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Yolanda Handayani
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INDONESIA
Respiratory Science
Published by Perhimpunan Dokter Paru Indonesia
ISSN : -     EISSN : 27471306     DOI : https://doi.org/10.36497/respirsci.v1i3.17
Core Subject : Health,
Health Professions Medicine & Pharmacology
Focuses on original article reviews and case reports in pulmonary and critical care medicine Scope: 1. Asthma 2. Chronic Obstructive Pulmonary Disease (COPD) 3. Lung Physiology and Sleep-Related Disorder 4. Lung Infection 5. Thoracic Oncology 6. Interstitial Lung Disease 7. Environmental Lung Disease 8. Tobacco Control 9. Occupational Pulmonary Disease 10. Pulmonary Intervention and Emergency Medicine 11. Respiratory critical care 12. Respiratory immunology and biomolecular
Arjuna Subject : Kedokteran - Kedokteran Paru dan Pernafasan
Articles 108 Documents
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Optimizing Early Recognition and Management of Sepsis Secondary to Pneumonia: A Literature Review Adhyaksa, I Wayan Pande
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.187

Abstract

Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, frequently complicates pneumonia, a leading global cause of morbidity and mortality. This review synthesizes current evidence on optimizing early recognition and management of sepsis secondary to pneumonia, highlighting critical diagnostic and therapeutic strategies. Streptococcus pneumoniae remains the predominant pathogen in community-acquired pneumonia (CAP), though antimicrobial resistance and atypical organisms pose growing challenges. Key risk factors include comorbidities (e.g., renal/liver disease, diabetes), immunosuppression, and socioeconomic determinants. Early diagnosis combines clinical assessment (e.g., SOFA, qSOFA scores) with biomarkers like procalcitonin, lactate, and neutrophil-to-lymphocyte ratio (NLR). Innovative tools, such as AI-driven analysis of blood count data, show promise for rapid sepsis detection. The cornerstone of management is the "1-hour bundle": immediate broad-spectrum antibiotics (tailored to local resistance patterns), fluid resuscitation with crystalloids, and vasopressors for refractory hypotension. Antibiotic selection must account for pathogen profiles, with macrolides or fluoroquinolones recommended for severe CAP. Fluid balance is critical to avoid pulmonary edema, while organ support (e.g., mechanical ventilation) is often required for respiratory failure. Despite therapeutic advances, sepsis mortality remains high (24–65% in Indonesia), driven by delays in treatment and comorbid conditions. Survivors frequently face long-term physical and cognitive impairments, necessitating comprehensive rehabilitation. Future efforts should prioritize rapid diagnostics, personalized therapy, and post-sepsis care to improve outcomes. This review underscores the importance of early, protocol-driven interventions to mitigate the global burden of sepsis complicating pneumonia.
Association Between Factory Workers’ Profile with Chest X-ray Finding and Spirometry at Industrial Company of X Wijaya, Dewi; Esha, Indi; Adrianison, Adrianison; Simatupang, Elvando Tunggul Mauliate; Amarudin, Amarudin
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.198

Abstract

Background: Factory workers are a group at high risk of developing occupational lung abnormalities. Continuous exposure to dust, smoke, or gas particles during work processes may lead to progressive lung damage. Chest X-ray and spirometry are essential diagnostic tools for assessing both structural and functional lung changes, allowing early detection and prevention of occupational lung disability, especially among workers exposed to airborne pollutants. Method: This analytical observational study employed a cross-sectional design to analyze the association between factory workers’ profiles and chest X-ray and spirometry findings. Lung function was assessed using spirometry parameters, including Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV₁), and FEV₁/FVC ratio to identify restrictive or obstructive patterns. Data were collected using total sampling during periodic health examinations and analyzed with SPSS version 26.0. Descriptive statistics were used to summarize characteristics, while inferential analysis using Chi-square or Fisher’s exact tests was conducted to determine associations between categorical variables, with a significance level set at P<0.05. Results: A total of 260 factory workers participated, most with ≤5 years of work experience (60.76%). Comorbidities were significantly associated with both chest X-ray findings and lung function (P=0.034 and P=0.004). Smoking history and length of work also showed significant relationships with lung function (P=0.027 and P=0.019). Conclusion: There is a significant association between smoking history and length of work with changes in lung function. Meanwhile, comorbidities have a significant association with lung structure and lung function. Periodic evaluation using spirometry and chest X-ray is essential for early detection and prevention of occupational lung abnormalities among factory workers.
A Rare Case of Completely Healed Pneumomediastinum Due to Asthma Exacerbation in A Young Male Patient Tarigan, Amira Permatasari; Pandia, Pandiaman; Pradana, Andika; Hutabarat, Eva Susanti Debora; Ramadhani, Adini Arifah
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.95

