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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 6 Documents
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Search results for , issue "Vol 3, No 2 (2021)" : 6 Documents clear
Studi Penambatan Maya dan Prediksi Toksisitas Turunan 5-Fluorouridin Monofosfat Pada Enzim Orotidin-5-monofosfat Dekarboksilase Andzar Fikranus Shofa; Anggie Fuji Lestari; Hafidh Agrestian Soputri; Kharisma Safenti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 2 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v3i2.24524

Abstract

Cancer is one of the leading causes of death in the world. Various cancer treatments had undergone many developments, one of which is through the process of drug discovery of cancer drugs. 5-Fluorouridine Monophosphate is a potential active metabolite of 5-fluorouracil and the ligand for the enzyme Orotidine-5-monophosphate decarboxylase (OMPD), so it deserves further development through structural modification. This study aims to predict the cytotoxic activity and toxicity of the parent compound 5-Fluorouridine Monophosphate and twenty derivative compounds as candidates for anticancer drugs. The mechanism of action of 5-Fluorouridine Monophosphate derivatives as anticancer by inhibiting OMPD, a carboxylation enzyme that is important in nucleotide biosynthesis in the process of cellular replication. Biological activity was predicted through molecular modeling called in silico assay using the Molegro Virtual Docker (MVD) program, while compound toxicity was predicted using the pkCSM online tools program. The in silico test is carried out by docking the compound whose activity will be predicted against the OMPD receptor target with the code PDB. 2QCF. The results of docking in the form of bond energy are indicated by the value of the Rerank Score (RS). Compounds that have a small RS value are predicted to have more stable ligand-receptor binding and have high activity. Based on the results of the in silico test, it can be concluded that all derivatives of 5-Fluorouridine Monophosphate meet the requirements of Lipinski's law. Then the results of molecular docking showed that the RS value of the derivative compound number 16 was lower than the parent compound 5-Fluorouridine Monophosphate, but had more hydrogen bonds with amino acid residues than the parent compound. Therefore, it can be concluded that the 16th derivative with the formula C16H25F2N2O7P is the most feasible to be synthesized and continued by testing its activity in vitro and in vivo.
Antidiabetic Activity of Noni (Morinda citrifolia) Extract on Swiss Webster Male Glucagon-Induced Mice Jessica Rusli
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 2 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v3i2.20183

Abstract

The antidiabetic activity of noni (Morinda citrifolia) extract on the blood glucose level of Swiss Webster male mice (Mus musculus) has been examined. This research aims to study the antidiabetic activity of noni fruit extract on blood glucose level by either induced or not induced with glucagon. Twenty-eight Webster male mice were divided into two main treatment groups. The first treatment group was further divided into four treatment sub-groups. These are (i) blank control (without any treatment), (ii) given distilled water only, (iii) given the extract in a dosage of 1,5 g/kg body weight (bw), and (iv) given the extract in a dosage of 3 g/kg bw. The second treated group was divided into three other treatment group. These are: (i) glucagon+ distilled water, (ii) glucagon+the extract in a dosage of 1,5 g/kg bw, and (iii) glucagon+the extract in a dosage of 3 g/kg bw. The experiment was done with four replicates to each sub-group. The volume of distilled water and the extract were given by gavage in a dosage of 10 ml/kg bw, whereas the glucagon was given through intramuscular injection in a dosage of 20 µg/kg bw. The treated sub-groups without glucagon were injected with distilled water and the extract once every two weeks for eight weeks (1th,3th,5th,7th week) with per week interval for blood sampling (zero,2nd,4th,6th,8th week). The blood glucose levels (BGL) of this sub-group is fasting blood glucose level (BGLf) and two hours post-prandial (2-hrs pp) blood glucose level). The sub-groups with glucagon injection were given distilled water and the extract once a week for four weeks (1th-4th week) with three times per week blood sampling, namely before glucagon injection (BGLa), 10 minutes after the injection (BGLb) and 2 minutes after distilled water or the extract. The results of the statistic test showed (ANOVA p<0,05) that BGL of noni fruit extract-treated mice (doses: 1,5 and 3 g/kg bw) without glucagon injection for eight weeks, tends to decrease. The distilled water feeding does not affect BGL. It can be seen that during 8 weeks of distilled water treatment, it appears that BGLf and BGLe of the distilled water group were not significantly different from the control group. Mice treated with noni fruit extract (doses: 1,5 and 3 g/kg bw) and glucagon injection for four weeks, showed constant BGL. The conclusion is that nony fruit extract helps to decrease blood glucose levels in both groups of mice either induced or not induced with glucagon. That can be seen from the result of statistical tests that shows BGLf and BGLe of the noni group, both at a dose of 1.5 g / kg bw and 3 g / kg bw, from week 2 to week 8 were significantly different from the control group. Meanwhile, in the mice treated with glucagon in the noni group with both doses, BGL decreased after administration of noni. That also shows the significant difference of BGLf and BGLe of the noni group with the control group
Kajian Mutu Produk Tablet Metformin Hidroklorida Extended-Release yang Dipasarkan di Indonesia Yuni Anggraeni; Umniyaty Mufidah; Umar Mansur
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 2 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v3i2.24755

