Article Per Year (5 Year)
p-Index From 2021 - 2026
1.606
P-Index
This Author published in this journals
All Journal VALENSI Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biotechnology Jurnal Ilmiah Medicamento Pharmaceutical And Biomedical Sciences Journal (PBSJ) Mimbar Agama Budaya Jurnal Kefarmasian Indonesia
Rosa Adelina
UIN Syarif Hidayatullah Jakarta
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

Published : 20 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 20 Documents
Search

 1   2 
Citrus reticulata’s Peels Modulate Blood Cholesterol Profile and IncreaseBone Density of Ovariectomized Rats Adelina, Rosa; Supriyati, Maria Dwi; Nawangsari, Dwi Ana; Jenie, Riris I; Meiyanto, Edy
Indonesian Journal of Biotechnology Vol 13, No 2 (2008)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.764 KB)

Abstract

Hormon Replacement Therapy is a common therapy for estrogen deficiency but in other side it will increase the risk of cardiovascular disease. Another alternative therapy which relatively more safe is using phytoestrogen. The Citrus reticulata’s peel contain flavanone and polimethoxyflavone which are suspected to give estrogenic effect, therefore it is potential to be used as phytoestrogen.The purpose of this study was to examine the estrogenic effect of Citrus reticulata’s peel extract in modulation of bone density and blood cholesterol profile of ovariectomized rats (OVX), an animal model of postmenopausal osteoporosis. Thirty six 7-weeks-old female Sprague Dawley rats were assigned to six groups: a SO group, an OVX group, an OVX+CMCNa group, an OVX+extract dose 500 mg/kgBW group, an OVX+extract dose 1000 mg/kgBW group, and an OVX+estradiol group. After 7 weeks, the rats were killed then blood and femoral were collected immediately. The rontgenogram indicated that extract and estradiol administration increase the bone density. And the data analysis with Oneway ANOVA test ,followed by Shceffé test (P 0.05) showed that extract can improve blood cholesterol profile in dose depend manner. These results suggest a possible role of Citrus reticulata’s peel extract as women’s health agent because of its beneficial effects on bone and lipids.
Citrus reticulata's Peels Modulate Blood Cholesterol Profile and IncreaseBone Density of Ovariectomized Rats Rosa Adelina; Maria Dwi Supriyati; Dwi Ana Nawangsari; Riris I Jenie; Edy Meiyanto
Indonesian Journal of Biotechnology Vol 13, No 2 (2008)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.764 KB) | DOI: 10.22146/ijbiotech.7800

Abstract

Hormon Replacement Therapy is a common therapy for estrogen deficiency but in other side it will increase the risk of cardiovascular disease. Another alternative therapy which relatively more safe is using phytoestrogen. The Citrus reticulata’s peel contain flavanone and polimethoxyflavone which are suspected to give estrogenic effect, therefore it is potential to be used as phytoestrogen.The purpose of this study was to examine the estrogenic effect of Citrus reticulata’s peel extract in modulation of bone density and blood cholesterol profile of ovariectomized rats (OVX), an animal model of postmenopausal osteoporosis. Thirty six 7-weeks-old female Sprague Dawley rats were assigned to six groups: a SO group, an OVX group, an OVX+CMCNa group, an OVX+extract dose 500 mg/kgBW group, an OVX+extract dose 1000 mg/kgBW group, and an OVX+estradiol group. After 7 weeks, the rats were killed then blood and femoral were collected immediately. The rontgenogram indicated that extract and estradiol administration increase the bone density. And the data analysis with Oneway ANOVA test ,followed by Shceffé test (P 0.05) showed that extract can improve blood cholesterol profile in dose depend manner. These results suggest a possible role of Citrus reticulata’s peel extract as women’s health agent because of its beneficial effects on bone and lipids.
Annona muricata's Leaves Ethanolic Extract Enhance p53 Expression in Rat Hepatic Cells Induced by Dimethylbenz(a)Anthracene (DMBA) Rosa Adelina; Intan Sari Oktoberia; Putri Reno Intan
Indonesian Journal of Cancer Chemoprevention Vol 4, No 1 (2013)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev4iss1pp483-487

