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Laury Marcia Ch. Huwae
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Jurusan Biologi - Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Pattimura Jl. Ir. M. Putuhena, Kampus Poka, Ambon, 97234, Maluku, Indonesia
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Biofaal Journal
Published by Universitas Pattimura
ISSN : -     EISSN : 27234959     DOI : https://doi.org/10.30598/biofaal.v1i1y2020
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Materials Science & Nanotechnology Medicine & Pharmacology
Biofaal Journal merupakan jurnal online yang menerima dan mempublikasikan tulisan-tulisan ilmiah dalam bentuk artikel hasil penelitian terbaru, short communication, maupun review terhadap artikel dari bidang keilmuan Biologi, Faal Tumbuhan, Faal Hewan, Faal Manusia dan Faal Olahraga. Biofaal Journal diterbitkan oleh Profesi Ahli Ilmu Faal, Jurusan Biologi FMIPA Universitas Pattimura. Dalam setahun Biofaal Journal memiliki 1 volume dan 2 Issue. Dewan editor, berasal dari rumpun ilmu biologi dan fisiologi yang aktif dalam publikasi ilmiah skala nasional dan internasional, sehingga mampu melakukan proses review secara profesional. Artikel yang diterima akan diterbitkan sesuai dengan waktu yang ditentukan yaitu pada bulan Juni dan Desember, dan akan tersedia gratis bagi pembaca
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "Vol 6 No 1 (2025): Biofaal Journal" : 8 Documents clear
Efficacy Test of Ethanol Extract From Matoa (Pometia pinnata) Stem Bark on Aedes aegypti Larval Mortality As An Effort to Control Dengue Fever Moniharapon, Debby Dijola; Moniharapon, Mechiavel
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp1-9

Abstract

Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by the dengue virus and transmitted primarily through the bite of the Aedes aegypti mosquito, the disease's primary vector. Controlling the population of this mosquito species is considered a strategic measure in preventing the spread of DHF. One potential biological control agent is the matoa plant (Pometia pinnata), a member of the Sapindaceae family widely distributed in tropical regions. This plant contains secondary metabolites such as flavonoids, tannins, and saponins, which exhibit natural insecticidal activity. This study aims to evaluate the efficacy of ethanol extract derived from the bark of P. pinnata against A. aegypti larvae. The extraction process was conducted using ethanol as a solvent, and the resulting extract was tested against mosquito larvae at concentrations of 25 ppm, 50 ppm, 70 ppm, and 90 ppm. Larval mortality data were analysed using Analysis of Variance (ANOVA) via SPSS software version 24.00. The results demonstrated that the ethanol extract of P. pinnata bark had a significant dose-dependent effect on larval mortality. These findings suggest the potential of the extract as a natural active ingredient in the formulation of plant-based larvicides, contributing to environmentally friendly and sustainable dengue vector control strategies.
The Role of Telomerase in Celullar Senescence and Its Implications For Anti-Aging Therapy Defi, Ratna Shintia; Ernestia, Henrita; Pukan, Ferdinandus Krisna
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp20-28

Abstract

Aging is a complex biological process influenced by genetic, environmental, and lifestyle factors. One of the primary mechanisms contributing to aging is telomere shortening, which plays a crucial role in genome stability and cellular regeneration. As individuals age, progressive telomere shortening can trigger cellular apoptosis and tissue dysfunction, impacting health and skin aesthetics. Consequently, telomere-based anti-aging therapies have become a significant focus of strategies aimed at slowing the aging process and improving quality of life. Several studies have explored various therapeutic approaches, including telomerase activation, bioactive compounds, and genetic engineering technologies to maintain telomere length and enhance cellular function. This literature review aims to analyze recent developments in telomere-based anti-aging therapies, evaluate their effectiveness, and discuss their potential applications in health and aesthetic medicine. A deeper understanding of telomere mechanisms and their therapies is expected to facilitate the development of more effective and sustainable anti-aging strategies.
Therapeutic Effect of Pulai Bark Extract (Alstonia scholaris L. R. Br) on Body Weight of Streptozotocin-Induced Mice (Mus musculus) Assagaf, Abdur Rahman; Tarigan, Ulva Karolina
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp29-38

