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Jurnal Ilmiah Farmasi Akademi Farmasi Jember

jurnal_ilmiah_farmasi
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Published by Akademi Farmasi Jember

ISSN : 25034707 EISSN : 2615756X DOI : https://doi.org/10.53864/jifakfar

Core Subject : Health,

Medicine & Pharmacology

Jurnal Ilmiah Farmasi Akademi Farmasi Jember merupakan Jurnal yang menampung artikel ilmiah hasil penelitian di seluruh bidang Farmasi, seperti Farmasi Bahan Alam, Kimia Farmasi, Farmasetika, Farmasi Klinis, Farmasi Komunitas, dan bidang farmasi lainnya.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 9 Documents

Search results for , issue "2017: Desember - Vol.2 No.2" : 9 Documents clear

HUBUNGAN AKTIVITAS SEKSUAL USIA DINI DENGAN HASIL PEMERIKSAAN PAP SMEAR SEBAGAI DETEKSI DINI KANKER SERVIKS DI KABUPATEN SIDOARJO Acivrida Mega Charisma, Farida Anwari
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

Cervical cancer is the number one cause of death in Indonesian women. Cervical cancer is a malignant tumor that grows inside the cervix / cervix is the lowest part of the uterus attached to the top of the vagina.Terjantung cancer always begins with precancerous conditions which further leads to advanced cancer conditions. Pap smear test is a test that is accurate enough to detect early cervical cancer if routinely performed, because this test can detect any abnormal cells changes. This study aims to determine the relationship between sexual activity performed at an early age by the respondents with the results of pap smear examination.This research use cross sectional analysis method, simple random sampling sample of 184 people. The result is made of frequency table, cross tabulation and then analyzed by chi square test and spearman correlation test.The results showed that the results of Pap smears class II and III (Not In Normal Limit) on the respondents who do sexual activity at age 18 years there are 45 (71.4%) people and the respondents who do not do sexual activity at age 18 years only 41 (33.9%) people. The same thing happened for the age factor, in respondents with age 35 (at risk) there were 66 (54,2%) people who had the result of examination of Class II and III papsmear (Not in Normal Limit) and at age 35 years old only 20 (33.3%) persons who have the results of papsmear examinations Class II and II (Not In Normal Limit). The analysis using chi square test showed significant correlation between age and early age sexual activity with pap smear with indigo ρ = 0.025 and ρ = 0.018 (α = 0.05).The hope of this study can be an important lesson for the younger generation to be able to control the association in order to avoid doing activities at the age of too young and for all married women (ever doing sexual activity) to perform pap smear examination early to detect any abnormalities before developed into cancer.Keywords : early childhood sexual activity, cervical cancer, pap smear, cervical cancer risk factor

OPTIMASI HIDROLISIS MEDIA PRODUKSI CANGKANG UDANG MENGGUNAKAN KITINASE SERRATIA MARCESCENS KAHN.15.12 TERHADAP KADAR N-ASETIL GLUKOSAMIN SEBAGAI BAHAN SEDIAAN Siti Nur Azizah, Rosida
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

Limbah cangkang udang mengandung kitin yang tinggi yaitu sekitar 17-40%. Kitin tersebut dapat digunakan sebagai substat pertumbuhan bakteri kitinolitik yaitu S.marcescens KAHN 15.12. Bakteri tersebut akan mensekresikan enzim kitinase untuk mendegradasi kitin sebagai media pertumbuhannya hingga menghasilkan monomer N-asetil glukosamin (GlcNac). N-asetil glukosamin dapat dimanfaatkan sebagai bahan sediaan suplemen osteoartritis. Penelitian ini bertujuan untuk memproduksi GlcNac hasil hidrolisis kitin cangkang udang menggunakan kitinase Serratia marcescens KAHN.15.12. Hasil konfirmasi aktivitas kitinolitik menggunakan media selektif yaitu agar koloidal kitin 0,3% menunjukkan bahwa Serratia marcescens KAHN 15.12 memiliki index kitinolitik sebesar 2,3 yang ditunjukkan dengan adanya zona bening disekitar koloni. Hasil optimasi perbedaan konsentrasi media produksi menunjukkan bahwa tepung cangkang udang 2% menghasilkan kadar GlcNac tertinggi yaitu sebesar 376,35 μg/ml setelah diuji dengan metode kolorimetri menggunakan reagen shcales pada panjang gelombang 420nm. Berdasarkan hasil tersebut menunjukkan bahwa setiap hidrolisis 1 gram tepung cangkang udang yang mengandung 18,7% kitin akan menghasilkan sebesar 70,54 mg GlcNAc.Kata Kunci: N-asetil glukosamin, kitinase, Serratia marcescens