Abstract

Background: The term pneumomediastinum (PNM) refers to the presence of air within the mediastinal cavity. This illness is uncommon but can arise in adolescents with severe asthma attacks. In children aged 5 to 34, the incidence of pneumomediastinum after an acute asthma attack is 1 in 25,000. Men made up the majority of patients (76 percent of all cases). Pneumomediastinum can be diagnosed with the assistance of a chest CT scan. Case: A young man was diagnosed with pneumomediastinum due to an acute asthma attack in this case report. Symptoms of uncontrolled asthma include shortness of breath that worsens with wheezing, chest tightness, and a nonproductive cough. Since the age of 12, the patient in this instance has been receiving salbutamol inhalers. The physical examination revealed polyphonic lung respiration and subcutaneous crepitus in the neck, shoulders, and anterior chest. With adequate management of an asthma episode, pneumomediastinum recovers spontaneously, followed by recurrent symptomatic status, physical examination, and radiography examination. Discussion: Acute asthma exacerbations are one of the factors that can lead to spontaneous pneumomediastinum, in which mediastinal air can permeate the tissue and generate a pneumothorax, and if there is air in the subcutaneous area, it can lead to subcutaneous emphysema. Conclusion: Pneumomediastinum was a rare incidence, pulmonologists examining young adults with acute asthma exacerbations should evaluate for pneumomediastinum. In usual asthma therapy, a chest CT-scan is essential to screen for pneumomediastinum.
Lung Cancer In Former Tuberculosis Patients at Arifin Achmad General Hospital, Riau Province Martarita, Evitrie; Erdayani, Rita; Munir, Sri Melati; Fauzi, Zarfiardy Aksa; Simanjuntak, Arya Marganda
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.97

Abstract

Background: There is ongoing discussion over the connection between lung cancer and pulmonary tuberculosis (TB). Future lung cancer cases in Indonesia, which has the second-highest TB case burden, are a cause for concern. The purpose of this study is to ascertain the connection between TB and LC at Arifin Achmad General Hospital in the province of Riau. Method: From 2015 to 2018, we looked back on lung cancer patients at Arifin Achmad General Hospital in Riau Province who had received pulmonary tuberculosis and anti-tuberculosis treatment (ATT). Results: From 203 patients, 24 patients (11.8%) had histories of TB. The patients' ages were from 41 years to 60 years. The most prevalent pathological findings were adenocarcinoma in 13 patients (54.0%). The most common cancer stage was advanced stage IIIB in 7 patients (29.2%) Conclusion: The cases of TB infections were apparent in lung cancer patients, approximately around 11% of lung cancer cases. Therefore, it is necessary to assess the history of TB in lung cancer patients.
Diagnosis and Management for Pulmonary Tuberculoma Syahruddin, Elisna; Burhan, Erlina; Saputra, Tetra Arya
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.107

Abstract

Pulmonary tuberculoma, prevalent particularly in tuberculosis (TB)-endemic regions, often appears as a solitary nodule of less than 30 mm, or a tumor of more than 30 mm on radiological examinations. It may also present with a combination of abnormalities, such as multiple nodules with infiltration or pleuritis. Benign solitary pulmonary nodules represent up to 25% of all resected solitary pulmonary nodules, with approximately 5-24% of these identified as pulmonary tuberculoma post-surgery. This condition is prevalent particularly in TB-endemic regions, and must be considered while determining the diagnosis, especially for patients at high risk for lung cancer. Modalities for diagnosing pulmonary tuberculoma include chest radiography, USG, CT scan, PET scan and bronchoscopy with transbronchial biopsy. The treatments for pulmonary tuberculoma are anti-TB drugs and surgery. Pulmonary tuberculoma responds poorly to anti-TB drugs and requires long-term treatment. Surgery is performed when the diameter of tuberculoma still increases after adequate anti-TB treatment.
Characteristics of Lung Cancer Patients with Brain Metastases based on Baseline Head Computerized Tomography (CT)-scan in Arifin Achmad Hospital October 2022 - June 2023 Sari, Rezki Permata; Fauzi, Zarfiardy Aksa; Simanjuntak, Arya Marganda
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.108