Abstract

Type 1 and type 2 diabetes mellitus are metabolic disorders characterized by elevated blood sugar levels (hyperglycemia) due to the body’s inability to produce insulin effectively. Sustained hyperglycemia can affect various physiological parameters, including changes in body weight. Alstonia scholaris L. R. Br is a plant widely found in Southeast Asia. Alstonia scholaris stem bark extract contains bioactive compounds of flavonoids, saponins, and polyphenols that can be antidiabetic. This study aims to determine the therapeutic effect of pulai bark extract (Alstonia scholaris L. R. Br) on the body weight of mice (Mus musculus) induced by Streptozotocin. This research is experimental. A total of 18 mice were divided into 6 groups, namely the normal control group (KN), negative control group (K-), positive control group (K+), and DM mice group given the extract at a dose of 0.4 ml/mencit/day (P1), a dose of 0.8/ml/mencit/day (P2) and 1.6 ml/mencit/day (P3). Before treatment, all mice were weighed, and initial blood sugar levels were. After that, the K-, K+, P1, P2, and P3 groups were induced with streptozotocin mice at a dose of 0.3 ml for 14 days. Furthermore, suppose there is an increase in blood sugar levels. In that case, the K+ group is given the drug metformin, and the P1, P2, and P3 groups are given Alstonia scholaris stem bark extract at a predetermined dose. Data from the study were analyzed using an ANOVA test. The results showed that giving Alstonia scholaris stem bark extract can increase the body weight of DM mice.
Expresion of Tumor Necrosis Factor Alfa (TNF-α) in The Pancreas of Diabetic Mice (Mus musculus) Following Adminstration of Catharantus roseus Extract Kaliky, Nunun Ainun Putri Sari Banun; Moniharapon, Mechiavel; Eddy, La
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp10-19

Abstract

Catharanthus roseus is a plant that contains compounds such as alkaloids, flavonoids, saponins, and carotenoids, which act as antioxidants. This study aimed to investigate the effect of Catharanthus roseus extract on the reduction of TNF-α expression in the pancreas of diabetic mice (Mus musculus). In this study, mice with an average body weight of 30 g were induced with streptozotocin (0.1 ml/BB) to induce diabetes mellitus. Subsequently, the diabetic mice were administered Catharanthus roseus extract, using methanol and petroleum benzene solvents at a concentration of 5%, with a dose volume of 1.5 ml/BB, for 14 days. On the final day, the mice were sacrificed, and the pancreas organs were collected, followed by histological preparation using immunohistochemistry methods. The results indicated that administration of Catharanthus roseus extract with methanol and petroleum benzene solvents reduced TNF-α expression. The Catharanthus roseus extract with methanol solvent was more effective in lowering TNF-α expression.
Carcass and Prime Cut of Brahman Cross Steers at Different Age Levels Permata, Anggun Sari; Hasman, Hasman; Hasrin, Hasrin; Hidayah, Asmaul Fitria Nur; Wulandari, Sri Helda; Syamsuddin, Syamsuddin; Latief, Muhammad Fadlirrahman
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp39-46

Abstract

This study aimed to evaluate the effect of age on carcass yield and prime cuts in steer Brahman Cross (BX) cattle. The research was conducted from September 2 to 22, 2015, at PT Cianjur Arta Makmur slaughterhouse, Cianjur Regency, West Java. A total of 68 steer BX cattle were used, divided into four age groups based on permanent incisor eruption: PI0 (<18 months, n=15), PI2 (18–24 months, n=19), PI4 (>24–36 months, n=21), and PI6 (>36–42 months, n=13). Measured variables included slaughter weight, hot carcass weight, cold carcass weight, carcass percentage, and prime cut yields (tenderloin, striploin, cube roll). Data were analyzed using one-way ANOVA. The results showed no significant differences (p>0.05) among age groups in terms of slaughter weight (507.07 ± 44.58 kg), hot carcass weight (287.97 ± 23.85 kg), cold carcass weight (273.31 ± 23.57 kg), carcass percentage (53.95 ± 1.92%), and prime cut weights: tenderloin (3.73 ± 0.39 kg), striploin (10.27 ± 1.28 kg), cube roll (5.01 ± 0.61 kg). Although age did not significantly affect carcass and cut yields, the highest retail sales value was observed in PI2 cattle at Rp23,110,648. These findings suggest that while age level does not significantly influence carcass or prime cut weights, economic returns may vary based on carcass composition and retail pricing.
Effectiveness of Methanol and Petroleum Benzene Extracts of Catharantus roseus Leaves in Reducing Blood Sugar Levels in Mice (Mus musculus) Diabetes Mellitus Model Siscawati, Winda; Baszary, Chomsa Dintasari Umi
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp47-59

