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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by HM Publisher

ISSN : - EISSN : 25980580 DOI : https://doi.org/10.37275/bsm

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to : 1.Rhemumatology 2.Molecular aspect of Indonesia Traditional Herb 3.Cardiology and Cardiovascular diseases 4.Genetics 5.Immunology 6.Environmental health 7.Toxicology 8. Neurology 9. Pharmacology 10. Oncology 11. Other multidisciplinary studies related medicine. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 1,258 Documents

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Dual-Modality Salvage of Recurrent Pacemaker Extrusion in Severe Malnutrition: A Technique Using PTFE Mesh Encapsulation and Fasciocutaneous Flap Coverage Rani Septrina; Fidi Bhawana Jaya; Euis Maryani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1568

Background: Permanent pacemaker implantation in pediatric patients with severe malnutrition presents a unique surgical challenge due to the absence of a viable subcutaneous protective envelope. In this population, standard device fixation frequently results in recurrent wound dehiscence and device extrusion, often necessitating lead abandonment or epicardial placement. This study evaluates the efficacy of a dual-modality salvage technique integrating a Polytetrafluoroethylene (PTFE) mesh barrier with vascularized fasciocutaneous tissue coverage. Case presentation: We present the case of a 3-year-old male with congenital complete atrioventricular block and severe acute malnutrition, defined by a Weight-for-Height Z-score of less than -3 SD. The clinical course was complicated by three consecutive implant failures over an 8-month period, including two thoracic and one abdominal extrusion, characterized by aseptic pressure necrosis. To salvage the cardiac hardware, a novel sealed-device technique was employed. The pulse generator was encapsulated in a non-absorbable PTFE mesh to minimize the coefficient of friction and placed in a sub-fascial plane. Simultaneously, a random-pattern fasciocutaneous rotation flap was harvested to provide robust, vascularized coverage. Biochemical analysis revealed severe hypoalbuminemia (2.1 g/dL) and anemia pre-operatively. Conclusion: At the 12-month follow-up, the surgical site demonstrated complete physiological integrity with no recurrence of erosion, seroma, or infection. The combination of PTFE encapsulation to mitigate mechanical shearing forces and a fasciocutaneous flap to restore perfusion offers a durable salvage strategy for refractory device extrusion in cachectic pediatric patients.

Structural Restoration of the Empty Nose: A Quantitative Case Report on Post-Infectious Saddle Nose Deformity Using Autologous Sixth Costal Cartilage Made Dalika Nareswari; Agus Rudi Asthuta; Eka Putra Setiawan; I Wayan Sucipta; I Ketut Suanda
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1569

Background: Septal abscess represents a catastrophic failure of the nasal structural framework, often resulting in rapid ischemic necrosis of the quadrangular cartilage and a severe saddle nose deformity. This empty nose phenomenon poses unique reconstructive challenges due to the total loss of the L-strut and compromised mucosal envelope. Case presentation: We report the case of a 34-year-old female presenting with a Type IV saddle nose deformity and bilateral nasal valve collapse following a septal abscess. Preoperative assessment demonstrated a severe Nasal Obstruction Symptom Evaluation (NOSE) score of 85 out of 100 and compromised Minimum Cross-Sectional Area (MCA) on acoustic rhinometry (mean 0.365 cm2). The patient underwent open septorhinoplasty utilizing autologous sixth costal cartilage. The graft was fabricated using the concentric carving principle to create extended spreader grafts and a columellar strut, re-establishing the dorsal and caudal support. Conclusion: At the 6-month postoperative follow-up, the NOSE score improved by 82.3% (score 15 out of 100), and objective acoustic rhinometry confirmed a 54% expansion in mean MCA. Physical examination revealed a stable dorsal profile with no early evidence of graft warping or resorption. Autologous sixth costal cartilage provides the necessary biomechanical bulk and structural rigidity for restoring the post-infectious nasal skeleton, though long-term monitoring for cartilage memory remains essential.

