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JOURNAL LA MEDIHEALTICO
Published by Newinera Publisher
ISSN : 27211215     EISSN : 27211231     DOI : 10.37899/journallamedihealtico.v6i2.1959
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Journal La Medihealtico is peer reviewed, open access Academic and Research Journal which publishes Original Research Articles, Review Article, Case Report editorial comments etc. in all fields of medical sciences and health sciences including Health Care Delivery, Health Care Research, Epidemiology, Medical Care, Nursing, Nursing Education, Neonatal nurse, Home Health Nursing Community and Homecare, Information Technology in Nursing, Occupational Health and Safety, Midwifery, Health Care Administration, Hospital Science and Management, Innovations in Patient Care, Public Health, Health Psychology, Social Health, Physical health, Quaternary Care, Secondary Care, Veterinary Nursing, Medical Sciences and Pharmaceutical Sciences, Hospital and Clinical Pharmacy, Pathology, Physiotherapy & Rehabilitation, Ergonomics, Food and Nutrition, Veterinary Medicines.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 528 Documents
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Literature Review: Major Depression with Somatic Comorbidities Andini Yusuf; Muhammad Alim Jaya; Zulfitriani Murfat
Journal La Medihealtico Vol. 7 No. 3 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i3.3366

Abstract

Major depressive disorder (MDD) is a mood disorder often accompanied by somatic symptoms and chronic physical illness. Complaints such as pain, fatigue, insomnia, headaches, and palpitations are often the primary reasons patients seek medical help, often resulting in a delayed diagnosis. This study aims to determine the relationship between major depression and somatic comorbidities based on published research. The method used was a literature review with a narrative review design. Articles were searched in the PubMed and Google Scholar databases using the keywords "major depressive disorder," "major depression," and "somatic comorbidities." A selection process based on inclusion and exclusion criteria yielded 12 articles published between 2016 and 2026. The review results indicate that major depression is significantly associated with somatic symptoms and chronic physical illnesses such as cardiovascular disease, diabetes mellitus, heart failure, migraines, and metabolic disorders. This relationship is bidirectional, with physical illnesses increasing the risk of depression and depression worsening physical conditions. Management of major depression requires a holistic approach through pharmacotherapy, psychotherapy, and optimal management of physical illnesses.
The Role of Ferritin as an Inflammation and Prognostic Marker in Systemic Infectious Diseases: A Litterature Review Nurafni Maharani Nawawi; Irna Diyana Kartika Kamaluddin; Abbas Zavey Nurdin; Muhammad Jabal Nur; Akhmad Kadir
Journal La Medihealtico Vol. 7 No. 3 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i3.3367

Abstract

Systemic infectious diseases, including sepsis, COVID-19, and tuberculosis, remain major causes of morbidity and mortality worldwide and require reliable biomarkers for early risk stratification and prognosis. This literature review aims to evaluate the role of serum ferritin as an inflammatory and prognostic marker in systemic infectious diseases. This study used a systematic literature review design guided by the PICOS framework. Articles were identified through electronic databases, including PubMed, Google Scholar, ScienceDirect, ResearchGate, and other relevant sources, focusing on studies published between 2020 and 2026. The review included peer-reviewed full-text studies that measured serum ferritin levels and reported relevant clinical outcomes, such as disease severity, mortality, length of hospitalization, intensive care requirement, or inflammatory parameters. A total of 15 eligible studies were included in the synthesis. The findings showed that elevated serum ferritin is closely associated with systemic inflammation through cytokine-mediated pathways, macrophage activation, and neutrophil extracellular trap formation. In sepsis, high ferritin levels were consistently associated with increased mortality, longer intensive care stay, and multiorgan dysfunction. In COVID-19, ferritin was higher in severe cases and was related to ICU admission and mortality. In tuberculosis, ferritin was more relevant for monitoring treatment response and persistent infection. Overall, serum ferritin has important clinical value as an accessible and affordable biomarker for assessing inflammation, disease severity, and prognosis in systemic infectious diseases, although standardized cut-off values remain necessary for broader clinical application.
Effectiveness of Turmeric (Curcumin Longa L) Against CRP and IL-6: Literature Review Eka Nur Maulidya; Irna Diyana Kartika; Abdi Dwiyanto
Journal La Medihealtico Vol. 7 No. 3 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i3.3370