Abstract

Background: The majority of lung cancer cases are often discovered at a late stage because it frequently develops without symptoms in the early stages. Many lung cancer deaths are caused by metastases to other organs. The purpose of this study was to examine the features of lung cancer patients with brain metastases using baseline CT scan data. Method: Between October 2022 and June 2023, a cross-sectional study was conducted at the Arifin Achmad Hospital in Pekanbaru on all newly diagnosed lung cancer patients with brain metastases who also met the inclusion and exclusion criteria. Results: Eight subjects of lung cancer with brain metastasis were found from 49 patients. All subjects were male with age mostly in between 40 and 60 years. Three subjects (37.5%) were Squamous Cell Carcinoma (SCC), four subject (50%) were adenocarcinoma and 1 (12.5%) were SCLC. Conclusion: This study discovered that 16.3% of patients who met the inclusion criteria had lung cancer with brain metastases. Further research should be done on a cohort study and a preventive strategy for lung cancer with brain metastases.
Profile of COVID-19 Patients at Arifin Achmad Hospital, Riau Province Between January 2021 and June 2021 Syaf, Syarlidina; Adrianison, Adrianison; Simanjuntak, Arya Marganda
Respiratory Science Vol. 4 No. 3 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i3.113

Abstract

Background: Coronavirus disease 2019 (COVID-19) is a disease caused by a new coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously called 2019 novel coronavirus) which was first identified in Wuhan City, Hubei Province, China. World Health Organization declared COVID-19 a global pandemic on March 12 2020 and until June 2021 there were 184 million cases with 3.9 million deaths worldwide. In Indonesia, until June 2021 there have been 2.2 million positive cases of COVID-19 and 60 thousand deaths. Method: The data collection method used in this study is a descriptive cross-sectional approach. According to the inclusion criteria, samples were collected for six months, and the results are shown as a distribution table. Results: The number of patients treated for the period from January to June 2021 totaled 1,442 people. The highest number of patients treated according to age was middle-aged (40.6%) and children (1.1%). The number of COVID-19 patients based on length of treatment from January to June was suspected (2-4 days) 28.13%, confirmed (5–45 days) 61.6%, discharged at own request 9.78%, referred 0.48%. The number of cured COVID-19 patients being treated at the Arifin Achmad Hospital in Riau Province from January to June 2021 has recovered 75.9% and died 13.7%. Conclusion: In Indonesia, until June 2021 there have been 2.2 million positive cases of COVID-19 and 60 thousand deaths. Riau Province as of June 2021 has recorded 70,520 confirmed cases and 1,931 deaths. The Arifin Achmad Pekanbaru General Hospital from March 2020 to June 2021 recorded 1,524 confirmed cases and 148 deaths.
The Relationship Between SpO2/FiO2 Ratio to Community Acquired Pneumonia Patient Outcomes at Kolonel Abunjani Bangko General Hospital Lindra, Derallah A; Sari, Oktriga A.
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.118

