cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Yolanda Handayani
Contact Email
yola.aksel@gmail.com
Phone
+6282157048069
Journal Mail Official
respirologyscience@gmail.com
Editorial Address
Jalan Cipinang Bunder No. 19, Cipinang, Pulogadung, Jakarta Timur, DKI Jakarta 13240, Indonesia
Location
Kota adm. jakarta timur,
Dki jakarta
INDONESIA
Respiratory Science
Published by Perhimpunan Dokter Paru Indonesia
ISSN : -     EISSN : 27471306     DOI : https://doi.org/10.36497/respirsci.v1i3.17
Core Subject : Health,
Health Professions Medicine & Pharmacology
Focuses on original article reviews and case reports in pulmonary and critical care medicine Scope: 1. Asthma 2. Chronic Obstructive Pulmonary Disease (COPD) 3. Lung Physiology and Sleep-Related Disorder 4. Lung Infection 5. Thoracic Oncology 6. Interstitial Lung Disease 7. Environmental Lung Disease 8. Tobacco Control 9. Occupational Pulmonary Disease 10. Pulmonary Intervention and Emergency Medicine 11. Respiratory critical care 12. Respiratory immunology and biomolecular
Arjuna Subject : Kedokteran - Kedokteran Paru dan Pernafasan
Articles 123 Documents
 9   10   11   12   13 
The Relationship Between Diaphragmatic Thickness and Pulmonary Function In Patients with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study Andika Pradana; Amira Permatasari Tarigan; Pandiaman Pandia; Dimas Pangestu; Nanda Andini
Respiratory Science Vol. 6 No. 3 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i3.231

Abstract

Background: Diaphragm dysfunction plays an important role in the pathophysiology of chronic obstructive pulmonary disease (COPD) and may contribute to respiratory symptoms and functional limitation. Ultrasonographic assessment of diaphragm thickness has emerged as a non-invasive method to evaluate respiratory muscle involvement, but its relationship with pulmonary function remains unclear. This study aimed to assess diaphragm thickness and its correlation with pulmonary function in patients with COPD. Method: A cross-sectional study was conducted involving patients with COPD. Demographic and clinical characteristics, including symptom severity based on the modified Medical Research Council (mMRC) scale and GOLD classification, were recorded. Diaphragm thickness was measured using ultrasonography. Pulmonary function was assessed using spirometry, including FEV1/FVC, percent predicted FEV1, and percent predicted FVC. Correlation analyses were performed to evaluate the relationship between diaphragm thickness and pulmonary function parameters. Results: The study population consisted predominantly of older male patients with moderate to very severe airflow limitation. The mean diaphragm thickness was 0.30±0.08. Diaphragm thickness showed a weak negative correlation with FEV1/FVC (r = −0.184; P=0.201), weak positive correlations with percent predicted FEV1 (r = 0.188; P=0.190), and percent predicted FVC (r = 0.168; P=0.243). None of these correlations were statistically significant. Conclusion: Diaphragm thickness was not significantly associated with spirometric parameters in patients with COPD. These findings suggest that static diaphragm thickness alone may not adequately reflect impairment in pulmonary function, necessitating a multidimensional assessment of respiratory muscle involvement.
Levofloxacin as Tuberculosis Preventive Therapy for Household Contacts of Drug-Resistant Tuberculosis: Global Evidence and Implementation in Indonesia Kemas Rakhmat Notariza; Erlina Burhan
Respiratory Science Vol. 6 No. 3 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i3.235

