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Muhamad Thohar Arifin MD. PhD. Faculty of Medicine, Diponegoro University Jl. Prof. Soedarto, Tembalang, Kec. Tembalang, Kota Semarang, Jawa Tengah 50275 Email: dimjoffice@gmail.com
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Diponegoro International Medical Journal (DIMJ)
Published by Universitas Diponegoro
ISSN : Without     EISSN : 27455815     DOI : https://doi.org/10.14710/dimj
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol 2, No 1 (2021): July" : 6 Documents clear
Risk Factors for Mortality among HIV/AIDS Patients Zaki Mita Kusumaadhi; Nur Farhanah; Muchlis Achsan Udji Sofro
Diponegoro International Medical Journal Vol 2, No 1 (2021): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i1.9667

Abstract

Background: Morbidity and mortality of HIV/AIDS infections is still high and as  a global health problem particularly in Low-Middle Income Countries (LMICs). Indonesia ranks third in Asia Pacific in increasing HIV infection. A Study on risk factors for mortality in HIV/AIDS patients in Dr. Kariadi General Hospital has never been conducted. This study analyzed the risk factors for mortality among HIV/AIDS patients.Methods: Case control study, data from medical records of inpatients and outpatients in Dr. Kariadi General Hospital from January 2015 to December 2017.Results: Study subject: Two hundred and ten HIV/AIDS patients, were included; 105 (56.75%) as cases and 105 (9.65%) control patients. The significant risk factors for mortality were as follow: male sex (p = 0.030); age ≥ 45 years (p = 0.035); non compliance to treatment (p = 0,000); WHO clinical stage III and IV (p = 0,000); co-infection of pulmonary tuberculosis (p = 0,000); CD4 cell count < 200 cells/mm3 (p = 0,000); eGFR < 60 mL/minute/1.72 m2 (p = 0.001) and Haemoglobin level < 10 g/dL (p = 0.008). The non-significant risk factors for mortality were as follow: level of education (p = 0.650); Hepatitis B co-infection (p = 0.153) and Hepatitis C co-infection (p = 0.506). The most important risk factors for mortality in this study in were non compliance to treatment (p = 0.003; OR = 3.285) and CD4 count < 200 cells/mm3 (p = 0.014; OR = 5.480).Conclusion: In this study, the risk factors for mortality in HIV/AIDS patients were male sex; age ≥ 45 years; non compliance to treatment; WHO clinical stage III and IV; co-infection of pulmonary tuberculosis, CD4 count < 200 cells/mm3; eGFR < 60 mL/minute/1.72 m2 and Hb level < 10 g/dL. The most important risk factors for mortality were non compliance to treatment and CD4 count < 200 cells / mm3.
The Effect of Using Blue Light Filter Feature on Smartphones with Asthenopia Occurrence Arnan Victor Wiryawan; Maharani Maharani; Tanti Ajoe Kesoema; Riski Prihatningtias
Diponegoro International Medical Journal Vol 2, No 1 (2021): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i1.9761