Abstract

Inflammation is a biological response to infection, injury, or tissue damage and is commonly marked by increased inflammatory biomarkers, including C-Reactive Protein (CRP) and Interleukin-6 (IL-6). Turmeric (Curcuma longa L.), particularly its active compound curcumin, has been widely studied for its anti-inflammatory potential through the inhibition of nuclear factor-kappa B (NF-κB), cyclooxygenase-2 (COX-2), and pro-inflammatory cytokines. This study aimed to review the effectiveness of turmeric/curcumin in reducing CRP and IL-6 levels based on previously published studies. This research used a narrative literature review design by collecting relevant articles from Google Scholar, Semantic Scholar, PubMed NCBI, and ResearchGate. The inclusion criteria consisted of full-text articles published between 2021 and 2026, written in Indonesian or English, and discussing the effect of turmeric or curcumin on CRP and/or IL-6. A total of 10 articles were reviewed and analyzed descriptively. The findings showed that turmeric/curcumin supplementation generally demonstrated anti-inflammatory effects, particularly in reducing CRP levels. Several studies also reported significant reductions in IL-6, especially in chronic inflammatory conditions such as type 2 diabetes mellitus, asthma, and other metabolic disorders. However, the effectiveness of curcumin on IL-6 remained inconsistent across different clinical conditions, including chronic kidney disease, rheumatoid arthritis, and systemic lupus erythematosus. These variations may be influenced by dosage, duration of supplementation, disease severity, sample characteristics, and curcumin bioavailability. In conclusion, turmeric/curcumin has potential as an adjunctive anti-inflammatory therapy, particularly for reducing CRP levels, while its effect on IL-6 requires further confirmation through well-designed clinical studies with larger sample sizes and standardized formulations.
Ascariasis with Paralytic Ileus and Acute Gastroenteritis in a 2-Year-Old Child: A Case Report Andi Husni Esa Darussalam; Irmayanti Irmayanti; Nurfachanti Fattah
Journal La Medihealtico Vol. 7 No. 3 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i3.3371

Abstract

Ascariasis, caused by Ascaris lumbricoides, is a common soil-transmitted helminth infection among children in developing countries. Severe infestation may cause gastrointestinal complications, including intestinal obstruction and ileus. This case report describes the clinical presentation, diagnostic findings, and management of a pediatric patient with ascariasis complicated by ileus, acute gastroenteritis, dehydration, and electrolyte imbalance.A 2-year-old girl presented with watery diarrhea for three days, vomiting, fever, decreased appetite, and a history of passing worms in her stool. Physical examination revealed a moderately ill appearance, a tympanic abdomen, and decreased bowel peristalsis. Laboratory findings showed eosinophilia, basophilia, hypokalemia at 3.2 mmol/L, and hypochloremia at 93.1 mmol/L. Stool examination revealed watery stool with mucus, 6–11 leukocytes per high-power field, and Ascaris lumbricoides eggs. Abdominal radiography demonstrated dilated small and large bowel loops with a herringbone pattern suggestive of ileus.The patient was diagnosed with ascariasis complicated by ileus, acute gastroenteritis, mild-to-moderate dehydration, and electrolyte imbalance. Management included intravenous rehydration, nasogastric decompression, ondansetron, albendazole 400 mg as a single dose, zinc supplementation, oral rehydration therapy, and empirical ceftriaxone. During hospitalization, gastrointestinal symptoms gradually improved, accompanied by continued passage of worms in the stool.This case emphasizes the importance of prompt diagnosis and comprehensive management of complicated pediatric ascariasis. Hygiene education, environmental sanitation, and regular deworming remain essential to prevent infection and reinfection in endemic areas.
Description of Medical Students' Understanding of Islamic Values in Forming the Professional Character of Muslim Doctors: Literature Review Ade Lutfia Widya N; Sri Julyani; Rachmat Faisal Syamsu
Journal La Medihealtico Vol. 7 No. 3 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i3.3372

Abstract

Professionalism is a core competency in medical education and requires not only scientific knowledge and clinical skills but also ethical, moral, and spiritual values. In Islamic medical education, values such as amanah, ṣidq, raḥmah, ‘adl, ihsan, ikhlas, and sabar are considered essential in shaping the professional character of Muslim doctors. This study aimed to describe medical students’ understanding of Islamic values and their role in forming the professional character of Muslim physicians. This study used a narrative literature review design. Literature was searched through PubMed/MEDLINE, Google Scholar, ResearchGate, and manual reference searches. From 160 initially identified articles, 15 articles published between 2021 and 2025 met the inclusion criteria and were analyzed using narrative synthesis. The findings showed that medical students generally demonstrated good cognitive and affective understanding of Islamic values, particularly in relation to integrity, responsibility, and spiritual awareness. However, the behavioral implementation of these values in clinical settings remained limited. Several studies showed a gap between students’ understanding of Islamic values and their professional behavior, including low consistency in applying Islamic etiquette and limited courage to report professional misconduct. The internalization of Islamic values was influenced by curriculum integration, role models, academic culture, clinical experience, spirituality, psychological well-being, and peer pressure. This review concludes that Islamic values are highly relevant to medical professionalism, but their implementation requires structured curriculum integration, continuous character assessment, reflective clinical learning, and strong role models from senior clinicians.
The Role of Maternal Stress Epigenetics in the Risk of Stunting among Children Aged 0–24 Months: A Community-Based Longitudinal Study Juli Purnama Hamudi; Via Zakiah; Harni Harni
Journal La Medihealtico Vol. 7 No. 4 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i4.3376

