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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by HM Publisher

ISSN : - EISSN : 25980580 DOI : https://doi.org/10.37275/bsm

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to : 1.Rhemumatology 2.Molecular aspect of Indonesia Traditional Herb 3.Cardiology and Cardiovascular diseases 4.Genetics 5.Immunology 6.Environmental health 7.Toxicology 8. Neurology 9. Pharmacology 10. Oncology 11. Other multidisciplinary studies related medicine. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 1,265 Documents

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Anesthetic Management of High-Risk Mitral Valve Replacement in a Young Adult with Posterior Leaflet Prolapse, Biventricular Dysfunction Risk, and Pulmonary Hypertension: A Case Report Vera Muharrami; Robfadli Purnanda; Elwistrihady
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1608

Background: Mitral valve disease with concurrent pulmonary hypertension and biventricular dysfunction represents a complex surgical challenge requiring meticulous perioperative management. This case report presents the anesthetic approach to a 43-year-old male with severe mitral regurgitation secondary to posterior leaflet prolapse, Grade III diastolic dysfunction, and intermediate probability pulmonary hypertension undergoing elective mitral valve replacement. Case presentation: The patient presented with 6-month progressive dyspnea, chronic cough, bilateral lower-limb edema, and abdominal distension. Transthoracic echocardiography revealed severe mitral regurgitation with an effective regurgitant orifice area of 2.7 cm², bilateral atrial dilation, moderate tricuspid regurgitation, reduced tricuspid regurgitation jet velocity suggesting intermediate pulmonary hypertension probability, and preserved left ventricular ejection fraction of 68% with severely restrictive diastolic filling pattern. The patient underwent uncomplicated elective mitral valve replacement under general anesthesia with cardiopulmonary bypass. Intraoperative management emphasized hemodynamic stability through judicious fluid administration, careful anesthetic agent selection, and appropriate pulmonary vascular protection strategies. Cardiopulmonary bypass time was 125 minutes with an aortic cross-clamp time of 57 minutes. The postoperative course was uneventful with prompt extubation and discharge from intensive care on postoperative day three. Conclusion: This case illustrates the importance of comprehensive preoperative optimization, multimodal monitoring, and tailored intraoperative management in patients presenting with the complex intersection of severe organic mitral valve disease, pulmonary hypertension, and advanced diastolic dysfunction. The use of sevoflurane-based anesthesia, preservation of systemic vascular resistance, and lung-protective ventilation strategies contributed to favorable perioperative outcomes. This case highlights unique management considerations that may not be extensively detailed in standard anesthetic textbooks and demonstrates successful outcomes despite significant preoperative cardiac compromise.

Rhodomyrtus tomentosa Leaf Extract Cream Suppresses MMP-1 Expression and Epidermal Thickening in UVB-Irradiated Swiss Webster Mice Defa Agripratama Ali; Zen Hafy; Veny Larasati; Nora Ramkita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1609

Background: Ultraviolet B (UVB) radiation induces matrix metalloproteinase-1 (MMP-1) expression and epidermal hyperplasia, contributing to photoaging. Rhodomyrtus tomentosa (karamunting) is rich in polyphenolic compounds with documented antioxidant properties, but its in vivo photoprotective effects remain unexplored. Methods: We investigated the effects of R. tomentosa leaf extract cream at varying concentrations (0%, 12.5%, 25%, 50%) on UVB-irradiated Swiss Webster mice (n=4 per group). UVB exposure was standardized at approximately 150 mJ/cm² per session over seven consecutive days. Vitamin E cream served as a positive control. Immunohistochemical staining quantified MMP-1 expression as a percentage of positive cells, while hematoxylin-eosin histology measured epidermal thickness. Results: Kruskal-Wallis testing revealed significant differences in both MMP-1 expression (H=10.43, p=0.015) and epidermal thickness (H=10.88, p=0.012). The 25% extract concentration optimally suppressed MMP-1 expression (mean 45.94% of positive cells) compared to the untreated UVB control (89.53%). A biphasic dose-response pattern emerged, with hormetic effects observed at 50% concentration (76.45%), suggesting polyphenol pro-oxidant activity at excessive concentrations. Epidermal thickness normalized with 25% treatment (71.8 μm) versus UVB control (93.4 μm). Immunohistochemical intensity decreased progressively with treatment intensification through 25%, supporting suppression of MMP-1-mediated collagen degradation. Conclusion: R. tomentosa leaf extract cream at 25% concentration effectively suppresses MMP-1 expression and normalizes UVB-induced epidermal thickening in mice. The hormetic response at higher concentrations highlights the importance of dose optimization in phytotherapeutic development. This work establishes the first in vivo evidence for karamunting leaf extract as a photoprotective agent and supports further clinical translation.

Atypical Presentation of Clinically Non-Functioning Pituitary Macroadenoma: Case Report of Concurrent Graves' Disease and Multi-Axis Pituitary Hypofunction in a 40-Year-Old Female Rizkha Amaliya; Dolly Irfandy; Hesty Lidya Ningsih; Alexander Kam; Mardijas Efendi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1610

