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Yolanda Handayani
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INDONESIA
Respiratory Science
Published by Perhimpunan Dokter Paru Indonesia
ISSN : -     EISSN : 27471306     DOI : https://doi.org/10.36497/respirsci.v1i3.17
Core Subject : Health,
Health Professions Medicine & Pharmacology
Focuses on original article reviews and case reports in pulmonary and critical care medicine Scope: 1. Asthma 2. Chronic Obstructive Pulmonary Disease (COPD) 3. Lung Physiology and Sleep-Related Disorder 4. Lung Infection 5. Thoracic Oncology 6. Interstitial Lung Disease 7. Environmental Lung Disease 8. Tobacco Control 9. Occupational Pulmonary Disease 10. Pulmonary Intervention and Emergency Medicine 11. Respiratory critical care 12. Respiratory immunology and biomolecular
Arjuna Subject : Kedokteran - Kedokteran Paru dan Pernafasan
Articles 123 Documents
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THE RELATIONSHIP BETWEEN DIAPHRAGMATIC THICKNESS AND PULMONARY FUNCTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A CROSS SECTIONAL STUDY Andika Pradana; Amira Permatasari Tarigan; Pandiaman Pandia; Dimas Pangestu; Nanda Andini
Respiratory Science Vol. 6 No. 3 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i3.231

Abstract

Background: Diaphragm dysfunction plays an important role in the pathophysiology of chronic obstructive pulmonary disease (COPD) and may contribute to respiratory symptoms and functional limitation. Ultrasonographic assessment of diaphragm thickness has emerged as a non-invasive method to evaluate respiratory muscle involvement; however, its relationship with pulmonary function remains unclear. This study aimed to assess diaphragm thickness and its correlation with pulmonary function in patients with COPD. Methods: A cross-sectional study was conducted involving patients with COPD. Demographic and clinical characteristics, including symptom severity based on the modified Medical Research Council (mMRC) scale and GOLD classification, were recorded. Diaphragm thickness was measured using ultrasonography. Pulmonary function was assessed using spirometry, including FEV1/FVC, percent predicted FEV1, and percent predicted FVC. Correlation analyses were performed to evaluate the relationship between diaphragm thickness and pulmonary function parameters. Results: The study population consisted predominantly of older male patients with moderate to very severe airflow limitation. The mean diaphragm thickness was 0.30 ± 0.08. Diaphragm thickness showed a weak negative correlation with FEV1/FVC (r = −0.184, p = 0.201) and weak positive correlations with percent predicted FEV1 (r = 0.188, p = 0.190) and percent predicted FVC (r = 0.168, p = 0.243). None of these correlations were statistically significant. Conclusion: Diaphragm thickness was not significantly associated with spirometric parameters in patients with COPD. These findings suggest that static diaphragm thickness alone may not adequately reflect pulmonary function impairment, highlighting the need for multidimensional assessment of respiratory muscle involvement.
Tuberculosis Preventive Therapy for Contacts of Drug-Resistant Tuberculosis: A Narrative Review Kemas Rakhmat Notariza; Erlina Burhan
Respiratory Science Vol. 6 No. 3 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

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Abstract

Drug-resistant (DR) tuberculosis (TB), including multidrug-resistant (MDR) and rifampicin-resistant (RR) TB, remains a major global public health problem. This narrative review aims to discuss tuberculosis preventive therapy (TPT) among contacts of DR-TB. The clinical spectrum of TB spans from infection to active disease, the progression of which can be prevented through TPT. Drug resistance in TB develops through genetic mutations. Levofloxacin (Lfx) exerts antimycobacterial activity by inhibiting the deoxyribonucleic acid (DNA) gyrase enzyme. The Vietnam Quinolones for MDR-TB Trial (VQUIN) demonstrated an incidence rate ratio of TB disease of 0.55 (95% confidence interval [CI] 0.19–1.62) in the Lfx group compared with the placebo group. In the Tuberculosis Child Multidrug-Resistant Preventive Therapy (TB-CHAMP) trial, the hazard ratio for TB disease was 0.44 (95% CI 0.15–1.25) in the Lfx group compared with placebo. Although neither trial individually achieve statistical significance in reducing TB incidence, a meta-analysis of both studies revealed a significant relative reduction in cumulative TB incidence of 0.41 (95% CI 0.18–0.92) in the Lfx group compared with placebo. The administration of Lfx was associated with low-grade musculoskeletal adverse events (risk ratio 6.36; 95% CI 4.30–9.42). Overall, daily administration of Lfx for six months is recommended as the standard TPT regimen for DR-TB, particularly among household contacts of MDR/RR-TB cases.
Multiplex PCR Respiratory Panel in Indonesia: A Literature Review Johan Nathan; Fariz Nurwidya; Anis Karuniawati
Respiratory Science Vol. 6 No. 3 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

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Abstract

Acute Respiratory Infections (ARIs) are a major cause of morbidity and mortality globally, especially among children under five years and elderly populations. Clinical symptoms-based diagnosis of ARI often fails to differentiate viral and bacterial etiologies, resulting in inappropriate antibiotic use or delayed antiviral administration. Conventional diagnostic methods such as culture and antigen detection have limitations in speed and accuracy. Multiplex PCR respiratory panels give a solution through simultaneous detection of various ARI-causing pathogens from a single clinical specimen. These panels demonstrate 30-50% higher sensitivity compared to conventional methods with the capability to identify up to 26 pathogen targets with significantly shorter turnaround times. This results in reduced hospitalization duration and optimized antimicrobial stewardship. Various commercial platforms are available in Indonesia with different characteristics, performance metrics, and pathogen coverage. Despite demonstrating significant advantages, these panels have limitations including inability to differentiate active pathogens from non-viable pathogens or colonization, high cost, and incomplete pathogen coverage. Optimal implementation requires appropriate clinical context consideration to maximize diagnostic benefit while minimizing risks of overdiagnosis and overtreatment.

Page 13 of 13 | Total Record : 123

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