In Vitro Dissolution Profiling and Release Kinetics of Abelmoschus manihot L. Ethanolic Extract Mucoadhesive Granules: A Higuchi Diffusion Model Analysis Siti Mardiyanti; Nila Isnaini Rahmawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1570

Background: Peptic ulcer disease presents a persistent clinical challenge characterized by a critical imbalance between mucosal defensive mechanisms and aggressive luminal factors, including Helicobacter pylori infection and non-steroidal anti-inflammatory drug administration. The ethanolic extract of Abelmoschus manihot L. possesses potent antioxidant flavonoids, specifically quercetin, which exhibit significant gastroprotective potential. However, the therapeutic efficacy of conventional herbal extracts is often compromised by rapid physiological gastric emptying. The aim of this study was to formulate gastroretentive mucoadhesive granules containing the ethanolic extract of A. manihot using Hydroxypropyl Methylcellulose (HPMC) as a matrix polymer and to elucidate the drug release mechanism through advanced mathematical kinetic modeling. Methods: The extract was standardized for total flavonoid content and antioxidant activity using the DPPH assay. Mucoadhesive granules were engineered via wet granulation with varying concentrations of HPMC (F1: 15%, F2: 20%, F3: 25%) and a constant 15% Carbopol. The formulations underwent rigorous physicochemical characterization, ex vivo wash-off mucoadhesion testing on porcine tissue, and in vitro dissolution profiling in artificial pH 1.2, 6.8, and 7.4 media. Release data were evaluated using Zero-order, First-order, and Higuchi kinetic models, validated via the Akaike Information Criterion (AIC). Results: The standardized extract demonstrated potent antioxidant activity with an IC50 of 27.14 +/- 1.05 mcg/mL and a high total flavonoid content of 162.8 mg QE/g. All granule formulations exhibited excellent flowability. Formula F3 (25% HPMC) displayed superior swelling capacity (15.2-fold expansion) and mucoadhesion (30.0% retention at 60 minutes). Dissolution testing revealed F3 retarded drug release significantly compared to F1, releasing only 41.92% in pH 1.2 over 6 hours. Kinetic analysis confirmed that F3 strictly followed the Higuchi diffusion model, indicating release governed by diffusion through the swollen polymer matrix. Conclusion: The HPMC-Carbopol mucoadhesive granules of A. manihot successfully achieved sustained release and enhanced structural mucoadhesion. Formula F3 represents a mechanistically sound gastroretentive delivery system, driven by complex polymer hydration dynamics, for the localized management of peptic ulcers.

Synergistic Attenuation of the TNF-α/NF-κB Inflammatory Axis in Colorectal Carcinogenesis: Lactococcus lactis D4 as a Mucosal-Protective Adjuvant to Capecitabine Leonard Khriestsandi Saleh; M Iqbal Rivai; Rini Suswita; Irwan; Avit Suchitra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1571

Background: Capecitabine serves as a standard chemotherapeutic agent for colorectal cancer, but its clinical efficacy is frequently hindered by severe gastrointestinal toxicity and incomplete suppression of the inflammatory tumor microenvironment. We evaluated the synergistic potential of Lactococcus lactis D4, a probiotic strain isolated from traditional fermented buffalo milk, as an immunonutritional adjuvant to Capecitabine in a 1,2-dimethylhydrazine-induced colorectal cancer rat model. Methods: Sprague-Dawley rats were maintained on a standardized AIN-93G diet and induced with 1,2-dimethylhydrazine. Animals were randomized into Negative Control, Cancer Control, L. lactis D4 monotherapy, Capecitabine monotherapy, and Combination therapy. Treatments were administered for 14 days. We assessed cachexia, macroscopic microadenoma multiplicity, and TNF-α expression utilizing immunohistochemistry. Synergy was mathematically validated using the Coefficient of Drug Interaction. Results: The Combination group significantly prevented chemotherapy-induced cachexia, demonstrating a 2.1% weight gain compared to a 4.5% weight loss in the Capecitabine monotherapy group (p < 0.05). Macroscopic microadenomas were rapidly reduced in the combination group. Furthermore, the combination therapy synergistically suppressed colonic TNF-α protein expression (Coefficient of Drug Interaction = 0.83). Additionally, L. lactis D4 entirely mitigated capecitabine-induced mucositis. Conclusion: L. lactis D4 functions as a highly potent adjuvant to Capecitabine. It prevents cachexia, protects mucosal architecture, and exerts a mathematically proven synergistic suppression of the TNF-α inflammatory axis.

