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Saprizal Hadisaputra
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Jurnal Pijar MIPA
Published by Universitas Mataram
ISSN : 19071744     EISSN : 24601500     DOI : -
Core Subject : Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Mathematics Physics
Jurnal Pijar MIPA (e-ISSN: 2460-1500 & p-ISSN: 1907-1744) is an open-access scientific periodical journal published by the Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA publishes original articles on current issues and trends in mathematics-science-science education studies. In addition, this journal addresses issues concerning environmental education and environmental science. The journal scopes are: a. Physics and Physics Education b. Chemistry and Chemistry Education c. Biology and Biology Education d. Natural Science and Science Education e. Mathematics and Mathematics Education f. Environmental and Environmental Education
Arjuna Subject : Umum - Umum
Articles 1,217 Documents
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Kombucha from Edible Plants as a Functional Beverage with Hypoglycemic Potential: A Review Nadya Treesna Wulansari; Ni Wayan Kesari Dharmapatni; Ida Ayu Manik Damayanti
Jurnal Pijar Mipa Vol. 21 No. 2 (2026): in Progress
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i2.10668

Abstract

Diabetes mellitus (DM) is an endocrine disorder caused by a deficiency or ineffective production of insulin by the pancreas, leading to abnormal blood glucose levels. Hypoglycemia is a significant complication of diabetes therapy, referring to the condition or mechanisms that lower blood glucose levels. Kombucha is a functional beverage known for its health benefits, particularly its potential to reduce blood glucose levels. The data collection strategy used in this review was a systematic review.  Ten articles were used in this systematic review. Several plants, including sappan wood, Rhizophora mucronata leaves, snake fruit, Cyperus rotundus L. rhizomes, black tea, green tea, Solanum betaceum Cav., strawberry, Syzygium polyanthum (Wight) Walp. leaves, and red ginger, have demonstrated potential hypoglycemic effects. The mechanisms involved include inhibition of α-glucosidase enzyme activity, reduction of fasting plasma glucose (FPG), and decreased blood glucose concentration. The presence of secondary metabolites in these plants, combined with the fermentation process involving microorganisms, contributes to their antidiabetic potential through hypoglycemic mechanisms and α-glucosidase inhibition.
Chemical Profiling of Scoparia dulcis L. Leaf Ethanol Extract and In Silico Antiaging 2Y9X Inhibitor Study Anjani Fadia Putri; Tukiran Tukiran
Jurnal Pijar Mipa Vol. 21 No. 2 (2026): in Progress
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i2.11619

Abstract

The intensity of UV radiation that is quite high in the tropics can make the skin age quickly, such as wrinkles, dry, dull skin, or dark spots. In Indonesia, it turns out that 76% of women experience premature aging in this way. The cause is exposure to UVA and UVB radiation, which triggers the production of Reactive Oxygen Species (ROS). Many local plants have been researched for anti-aging, but no one has discussed the anti-aging activity of Scoparia dulcis L. Previous research indicates that Scoparia dulcis L. leaves exhibit antibacterial, antimicrobial, antioxidant, anti-inflammatory, and antidiabetic effects. Therefore, this study aimed to identify potential anti-aging compounds in the ethanol extract of Scoparia dulcis L. leaves as inhibitors of tyrosinase enzyme (PDB ID: 2Y9X), which plays a role in melanin production. Plant material was macerated to preserve flavonoid compounds. Chemical profiling of the extract was analyzed using LC-MS, which identified 104 secondary metabolite compounds. Then, use an in silico approach through molecular docking with AutoDock Vina to evaluate anti-aging compounds in the ethanol extract of Scoparia dulcis L. leaves. The docking results indicated that six compounds showed promising inhibitory potential, with binding affinities better than that of the positive control (-6.0 kcal/mol). These compounds were vanillic acid (-6.2 kcal/mol), caffeic acid (-6.0 kcal/mol), scopoletin (-6.4 kcal/mol), scoparone (-6.2 kcal/mol), jasmonic acid (-6.2 kcal/mol), and budlein A (-6.2 kcal/mol). The six compounds were also analyzed again using Lipinski's Rule of Five so that they could be used as a reference for further experiments for oral drugs. As a result, all of six compounds met that rule and had a smaller bond affinity value than the positive control.
Effect of Guided Inquiry Learning Model Through Ice Cream-Making Experiments on Students Higher Order Thinking Skills (HOTS) Arinda Salsabila Putri; Fitria Wulandari
Jurnal Pijar Mipa Vol. 21 No. 2 (2026): in Progress
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i2.11622