Abstract

Background: Smartphone users can be found in almost every class society in Indonesia. Excessive use of smartphones and the blue light emitted by smartphones play an important role in causing asthenopia symptoms. Smartphone development companies have developed a blue light filter feature, which is expected to reduce the incidence of Asthenopia symptoms.Objective: To evaluate the Asthenopia questionnaire's comparison results before and after smartphone use with various levels of opacity in the blue light filter.Methods: This study used a quasi-experimental pre-posttest study. The research subjects were students of the Faculty of Medicine, Diponegoro University (n = 30), selected by purposive sampling. In this study, research subjects saw an hour-long smartphone with a predetermined opacity level for the blue light filter, with the same room lighting. Before and after the treatment, the subjects were asked to fill out the Asthenopia questionnaire. Data were analyzed using the Wilcoxon test, Mann Whitney U test, and Kruskal Wallis test.Results: The results of the Asthenopia questionnaire before and after using a smartphone with a blue light filter opacity level of 0% and 100% showed a significant difference in results (p <0.05), and there was no significant difference for the pre-posttest using a smartphone with a blue light filter with 50% opacity level. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 0% and 50% only showed a significant difference in sore/aching eye symptoms. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 50% and 100% only showed a significant difference in sleepy eye symptoms. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 0%, 50%, and 100%, did not show a significant difference.Conclusion: There were no significant differences between the Asthenopia questionnaire results with 0%, 50%, and 100% opacity blue light filters after one hour of smartphone use.
Differences of Ampicillin and Cefazolin Effects in Reducing hs-CRP Level in Premature Rupture of Membranes Ahmad Bukhoeri; Syarief Thaufik Hidayat; Ediwibowo Ambari; Julian Dewantiningrum; Putri Sekar Wiyati; Besari Adi Pramono
Diponegoro International Medical Journal Vol 2, No 1 (2021): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i1.8428

Abstract

Background: Premature rupture of membranes (PROM) is a rupture of amniotic sac before delivery. PROM is associated with an increased incidence of preterm labor and infection. The use of prophylactic antibiotic may reduce the risks of infection. High-sensitivity C-reactive protein (hs-CRP) is an acute-phase reactant protein that is associated with PROM. How much effect of prophylactic antibiotic to hs-CRP level remains unclear.Objective: To compare the reduction in hs-CRP levels in premature rupture of membranes before and after given ampicillin or cefazolin.Methods: The design of this study was true experimental design (pre and post-test) conducted at Dr. Kariadi General Hospital Medical Center Semarang and Kartini General Hospital Jepara from September 2019 to January 2020. Study samples are pregnant women with premature rupture of membranes that came to the Emergency Department and Maternity Ward Dr. Kariadi General Hospital Medical Center Semarang and Kartini General Hospital Jepara. Samples were divided into two groups, a group treated with ampicillin and the other with cefazolin therapy. All samples were subjected to a hs-CRP examination. Statistical analysis was performed by Mann-Whitney and Wilcoxon.Results: There are no significant differences in the age variable (28.8 ± 6.54 vs 29.1 ± 5.93), gestational age (36.3 ± 2.55 vs 36.3 ± 2.90), and parity (2,2 ± 0.99 vs 2.47 ± 1.19) in the ampicillin and cefazolin groups (p> 0.05). In this study, 37.1% patients have a history of PROM while 62.9%. had no history of PROM. Reduction in hs-CRP levels after administration of ampicillin and cefazolin was significant (4.4 ± 2.65 mg/L vs 6.3 ± 4.43 mg/L, respectively, p = 0.03). The difference in the decrease in hs-CRP levels before and after given ampicillin and cefazolin was significant (p = 0.0001). Conclusion: There is a decrease in hs-CRP levels after the administration of ampicillin or cefazolin in PROM, whereas cefazolin induced higher reduction in hs-CRP levels. Ampicillin can still be used as a first-line prophylactic antibiotic in primary healthcare facilities.
The Correlation Between Cobb’s Angle and Pedicle Rotation in Adolescent Idiopathic Scoliosis After Surgical Treatment Danu Purnama Aji; Hermina Sukmaningtyas; Agus Priambodo; Christina Hari Nawangsih
Diponegoro International Medical Journal Vol 2, No 1 (2021): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i1.9531

