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Muhamad Thohar Arifin
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Muhamad Thohar Arifin MD. PhD. Faculty of Medicine, Diponegoro University Jl. Prof. Soedarto, Tembalang, Kec. Tembalang, Kota Semarang, Jawa Tengah 50275 Email: dimjoffice@gmail.com
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Diponegoro International Medical Journal (DIMJ)
Published by Universitas Diponegoro
ISSN : Without     EISSN : 27455815     DOI : https://doi.org/10.14710/dimj
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol 1, No 2 (2020): December" : 6 Documents clear
Correlation of Obesity Status with Zinc Serum Levels and Insulin Resistance in Perimenopause Obese Women Heidi Listya; Muhammad Sulchan; Etisa Adi Murbawani; Niken Puruhita; Amalia Sukmadianti
Diponegoro International Medical Journal Vol 1, No 2 (2020): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i2.9559

Abstract

Background : Obesity is one of the global health problems. The prevalence of obesity in women is higher than men. Various metabolic problems are caused by obesity, such as insulin resistance and deficiency of micronutrients such as zinc. The occurrence of insulin resistance in obesity is also influenced by zinc deficiency.Objectives : To analyse the correlation of obesity status with serum zinc levels and insulin resistance in perimenopause obese women.Methods : Correlational research with 62 perimenopause obese women subject aged  40-50 years old who met the inclusion and exclusion criteria. Serum zinc levels were measurement using AAS and insulin resistance using HOMA IR formula.  Serum zinc levels, fasting insulin, fasting blood glucose taken from venous blood. Hypothesis testing uses Pearson correlation.Results : 12.9% had low serum zinc levels and high HOMA IR 9.09%. There was a significant negative correlation between BMI with serum zinc levels   (r = -0.402; p = 0.001) and significant positive correlation between BMI   with insulin resistance (r = 0.396; p = 0.001). There was a significant negative correlation between WC with serum zinc levels    (r = -0.18 , p = 0.161) and significant positive correlation between WC with insulin resistance ( r =0.284  , p =0.025  ). and significant negative correlation between serum zinc levels with insulin resistance (r = -0.404; p = 0.001).Conclusion : There is a correlation between obesity status with serum zinc levels  and correlation between obesity status with insulin resistance  in perimenopause obese women.
Correlation Between Level of Depression and Risk of Suicide in Elderly at Purwodadi, Grobogan Rilla Fiftina Hadi; Titis Hadiati; Natalia Dewi Wardani
Diponegoro International Medical Journal Vol 1, No 2 (2020): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i2.9585

Abstract

Background: According to WHO, the elderly people have physical and mental challenges, including depression. The incidence of depression lead to suicide on elderly is about 12.7%. In Grobogan Regency, Purwodadi, Central Java, there has been an increase of depression in the last 5 years. Purwodadi Subdistrict depends on the number of orders with the highest number of traffic cases and the elderly.Objective: To determine the correlation between depression level and the risk of suicide.Methods: This research is a quantitative study with cross sectional design in which all respondents were observed and variables were measured at one time. Samples were taken from elderly outpatient of primary health care and Posyandu lansia at Purwodadi, who met the inclusion and exclusion criterias. Research samples were selected based on nonprobability sampling method through purposive sampling. This research used the Indonesian version of the GDS (Geriatric Depression Scale) and CSSRS (Columbia Suicide Severity Rating Scale) questionnaire.Results: The prevalence of elderly depression is 63.3%, and a significant correlation was found between severe depression and low risk of suicide (p <0.05)Conclusion: significant correlation was found between severe depression and low risk of suicide.
Adverse Outcome in a Near Term, High-Risk Twin Pregnancy Complicated by COVID-19: A case report Razmaeda Sarastry; Crismanto Layarta; Ussisti Aladini; Alini Hafiz; Besari Adi Pramono
Diponegoro International Medical Journal Vol 1, No 2 (2020): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i2.7937

Abstract

Background: COVID-19 affecting the outcome of pregnancy is still under investigation. Here we report a case of primigravida with monochorionic diamniotic twin pregnancy with superimposed preeclampsia who develop symptoms of COVID-19 infection on her near term pregnancy and was confirmed later on as COVID-19 positive after cesarean section. The pregnancy was terminated abdominally due to the intrauterine fetal demise of both twins using COVID-19 standard equipment.Case Presentation: A 29-year-old female, gravida 1, para 0 presented with a twin pregnancy at the gestational age of 36 weeks was referred to our emergency department for further management of intrauterine fetal death of both twins. Six days before admitted to our emergency department, she has been experienced a remittent fever which followed by a mild cough. Four days before admission, she complained of decrease movement of the babies. She went to the Secondary Hospital to check her pregnancy and both fetal heart rates were not found.  The patient is obese (BMI 49.2 kg/m2) and had prior uncontrolled hypertension but no other medical history, including epilepsy, allergies, asthma, heart disease as well as Diabetes Mellitus.Conclusion: A research about placental pathology in pregnancy with confirmed case of COVID-19 infection showed no pathognomonic feature in the histopathologic examination but mostly, there were maternal vascular malperfusion (decidual arteriopathy in particular) and intervillous thrombi. In the end, a further examination is suggested to evaluate the course and causal factors pertaining to this case.
The Effect of Nigella Sativa on Clinical Improvement of Laryngopharyngeal Reflux Patients Lusia Lusia; Farokah Farokah; Rery Budiarti
Diponegoro International Medical Journal Vol 1, No 2 (2020): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i2.8992