HUBUNGAN TINGKAT PENGETAHUAN DENGAN TINDAKAN PENCEGAHAN KANKER SERVIKS PASCA PENYULUHAN PADA WANITA USIA SUBUR Farida Anwari, Acivrida Mega Charisma
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

Cervical cancer is the number one cause of death in Indonesian women. Cervical cancer is a malignant tumor that grows inside the cervix / cervix is the lowest part of the uterus that attaches to the top of the vagina. The high number of cases is due to limited access to screening, treatment and lack of information and services to the disease. This cervical cancer can be detected early by doing pap smaer examination.This study aims to determine the relationship between the knowledge level of cervical cancer and its prevention measures in women of childbearing age in Kabupatn Gresik East Java.Design The research used is descriptive, data collection using questionnaires given to women participants counseling in Gresik district of East Java with the total population of 68 respondents and the number of samples were 53 respondents, the selection of respondents based on age is fertile age (15-46 years), married and sexually active.The result of this research by using chi square test showed that there was no significant correlation between age with cervical cancer prevention at post counseling (ρ = 0.187 α = 0.05), there was a significant correlation between level of knowledge with precancement of cervical cancer at post counseling (ρ = 0.025 α = 0.05).It is hoped that this research can be a reference for health workers in counseling about cervical cancer in women of childbearing age throughout Indonesia, and suggest that people can increase their knowledge about servical cancer and can take precautions by avoiding the risk factors of cervical cancer.Keywords : Knowledge of cervical cancer, cervical cancer risk factor, Prevention of cervical cancer

UJI AKTIVITAS EKSTRAK LABU AIR (Lagenaria siceria) TERHADAP LUKA BAKAR TIKUS JANTAN GALUR WISTAR Holdin Eka Prilia, Rosida
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

Water pumpkin (Lagenaria siceria) is a useful plant in Indonesian. People used water pumpkin flesh as a drug wound, especially as wound burning. This study was prove the activity of water pumpkin flesh extract as wound burning in male rats Wistar strain. The method in this research used experimental. This study used 25 male rats Wistar strain divided into 5 groups. The positive control group was given bioplacenton, the negative control group was given CMC-Na base gel, the other group was given water pumpkin gel extract at doses 2.5%, 5% and 7.5%. compount of water pumpkin extract are flavonoid and saponin. This compount have activity as a burn medicine in male rats wistar strain. At activity level 2.5% has activity 40,06%, at dose 5% has activity 49,75%, and at dose 7.5% has activity 60,11%. Water pumpkin gel extract at 2.5%, 5%, 7.5% dose had different activity with negative control group with CMC-Na gel base, but no significant difference (sig 0,05) 25%, 50%, 75%.Keyword : Healing burn medicine, Water Pumpkin, and male rats wistar strain.