Abstract

Catharanthus roseus, a plant belonging to the Apocynaceae family, contains various chemical compounds. The roots, stems, leaves, and seeds of Catharanthus roseus contain over 70 types of alkaloids, including 28 bi-indole alkaloids found throughout the plant. These compounds, many of which are beneficial in medicine, exhibit blood sugar-lowering (hypoglycemic) properties. This study aims to evaluate the effects of pure methanol extracts of Catharanthus roseus leaves on diabetes mellitus in mice, providing comprehensive evidence of its efficacy. Methanol and petroleum benzene extracts of Catharanthus roseus leaves were diluted to a 5% concentration and administered to test animals at a dose of 1.5 ml. After a two-week testing period, the results showed a significant reduction in blood sugar levels in the diabetes mellitus model mice. This demonstrates the hypoglycemic effect of methanol and petroleum benzene extracts of Catharanthus roseus leaves in lowering blood glucose levels in streptozotocin-induced mice.
A Case Report on Internal Bleacing of a Discolored Central Incisor Using 35% Hydrogen Peroxide Sutowijoyo, Aryo; Nerito, Prima
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp60-66

Abstract

A patient presented with tooth discoloration due to trauma, which had caused a tooth to become non-vital. Such trauma can damage the pulp tissue, eventually leading to necrosis and discoloration over time. In cases like this, internal bleaching is a treatment procedure aimed at improving the color of non-vital teeth. Discoloration of teeth after endodontic treatment often raises concerns for both patients and dentists. Whitening the tooth after root canal treatment is important to restore its original color before a permanent restoration is placed. The objective of this report is to present the successfull outcome of internal bleaching in patient who had undergone root canal treatment en years earlier. A 39-year-old male presented with a complaint of discoloration in the right maxillary central incisor. The patient had a history of root canal treatment on the tooth performed ten years prior. Radiographic examination confirmed that tooth 11 had undergone root canal treatment. Internal bleaching was performed on tooth 11, which appeared darker than the adjacent teeth. Whitening was carried out using 35% hydrogen peroxide. By the fourth visit (one week after the third application), the tooth color had changed to shade D3, which matched the desired color. This indicated a significant improvement in shade. Internal bleaching using 35% hydrogen peroxide resulted in color enhancement consistent with patients expectations. The treatment proved effective in restoring the esthetics of a non-vital tooth discolored due to trauma.
Effectiveness of Acupressure on Improving Sleep Quality of The Elderly Jotlely, Hery; Herwawan, Joan Herly; Tasijawa, Fandro Armando; Nindatu, Maria
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp67-75

Abstract

Sleep disorders increase with age, with prevalence approaching 50% in the elderly (65 years and above). In Indonesia, about 30% of the elderly experience sleep disorders. Several studies have shown that older people who have poor sleep patterns or who experience sleep disorders are at risk of dementia, mental illness, including anxiety and depression, hypertension, and cardiovascular disease. Sleep disorders can be treated with medication, but it can cause side effects such as drowsiness, poor concentration, and dementia. These side effects contribute to the risk of falls, accidents, and cognitive impairment. So to avoid these effects, a non-pharmacological approach can be taken, one of which is acupressure. Acupressure is the application of finger or thumb pressure on acupoints. This study aims to determine the effectiveness of acupressure on sleep quality in the elderly. The research used quantitative methods with a quasi-experimental research design. This design has a comparison group (control) and an intervention/treatment group, but before being given treatment (intervention), a pretest and posttest are carried out. The number of samples in this study amounted to 96 respondents, with the sampling technique used being purposive sampling. 96 respondents will be divided into control groups and intervention groups. The statistical analysis method used is the Wilcoxon test. The difference in the quality of elderly sleep before and after applying acupressure in the intervention group with an average (mean) of 0.479. As for the control group, -0.021. It can be seen that in the control group, there was an increase in value after applying acupressure. The p-value of the intervention group is 0.001 (p <α), where it can be concluded that there is a real (significant) difference in the average improvement in the quality of elderly sleep as seen from the value of each assessment before and after acupressure is applied.

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