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Asian Journal of Health Research
Published by Ikatan Dokter Indonesia Wilayah Jawa Timur
ISSN : 28292979     EISSN : 28289269     DOI : https://doi.org/10.55561/ajhr
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Asian Journal of Health Research (AJHR) is an open access journal published by Ikatan Dokter Indonesia Wilayah Jawa Timur and launched in 2022. This journal is peer reviewed publishing to communicate high quality research, general articles, and all fundamental research/ clinical studies relevant to health science. The journal publishes articles Medical Sciences scope including (Obstetrics and Gynaecology, Pediatrics, Internal medicine, Ophthalmology, Surgery, Neurology, Otolaryngology, Cardiology and Vascular Medicine, Anaesthesiology and Reanimation, Dermatovenerology, Orthopaedics and Traumatology, Urology, neurosurgery, Cardiothoracic surgery, Orthopaedics and Traumatology, Plastic Reconstructive Surgery and Aesthetics, Pulmonology and Respiratory Medicine, Forensic Medicine, and Medicolegal, Psychiatry Medicine and Rehabilitation). AJHR journal is published three times per year in April, August, and December.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 178 Documents
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Coexistence of Umbilical Endometriosis and Sacrouterine Deep Endometriosis Sutrisno; Tatit Nurseta; Ferdinand Umbu Pati
Asian Journal of Health Research Vol. 5 No. 1 (2026): Volume 5 No 1 (April) 2026
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v5i1.325

Abstract

Introduction: Endometriosis is a chronic gynecological condition affecting +10% of women of reproductive age, characterized by endometrial-like tissue outside the uterus causing pelvic pain, dysmenorrhea, and infertility due to inflammatory pathogenesis. While typically pelvic, rare extrapelvic manifestations like primary umbilical endometriosis present as painful umbilical nodules often mistaken for abscesses or hernias. This report aims to increase awareness of this uncommon condition to improve its recognition and management in clinical practice. Case Presentation: A 41-year-old woman presented with cyclical umbilical bleeding and a tender 2 cm umbilical mass, alongside longstanding dysmenorrhea since menarche. She had no prior surgeries or significant medical history. Ultrasound revealed a 3.75 cm ovarian endometrioma, leading to clinical diagnosis of umbilical and ovarian endometriosis. Laparoscopy confirmed umbilical endometriosis (Villar's nodule) with more extensive pelvic disease than anticipated, including uterosacral ligament lesions and suspected adenomyosis. The umbilical nodule and ovarian endometrioma were resected; histopathology confirmed ectopic endometrial tissue in all specimens. Postoperatively, she received six months of Leuprolide Acetate and remained asymptomatic at follow-up, with no recurrence at one-year evaluation. Conclusion: This report describes coexisting sacrouterine and umbilical endometriosis in a 41-year- old woman. Imaging and histopathology confirmed diagnosis after nonspecific symptoms. Surgical resection was performed. The umbilical nodule indicated more extensive pelvic disease, supporting theories of lymphovascular dissemination or metaplasia. This case highlights the need for clinical vigilance and comprehensive evaluation in endometriosis patients.
Radiographic Differentiation of Tibiofemoral Joint Space Width in Kellgren–Lawrence Grade 2 and 3 Osteoarthritis in Malang Irma Darinafitri; Suaydiy Okdiyanzah
Asian Journal of Health Research Vol. 5 No. 1 (2026): Volume 5 No 1 (April) 2026
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v5i1.329