Evaluating the Indigenous Probiotic Lactococcus lactis D4 as an Adjuvant to Capecitabine: Modulation of NF-κB in a Colorectal Carcinogenesis Model Arli Suryawinata; M Iqbal Rivai; Rini Suswita; Irwan; Avit Suchitra; Raflis Rustam
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1572

Background: Chronic inflammation driven by the nuclear factor kappa-B (NF-κB) signaling pathway is a fundamental driver of colorectal cancer (CRC) pathogenesis, promoting tumor survival, mucosal proliferation, and profound chemoresistance. Capecitabine is a standard first-line fluoropyrimidine chemotherapy; however, its clinical utility is frequently compromised by dose-limiting toxicities and the activation of inflammatory feedback loops. Lactococcus lactis D4, a novel probiotic strain isolated from traditional Indonesian fermented buffalo milk (dadih), possesses well-documented immunomodulatory properties. Methods: A randomized controlled experimental study was conducted utilizing male Sprague-Dawley rats (n=37). Colorectal carcinogenesis was chemically induced via intraperitoneal administration of 1,2-dimethylhydrazine (DMH). Following strict histopathological confirmation of malignancy, the cohort was randomized into five distinct groups: Negative Control, Positive Control, L. lactis D4 monotherapy, Capecitabine monotherapy, and Combination therapy. Interventions were administered daily for 14 days. Outcomes included NF-κB protein expression assessed via immunohistochemistry (IHC) and targeted gene expression quantification via RT-qPCR. Results: Immunohistochemical analysis demonstrated that the positive control group exhibited significantly elevated NF-κB protein expression (35.87 ± 13.53%). Capecitabine monotherapy significantly reduced this expression to 16.07 ± 3.79% (p=0.003). The Combination therapy achieved a profound reduction in NF-κB protein expression down to 12.99 ± 4.92%; however, this was not statistically superior to Capecitabine alone (p=1.000). Conversely, RT-qPCR analysis revealed no statistically significant difference in NF-κB mRNA levels among the experimental groups (p=0.094). Conclusion: The combination of L. lactis D4 and Capecitabine effectively reduces NF-κB protein expression in a preclinical CRC model, achieving suppression levels comparable to primary chemotherapy. The distinct discordance between the significant protein suppression and the sustained mRNA expression levels suggests potential post-transcriptional or post-translational regulatory mechanisms that warrant further targeted molecular investigation.

Synergistic Effects of Stem Cell Integration on Cochlear Implant Performance in Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis of Neural Preservation and Speech Perception Dinera Anjani; Theresa Puspanadi; Ajeng Shanaz Santya Putri; Amelia Nisa
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1573

Background: Cochlear implantation represents the paramount intervention for severe-to-profound sensorineural hearing loss. However, device efficacy is fundamentally constrained by retrograde degeneration of spiral ganglion neurons and post-insertional intracochlear fibrosis. This study aimed to quantitatively evaluate the synergistic efficacy of integrating stem cell therapies with cochlear implants to preserve neural architecture and enhance auditory functional outcomes. Methods: A systematic review and meta-analysis were executed following PRISMA guidelines. Comprehensive searches of electronic databases utilized specific Medical Subject Headings targeting biohybrid electrodes, mesenchymal stem cells, and spiral ganglion survival. Inclusion criteria strictly selected controlled in vivo preclinical models and human clinical trials evaluating concurrent stem cell application with implantation. Risk of bias was assessed utilizing SYRCLE and ROBINS-I tools. Random-effects models synthesized Standardized Mean Differences for neural preservation, with subgroup analyses evaluating delivery modalities. Results: Eight pivotal studies met stringent inclusion criteria. Meta-analysis demonstrated a highly significant preservation of spiral ganglion density in stem cell-integrated cohorts compared to implant-alone controls (Pooled Standardized Mean Difference = 2.45; 95% Confidence Interval: 1.54–3.36; p < 0.001). Subgroup analysis revealed that electrode coating yielded superior neuroprotection compared to bolus injections. Electrophysiological data demonstrated significantly lowered Electrically Evoked Auditory Brainstem Response thresholds. Clinical cohorts exhibited stable impedances and rapid improvements in speech perception. Conclusion: Stem cell-integrated cochlear implants orchestrate a potent bio-electronic synergy, modulating neuroinflammation and mitigating neural degeneration primarily through paracrine neurotrophic signaling. This bio-electronic integration represents a transformative paradigm in auditory rehabilitation, maximizing the fidelity of neural stimulation and optimizing clinical outcomes.

