrators of criminal acts. The head is an organ that is often the target of violent blunt crimes. The brain and the surrounding layers are easily susceptible to trauma, resulting in death compared to other body parts. The wound is in accordance with Criminal Code article 90 concerning serious injuries, which results in injuries that do not give any hope of healing at all.
Late Referral of Eisenmenger Syndrome in Pregnancy at Dr. Soetomo Hospital Surabaya Ali Abdat, Amira; Yusuf, Muhammad
Jurnal Medis Islam Internasional Vol 1 No 2 (2020): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i2.1588

Abstract

Background: Pregnancy with Eisenmenger syndrome is an obstetric problem which numbers keep rising every year. The cases require specific,decisive,and multidisciplinary approach.The unavailability of accurate diagnostic procedures, as well as the national consensus that has not been agreed on, all contributes to the increasing number of late referral that cause morbidity and the high risk of mortality. Purpose:  To know number and cause of late referral cases with Eisenmenger syndrome at Dr. Soetomo General Hospital, Surabaya in 2018-2019. Methods: Retrospective study by using medical records data of Dr. Soetomo General Hospital, Surabaya on January 2018- December 2019. Result: There are 18 cases of Eisenmenger syndrome from January 2018 to December 2019. Approximately 3 cases are timely referral while 15 cases are late referral cases. From those 15 late referral cases, about 12 cases (80%) are pregnant. Based on the risk factors, 73% of the patients have a congenital heart disease (Atrial septal defect) and severe pulmonary hypertension. In the postpartum referral cases group, 3 cases were referred because of suspected heart disease postpartum. Nearly all of the late referred cases have a bad prognosis those maternal deaths. There were 7 maternal deaths caused by cardiogenic shock. Regarding the source of referral, the majority of referred pregnant patient comes from out of Surabaya (73%), while for the postpartum patient, 13 % was referred from out of Surabaya.  According to the referral types, the majority of the late referral cases are emergency referral (73%), as for the postpartum referral, 20% are emergency referral. Conclusion: The number of late referral in Eisenmenger syndrome in Dr. Soetomo general hospital is still high. Further socialization and trainings regarding the early detection and management of Eisenmenger syndrome is still very much needed.
Management of Traumatic Intracranial Hemorrhage on Anticoagulant Regiment: A Literature Review Apriawan, Tedy; Kartosen, Ade Anugrah; Ishlahy, Ahmad Z. S.; Broto, Endang Pati; Herjuna, Hana Ranu; Permana, Khrisna Rangga; Meizikri, Rizki; Drehem, Shaleh; Bajamal, Abdul Hafid
Jurnal Medis Islam Internasional Vol 1 No 2 (2020): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i2.1611

Abstract

Oral anticoagulant and antiplatelet are often prescribed in clinical practice. These drugs are mainly consumed by geriatric patients to prevent or treat cerebrovascular, systemic embolism, or heart condition.  Managing anticoagulated TBI patients is a challenging task for surgeons. This study aims to review available literatures regarding anticoagulated TBI patients and to suggest a treatment algorithm for such cases. Based on several retrospective and prospective studies, it might be wasteful to do a routine follow-up CT scan on anticoagulated TBI patients. The risk of new lesion development or presenting lesion progression seems to be especially low among patients with negative initial CT scan. We suggest to reserve repeat CT scan for patients with evident neurological deterioration. Tighter observation for anticoagulated patients with positive initial CT scan might be useful. Anticoagulation reversal is recommended by the American College of Cardiology, but some studies reported that reversal should be directed by INR. Acute antiplatelet cessation is still controversial for aspirin, but it is advised for clopidogrel. Preoperative management of both anticoagulant and antiplatelet should take into account the bleeding risk of the surgical procedure. Blind cessation and reversal of anticoagulant and/or antiplatelet might delay the timing of surgery and thus would better be avoided
Body Mass Index and Albumin Level In Severe Preeclampsia Conservative Treatment Cases Winarko, Esmond; Yusuf, Muhammad
Jurnal Medis Islam Internasional Vol 1 No 2 (2020): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i2.1614

Abstract

Background : Severe preeclampsia is an obstetrical problem and one of the leading cause of death in obstetric. Conservative treatment for severe preeclampsia is a complicated and risky choice, but still a considerable option to achieve a better fetal outcome. Many factors that influence the results of conservative management are complex and still very much controversial. Objective: To study the BMI and albumin level of severe preeclampsia patients who underwent conservative management in dr. Soetomo General Hospital obstetric ward in 2018 – 2019. Method: This is a descriptive cross sectional study, where the data are obtained from morning reports, obstetric ward registry and dr. Soetomo General Hospital medical record during 2018 – 2019. Results: The total conservative cases were 51 in 2018 and 69 in 2019. The majority of the patients were 20-34 years old, multigravida, non-booked cases, Javanese ethnicity, and addressed in Surabaya. Most of them were obese (with BMI ≥ 30 kg/m2) with similar BMI distribution in the successful and unsuccessful conservative management groups. Most of our patients had albumin level below 3,5 g/dl. The majority of the patients were terminated by caesarean section with the fetal outcome mostly weighed less than 2000 g. Conclusion: The majority of the patients treated conservatively were 20-34 years old, multigravida, non-booked cases, Javanese ethnicity, and addressed in Surabaya. Most of the patients have BMI ≥ 30 kg/m2 and albumin levels below 3,5.
Maternal and Neonatal Outcome in Pregnant Women with Obesity in a Single Tertiary Referral Hospital in January - December 2017 Virdayanti, Dian Puspita; Gumilar, Khanisyah Erza
Jurnal Medis Islam Internasional Vol 1 No 2 (2020): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i2.1616

Abstract

Background: Maternal obesity is defined when BMI is above 30. It is now considered one of the most commonly occurring risk factors seen in obstetric practice and it increased risks of specific complications, and to medical, surgical and technical challenges in providing safe maternity care. Objectives: This study aims to review maternal dan neonatal outcomes and complications from pregnant women with obesity in Soetomo General Hospital on January - December 2017. Methods: Retrospective cross-sectional study by using medical record data of Dr. Soetomo General Hospital on January - December 2017. Results: There were 297 (21,5%) of maternal obesity from 1384 deliveries, in which the majority age range from 20-34 years old and multiparity. The most BMI category was BMI class 1 (61%). Caesarean section (77,4%) in this study became a major proportion in mode of delivery. In our study, the incidence of hypertension in pregnancy was high (45,4%), while the incidence of severe preeclampsia were 20,9%. The incidence of gestational diabetes were 7,1%, and pregestational diabetes were 3,4%. In our cases, there were 294 cases (94,2%) of livebirth, while there were four stillbirth cases. The incidence of intrauterine fetal death were four cases. There were 11 cases of macrosomia, 7 in 11 came from mother with obesity class III. Other neonatal complications are intrauterine growth restriction which were 26 cases and 18 cases congenital malformation. Conclusion: Most maternal complications in obese pregnant women are severe preeclampsia with mode of delivery by cesarean section. Gestational diabetes cases were found mostly in maternal obesity class I, while pregestational diabetes cases were found mostly in maternal obesity class II. Most neonatal Apgar score in our study were between 7-10, while most of congenital malformation was omphalocele

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