Abstract

Introduction: Osteoarthritis (OA) is a leading cause of disability worldwide. Although the Kellgren–Lawrence (KL) grading system is widely used, it remains subjective. Quantitative fixed joint space width (fJSW) offers a more objective assessment of structural severity, and is particularly relevant in populations such as Javanese communities, where habitual squatting may influence knee joint loading patterns, making evaluation in Malang, East Java, of specific interest. Material and Methods: This study analyzed 111 knees (KL grade 2 or 3) at Saiful Anwar Hospital in 2024. Medial and lateral fJSW were measured on standardized weight-bearing radiographs using a perpendicular subchondral technique. Results: The participants were predominantly female (69.86%) and aged 40-60 years (47.95 %). KL grade 2 was more frequent than grade 3 (56.76% vs. 43.24%), with more bilateral involvement observed (52.05%). Mean medial fJSW are 3.55 ± 1.72 mm in KL 2 and 3.12 ± 1.89 mm in KL 3, while mean lateral fJSW are  4.47 ± 1.26 mm in KL 2 and 5.15 ± 2.27 mm in KL 3. An optimal medial cutoff of 5.03 mm demonstrated high sensitivity (93.8%) but low specificity (25.4%) for disease staging. Despite limited specificity, this threshold may be useful as a screening tool to reduce underdiagnosis of KL grade 3 osteoarthritis by prioritizing sensitivity in detecting more advanced disease. Conclusion: Findings confirm a pattern of medial narrowing and lateral preservation characteristic of varus-driven attrition. However, the low specificity of fJSW suggests that quantitative narrowing alone is insufficient for grading; it must be integrated with other structural domains, such as osteophyte formation, to differentiate KL2 from KL3.
Case Report: Psoriasis Pustulosa Generalisata in A Patient with Primary Hypothyroidism Sri Adila Nurainiwati; Prajnamita Manindhya El Farah; Isbandiyah; Jodii Arlan Kurnia
Asian Journal of Health Research Vol. 5 No. 1 (2026): Volume 5 No 1 (April) 2026
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v5i1.334

Abstract

Introduction: Psoriasis is a chronic relapsing pathological skin condition with a genetic basis. Generalized pustular psoriasis (GPP) is the most severe type with an incidence rate of 0.9%. Psoriasis can be associated with various other diseases, one of which is hypothyroidism. Case Presentation: A 47-year-old woman presented with red patches, scaling, pustules on her face spreading throughout the body accompanied by pruritus, burning sensation, and fever. The patient had a 10-year history of recurrent erythematous scaly skin lesions and a known history of primary hypothyroidism treated with levothyroxine. Management given ceftriaxone IV 2x1g, diphenhydramine IV 2x10mg, ondansetron IV 3x4mg, paracetamol IV 1g PRN, methotrexate tablet 2x2.5mg, inbion tablet 1x1, euthyrox tablet 1x100mg. Conclusion: GPP is a rare and potentially severe form of psoriasis that requires early recognition and comprehensive management. This case highlights the coexistence of GPP and primary hypothyroidism, suggesting the importance of evaluating thyroid dysfunction and other comorbidities in patients with severe psoriasis. Multidisciplinary management, systemic therapy, laboratory monitoring, and regular follow-up are essential to improve clinical outcomes and prevent complications.
Postpartum Depression and Breastfeeding Success among Postpartum Mothers: A Systematic Review Maharani
Asian Journal of Health Research Vol. 5 No. 1 (2026): Volume 5 No 1 (April) 2026
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v5i1.345