Admission Serum Procalcitonin Thresholds and the PELOD-2 Score: A Prospective Analytical Study for Identifying Risk Ratios of Severe Organ Dysfunction in Pediatric Critical Care Raisa Amini; Pudjiastuti; Sri Lilijanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1574

Background: Multiple organ dysfunction syndrome (MODS) remains a predominant cause of mortality in Pediatric Intensive Care Units (PICUs). While the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score is the established standard for assessing severity, it requires time-consuming serial calculations. There is an urgent need for a rapid, admission-based prognostic biomarker. This study evaluates the association between serum procalcitonin (PCT) and the severity of organ dysfunction in critically ill children. Methods: A prospective cross-sectional study was conducted at Dr. Moewardi Regional General Hospital, Indonesia, involving 25 children aged 1 month to 18 years with suspected infection. Organ dysfunction was quantified using the PELOD-2 score, and serum PCT was measured via Enzyme-Linked Fluorescent Assay (ELFA) within 24 hours of admission. Statistical analysis utilized Spearman’s rank correlation, multivariate linear regression, and Receiver Operating Characteristic (ROC) curve analysis. Results: The cohort had a median age of 12 months. The median PCT level was 0.88 ng/mL. A significant positive correlation was observed between serum PCT and PELOD-2 scores (r = 0.39, p = 0.051; multivariate beta = 0.42, p = 0.043). ROC analysis identified a PCT threshold of greater than 11 ng/mL as the optimal indicator for moderate-to-severe organ dysfunction (AUC 0.82). Patients exceeding this threshold had a significantly elevated risk (Risk Ratio = 2.20; 95 percent CI: 1.15–4.24; p = 0.035). Conclusion: Early serum procalcitonin measurement serves as a powerful independent factor associated with organ dysfunction severity. A cutoff value of greater than 11 ng/mL significantly stratifies risk, allowing clinicians to anticipate the progression of organ failure.

Severity Matters: The Differential Impact of Mild versus Severe Portal Hypertension on Post-Hepatectomy Liver Failure — A Systematic Review and Meta-Analysis Aflis; Ketut Wahyu Ananda Putra; Made Agus Dwianthara Sueta
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1575

Background: Post-hepatectomy liver failure (PHLF) remains the principal cause of mortality following liver resection for malignancies, particularly in the context of hepatocellular carcinoma (HCC) and cirrhosis. While portal hypertension (PH) has traditionally been viewed as a monolithic contraindication to surgery, emerging evidence suggests that the risk it confers is heterogeneous. This study investigates the hypothesis that the risk of PHLF is strictly severity-dependent. Methods: A systematic review and meta-analysis were conducted on observational studies involving patients undergoing hepatectomy for liver malignancies. Search strategies targeted studies stratifying outcomes by PH severity (mild vs. severe). Primary outcomes were the incidence of PHLF defined by ISGLS criteria. Data were synthesized using random-effects models to calculate pooled odds ratios (OR). Results: Ten studies comprising 4,978 patients were included. The overall presence of PH significantly increased PHLF risk (Pooled OR 3.12; 95% CI: 2.15–4.53; p<0.001). However, stratification revealed a profound divergence: Severe PH (defined as HVPG ≥10 mmHg or clinically significant varices) was associated with a drastic risk escalation (OR 5.86; 95% CI: 2.19–15.65), whereas Mild PH showed a significantly lower risk profile (OR 2.45; 95% CI: 1.10–5.40). Sensitivity analyses confirmed that non-invasive surrogates for PH performed comparably to invasive hemodynamic monitoring in predicting failure. Conclusion: The risk of PHLF is not binary but graded. Severe portal hypertension represents a prohibitive risk state characterized by hemodynamic intolerance to parenchymal reduction. Conversely, mild portal hypertension constitutes a distinct, manageable clinical entity where liver resection remains safe under optimized conditions. Surgical candidacy should be determined by severity grading rather than the mere presence of portal hypertension.