Abstract

Some metformin hydrochloride extended-release (MetHCl-XR) tablet products have been marketed in Indonesia with varying prices. In general, price is considered to indicates the quality of a product. This research was conducted to review the products quality, especially the dissolution rate of the products, and to find out if the price is an indicator of the product quality. Three brands of MetHCl 500 mg XR tablets were randomly selected, namely Tablet A, B, and C which the price of Tablet B > A > C, then the Tablets were characterized. The results showed that Tablet A, B, and C contain MetHCl with an average of 100.61%, 98.72%, and 101.15% respectively, and met the uniformity of dosage unit requirement. Tablet A met the requirements of dissolution tests 1, 2, 3, and 4, while Tablet B and C met the requirements of dissolution tests 1 and 3. The cumulative percentage of MetHCl release at the 10th hour of Tablet A, B, and C were 94.18%, 97.24%, and 94.59% respectively with the release kinetics of Tablet A and B following Higuchi model, whereas Tablet C following a first-order. Drug release of all tablets occurred in non-Fick diffusion. In conclusion, the three tablets met the standards required by USP 43 and the price is not an indicator of MetHCl-XR tablet products quality.
Pengaruh Intervensi terhadap Kepatuhan Penggunaan Analgesik Opioid dan Skala Nyeri Pasien Kanker Rurynta Ferly Shavira; Retnosari Andrajati; Risani Andalasia Putri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 2 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v3i2.23682

Abstract

Cancer pain patients who receive opioid analgesics need to be given educational interventions to increase patient knowledge that can have a positive impact on patient adherence, especially in outpatients who will take opioid analgesics without being accompanied by professional. To maximize the effectiveness of the intervention, it is necessary to know the relationship between the intervention to adherence and the intervention to the pain scale. This study aimed to analyze the effect of the intervention and other factors on patient adherence in using opioid analgesics and the cancer pain scale. This study was conducted at Dharmais Cancer Hospital from March-April 2021 using a quasi-experimental design in the form of nonequivalent control group. In this study, the method used are pill count to measure adherence and NRS (Numerical Rating Scale) to measure the pain scale. Measurement of adherence using pill count was conducted after the intervention, but the measurement of the pain scale was conducted before and after the intervention. A total of 134 respondents were divided into 2 intervention groups, namely the counseling group and the digital booklet group. The results of the multivariate analysis showed that there was no variable that interfered with the relationship between the intervention and respondent's adherence. The adherence of respondents who received counseling was 4 times higher than the respondents who received digital booklet. From the results of this study, it can also be concluded that the more obedient the respondent is, the lower the pain scale.
Isolasi dan Karakterisasi Bakteri Endofit dari Daun Sirsak Annona Muricata L. dan Aktivitas Antibakterinya terhadap Beberapa Bakteri Patogen Isra Janatiningrum; Akhmad Endang Zainal Hasan; Eny Ida Riyanti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 2 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v3i2.24321

Abstract

Soursop (Annona muricata L.) is a plant with many health benefits. Soursop leaves are widely used as traditional medicine by Indonesian citizen for wound infection healing. The antibacterial activity of soursop leaves cannot be separated from the presence of endophytic microbes that live inside. Endophytic bacteria live in plant tissues and have beneficial for their host plants. Endophytic microbes are able to produce same secondary metabolites as their host such as producing antibacterial compounds. Thirty one bacterial endophytes were isolated from soursop leaves that from 3 different regions: Garut, Cianjur, and Sukabumi. Morphologically, endophytic bacterial isolates from the three regions had different diversity. Bacterial isolates were tested for their activity against 4 test pathogenic bacteria, such as Pseudomonas aeroginosa, Escherichia coli, Staphylococcus mutans, and Streptococcus aureus. Antibacterial test using disc diffusion method with chloramphenicol 500 m/mL as positive control. Based on the antibacterial activity test, isolate G42 was able to inhibit all types of test bacteria. G42 isolates forms a zone of inhibition up to 17 mm in P. aeroginosa. Based on 16S rRNA, G42 isolates had similarity with Pantoea wallisii up to 93.24%. This study shows that endophytic bacteria isolated from soursop leaves have the potential to be developed into antibacterial agents.
Kajian Repurposing Drug sebagai Prioritas Metode Pengembangan Obat Rosa Adelina
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 2 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v3i2.24345

Abstract

COVID-19 pandemic happened 100 years after Spanish Flu which caused high mortality in the world. It raised awareness about the importance to have drug development strategy acceleration. One of the drug development methods is drug repurposing. The urge for a deeper review of this method will be discussed in this article. The research method was reviewer literature that describes the terminology, the use of drug repurposing in cancer, COVID-19 and other diseases therapies and also the advantages to using drug repurposing method in drug development. The results showed some similar terms in drug repurposings such as drug repositioning, drug reprofiling, and drug rediscovery that makes drug repurposing preferred for old drug in new indication. Drug repurposing for anticancer are thiotepa, doxorubicine, gemcitabine, and raloxifene. Drug repurposing for COVID-19 are dexamethasone, methylprednisolone, sarilumab, heparine, enoxasaparine, rivaroxabane, and fondaparinux. The other uses are zidovudine, minoxidil, sildenafile, rituximab, and ketoconazole. The advantages from this method are higher time and cost-efficiency. Hesitance, drug therapy with drug repurposing method should be a priority for drug development nowadays.

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