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JOURNAL LA MEDIHEALTICO
Published by Newinera Publisher
ISSN : 27211215     EISSN : 27211231     DOI : 10.37899/journallamedihealtico.v6i2.1959
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Journal La Medihealtico is peer reviewed, open access Academic and Research Journal which publishes Original Research Articles, Review Article, Case Report editorial comments etc. in all fields of medical sciences and health sciences including Health Care Delivery, Health Care Research, Epidemiology, Medical Care, Nursing, Nursing Education, Neonatal nurse, Home Health Nursing Community and Homecare, Information Technology in Nursing, Occupational Health and Safety, Midwifery, Health Care Administration, Hospital Science and Management, Innovations in Patient Care, Public Health, Health Psychology, Social Health, Physical health, Quaternary Care, Secondary Care, Veterinary Nursing, Medical Sciences and Pharmaceutical Sciences, Hospital and Clinical Pharmacy, Pathology, Physiotherapy & Rehabilitation, Ergonomics, Food and Nutrition, Veterinary Medicines.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 528 Documents
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Computational and Experimental Evaluation of Alkaloid Compounds from Papaver somniferum as Dual COX-2 and TNF-α Inhibitors Poyizar Poyizar; Nurfitriyana Rahmat; Syaiful Katadi; Rahayu Aprianti; Irman Idrus
Journal La Medihealtico Vol. 7 No. 1 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i1.3065

Abstract

This study aimed to evaluate the computational and experimental potential of alkaloid compounds isolated from Papaver somniferum as dual inhibitors of cyclooxygenase-2 (COX-2) and tumor necrosis factor-alpha (TNF-α) in an in vitro inflammatory model. The alkaloid fraction was purified from dried capsules/latex of Papaver somniferum and subsequently tested using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Anti-inflammatory activity was assessed by measuring reductions in prostaglandin E₂ (PGE₂) production as an indicator of COX-2 inhibition and TNF-α levels in the cell culture supernatant. Preliminary safety evaluation was conducted using an MTT cytotoxicity assay on non-tumor cells, along with analysis of COX-2 and TNF-α gene expression using RT-qPCR. The alkaloid fraction exhibited concentration-dependent inhibitory effects on both PGE₂ and TNF-α production, with IC₅₀ values observed within the intermediate concentration range. In contrast, the CC₅₀ value in non-tumor cells was substantially higher, resulting in a favorable selectivity index that suggests a relatively wide therapeutic window. Furthermore, treatment with non-toxic concentrations of the alkaloid fraction led to a significant downregulation of COX-2 and TNF-α mRNA expression, supporting the hypothesis that its anti-inflammatory mechanism involves modulation of pro-inflammatory transcriptional pathways. Overall, the alkaloid fraction derived from Papaver somniferum demonstrates promising potential as a multitarget anti-inflammatory agent and warrants further investigation as a source of lead compounds or phytopharmaceutical candidates for the treatment of chronic inflammatory diseases.
Strategies to Enhance Inpatients’ Revisit Intention through the Blue Ocean Strategy and Customer Satisfaction Index A. Dwi Hermin Alfian; Yusriani Yusriani; Yuliati Yuliati; Nur Ulmy Mahmud; Muh. Khidri Alwi
Journal La Medihealtico Vol. 7 No. 1 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i1.3066

Abstract

Patients’ revisit intention represents a crucial indicator of hospital service sustainability and is strongly influenced by service quality and patient satisfaction. Amid increasingly intense competition among healthcare providers, hospitals are required to develop innovative strategies that emphasize value creation and patient experience. The Blue Ocean Strategy approach, combined with patient satisfaction measurement using the Customer Satisfaction Index (CSI), offers a strategic alternative for enhancing hospital competitiveness. This study aimed to analyze the relationship between the implementation of the Blue Ocean Strategy and the Customer Satisfaction Index with patient satisfaction, as well as their association with inpatient revisit intention at Permata Hati Mother and Child Hospital, Makassar City. This study employed an analytic quantitative design with a cross-sectional approach. A total of 190 hospitalized patients were selected as respondents using purposive sampling techniques. Data were analyzed descriptively and bivariately using Pearson correlation and Chi-square tests. The results indicated that the majority of respondents were aged 30–39 years, female, and users of the National Health Insurance (BPJS Kesehatan) scheme. Bivariate analysis revealed a significant relationship between the implementation of the Blue Ocean Strategy and inpatient satisfaction (p < 0.05), as well as a significant association between the Customer Satisfaction Index and patient satisfaction (p < 0.05). Furthermore, patient satisfaction was found to be significantly associated with inpatient revisit intention at Permata Hati Mother and Child Hospital, Makassar City (p < 0.05). In conclusion, the implementation of innovative service strategies and higher levels of patient satisfaction are significantly associated with inpatients’ revisit intention.
Literature Review: A Comparative Analysis of Postoperative Urinary Tract Infection Risk between Long-Term and Short-Term Catheterization Nurfaisah Fadilah; Aziz Beru Gani; Hasan Hasan
Journal La Medihealtico Vol. 7 No. 1 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i1.3073