PENGARUH PENAMBAHAN ASAM SITRAT PADA EKSTRAKSI DAUN JATI (Tectona grandis Linn.f.) TERHADAP SIFAT FISIK SEDIAAN SHEER LIPSTICK Mikhania C.E., Kukuh Judy Handojo, Lailatul Fitriyah
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

The aim of this study was to know the influence of citric acid addition on teak leaf (Tectona grandis Linn.f.) extraction to the physical properties of sheer lipstick. Physical properties of sheer lipstick include organoleptic test and pH test. The result data for organoleptic test of sheer lipstick color using teak leaves extracted with 3% citric acid addition (F1) was yielded pink, 5% (F2) was red and 7% (F3) was dark red. The organoleptic test of the aroma from three formulas has the same particular odor of essence strawberry. Data of pH test result from three formulations of sheer lipstick using teak leaves extracted with 3% citric acid (F1) was 3,867 ± 0,115, 5% (F2) was 3,467 ± 0,208 and 7% (F3) was 3,233 ±0,057. Data analysis of pH using One Way Anova obtained significance value 0,004 (p 0,05) therefore can be interpreted that there was significant difference of pH from all formulation. From the results it can be concluded that the preparation sheer lipstick using teak leaf extract with addition of citric acid 3%, 5% and 7% influence physical properties of color and pH, but didn’t influence odor.Keywords: citric acid, teak leaf, sheer lipstick

AKTIVITAS ANTIINFLAMASI FRAKSI ETANOL DAUN GEDI (Abelmoschus manihot L. Medik) PADA TIKUS PUTIH GALUR WISTAR Agnis Pondinekaria Aditama
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

Gedi leaves (Abelmoschus manihot L. Medik) has been used empirically by the people of North Sulawesi to cure the disease. Flavonoids and steroids in Gedi leaves suspected to have anti-inflammatory effects. This Study aims to examine the anti-inflammatory effects of ethanol fraction from Gedi leaves (Abelmoschus manihot L. Medik) on edema of white males wistar foot induced with 1 % caragen, and to determine an effective dose of fraction to decrease the edema volume of Rat foot. The test was done using Rat Hind Paw Edeme or esthablished an artificial inflammation in left foot of white male rats. The treatments were carried out on five groups, the positive control group was administered with diclofenac sodium, the negative control group was administered with CMC Na 0,5 % solution, and the fraction groups were administered with 12 mg/Kg BB, 27 mg/Kg BB, 54 mg/Kg BB. Edema volume were measured every hour for 5 hours using a pletismometer. The average of edema volume (mL) and time (hour) were used to calculate the percentage of anti-inflammatory on each group compared to the negative control group. Obtained data were analyzed by one-way ANOVA followed by LSD test with confident level was 0,05. The result of this study indicate that gedi leaves can reduce edema volume of rat foot that induced with 1 % caragen and anti-inflammatory activity showed in ethanol fraction from Gedi leaves 12 mg/Kg BB by 55,2 %, 27 mg/Kg BB by 64,4% and 54 mg/Kg BB by 62,2%.Keywords : Daun Gedi (Abelmoschus manihot L. Medik), anti-inflammatory, edema

PENGARUH VARIASI SUHU PENYIMPANAN TERHADAP STABILITAS FISIK SUSPENSI AMOXICILLIN Dewi Rashati, Mikhania C.E, Dewi Nisa
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

This study aims to investigate effect of variation storage temperature on the physical stability of amoxicillin suspension. The physical stability of the amoxicillin suspension included organoleptic, pH, viscosity and volumes of flocculation and deflocculation sedimentation. The research method used true experimental design method with pre-test and post-test control group design. The sample used amoxicillin suspension with temperature storage variation were cold temperature, room temperature and warm temperature. The results of research data on physical stability of organoleptic were processed compared with the condition before storage. The results of research data on physical stability of pH, viscosity and volume of flocculation sedimentation were analyzed using One Way Annova. From the organoleptic suspension of amoxicillin there is significant difference. Data using SPSS with One Way Anova method. All samples at amoxicillin suspension pH with variation of storage temperature got significance value of p0,05, stability of pH has a difference. Viscosity of amoxicillin suspension with variation of storage temperature, the significance value of p0.05, the viscosity physical stability has a significant difference. In flocculation of amoxicillin suspension with variation of storage temperature, the significance value of p0.05 means flocculation in the has a significant difference. In this study the amoxicillin control suspension and all temperature storage did not occur deflocculation.Keywords: Physical stability, Amoxicillin, Suspension

AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 96% KULIT PISANG RAJA (Musa paradisiaca L) TERHADAP Escherichia coli Agnis Pondinekaria Aditama, Rizqiyah Akbar Mauliddah
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

Banana peel is a material that can be used as a natural antibacterial because of its secondary metabolites content. The present study aimed to evaluate antibacterial activity of ethanol 96% extracted from banana (Musa paradisiaca L) peel against Escherichia coli. Result of phytochemical screening indicated that banana peel extract has alkaloid, flavonoid (tannin), and saponin compound that can act as antibacterial. Banana peel extract showed antibacterial activity that was proved by clear zone formed around disk paper. Sample of 64% extract concentration had the largest inhibition zone (9.6 mm) compared to sample of 16% and 32% concentration, inhibition zone of which was 4.4 mm and 6.26 respectively. One Way Anova analysis showed that sample of 64% concentration was significantly different from negative control, 16%, and 32% concentration. Nevertheless, there was no significant difference between 16% and 32% concentration.Keywords: Musa paradisiaca L, Escherichia coli, antibacterial

KARAKTERISASI SENYAWA ANALGETIKA-ANTIINFLAMASI N-(4t-BUTILBENZOIL)-p-AMINOFENOL YANG DISINTISES DENGAN KATALIS ASAM Hadi Barru Hakam Fajar Siddiq, Dewi Rashati, Farida Suryaningsih
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

The N-(4t-Butylbenzoyl)-p-Aminophenol compound was a synthesis compound between p-aminophenol and 4t-Butylbenzoyl chloride by using H2SO4 catalyst. The addition of H2SO4 catalyst purposed to accelerate the rate of rection in the synthesis of the compound and increased yield of product. The N-(4t-Butylbenzoil)-p-Aminophenol compound is beneficial as an antiinflammatory analgesic. This research were proposed to determine characteristics of the anti-inflammatory analgesic synthesis of N-(4t-Butylbenzoyl)-p-Aminophenol compound by using H2SO4 catalyst. Characterization conducted in this research were physical and chemical characterization. The physical characterization were organoleptic test, crystal form test and melting point test. While chemical characterization were UV-Vis spectrophotometry and FTIR. Result of organoleptic test showed sample had powder form, white-gray colour and not taste. Melting point of N-(4t-Butylbenzoyl)-p-Aminophenol compound was 193.33 °C. The optimum wavelength of UV-Vis spectrophotometry got 2 peaks at the wavelengths 290 and 295 nm. The result of FTIR showed that N-(4t-Butylbenzoyl)-p-Aminophenol compound had peaks.Keywords: N-(4t-butyl benzoil)-p-aminophenol, catalyst

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Hadi Barru Hakam Fajar Siddiq

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jifakfar@gmail.com

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Lembaga Penelitian dan Pengabdian Masyarakat Akademi Farmasi Jember. Jl. Pangandaran No. 42 Antirogo, Jember

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Kab. jember,

Jawa timur

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Hadi Barru Hakam Fajar Siddiq

Contact Email hakamfajar@gmail.com

Phone +62331338888

Journal Mail Official jifakfar@gmail.com

Editorial Address Lembaga Penelitian dan Pengabdian Masyarakat Akademi Farmasi Jember. Jl. Pangandaran No. 42 Antirogo, Jember

Location Kab. jember, Jawa timur INDONESIA

Abstract

Abstract

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Contact Name
Hadi Barru Hakam Fajar Siddiq

Contact Email
hakamfajar@gmail.com

Phone
+62331338888

Journal Mail Official
jifakfar@gmail.com

Editorial Address
Lembaga Penelitian dan Pengabdian Masyarakat Akademi Farmasi Jember. Jl. Pangandaran No. 42 Antirogo, Jember

Location
Kab. jember,

Jawa timur

INDONESIA