Abstract

Background: Adolescent Idiopathic Scoliosis (AIS) is a 3-dimensional deformity that involves not only curve in the coronal and sagittal planes but also rotation of vertebrae based on pedicle rotation. The Cobb’s angle is  the gold standard for measuring the lateral curve that could show severity of the spine deformity. The Cobb’s method only evaluate the lateral curve,and the method to determine the pedicle rotation can be used the Nash and Moe’s method.The higher pedicle rotation grade had higher Cobb’s angle. Surgical treatment for scoliosis is indicated for the curve exceeding 40o. Posterior spinal fusion is the most commonly used technique in scoliosis surgery.Objective: To identify the correlation between the Cobb’s Angle and pedicle rotation in AIS after surgical treatment.Methods: The research design used in this study was Cross Sectional. The sample size of this study were 22 subjects using purposive sampling, the independent variable of this study was Cobb’s angle while the dependent variable was pedicle rotation. Spearman’s rank correlation was used to analyze the correlation between variable.Results: The spearman’s rank correlation revealed a significant correlation between the Cobb’s Angle and pedicle rotation in AIS after surgical treatment with the  p 0,005 and r 0,462.Conclusion: This study demonstrates there is a significant correlation between Cobb’s angle and pedicle rotation in AIS after surgical treatment with medium strength. 
Correlation between Prolactin Serum with Neutrophil Lymphocyte Ratio (NLR) in Systemic Inflammatory Response Syndrome Dwi Retnoningrum; Meita Hendrianingtyas; Hermawan Istiadi; Ardhea Jaludamascena
Diponegoro International Medical Journal Vol 2, No 1 (2021): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i1.9546

Abstract

Background: Systemic inflammatory response syndrome (SIRS) is a state of systemic inflammatory activation by various causes. SIRS have a high mortality rate. Prolactin is known to regulate cellular function of immune system.  Neutrophil-lymphocyte ratio (NLR) is simple, cost effective and easy parameter that currently used as inflammation marker.Objective: The aims of this study is to determine the correlation between prolactin serum with NLR in SIRS patients.Methods: A cross sectional study was conducted on 50 clinically SIRS patients. Prolactin serum was measured by enzyme linked immunosorbent assay (ELISA) and NLR was calculated manually from absolute neutrophil and lymphocyte count measured by automatic hematology analyzer. Non-parametric Spearman test was used to analyze the correlation between prolactin with NLR.Results: Median value of serum prolactin level was 11.32 ng/mL (2.76-194.81), whereas the mean value NLR was 16.36 ± 11.58. The correlation between prolactin levels with NLR was r = 0.345, p = 0.014.Conclusion: There is a weak positive significant correlation between prolactin with neutrophil lymphocyte ratio in SIRS
Efficacy of Vitamin B1, B6, and B12 Forte Therapy in Peripheral Neuropathy Patients Meyvita Silviana; Dodik Tugasworo; Maria Belladonna
Diponegoro International Medical Journal Vol 2, No 1 (2021): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i1.9549

Abstract

Background: Peripheral neuropathy can be caused by diabetes mellitus, nutritional deficiencies, entrapment or Carpal Tunnel Syndrome (CTS), and idiopathic.Objective: To determine the therapeutic efficacy of Vitamin B1, B6, and B12 forte in relieving symptoms of peripheral neuropathy.Methods: This was pre- and post-experimental study involving patients with moderate peripheral neuropathy (Toronto Clinical Neuropathy Score [TCNS] ≥6 and Michigan Neuropathy Screening Instrument [MNSI] ≥7) taken from outpatient neurological clinic of Dr. Kariadi Hospital, Semarang. The patient was prescribed Vit B1 100 mg, B6 100 mg, and B12 5000 mcg once daily for 2 months. Evaluation of the numerical pain rating scale in the form of VAS and Total Symptom Score (TSS) was conducted at the first and second month. The VAS score difference test was conducted with the Wilcoxon test and TSS with the Post Hoc test and considered significant if p <0.05.Results: There were 30 patients aged 18 - 65 years, consisted of 70% female and 30% male. The etiology of peripheral neuropathy were idiopathic (40%), CTS (26.7%), DM (23.3%), and HNP (10%). There were significant differences of the VAS scale  and TSS at every evaluations.Conclusion: Administration of VitB1, B6, and B12 forte relieved symptoms of moderate peripheral neuropathy with improvement of VAS and TSS scores

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