Abstract

Background: Acute lower respiratory tract infection causes high morbidity and mortality, which can be found in the form of pneumonia. Community acquired pneumonia (CAP) severe pneumonia can lead to acute respiratory distress. To diagnose acute respiratory disorders, namely Acute Lung Injury (ALI) and Acute Respiratory Stress Syndrome (ARDS), the ratio PaO2/FiO2 is used. This requires invasive action by taking an arterial blood sample, which is expensive and not available in all health facilities. An alternative is pulse oximetry, which measures the SpO2/FiO2 ratio and is available in health facilities. It is inexpensive and non-invasive. This study aims to determine the relationship between SpO2 and FiO2 with the outcome of community pneumonia patients at Kolonel Abunjani Bangko Hospital. Method: The study design was a retrospective descriptive cross-sectional design. The research subjects were a total sampling of medical record data from inpatients with community acquired pneumonia for the period January-December 2022. The study variables included gender, age, SpO2/FiO2 ratio, and outcomes of pneumonia patients. Univariate and bivariate statistical tests were used to analyze the data. Results: In this study, there were 43 subjects who met the inclusion criteria. The distribution of inpatient community acquired pneumonia patients, especially in the gender was mostly male (67.4%), the highest age was 56–65 years and >65 years (both 37.2%), the median SpO2 was 94% (36-99%), the median SpO2/FiO2 ratio was 447 (171-471%), the highest outcomes were alive patients (36 patients). The ratio of SpO2/FiO2 >316 was the majority (33 patients). Based on the relationship between the SpO2/FiO2 ratio and the outcome of CAP with alive outcome was a SpO2/FiO2 ratio >236 was more numerous than SpO2/FiO2 ratio <236 with value of P=0.0005. Conclusion: There is a significant relationship between the SpO2/FiO2 ratio and the outcome of community acquired pneumonia patients at Kolonel Abundjani Hospital Bangko.
Current Knowledge of Mycobacterium Other Than Tuberculosis (MOTT) in this Current Era: Definition, Taxonomy, and Diagnose Indriani, Sri Indah; Pratiwi, Adelia; Simatupang, Elvando Tunggul Mauliate; Simanjuntak, Arya Marganda
Respiratory Science Vol. 4 No. 3 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i3.122

Abstract

Globally, Pulmonary Tuberculosis (PTB) remains a health concern, with an annual increase in cases. Indonesia is the second-highest contributor to PTB cases globally, below India, which also saw an increase in cases, particularly after the COVID-19 pandemic. Nontuberculous Mycobacteria (NTM) infections contribute to the increase in PTB cases through misdiagnosis and overlapping conditions. The occurrence of changes in the composition of NTM species in the Mycobacterium genus is the premise for updating the diagnosis of NTM with several supporting examination modalities. Clinical, radiological, and microbiological criteria have been established by the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) for the diagnosis of NTM. The relationship between these three criteria is essential as a guideline for distinguishing infections caused by Mycobacterium tuberculosis (Mtb) from those caused by NTM.
Bronchoscopic Balloon Dilatation for Tuberculosis-related Bronchial Stenosis: A Rare Case Wahyuni, Titis Dewi; Alatas, Mohamad Fahmi; Widysanto, Allen; Siahaan, Sylvia Sagita; Muljadi, Rusli; Carolline, Chaifung
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.125

Abstract

Background: Bronchial stenosis is known as a complication of endobronchial tuberculosis (EBTB). The incidence of stenosis affects quality of life. A minimally invasive therapeutic strategy, bronchoscopic balloon dilatation (BBD), can be chosen to manage the disease. Case: A 29-year-old woman suffered from bronchial stenosis, which appeared after completing treatment for tuberculosis (TB). She was diagnosed with TB around the middle of her pregnancy. She received anti-tuberculosis treatment for six months. Two years later, she complained of a persistent cough for two weeks prior to hospitalization. A complete stenosis of the left main bronchus with atelectatic on the left lung was seen on a chest CT scan. The result was confirmed with a bronchoscopy procedure. There were no mycobacteria or other suspicious organisms found in bronchial washings. Bronchoscopic balloon dilatation action was successful. Discussion: Endobronchial tuberculosis is a tuberculous infection that affects the tracheobronchial tree. It can be treated with minimally invasive procedures like bronchoscopy or surgical interventions. If the stenosis is mild or moderate, several procedures such as balloon dilatation, stents, laser photoresection, argon plasma coagulation, and cryotherapy are often performed. Bronchoscopy balloon dilatation nowadays has become a more preferred treatment option for tracheal and bronchial stenosis because  it may be areliable and effective method.    Conclusion: The BDD procedure in this patient showed good results. This procedure is fast, easy, safe, minimally invasive, and the symptoms resolve quickly. It can be concluded that BBD is a safe and effective therapy for TB-related bronchial stenosis, but the long-term effects of the procedure remain to be monitored.

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