Abstract

Introduction: Postpartum depression is a frequent maternal mental health concern that can disrupt confidence, responsiveness, and daily care during the early postpartum period. Breastfeeding success is not limited to exclusive breastfeeding, but also includes early initiation, continuation, maternal satisfaction, and breastfeeding self-efficacy. This systematic literature review synthesized recent evidence on the relationship between postpartum depression and breastfeeding success among postpartum mothers.    Methods: A PRISMA-guided review was conducted using Scopus as the target database. The search combined terms for postpartum depression, postnatal depression, maternal depression, breastfeeding, exclusive breastfeeding, lactation, breastfeeding self-efficacy, mother, maternal, and postpartum. English language open-access articles published from 2020 to 2026 were screened. Forty-five studies met the eligibility criteria and were synthesized narratively.     Results: The evidence consistently indicated that postpartum depressive symptoms were associated with lower exclusive breastfeeding, early cessation, reduced breastfeeding self-efficacy, and more negative breastfeeding experiences. Longitudinal, cross-sectional, review, and intervention studies also showed that social support, maternal stress, breastfeeding pressure, prenatal planning, and midwife-led support shaped this association.    Conclusion: Postpartum depression and breastfeeding success should be addressed as integrated maternal outcomes. Midwifery practice needs routine psychological screening, lactation counseling, partner involvement, and non-judgmental support for mothers who breastfeed, combine feeding, or discontinue breastfeeding. 
The Effect of Nigella sativa on Hepatocyte TNF-α Expression and Histopathological Changes in a Preeclampsia Mouse Model Leny Silviana Farida; Suheni Ninik Hariyati; Onni Dwi Arianto; Nugrahanti Prasetyorini; Luqman Fadli
Asian Journal of Health Research Vol. 5 No. 2 (2026): Volume 5 No 2 (August) 2026
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v5i2.333

Abstract

Introduction: Preeclampsia affects approximately 4.6% of pregnancies worldwide and remains a major cause of maternal mortality and severe morbidity. Its pathogenesis involves an exaggerated pro-inflammatory response, in which tumor necrosis factor-alpha (TNF-α) contributes to endothelial injury and subsequent multi-organ dysfunction, including hepatic damage. Nigella sativa (black seed), particularly its principal bioactive constituent, thymoquinone, exhibits antioxidant and anti-inflammatory properties that may attenuate TNF-α-mediated signaling and protect hepatocytes. This study evaluated the effects of ethanolic Nigella sativa extract on hepatocyte TNF-α expression and liver histological changes in a preeclampsia mouse model (Mus musculus). Material and Methods: An in vivo true experimental study with a post-test-only controlled-group design was conducted. Preeclampsia was induced in pregnant mice through intraperitoneal injection of pooled serum obtained from women with severe preeclampsia. Ethanolic Nigella sativa extract was administered by gavage at doses of 500, 1000, 1500, and 2000 mg/kgBW/day from gestational days 15 to 20. Outcomes included systolic and diastolic blood pressure, urinary protein excretion, hepatocyte TNF-α expression assessed by immunohistochemistry, and liver histomorphology evaluated using hematoxylin-eosin staining. Data were analyzed using SPSS version 25.0. Results: Nigella sativa extract at 1500 mg/kg BW significantly reduced hepatocyte TNF-α expression (p = 0.048), attenuated hepatocyte degeneration and necrosis, and decreased hepatic inflammation (p < 0.05). Conclusion: Ethanolic Nigella sativa extract reduces hepatocyte TNF-α expression and improves hepatic histological alterations in a preeclampsia mouse model (Mus musculus).
Effects of Nigella sativa Extract on Renal Tubular Necrosis and TNF-α Expression in a Preeclampsia Mouse Model M. Luqman Fadli; Puspita Handayani; Annisa Rusfandi
Asian Journal of Health Research Vol. 5 No. 2 (2026): Volume 5 No 2 (August) 2026
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v5i2.351

