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JOURNAL LA MEDIHEALTICO
Published by Newinera Publisher
ISSN : 27211215     EISSN : 27211231     DOI : 10.37899/journallamedihealtico.v6i2.1959
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Journal La Medihealtico is peer reviewed, open access Academic and Research Journal which publishes Original Research Articles, Review Article, Case Report editorial comments etc. in all fields of medical sciences and health sciences including Health Care Delivery, Health Care Research, Epidemiology, Medical Care, Nursing, Nursing Education, Neonatal nurse, Home Health Nursing Community and Homecare, Information Technology in Nursing, Occupational Health and Safety, Midwifery, Health Care Administration, Hospital Science and Management, Innovations in Patient Care, Public Health, Health Psychology, Social Health, Physical health, Quaternary Care, Secondary Care, Veterinary Nursing, Medical Sciences and Pharmaceutical Sciences, Hospital and Clinical Pharmacy, Pathology, Physiotherapy & Rehabilitation, Ergonomics, Food and Nutrition, Veterinary Medicines.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 533 Documents
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Relationship Between Hypertension History and Nutritional Status with the Incidence of Preeclampsia in Pregnant Women: Literature Review Arifah Ayu Tri Wahyuni; Susiawaty Mustafa Syarief; Muhammad Jabal Nur; Nurhikmawati Nurhikmawati; Akina Maulidhany Tahir
Journal La Medihealtico Vol. 7 No. 4 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i4.5923

Abstract

Preeclampsia is one of the leading causes of perinatal morbidity and mortality worldwide, particularly in developing countries. High intake of saturated fats, pro-inflammatory diets, and excess body weight increase the risk of hypertension during pregnancy. A history of hypertension and maternal nutritional status are recognized as important risk factors contributing to the occurrence of preeclampsia. This literature review aimed to determine the relationship between a history of hypertension and nutritional status with the incidence of preeclampsia in pregnant women, based on several sources obtained through the internet, including research findings from international and national journals, citations from the Faculty of Medicine UMI, ClinicalKey, textbooks, and conference proceedings published between 2015 and 2026. The review findings indicate that the majority of studies reported that a history of hypertension significantly increases the risk of preeclampsia. In addition, excessive nutritional status such as overweight and obesity is strongly associated with a higher incidence of preeclampsia through mechanisms involving chronic inflammation, insulin resistance, oxidative stress, and endothelial dysfunction. Conversely, undernutrition and deficiencies of certain micronutrients may worsen the risk through impaired placental perfusion. The combination of a history of hypertension and suboptimal nutritional status exerts a synergistic effect on increasing the risk of preeclampsia. It is concluded that a history of hypertension and nutritional status are important determinants of preeclampsia; therefore, preconception screening, blood pressure control, and nutritional interventions need to be strengthened as preventive strategies.
The Role of HbA1c Levels in DM Patients with Coronary Heart Disease Incidents Putri Aulia Cahyani; Akina Maulidhany Tahir; Rezky Putri Indarwati Abdullah; Irna Diyana Kartika Kamaluddin; Abdul Mubdi Ardiansar Arifuddin Karim
Journal La Medihealtico Vol. 7 No. 4 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i4.5924

Abstract

Diabetes mellitus is a major risk factor for coronary heart disease (CHD), particularly when long-term glycemic control is inadequate. Glycated hemoglobin (HbA1c) reflects average blood glucose levels over the previous two to three months and may serve as an indicator of cardiovascular risk. This study aimed to examine the role of HbA1c levels in the incidence, severity, and clinical outcomes of CHD among patients with diabetes mellitus. A narrative literature review was conducted using articles published between 2021 and 2026 and retrieved from Google Scholar, PubMed, ScienceDirect, and ResearchGate. Studies were selected according to predetermined inclusion and exclusion criteria and critically evaluated using the Joanna Briggs Institute appraisal instruments. A total of 29 relevant studies were reviewed and synthesized narratively. Most studies demonstrated that elevated HbA1c levels were associated with an increased risk of CHD, greater coronary artery stenosis, more severe atherosclerotic lesions, and poorer cardiovascular outcomes, including major adverse cardiovascular events, restenosis following percutaneous coronary intervention, hospital readmission, and mortality. However, several cross-sectional studies reported no statistically significant association, possibly because of differences in sample characteristics, study design, duration of diabetes, assessment methods, and accompanying cardiovascular risk factors. Overall, poor glycemic control contributes to the development and progression of CHD through chronic hyperglycemia, oxidative stress, endothelial dysfunction, inflammation, and accelerated atherosclerosis. Regular HbA1c monitoring and individualized glycemic control are therefore important components of cardiovascular risk prevention and diabetes management.
Systematic Review: The Effect of Preemptive Ketamine Administration on Post-Surgical Neutrophil to Lymphocyte Ratio And Interleukin-6 (Il-6) Levels Muhammad Fakhri R; Muhammad Wirawan Harahap; Herawaty Baderu
Journal La Medihealtico Vol. 7 No. 4 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i4.5985

Abstract

Surgical stress induces systemic inflammation characterized by increased neutrophil-to-lymphocyte ratio and interleukin-6 levels, which may contribute to postoperative pain, immune dysfunction, and complications. This systematic review aimed to evaluate the effects of preemptive ketamine administration on postoperative neutrophil-to-lymphocyte ratio and interleukin-6 levels. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Relevant studies were identified through PubMed, ScienceDirect, the Cochrane Central Register of Controlled Trials, Google Scholar, and ClinicalKey. Study selection was based on predefined population, intervention, comparison, outcome, and study-design criteria. Data were extracted using standardized tables, methodological quality was assessed using appropriate risk-of-bias instruments, and the findings were synthesized narratively according to ketamine dose, surgical procedure, biomarker measurement time, and clinical outcomes. Of 807 records identified, 17 studies were included in the final synthesis. Preemptive intravenous ketamine or S-ketamine generally reduced the early postoperative increase in the neutrophil-to-lymphocyte ratio and suppressed interleukin-6 secretion, particularly at subanesthetic doses of 0.3–0.75 milligrams per kilogram. These immunomodulatory effects were accompanied by lower postoperative pain scores, reduced opioid requirements, fewer episodes of postoperative nausea and vomiting, and a lower risk of chronic postsurgical pain. However, variations in dosage, surgical procedures, anesthetic techniques, and biomarker measurement times limited direct comparisons between studies. Preemptive ketamine appears to provide beneficial analgesic and immunomodulatory effects by attenuating postoperative systemic inflammation, although further standardized randomized trials are required to determine the optimal dosing regimen.

Page 54 of 54 | Total Record : 533

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