Abstract

Drug-resistant (DR) tuberculosis (TB), including multidrug-resistant (MDR) and rifampicin-resistant (RR) TB, remains a major global public health problem. This narrative review aims to summarize evidence regarding the effectiveness and safety of levofloxacin as tuberculosis preventive therapy (TPT) among household contacts of DR-TB patients and its implementation in Indonesia. The clinical spectrum of TB spans from infection to active disease, the progression of which can be prevented through TPT. Drug resistance in TB develops through genetic mutations. Levofloxacin (Lfx) exerts antimycobacterial activity by inhibiting the deoxyribonucleic acid (DNA) gyrase enzyme. The Vietnam Quinolones for MDR-TB Trial (VQUIN) demonstrated an incidence rate ratio of TB disease of 0.55 (95% confidence interval [CI]=0.19–1.62) in the Lfx group compared with the placebo group. In the Tuberculosis Child Multidrug-Resistant Preventive Therapy (TB-CHAMP) study, the hazard ratio for TB disease was 0.44 (95% CI=0.15–1.25) in the Lfx group compared with placebo. Although neither trial individually achieves statistical significance in reducing TB incidence, a meta-analysis of both studies revealed a significant relative reduction in cumulative TB incidence of 0.41 (95% CI=0.18–0.92) in the Lfx group compared with placebo. The administration of Lfx was associated with low-grade musculoskeletal adverse events (risk ratio=6.36; 95% CI=4.30–9.42). Overall, daily administration of Lfx for six months is recommended as the standard TPT regimen for DR-TB, particularly among household contacts of MDR/RR-TB cases.
Multiplex PCR Respiratory Panel in Indonesia: A Narrative Review Johan Nathan; Fariz Nurwidya; Anis Karuniawati
Respiratory Science Vol. 6 No. 3 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i3.237

Abstract

Acute Respiratory infections (ARIs) remain a major cause of illness and death worldwide. Conventional diagnostic methods are often slow or have limited sensitivity. Multiplex (Polymerase Chain Reaction) PCR respiratory panels allow rapid detection of multiple respiratory pathogens from a single specimen and are increasingly available in Indonesia. This review summarizes the respiratory panels available in Indonesia and discusses their potential clinical use. A narrative review was conducted using literature from PubMed, manufacturer technical documents, and the Indonesian Ministry of Health medical device registry. Information on pathogen coverage, diagnostic performance, specimen requirements, and clinical applications was reviewed. There are six respiratory panel platforms currently available in Indonesia: VITRO Respiratory Flow Chip Kit, BioFire FilmArray Respiratory Panel 2.1 Plus, BioFire FilmArray Pneumonia Panel Plus, QIAstat-Dx Respiratory SARS-CoV-2 Panel, ALLPLEX Respiratory Panel, and COBAS Respiratory Flex. Most platforms focus on respiratory viruses and atypical bacteria using nasopharyngeal/oropharyngeal specimens, whereas BioFire FilmArray Pneumonia Panel Plus is designed for lower respiratory tract infections and additionally detects common bacterial pathogens, antimicrobial resistance genes, and provides semi-quantitative results. BioFire, QIAstat-Dx, and COBAS offer highly automated sample-to-answer workflows with minimal hands-on time, whereas VITRO and ALLPLEX require more manual processing but provide greater flexibility through open systems. Despite these advantages, implementation remains challenged by high costs and limited access in Indonesia. Six multiplex PCR respiratory panel platforms are available in Indonesia, each with different diagnostic characteristics and potential clinical applications. No single platform is optimal for all situations. Therefore, test selection should be tailored to the clinical setting, laboratory capacity, and available resources. Appropriate implementation may improve respiratory pathogen diagnosis and antimicrobial stewardship, although local evidence regarding clinical impact and cost-effectiveness is still needed.

Page 13 of 13 | Total Record : 123

 9   10   11   12   13 

Filter by Year

2020 2026


Reset
Filter By Issues
All Issue Vol. 6 No. 3 (2026): Respiratory Science Vol. 6 No. 2 (2026): Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science Vol. 5 No. 3 (2025): Respiratory Science Vol. 5 No. 2 (2025): Respiratory Science Vol. 5 No. 1 (2024): Respiratory Science Vol. 4 No. 3 (2024): Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science Vol. 4 No. 1 (2023): Respiratory Science Vol. 3 No. 3 (2023): Respiratory Science Vol. 3 No. 2 (2023): Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science Vol. 2 No. 2 (2022): Respiratory Science Vol. 2 No. 1 (2021): Respiratory Science Vol. 1 No. 3 (2021): Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science More Issue