Abstract

Introduction: Preeclampsia is associated with endothelial dysfunction, systemic inflammation, and renal injury, including proximal tubular necrosis mediated by pro‑inflammatory cytokines such as TNF‑α. Nigella sativa possesses anti‑inflammatory properties that may attenuate these pathologic processes. This study evaluated the effect of ethanolic Nigella sativa seed extract on proximal renal tubular cell necrosis and TNF‑α expression in a pregnant mouse (Mus musculus) model of preeclampsia. Material and Methods: Using a true experimental post‑test design with 24 mice (4/group, 6 groups including negative control, preeclampsia positive control, and treatment groups), this study administered ethanolic Nigella sativa extract orally at 500‑2000 mg/kg/day on gestational days 15‑20, after which necrosis was assessed via H&E staining and TNF‑α expression via immunohistochemistry. Results: Administration of the ethanol extract of Nigella sativa seeds showed a trend toward reducing the percentage of proximal tubular cell necrosis and TNF‑α expression in a preeclampsia mouse model. The lowest values were observed at 2000 mg/kg (necrosis: 18.84±2.89%; TNF‑α: 19.80±12.98%). Necrosis differed significantly between groups (p<0.005); however, TNF‑α expression did not differ significantly between groups (p>0.005). Linear regression showed a negative dose‑dependent association with necrosis (R²=0.358; p=0.002; coefficient −0.005). Conclusion: Ethanolic Nigella sativa seed extract improved proximal tubular injury significantly, but did not significantly reduce TNF‑α expression, showing only a trend toward lower TNF‑α levels in a preeclampsia model, with the most evident effect at 2000 mg/kg body weight/day.
Effectiveness of the SIMPOL Web-Based Educational Intervention for Village Midwives in Improving Polio Immunization Coverage: A Quasi-Experimental Study Ita Susanti; Erlia Rosita; Maharani Maharani
Asian Journal of Health Research Vol. 5 No. 2 (2026): Volume 5 No 2 (August) 2026
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v5i2.360

Abstract

Introduction: Polio is a disease caused by the enterovirus (poliovirus) that attacks the brain's nervous system, causing paralysis in children. Although Indonesia has been a polio-free country since 2014, vigilance against the re-emergence of polio virus cases must still be increased by increasing polio immunization coverage. The use of website-based SIMPOL (Polio Immunization Education) media is one of the best alternatives for village midwives in delivering counseling. This greatly assists the government's program in increasing polio immunization coverage. Website-based media has the ability to disseminate information quickly, practically, and easily accessed, making it easier for village midwives to deliver counseling. Thus, the website-based counseling process is believed to increase public awareness to immunize their children. The purpose of this study is to evaluate the effectiveness of the SIMPOL Web-Based Educational Intervention for Village Midwives in Improving Polio Immunization Coverage. Material and Methods: This study employs a quasi-experimental design with a one-group pretest-posttest approach. Results: The mean village-level complete polio immunization coverage increased from 31.05% at baseline to 70.82% following implementation of the SIMPOL web-based educational intervention. This represented a statistically significant increase of 39.78 percentage points (95% CI: 37.58–41.97; t(23) = 37.44, p < 0.001). Conclusion: The SIMPOL web-based educational intervention was associated with a significant improvement in complete polio immunization coverage. Integrating SIMPOL into routine health education delivered by village midwives may strengthen polio immunization programs in primary healthcare settings.
Saving Indonesian Women: Why Preventable Maternal Deaths Must No Longer Be Accepted Sutrisno, MD, PhD, OG (REI)
Asian Journal of Health Research Vol. 5 No. 2 (2026): Volume 5 No 2 (August) 2026
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v5i2.362

Abstract

A nation cannot claim progress while pregnancy, childbirth, and the weeks after delivery remain a passage through avoidable danger. “Save Indonesian Women” must therefore be more than a campaign slogan. It must become a standard by which health systems, professional organizations, governments, hospitals, communities, and families are judged. The experience of East Java shows that maternal survival can improve when data are converted into coordinated action. It also delivers a sobering warning: declining mortality is not the same as a completed mission. Between 2023 and 2025, the maternal mortality ratio in East Java fell from 93.34 to 82.56 and then to 68.70 per 100,000 live births. The recorded number of maternal deaths declined from 499 in 2023 to 484 in 2024 and 399 in 2025. These figures represent progress. Yet the deeper message lies within the audit findings. Among maternal deaths reviewed in 2024, 66% were classified as preventable; in 2025, the proportion rose to 69%. Improvement in the headline number, therefore, coexisted with a persistent burden of deaths that the system itself considered avoidable.

Page 18 of 18 | Total Record : 178

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