Abstract

The insertion of a urinary catheter is a routine procedure in various surgical interventions to keep the bladder empty; however, prolonged catheterization is known to increase the risk of urinary tract infection (UTI) through biofilm formation, bacterial colonization, and enhanced antimicrobial resistance. This study aims to compare postoperative UTI risk between short-term and long-term catheterization to determine the safest optimal duration. The research method uses a narrative literature review of nationally and internationally indexed journals published between 2015 and 2025, using keywords related to CAUTI, short-term catheterization, long-term catheterization, and catheter duration. Analysis of 25 cohort studies showed that long-term catheter use (>7 days) results in a significantly higher incidence of CAUTI (26.7% vs 7.1%) with a relative risk of 3.84, with infection onset rising sharply from day 3 and reaching a plateau after day 14, as well as a predominance of multidrug-resistant pathogens such as Pseudomonas aeruginosa and Enterococcus faecalis. The pathogenesis involves mature biofilm formation by days 7–10, increased expression of resistance genes, and enhanced horizontal gene transfer. These findings confirm that catheter duration is the strongest independent risk factor for CAUTI, and strategies such as early catheter removal, nurse-driven removal protocols, antimicrobial-coated catheters, and closed drainage systems have been shown to reduce CAUTI incidence by 40–60%. In conclusion, short-term catheterization is significantly safer than long-term use, and implementing protocols to reduce catheter duration is the most effective measure in preventing postoperative CAUTI.
Differences in Anti-Müllerian Hormone Levels Before and After Platelet-Rich Plasma–Based Ovarian Rejuvenation in Patients with Premature Ovarian Insufficiency Aprillia Tamitha Hoata; Kadek Ayu Restu Paharbumi; Ida Bagus Putra Adnyana; Anom Suardika; Made Darmayasa; Kadek Agus Wijaya; Made Angga Diningrat
Journal La Medihealtico Vol. 7 No. 1 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i1.3081

Abstract

Premature Ovarian Insufficiency (POI) is defined as a decline in ovarian function before the age of 40, with an estimated prevalence of approximately 3.7%, particularly higher in countries with low to medium Human Development Index (HDI). POI can negatively affect both physical and psychological health in women. Anti-Müllerian Hormone (AMH) is widely recognized as a biomarker to assess ovarian reserve. Recently, Platelet-Rich Plasma (PRP) therapy has been investigated as a novel approach to enhance AMH levels and rejuvenate ovarian function in POI patients. To evaluate the effect of PRP-based ovarian rejuvenation therapy on AMH levels in women with POI. This retrospective observational analytic study involved 33 women diagnosed with POI who underwent PRP ovarian rejuvenation therapy at Bali Royal Hospital between 2022 and 2024. Total sampling was employed, and secondary data were obtained from patient medical records. Data were analyzed using univariate and bivariate methods, specifically paired-sample t-tests. The study included 33 women with a mean age of 35.62 ± 5.68 years. The mean baseline AMH level was 0.53 ± 0.34 ng/mL, which increased to 0.66 ± 0.46 ng/mL three months after PRP therapy. Statistical analysis demonstrated a significant increase in AMH levels following PRP treatment (p ≤ 0.05). A statistically significant difference in AMH levels was observed before and three months after PRP-based ovarian rejuvenation therapy in women with POI treated at Bali Royal Hospital during the 2022–2024 period. These findings indicate that PRP may represent a promising adjunctive therapy for improving ovarian reserve in patients with POI.
The Influence of Leadership and Compensation on Work Motivation and its Impact on Nurse Performance Agus Wahyudianto; Taufik Zulfikar; Etty Sofia Mariati Asnar
Journal La Medihealtico Vol. 7 No. 1 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i1.3092