Abstract

Annona muricata or soursop contains acetogenin which can induce apoptosis in vitro and has cytotoxic effect. The study has been done to examine soursop leaves extract’s potency in vivo especially to induce apoptosis in 7,12-Dimethylbenz[a]anthracene (DMBA)-induced Sprague Dawley rats. The induction process was done twice a week for five weeks. The soursop leaves extract were given in three dosages, that are 200, 400, and 800 mg/kgBW for seventeen days after two weeks DMBA induction. Data analysis showed that Annona muricata leaves ethanolic extract could enhance p53 pathway significantly with a dose independent manner in DMBA-induced rats.Keywords: Proapoptosis,  Annona muricata leaves ethanolic extract, hepatoma
Kajian Repurposing Drug sebagai Prioritas Metode Pengembangan Obat Rosa Adelina
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 2 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v3i2.24345

Abstract

COVID-19 pandemic happened 100 years after Spanish Flu which caused high mortality in the world. It raised awareness about the importance to have drug development strategy acceleration. One of the drug development methods is drug repurposing. The urge for a deeper review of this method will be discussed in this article. The research method was reviewer literature that describes the terminology, the use of drug repurposing in cancer, COVID-19 and other diseases therapies and also the advantages to using drug repurposing method in drug development. The results showed some similar terms in drug repurposings such as drug repositioning, drug reprofiling, and drug rediscovery that makes drug repurposing preferred for old drug in new indication. Drug repurposing for anticancer are thiotepa, doxorubicine, gemcitabine, and raloxifene. Drug repurposing for COVID-19 are dexamethasone, methylprednisolone, sarilumab, heparine, enoxasaparine, rivaroxabane, and fondaparinux. The other uses are zidovudine, minoxidil, sildenafile, rituximab, and ketoconazole. The advantages from this method are higher time and cost-efficiency. Hesitance, drug therapy with drug repurposing method should be a priority for drug development nowadays.
Tipe Masker pada Murid Sekolah Dasar selama Pertemuan Tatap Muka Terbatas di Masa Pandemi COVID-19 Adelina, Rosa; Fajra, Jenisha Rani; Putri, Annisya Ayu; Zaafira, Reyhan Diva
Jurnal Ilmiah Medicamento Vol 10 No 1 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i1.8223

Abstract

In March 2020, the World Health Organization declared COVID-19 a pandemic. As a result, elementary school learning was primarily conducted online. However, in January 2022, the Government of Indonesia announced that limited face-to-face meetings in schools could be conducted due to the vaccination of elementary school students. Nevertheless, these meetings are still subject to health protocols, including wearing masks. This study aims to examine the types and brands of masks used, as well as elementary school students' knowledge regarding the layers of masks and sources of information on mask usage during limited face-to-face meetings. The research utilized a descriptive method and cross-sectional study design. The sample was obtained through purposive sampling of elementary school students in the Jabodetabek area, with a total of 408 students included in the study. Univariate data analysis was performed using SPSS 25 to describe the observed results. The findings indicate that the three most used types of masks were duckbill masks (33%), medical masks (25%), and KF94 masks (21%). The two highest response groups reported that 41.4% of respondents believed the masks to consist of only one layer, while the other 35% believed they consisted of three layers. The most used mask brands are those produced in China. Teachers and parents are the primary sources of knowledge regarding the use of masks among elementary school students. According to the study's findings, there is a strong correlation between the information received and the use of masks by these students.
Molecular Docking and Dynamic Simulation of Erythrina fusca Lour Chemical Compounds Targeting VEGFR-2 Receptor for Anti-Liver Cancer Activity Maharani, Dila Aulia; Adelina, Rosa; Aini, Anggun Qurrota; Supandi, Supandi
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.35295