Background: Non-functioning pituitary adenomas (NFPAs) present variable clinical manifestations depending on tumor size and location. Concurrent primary autoimmune thyroid disease in NFPA patients is exceptionally rare and requires careful diagnostic distinction from secondary hypothyroidism. Case presentation: A 40-year-old female presented with progressive bilateral peripheral vision narrowing over 3 months, chronic bifrontal headaches, secondary amenorrhea, and nocturia-predominant polyuria. Neuro-ophthalmologic examination revealed bitemporal hemianopsia with visual acuity 20/200 left eye and 20/25 right eye. Endocrine evaluation demonstrated: primary hyperthyroidism (TSH 0.02 µIU/mL, FT4 28.32 pmol/L, positive thyroid receptor antibodies), secondary adrenal insufficiency (cortisol 1 µg/dL, ACTH <5 pg/mL), and hypogonadotropic hypogonadism (LH 1.62 IU/L). Neuroimaging revealed a 2.13 × 2.28 × 3.05 cm sellar/suprasellar lesion with optic chiasm compression (Knosp Grade II). Endoscopic transsphenoidal surgery achieved complete gross total resection. Histopathology confirmed null-cell adenoma with low Ki-67 proliferation index (2%). Conclusion: Postoperative course was uncomplicated with rapid visual field improvement, complete resolution of bitemporal hemianopsia by 2 weeks, and normalization of all endocrine axes by 12 weeks, including menstrual recovery and gonadal axis restoration. This case illustrates the diagnostic challenge of distinguishing secondary hyperprolactinemia from primary prolactinoma in NFPA, the rarity of concurrent Graves' disease with pituitary macroadenoma, and favorable outcomes with complete surgical decompression achieving multisystem endocrine recovery.

Risk of Acute Myocardial Infarction in Patients with Systemic Lupus Erythematosus Compared with the General Population: A Systematic Review and Meta-Analysis Eli Novi; Wahyudi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1611

Background: Patients with systemic lupus erythematosus (SLE) are at substantially elevated risk of acute myocardial infarction (AMI) compared with the general population, attributable to a complex interplay of accelerated atherosclerosis, coronary microvascular dysfunction, antiphospholipid antibody-mediated thrombosis, and dysregulated innate immunity. Pooled estimates across published meta-analyses have not been formally synthesised. Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA 2020 guidelines. PubMed, MEDLINE, and EMBASE were searched through 2 April 2026 for studies reporting the relative risk (RR) of AMI in SLE patients versus the general population. Three eligible meta-analyses providing RR estimates were identified. Data were pooled using the DerSimonian-Laird random-effects model with Hartung-Knapp-Sidik-Jonkman (HKSJ) adjustment, implemented in R 4.5.3 (packages meta v8.2-1 and metafor v4.8-0). Heterogeneity was assessed using Cochran’s Q and I². Publication bias was evaluated using Egger’s precision-effect test. A sensitivity analysis incorporating all five eligible comparative studies with mixed effect measures (RR, rate ratio, OR) was performed, alongside subgroup analysis by study design. Results: Three meta-analyses incorporating 24 to 46 primary studies and representing data from approximately 168,000 SLE patients were eligible for the primary pool. The pooled RR of AMI in SLE patients was 2.95 (95% CI 2.57–3.39; p < 0.001). Heterogeneity was negligible (I² = 0.0%; Q = 0.04, p = 0.98; τ² = 0.000). Weights were: Bello et al. 2023 (61.5%), Yazdany et al. 2020 (31.5%), Gu et al. 2019 (7.0%). Sensitivity analysis, including all five comparative studies (mixed measures), yielded a pooled effect of 5.27 (95% CI 2.91–9.53) with substantial heterogeneity (I² = 92.7%, Q = 55.11, p < 0.001), consistent with expected heterogeneity from mixing incompatible effect measures. Subgroup analysis by design showed Q-difference = 55.07 (df = 2, p < 0.001). Egger’s test was non-significant (t = 1.63, p = 0.35). Conclusion: SLE patients face approximately a three-fold elevated risk of AMI compared with the general population, a finding derived from homogeneous, high-quality evidence and confirmed by sensitivity analyses. These findings underscore the need for systematic, SLE-specific cardiovascular risk management, including judicious use of hydroxychloroquine, lipid-lowering therapy, and multidisciplinary cardiorheumatology follow-up.

Perioperative Anesthesia Challenges in a Neonate with Concurrent Intussusception and Abdominal Compartment Syndrome: A Rare Clinical Scenario Pratama Nanda; Dino Irawan; Aditya Permana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1612

Background: Intussusception and abdominal compartment syndrome (ACS) are severe surgical emergencies in pediatric populations, particularly in neonates. The concurrent presentation of both conditions is exceptionally rare and presents formidable perioperative anesthetic challenges. Case presentation: We report the case of a 2-month-old male neonate weighing 6.9 kg who presented with a 4-day history of bloody stools and bilious vomiting following blunt abdominal trauma inflicted by a 12 kg sibling. Clinical examination and imaging confirmed concurrent intussusception with abdominal compartment syndrome. The patient presented with significant hematologic derangements including severe leukopenia (WBC 1,180/μL), anemia (hemoglobin 9.2 g/dL), thrombocytosis, coagulopathy (INR 1.88), and electrolyte abnormalities. Emergency rapid sequence induction anesthesia was employed with careful fluid management utilizing the Holliday-Segar formula to prevent exacerbation of compartment pressures. A successful exploratory laparotomy with resection of necrotic small bowel segments was performed. Conclusion: The case demonstrates the critical importance of comprehensive preoperative assessment, meticulous fluid management strategies, and multidisciplinary collaboration in managing complex neonatal surgical emergencies. This rare clinical scenario highlights unique anesthetic considerations and provides valuable insights into perioperative management of ACS in the neonatal population.

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Rachmat Hidayat

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Rachmat Hidayat

Contact Email dr.rachmat.hidayat@gmail.com

Phone +6281949581088

Journal Mail Official editor.bioscmed@gmail.com

Editorial Address Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location Kota palembang, Sumatera selatan INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
+6281949581088

Journal Mail Official
editor.bioscmed@gmail.com

Editorial Address
Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location
Kota palembang,

Sumatera selatan

INDONESIA