Abstract

Developing Higher Order Thinking Skills (HOTS) has become an important focus in elementary science education because students are expected not only to understand concepts but also to analyze, evaluate, and create solutions to real-life problems. This study aims to examine the effect of a guided inquiry learning model implemented through ice cream-making experiments on the Higher Order Thinking Skills (HOTS) of fourth-grade elementary school students. The research employed a quantitative approach with a nonequivalent control group quasi-experimental design. The participants were 53 fourth-grade students, including 25 in the experimental class and 28 in the control class. The experimental class received guided inquiry-based experimental learning, while the control class was taught using conventional methods. Students' higher-order thinking skills were assessed using essay exams that focused on three areas of advanced thinking: analyzing, evaluating, and creating. These tests were given before and after the learning period to measure progress. The data were checked for normality and homogeneity before conducting the independent-samples t-test. The results showed that the data followed a normal distribution and had similar variability, meeting the requirements for hypothesis testing. The t-test results showed a very low significance value of 0.000, which is less than 0.05. This indicates a significant difference in HOTS scores between the treatment and control groups. The experimental group scored higher, on average, in HOTS (88.10) than the control group (77.86). The average difference of 10.24 points shows a big improvement in the experimental group's ability to think critically and solve complex problems. The results show that using the guided inquiry learning method with ice cream-making experiments helps students improve their higher-order thinking skills in a meaningful way. Therefore, guided inquiry-based experiments can be an effective and relevant way to help students develop higher-order thinking skills in elementary science classes.
Influence of Gravity-Induced Axial Force on the Natural Frequencies of an Inclined Cantilever Beam Ananta Kusuma Yoga Pratama; Sunarko Sunarko
Jurnal Pijar Mipa Vol. 21 No. 2 (2026): in Progress
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i2.11634

Abstract

The limitations of conventional horizontal cantilever models in capturing gravity-induced axial effects in inclined structures that influence stiffness and natural frequencies. This study investigates the influence of gravity on the dynamic behavior of an inclined cantilever beam, with particular emphasis on a 10-m steel beam configuration. Unlike conventional horizontal cantilever models, structural inclination generates a spatially varying axial compressive force that increases from zero at the free end to a maximum value at the fixed support. The objective of this study is to analyze how this gravity-induced axial force distribution affects the natural frequencies and effective stiffness of the beam. To achieve this, a high-fidelity numerical model was developed in MATLAB, where the beam was discretized into 100 Euler–Bernoulli elements to capture the gradual variation of axial load and the resulting geometric softening effect. The analytical formulation is based on the Rayleigh–Ritz method, in which the spatial axial force distribution  is incorporated into the potential energy expression. The predicted natural frequencies were validated through frequency-domain analysis of the transient response obtained from numerical simulation. Both analytical and numerical results indicate that, for an inclination angle of 60°, the first and second natural frequencies are approximately 1.84 Hz and 11.61 Hz, respectively. These results demonstrate that beam inclination significantly reduces the effective structural stiffness due to gravity-induced geometric softening. The findings highlight the importance of incorporating spatially varying geometric stiffness in the dynamic analysis, stability assessment, and vibration-sensitive design of large-scale inclined cantilever structures.
Implementation of Turbidity Sensor Based on IoT for Measuring Seawater Turbidity Levels in Gorontalo Muhammad Yunus
Jurnal Pijar Mipa Vol. 21 No. 2 (2026): in Progress
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i2.11635

Abstract

Turbidity is the condition of water that is not clear due to suspended particles, such as mud, clay, organic matter, and microorganisms. This research aims to implement an Internet of Things (IoT)- based turbidity sensor to measure seawater turbidity levels in Gorontalo. The IoT-based turbidity sensor system was developed using the SEN-0175 turbidity sensor integrated with an ESP32 microcontroller. The Blynk application serves as a supporting platform for implementing IoT connected to a smartphone. Measurements of seawater turbidity were conducted in three locations in Gorontalo. The result for the first location is an area without residential areas, producing an average turbidity value of 16.5 NTU; the second location is a residential area with several food stalls, producing an average turbidity value of 24.99 NTU; and the third location is a culinary tourism area visited by many tourists, producing an average turbidity value of 50.56 NTU. These results show that the increasing number of human activities in coastal areas has the potential to pollute seawater. Excessive seawater pollution will increase seawater turbidity. Turbidity values exceeding the established seawater quality standards are unsuitable for Marine Tourism and disrupt marine biota; therefore, turbidity concentrations should be no more than 5 NTU. An IoT-based turbidity sensor is suitable for low-cost, real-time monitoring of seawater turbidity in Gorontalo, offering high precision, simple fabrication, and real-time operation.
Computational Evaluation of Vitamin D3 Binding to KRAS and TGF-β1 in Colorectal Cancer–Associated Signalling Pathways Jauharotus Shobahah; Wahyuningsih Sri Puji Astuti; Mochammad Aqilah Herdiansyah; M. Ainun Najib Aly
Jurnal Pijar Mipa Vol. 21 No. 2 (2026): in Progress
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i2.11643