Abstract

Liver cancer is a serious health concern characterized by abnormal cell growth, but currently, available treatment options are limited, suggesting the need for a new therapeutic method. Therefore, this research aimed to investigate the potential of chemical compounds obtained from the cangkring plant (Erythrina fusca) as anti-liver cancer agents targeting Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2). The investigation was conducted in silico through molecular docking and dynamic method. Molecular docking was performed using AutoDock Tools, followed by visualization with Biovia Discovery Studio. Additionally, molecular dynamics simulation was conducted using GROMACS software and visualized with Grace. A total of 36 chemical compounds from E. fusca were used as ligands for molecular docking. The results showed that Isobavachalcone (ISB) was the most effective test compound with a binding energy of -11.45 kcal/mol, compared to the positive control Sorafenib with a value of - 11.51 kcal/mol. In this context, hydrogen bonding, as well as hydrophobic, electrostatic, and unfavorable molecular interactions were identified. Moreover, molecular dynamics simulation provided RMSD, RMSF, Radius of Gyration (Rg), and hydrogen bond parameters. Analysis of these parameters further confirmed the superior stability of ISB in binding to VEGFR-2, suggesting the potential to suppress angiogenesis by blocking the receptor.
Profil Penggunaan Obat Antiinflamasi Nonstreoid di Indonesia Soleha, Maratu; Isnawati, Ani; Fitri, Nyoman; Adelina, Rosa; Soblia, Hamim Tsalis; Winarsih, Winarsih
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i2.316

Abstract

Nonsteroid Antiinflamation Drugs (NSAIDs) are available in drug store and be bought as a pain relief. Basic Health Research (Riskesdas) 2013 study the medicines stored in household. Basic Health Research (Riskesdas) 2013 was held in 33 provinces and 497 districts in Indonesia. The research encompasses 300.000 households in 12.000 blocks cencus. The participants were designated households and its member of the family. The study were interviewing the participants to obtain data of all drugs that are stored and used, including traditional medicines. The data including the brand, indication, the provenance (prescribed or unprescribed by doctor), the storage period and also observe drug condition. This study was further analysis of subset data in block IV of Riskesdas 2013 in households. The data were classified by its mechanism and its structure. The result showed that East Java was the highest user of AINS drugs was (15%). Non selectif COX-2 drug and partial selectif COX-2 was 38,3% bought from drug store and 14,4% from drug store. For rheumatism treatment was all used for more than a month. Widely use of NSAIDs as a pain relief indicated the necessity of a proper medicine use information to avoid side effect of NSAID drug.
Penilaian Air Minum Isi Ulang Berdasarkan Parameter Fisika dan Kimia di dan luar Jabodetabek Tahun 2011 Adelina, Rosa; Winarsih, Winarsih; Setyorini, Herni Asih
Jurnal Kefarmasian Indonesia VOLUME 2 NOMOR 2, AGUSTUS 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Quality drinking-water is human basic need in life. Jabodetabek as concentrated resident and industrial area, can’t supply drinking-water need so we need alternative source such as refill drinking water. Health Minister has been assigned quality drinking-water parameters whichis if one of the parameter out from criteria value so the drinking-water not feasible. Pharmacy Laboratory of NIHRD do routine test per year for drinking water. Some of the sample is refill drinking water that applied by community or refill drinking water seller. This article described the result of feasibility study of refill drinking-water on 2011. The design of this study is cross sectional study. The data comes from refill drinking-water test in and out Jabodetabek which applied by community to get feasibility certificate of drinking water in Pharmacy Laboratory, Biomedical and Basic Health Technology Center in January until November 2011. The data was analyzed by descriptive statistic in STATA 9. A hundred and thirty-nine (139) refill drinking-water comes from in and out Jabodetabek. From this data, 105 (75,5%) sample was feasible to drink. There are two variable which cause samples didn’t feasible to drink, Manganese level and degree of acidity value (pH).There is one sample which has Manganese level above maximum level and 33 (23,6%) samples have pH value below 6,5. Most of the refill drinking-water samples feasible and fulfill requirement of physical and chemical paremeters, except Manganese level and pH value. The best filter methods in this study is hexagonal method
Kajian Tanaman Obat Indonesia yang Berpotensi sebagai Antidepresan Adelina, Rosa
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 1, FEBRUARI 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Depression as a mental illness has many negative effects to people’s quality of life. The synthetic drugs has been developed to cure this illness but the side effect has compromized the therapy. Other side, the use of herbal medicine has been accepted in almost country in the world.The objective of this study is to find antidepressant drug from Indonesian herbal medicine. The study is an assessment derived from 53 publications of antidepressant effect of Indonesian herbal from national and international papers.The assessment include the active compounds, mechanism, and used part of plant. The result of this study is there are nine potential Indonesian plants to be a co-therapy or alternative drug as antidepressant. They are Valeriana javanica, Areca catechu Linn, Piper longumBl., Curcuma longaLinn, Momordica charantia Linn, Clitoria ternatea, Morinda citrifolia, Myristica fragrans, and Ocimum basilicum
Ekstrak Daun Annona muricata Linn. sebagai Antiproliferasi terhadap Sel Hepar Tikus Terinduksi 7,12 Dimetilbenz [a] antracene (DMBA) Adelina, Rosa; Febriyanti, Rahmi; Oktoberia, Intan Sari; Intan, Putri Reno
Jurnal Kefarmasian Indonesia VOLUME 4. NOMOR 1 FEBRUARI 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v4i1.2896