Abstract

This study aims to analyze the influence of Leadership and Compensation on Work Motivation and its impact on Nurse Performance at RSUD Aji Muhammad Parikesit Tenggarong. In the context of healthcare services, the role of effective leadership and a fair compensation system are crucial factors in enhancing both the motivation and performance of nursing staff. This research employs a quantitative method with purposive sampling technique, involving 213 nurses working at RSUD Aji Muhammad Parikesit Tenggarong. Data were collected through structured questionnaires and analyzed using path analysis. The results of the study indicate that Leadership has a positive and significant influence on Work Motivation and Nurse Performance, both directly and indirectly through Work Motivation. Compensation also shows a positive effect on Work Motivation and Performance, with the indirect effect through Work Motivation being greater than the direct effect. Furthermore, Work Motivation has a significant influence on improving Nurse Performance. These findings provide practical implications for hospital management, particularly in developing more effective leadership programs and improving the compensation system to enhance nurse motivation and performance.
Factors Influencing the Occurrence of Preeclampsia in Pregnant Women: Literature Review Citra Resy Ismail; Anna Sari Dewi; Muhammad Jabal Nur
Journal La Medihealtico Vol. 7 No. 3 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i3.3297

Abstract

Preeclampsia is a pathological condition characterized by an increase in blood pressure after 20 weeks of gestation, which may be accompanied by proteinuria as well as signs of organ dysfunction such as impaired liver, kidney, nervous system, and hematological function. The method used is a narrative review design of international literature from 2016–2025 obtained from Google Scholar, PubMed, ScienceDirect, ClinicalKey, and Garuda (Garba Rujukan Digital), using the keywords “preeclampsia,”“risk factors of preeclampsia,” “maternal risk factors,” “faktor risiko preeklamsia,” and “preeclampsia in pregnancy.” The results of the review indicate that preeclampsia is multifactorial, meaning it is not caused by a single factor but rather a combination of biological conditions, medical history, and maternal demographic characteristics. Medical and reproductive factors such as a history of hypertension and preeclampsia where women who previously experienced preeclampsia or have chronic hypertension have the highest risk primigravida (first pregnancy), and comorbidities such as diabetes mellitus, obesity (high BMI), and kidney disease further increase the burden on blood vessels.
Factors Influencing National Quality Indicator Reporting Compliance at Independent Medical and Dental Practices Yayang Putri Yudhistirha; Misnaniarti Misnaniarti; Alvera Noviyani
Journal La Medihealtico Vol. 7 No. 3 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i3.3346

Abstract

The National Quality Indicators (NQI) are instruments used to measure and evaluate the quality of healthcare services at health facilities, including Independent Medical and Dental Practices (IMDPs). Compliance with NQI reporting is an important component in monitoring and improving healthcare quality; however, its implementation still faces various challenges. This study aims to analyze the factors influencing compliance with National Quality Indicator reporting at Independent Medical and Dental Practices. This study employed a Systematic Literature Review (SLR) method guided by the PRISMA framework. Literature searches were conducted through Google Scholar, PubMed, ScienceDirect, Scopus, and Garuda for articles published between 2021 and 2025. Articles were selected based on predetermined inclusion and exclusion criteria and subsequently analyzed using a narrative synthesis approach. The review findings indicate that NQI reporting compliance is influenced by individual, organizational, and support system factors. Individual factors include the knowledge, understanding of quality indicators, competence, and motivation of healthcare workers. Organizational factors encompass management support, quality culture, supervision, audits, and feedback. Support system factors include workload, resource availability, and the utilization of information technology and health information systems. Knowledge and understanding of quality indicators were identified as the most dominant factors in improving reporting compliance. NQI reporting compliance at Independent Medical and Dental Practices is influenced by various interrelated factors. Improving reporting compliance requires strengthening the competencies of healthcare workers, optimizing health information systems, organizational support, and continuous monitoring and evaluation to support the improvement of healthcare service quality.
The Relationship Between Increased Neutrophils and Length of Hospitalization in Pediatric Pneumonia Patients Ade Amelyani Saputri; Abdi Dwiyanto Putra Samosir; Maya Susanti; A. Husni Esa Darussalam; Nur Aisya
Journal La Medihealtico Vol. 7 No. 3 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i3.3347