Efficacy, Safety, and Long-Term Continuation of Vaginal Pessaries for Pelvic Organ Prolapse: A Systematic Review and Meta-Analysis Heristanto; Rahajeng
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1576

Background: Pelvic organ prolapse (POP) represents a profound failure of pelvic floor anatomy, significantly impairing patient quality of life through complex functional and anatomical derangements. Vaginal pessaries stand as the primary conservative intervention. However, the contemporary literature remains fragmented regarding their long-term adherence kinetics and comparative pathophysiological efficacy against definitive surgical reconstruction. Methods: A systematic review and meta-analysis were conducted, adhering strictly to PRISMA 2020 guidelines. Major scientific databases, including PubMed, Scopus, and Cochrane CENTRAL, were systematically searched for randomized controlled trials and prospective cohorts published between 2016 and 2026. Data synthesis employed a random-effects model, calculating Standardized Mean Differences (SMD) for validated symptom scores and pooled prevalence for longitudinal continuation and adverse events. Results: Seven major studies comprising 2,772 participants were included. The pooled short-term continuation rate under twelve months was 76.6% (95% CI 68.2–85.0%), which demonstrated a predictable decline to 53.4% (95% CI 45.1–61.7%) beyond one year. Meta-analysis of validated symptom scores (PFDI-20) demonstrated a robust, transformative reduction in prolapse distress (SMD -1.24; 95% CI -1.56 to -0.92, p < 0.0001), showing statistical equivalence to surgical outcomes in advanced prolapse cohorts. Adverse events were uniformly mild, dominated by vaginal discharge (pooled prevalence 18.6%) and occult stress incontinence (11.4%). Conclusion: Vaginal pessaries provide a high magnitude of pathophysiological symptom relief that parallels surgical correction in the short to medium term. By biomechanically restoring the pelvic axes, pessaries neutralize visceral nerve traction. While long-term continuation inevitably declines due to behavioral fatigue, the superior safety profile establishes pessaries as a definitive therapeutic modality.

Digital Panoramic Radiography for Forensic Dental Age Estimation: A Biostatistical Validation Demonstrating the Superiority of the Willems Method over the Cameriere Approach in a Pediatric Cohort (6–14 Years) Asep Darya Darma Putra; Rahmatul Aini; Safitra Ade Erman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1577

Background: Accurate dental age (DA) estimation is critical in pediatric dentistry, orthodontics, and forensic identification. Radiomorphological and radiometric techniques are widely utilized, yet their accuracy varies across diverse ethnic populations. This study aims to evaluate and compare the accuracy of the Willems (radiomorphological) and Cameriere (radiometric) methods against chronological age (CA) in a pediatric population in Padang, Indonesia. Methods: A retrospective cross-sectional study was conducted using 168 digital panoramic radiographs of children (96 males, 72 females) aged 6 to 14 years. Dental maturation was assessed digitally utilizing CorelDraw X7. The Willems method evaluated the developmental stages of seven left mandibular teeth, while the Cameriere method measured open apices. Statistical analysis included paired t-tests, Pearson correlation coefficients, Mean Absolute Error (MAE), and Root Mean Square Error (RMSE) to rigorously assess accuracy. Results: The mean CA of the cohort was 9.91 ± 0.28 years. The Cameriere method consistently underestimated DA across all age cohorts, yielding a mean DA of 8.63 ± 0.93 years (p < 0.05). Conversely, the Willems method demonstrated a mean DA of 10.73 ± 1.06 years, showing higher overall concordance with CA without statistically significant broad-scale deviations in the overarching comparative model (p < 0.05), despite minor stage-specific variances. Both methods exhibited a near-perfect positive correlation with CA (r > 0.98). Conclusion: The Willems radiomorphological method significantly outperforms the radiometric Cameriere approach in this specific Southeast Asian pediatric demographic. The Cameriere method requires population-specific formulaic adaptation due to consistent physiological underestimation.

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Rachmat Hidayat

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Contact Name Rachmat Hidayat

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Journal Mail Official editor.bioscmed@gmail.com

Editorial Address Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location Kota palembang, Sumatera selatan INDONESIA

Abstract

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Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
+6281949581088

Journal Mail Official
editor.bioscmed@gmail.com

Editorial Address
Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location
Kota palembang,

Sumatera selatan

INDONESIA