Abstract

Annona muricata Linn. atau sirsak yang mengandung senyawa golongan acetogenin mampu menginduksi apoptosis pada secara in vitro dan bersifat sitotoksik. Telah dilakukan penelitian untuk membuktikan potensi ekstrak daun sirsak secara in vivo dalam menghambat perkembangan tumor hepar akibat induksi senyawa kimia 7,12 dimetilbenz [a] antracene (DMBA). Induksi dilakukan selama dua kali seminggu selama lima minggu, pada hewan coba tikus putih (Rattus novergicus) strain Sprague Dawley. Ekstrak daun sirsak diberikan dengan tiga peringkat dosis, yaitu 200, 400, dan 800 mg/kg BB, selama tujuh belas hari setelah dua minggu pemberian DMBA. Hasil pemeriksaan histopatologi dan penentuan aktivitas proliferasi sel hepar dengan AgNOR menunjukkan adanya penurunan aktivitas proliferasi sel hepar secara signifikan. Disimpulkan bahwa ekstrak daun sirsak berpotensi sebagai antiproliferasi pada tumor hepar secara in vivo.
Co-Authors Aini Nurul Aini, Anggun Qurrota Ani Isnawati Ani Isnawati Ani Isnawati Ani Isnawati Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Dwi Ana Nawangsari Dwi Ana Nawangsari, Dwi Ana Dwi Kurniadi, Rangga Edy Meiyanto Eltriya, Ninu Fajra, Jenisha Rani Hamim Tsalis Soblia Herni Asih Setyorini Herni Asih Setyorini Herni Asih Setyorini Herni Asih Setyorini Hunafa, Zulaila Indah Sulistyowati Indah Sulistyowati, Indah Intan Sari Oktoberia Intan Sari Oktoberia Intan Sari Oktoberia Ismiarni Komala Jenisha Rani Fajra Komala, Ismiarni Maharani, Dila Aulia Maratu Soleha Maratu Soleha Maria Dwi Supriyati Maria Dwi Supriyati, Maria Dwi Naila Nafisya, Siti Nanang Yunarto Nanang Yunarto Ninu Eltriya Nur Muhamad, Rawwdha Luthfi Nurul Aini Nyoman Fitri Nyoman Fitri Octaviani, Putri Putra, Sendi Handika Putri Reno Intan Putri Reno Intan Putri Reno Intan Putri, Annisya Ayu Rahmi Febriyanti Rangga Dwi Kurniadi Rani Fajra, Jenisha Rawwdha Luthfi Nur Muhamad Riris I Jenie Riris I Jenie, Riris I Siti Naila Nafisya Soblia, Hamim Tsalis Supandi Winarsih Winarsih Winarsih Winarsih Winarsih Winarsih Zaafira, Reyhan Diva Zulaila Hunafa