Abstract

Pneumonia remains one of the major respiratory infections affecting children and is often associated with increased morbidity, prolonged hospitalization, and higher healthcare burden. Neutrophils play an important role in the inflammatory response to infection and may serve as a useful laboratory indicator for evaluating disease severity and clinical outcomes in pediatric pneumonia. This study aimed to determine the relationship between increased neutrophil levels and length of hospitalization among pediatric pneumonia patients at Ibnu Sina Hospital Makassar during January to December 2025. This research used an observational analytic design with a cross sectional approach based on secondary data from medical records. The study population consisted of pediatric patients aged 0 to 18 years diagnosed with pneumonia, with complete blood count data available. Data were analyzed using univariate and bivariate analysis, with the Chi Square test applied to determine statistical significance. The results showed that most pediatric pneumonia patients were aged 1 to 10 years, were slightly more likely to be male, and were predominantly treated as inpatients. Most patients had a length of hospitalization of more than 4 days. Neutrophil examination showed that 50 patients had increased neutrophil levels, 38 had normal levels, and 9 had decreased levels. The analysis demonstrated a significant relationship between neutrophil levels and the incidence of pneumonia with a p value of 0.046. Furthermore, increased neutrophil levels were significantly associated with length of hospitalization, with a p value of 0.001. These findings indicate that increased neutrophil levels may reflect the severity of inflammatory response in pediatric pneumonia and may be useful as a clinical indicator for predicting longer hospitalization.
Analysis of the Effectiveness of the Implementation of the SEJAK-GO Application (Automatic Free Health Insurance Enrollment System) in the Registration of Regional Government PBPU Participants for BPJS Health at Hospitals Rieny Widyanty; Misnaniarti Misnaniarti; Rostika Flora
Journal La Medihealtico Vol. 7 No. 3 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i3.3362

Abstract

Digital transformation in healthcare services has become one of the key strategies for improving the effectiveness of health administration services, particularly for BPJS Health participants. One of the digital innovations utilized in health administration services is the SEJAK-GO application (Automatic Free Health Insurance Entry System), which is employed in the registration process of Regional Government PBPU BPJS Health participants at hospitals. This study aims to analyze the effectiveness of the SEJAK-GO application implementation in improving the quality of health administration services. The research method employed is a Systematic Literature Review (SLR), analyzing various scientific journals related to the digitalization of BPJS services, Mobile JKN, online registration systems, and Hospital Management Information Systems (SIMRS) within the period of 2021–2026. The review findings indicate that the implementation of digitally-based healthcare service systems is capable of improving administrative service effectiveness through accelerated patient registration processes, reduced service queues, integration of healthcare service data, and increased work efficiency of hospital administrative staff. The implementation of the SEJAK-GO application is interconnected with various BPJS digital service systems as it functions as an automatic data entry system for health insurance participants. Nevertheless, the effectiveness of digital system implementation is still influenced by technology infrastructure readiness, internet network quality, health information system integration, and human resource competency. Accordingly, the SEJAK-GO application has the potential to become a digital innovation that supports the improvement of BPJS PBPU Pemda administrative service quality at hospitals in a more effective, efficient, and integrated manner.
Risk Factors and Prevention Strategies for Recurrent Lower Urinary Tract Infections in Pregnant Women: A Literature Review Mutiara Andjani Arsyad; Amelia Abdullah; Asrini Safitri; M. Hamsah; Abadi Aman
Journal La Medihealtico Vol. 7 No. 3 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Urinary tract infections (UTIs) in pregnant women are among the most common health problems and may lead to serious complications for both the mother and the fetus. Physiological changes during pregnancy increase the risk of infection as well as recurrence of UTIs. Therefore, a comprehensive understanding of risk factors and effective preventive strategies is essential. This study aims to analyze the risk factors and preventive measures for recurrent UTIs in pregnant women based on current literature. This study employed a narrative review approach by examining various scientific articles obtained from databases including PubMed, ScienceDirect, Google Scholar, Garuda, and Neliti. The literature search was conducted using keywords relevant to the research topic. Results of the research showed that the main risk factors for UTIs in pregnant women include hormonal and anatomical changes, a history of previous UTIs, poor personal hygiene, sexual activity, and medical conditions such as diabetes mellitus. In addition, asymptomatic bacteriuria plays an important role in increasing the risk of complications. Effective preventive measures include routine screening, culture-based treatment of urine samples, health education, and the implementation of clean and healthy lifestyle practices. The occurrence and recurrence of UTIs in pregnant women are multifactorial in nature, requiring a comprehensive management approach to reduce risks and improve maternal and fetal health outcomes.

Page 52 of 53 | Total Record : 528

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