Abstract

Vitamin D3 has been widely investigated for its anticancer properties, yet the structural basis of its interaction with key oncogenic signaling proteins remains incompletely understood. This study aimed to evaluate the molecular interactions between vitamin D3 and KRAS and TGF-β1 using molecular docking and molecular dynamics simulations. Molecular docking analysis was performed using AutoDock Vina, followed by molecular dynamics simulation using CABS-flex to evaluate structural stability using root mean square deviation (RMSD), root mean square fluctuation (RMSF), and radius of gyration (Rg). Comparative benchmarking was performed against the reference inhibitors Sotorasib (KRAS) and Galunisertib (TGF-β pathway). Docking analysis revealed that vitamin D3 binds to KRAS (PDB ID: 4OBE) with a binding affinity of –7.8 kcal/mol, compared to –8.6 kcal/mol for Sotorasib. The interaction was localized within the nucleotide-binding pocket adjacent to the Switch I and Switch II regions, which are critical for conformational regulation. For TGF-β1 (PDB ID: 3KFD), vitamin D3 demonstrated a binding affinity of –8.2 kcal/mol, slightly exceeding that of Galunisertib (–8.1 kcal/mol), with interaction occurring at the receptor-binding interface. Molecular dynamics simulation showed stable complex formation, with RMSD values of 2.79 Å for the KRAS complex and 1.535 Å for the TGF-β1 complex, indicating acceptable structural stability. Residue fluctuation analysis further supported moderate flexibility without global destabilization. These findings suggest that vitamin D3 may function as a multi-target signaling modulator interacting with both intracellular and extracellular regulators of colorectal cancer pathways, providing a structural basis for further experimental investigation.
In Silico Study of Bioactive Compounds from Koro Benguk (Mucuna pruriens (L.) DC.) as Potential Modulators of CYP7A1 for Hypercholesterolemia Therapy Cleofany Aurhelya Paradhise; Trisna Kumala Sari
Jurnal Pijar Mipa Vol. 21 No. 2 (2026): in Progress
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i2.11676

Abstract

Hypercholesterolemia is a major risk factor for cardiovascular diseases and remains a significant global health concern. Cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in the classical bile acid synthesis pathway, plays a crucial role in hepatic cholesterol catabolism and represents a promising therapeutic target for cholesterol regulation. Natural product-derived compounds have attracted increasing attention as potential antihypercholesterolemic agents due to their structural diversity and biological activities. However, studies evaluating phytochemicals from Mucuna pruriens as CYP7A1 modulators remain limited, particularly those integrating molecular docking with pharmacokinetic prediction. Therefore, this study aimed to evaluate the potential of bioactive compounds from Mucuna pruriens as modulators of CYP7A1 using an in silico approach. Twenty-eight phytochemical compounds identified through GC-MS profiling were screened using Lipinski’s Rule of Five. Selected compounds were further analyzed by molecular docking against the CYP7A1 protein (PDB ID: 3DAX), followed by ADMET prediction. Docking protocol validation through redocking of the native ligand showed good conformational agreement at the active site (RMSD < 2 Å), confirming the reliability of the docking parameters. Binding affinity and RMSD were used to evaluate ligand–protein interaction stability. Sterculic acid exhibited the strongest binding affinity with a docking score of −6.6.1 kcal/mol and RMSD of 1.51 Å, slightly stronger than the reference ligand 7-ketocholesterol (−7.335 kcal/mol). Interaction analysis revealed hydrogen bonding with key residues, including Asn126 and Lys98, as well as hydrophobic interactions within the active pocket. Other fatty acid derivatives, including octadecanoic acid and heptadecanoic acid, also showed competitive binding energies. ADMET prediction indicated high intestinal absorption (HIA > 90%), no CYP3A4 inhibition, and low predicted toxicity. These results highlight sterculic acid as a promising CYP7A1 modulator and support the potential of Mucuna pruriens phytochemicals for further molecular dynamics studies and experimental validation in the development of hypercholesterolemia therapy.

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