Abstract

Background : Laryngopharyngeal Reflux (LPR) decribes as retrograde reflux from gaster into the laryngopharynx because of the premature relaxation upper esophageal sphincter. The management of LPR patients includes lifestyle and dietary arrangements, medical therapy and surgical management. Nigella sativa (NS) / black cumin  has anti-inflammatory, anti-oxidant and gastroprotective effects that are expected to provide clinical improvement in LPR patients.Objective : The purpose of this study was to determine the effectiveness of NS on the clinical improvement of LPR patients.Methods : This research is an intervention study using pre and post test design methods of 34 LPR patients in Dr. Kariadi, hospital and 2 affiliated hospital  from November 2019 - March 2020.Result : 24 patients with complete data while 10 patients were unable to evaluate RFS because of a pandemic. The treatment group (15 patients) were given  omeprazole 20 mg / 12 hours plus NS 1000 mg / 12 hours orally and control group (9 patients) were given omeprazole 20 mg / 12 hours orally and placebo. Data were tested by Shapiro Wilk test, followed by the appropriate parametric test, and Fisher's exact test. There were no differences in clinical improvement in LPR based on RSI and RFS values between groups given additional NS and groups without NS, p 0.105.Conclusion : there were no significant differences in clinical improvement between groups given additional NS and groups without NS.
The Association of Cervical Length, Bacterial Vaginosis, Urinary Tract Infection and Premature Rupture of Membranes to The Imminent Preterm Labour Hariyo Wirastomo Prajarto; Besari Adi Pramono
Diponegoro International Medical Journal Vol 1, No 2 (2020): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i2.9538

Abstract

Background: Research conducted at the Central General Hospital (RSUP) Dr. Kariadi Semarang in 2013 stated that out of 1,719 deliveries, 82 (5%) were preterm labor cases. Although there are many predictors for predicting imminent preterm labour, the complete prediction and prevention have not been established. Prevention of preterm labor through screening is the key to antenatal care. Good early prediction on a premature labor will provide adequate antenatal surveillance and special interventions.Objective: to analyze the relationship between cervical length, bacterial vaginosis, urinary tract infections, and premature rupture of membranes with the incidence of preterm labor.Methods: It is an observational analytic study in the form of the design of cross sectional with subject of pregnant women who experienced imminent preterm labour at gestational age 28-34 weeks and were treated at the ward of Obstetrics Gynecology Hospital Dr. Kariadi Semarang and network hospital during the study period (n=112). Subjects were assessed for the clinical risk (BV, premature rupture of the membrane, urinary tract infection) and sonography (cervical length). Statistical analysis was performed with paired t-test for normally distributed data and Mann Whitney if otherwise. Analysis of the relationship between variables and the incidence of preterm labor was carried out by the X 2 testResults: From 112 subjects, it was found that the Prevalence Ratio (PR) for cervical length, bacterial vaginosis, urinary tract infections and premature rupture of membranes to the incidence of imminent preterm labor was 2.2;2.32;1.99 and 2.36 respectively. From the multivariate analysis, it was found that bacterial vaginosis and premature rupture of membranes were the most influencing factors for the incidence of imminent premature labor with Odd Ratios of 6.497 and 21.362, respectively.Conclusion: There is a relationship between cervical length (≤25 mm ), bacterial vaginosis, urinary tract infections and premature rupture of membranes in the incidence of preterm labor.
Obstructive Sleep Apnea Syndrome (OSAS) Decrease Concentration Levels in Young Adults Fidela Hanan Zivana; Neni Susilaningsih; Dwi Marliyawati; Kanti Yunika
Diponegoro International Medical Journal Vol 1, No 2 (2020): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i2.9543

Abstract

Background: Obstructive Sleep Apnea Syndrome (OSAS) is sleeping-disorder that’s characterized by recurrent episodes of upper airway obstruction during sleep. Fourteen percent of world populations suffer from OSAS. OSA patients are 7.5 to 20 times more likely to have difficulties with concentration, learning new tasks, and execution of monotonous tasks.Objective: The primary objective of this study was to investigate the relationship between Obstructive Sleep Apnea Syndrome (OSAS) and concentration level in young adultsMethods: This is an analytic observational study with cross-sectional design. Sampling was carried out with total sampling. Samples that qualified the inclusion and exclusion criteria were assessed by OSAS using the Epworth Sleepiness Scale (ESS) questionnaire and Digit Symbol Substitution Test was used to assess the concentration level. The data were analyzed, using the chi-square test and the prevalence (PR) testResults: The Chi-square test showed that there was a significant relationship between OSAS and concentration level (p=0.033). The Prevalence Ratio test found that OSAS decreased concentration level by 1.55 compared to not OSASConclusion: There was a significant relationship between OSAS and concentration level in young adults. OSAS patients are 1.55 more likely to have a decrease concentration level when compared with healthy individuals

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