Abstract

Stunting is a major child health problem influenced by multiple factors, including maternal conditions during pregnancy. This study aimed to analyze the relationship between maternal stress, epigenetic mechanisms, and the risk of stunting in children aged 0–24 months. A community-based prospective longitudinal cohort design was employed, involving 30 pregnant women who were followed until their children reached 24 months of age. Maternal stress was assessed using the Perceived Stress Scale (PSS), while epigenetic analysis was conducted via DNA methylation of the IGF2 gene from umbilical cord blood samples. Stunting status was determined based on length-for-age (LAZ) according to WHO standards. The results indicated a tendency toward an increased risk of stunting among mothers with high stress levels (OR=9.00; p>0.05), along with increased IGF2 methylation. Although not statistically significant, the pattern of association was clinically consistent. It is concluded that maternal stress may increase the risk of stunting through epigenetic mechanisms. Integrating stress management into antenatal care is recommended as a strategy for stunting prevention.
Determinant Analysis of Electronic Medical Record Completeness Based on Physician Workload: A Systematic Literature Review Aditya Ihza Dwi Pangestu; Muzakar Isa; Noor Alis Setiyadi
Journal La Medihealtico Vol. 7 No. 3 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i3.3377

Abstract

Electronic Health Records (EHR) are crucial tools in the transformation of clinical governance and hospital information management. Despite offering numerous benefits, EHR implementation often conflicts with physicians’ heavy clinical workload, which risks reducing the level of documentation compliance and completeness. This incomplete medical data not only threatens patient safety but also hinders the insurance claims process and harms institutional operations. This study aims to systematically identify and analyze the factors determining EHR documentation completeness based on physician workload in inpatient facilities. The method used is a Systematic Literature Review (SLR) following the PRISMA 2020 framework. A comprehensive literature search was conducted using the Google Scholar database, focusing on publications from 2021 to 2026. From the initial identification to the final screening stage, 18 empirical study articles that met all inclusion criteria were extracted and analyzed thematically. The results of the literature review indicate that high operational burdens affect EHR completeness through two main determinant dimensions. First, the heavy workload during service hours triggers documentation delays, forcing physicians to perform additional administrative work outside of official duty hours (pajama time), resulting in reduced data accuracy. Second, the cognitive burden stemming from non-ergonomic EHR system interface designs leads to digital interaction fatigue (click fatigue) among medical personnel. In conclusion, excessive clinical and administrative workloads have been shown to significantly reduce the compliance rate for complete EHR documentation. Consequently, hospital management is advised to redesign system interfaces to better align with clinical workflows and provide support such as documentation assistants to optimize medical record quality without compromising physician well-being.
The Effectiveness of Combined Deep-Breathing Relaxation and Endorphin Massage in Reducing Pain and Anxiety During the Active Phase of the First Stage of Labor Via Zakiah; Juli Purnama Hamudi; Harni Harni
Journal La Medihealtico Vol. 7 No. 4 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i4.3380

Abstract

Pain and anxiety during the active phase of the first stage of labor may increase physiological stress responses and potentially interfere with labor progress. Complementary therapies, including deep breathing relaxation and endorphin massage, have been widely used as non-pharmacological approaches to improve maternal comfort. To analyze the effectiveness of a complementary therapy combining deep breathing relaxation and endorphin massage in managing pain and anxiety during the active phase of the first stage of labor. A quasi-experimental study with a pretest-posttest control group design was conducted from January to March 2026 in the coastal area of Kendari City, Southeast Sulawesi, Indonesia. A total of 30 participants were recruited using purposive sampling and divided into an intervention group (n=15) and a control group (n=15). Pain intensity was assessed using the Numeric Rating Scale (NRS), while anxiety levels were measured using the Hamilton Anxiety Rating Scale (HARS). The intervention group demonstrated a significant reduction in pain intensity from 7.80 to 4.20 (p=0.000) and in anxiety levels from 26.5 to 18.3 (p=0.000). The mean reduction in pain (3.60 ± 0.75) and anxiety (8.20 ± 1.90) was significantly greater than that observed in the control group (p = 0.000). The combination of deep breathing relaxation and endorphin massage is an effective complementary therapy for reducing pain intensity and anxiety during the active phase of the first stage of labor and may be integrated into routine maternity care.

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