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Asian Journal of Health Research
Published by Ikatan Dokter Indonesia Wilayah Jawa Timur
ISSN : 28292979     EISSN : 28289269     DOI : https://doi.org/10.55561/ajhr
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Asian Journal of Health Research (AJHR) is an open access journal published by Ikatan Dokter Indonesia Wilayah Jawa Timur and launched in 2022. This journal is peer reviewed publishing to communicate high quality research, general articles, and all fundamental research/ clinical studies relevant to health science. The journal publishes articles Medical Sciences scope including (Obstetrics and Gynaecology, Pediatrics, Internal medicine, Ophthalmology, Surgery, Neurology, Otolaryngology, Cardiology and Vascular Medicine, Anaesthesiology and Reanimation, Dermatovenerology, Orthopaedics and Traumatology, Urology, neurosurgery, Cardiothoracic surgery, Orthopaedics and Traumatology, Plastic Reconstructive Surgery and Aesthetics, Pulmonology and Respiratory Medicine, Forensic Medicine, and Medicolegal, Psychiatry Medicine and Rehabilitation). AJHR journal is published three times per year in April, August, and December.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 160 Documents
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Comprehensive Analysis of Artery Ligation Intervention in Placenta Percreta Management: A Systematic Review Nurseta, Tatit; Leksono, Setio
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.226

Abstract

Introduction: The artery ligation technique has been adopted as a life-saving strategy to minimize bleeding in obstetrical and pelvic procedures. However, there are only a few studies on the use of arterial ligation in surgeries for abnormally invasive placentation (AIP). The purpose of this systematic study is to assess how well arterial ligation in managing blood loss during placenta percreta surgery and assess the associated complications and adverse events.    Material and Methods: Systematic Reviews and Meta-Analyses Preferred Reporting Items (PRISMA) framework was used in this study. Studies on arterial ligation techniques in placenta percreta surgery were included based on criteria focusing on estimated blood loss, operative time, and adverse events. A comprehensive literature search across multiple databases was performed, resulting in three studies that met the inclusion criteria.    Results: The three studies included in the review with a total of 193 patients. The findings show that IIAL significantly decreased the projected amount of blood loss compared to control groups. In one study, bilateral IIAL showed lower blood loss (1076 ± 545 ml) compared to other interventions, while another study demonstrated that IIAL resulted in lower estimated blood loss compared to control groups. However, hypogastric artery ligation (HAL) was associated with higher blood loss in one study. Despite its effectiveness in controlling blood loss, complications such as common iliac artery thrombosis, pseudoaneurysms, and limb ischemia were reported, though with low incidence.    Conclusion: Arterial ligation, particularly IIAL, could be a viable strategy for managing blood loss during placenta percreta surgery.
Asherman's Syndrome due to Endometrial Tuberculosis: A Case Report and Literature Review Pratama, Anugerah Justi; Prabowo, Adityo; Tantular, Rezki; Fadli, M Luqman
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.251

Abstract

Introduction: Female genital tuberculosis, a rare form of extrapulmonary TB, often goes underdiagnosed despite its potential to cause significant reproductive complications such as amenorrhea and infertility. The theory behind this case emphasizes the need for heightened awareness and improved diagnostic approaches to effectively manage endometrial TB and its associated intrauterine adhesions. Case Presentation: A 31-year-old woman presented with a four-year history of oligomenorrhea and 3.5 years of primary infertility, undergoing various treatments including hormone therapy and ultrasound evaluations that revealed intrauterine masses and cervical issues. Following a hysteroscopic surgery that identified cervical stenosis and a tuberculous mass, she was treated for endometrial tuberculosis with anti-tuberculosis medication. Despite treatment, she continued to experience abnormal menstrual cycles, leading to further hysteroscopic evaluations that indicated significant uterine fibrosis and chronic cervicitis. The patient declined the insertion of a levonorgestrel-releasing intrauterine system (LNG-IUS) but received a Depo Medroxy Progesterone Acetate (DMPA) injection and was fitted with an IUD, alongside hormonal therapy with cycloproginova, with ongoing assessments showing improvements in uterine vascularity and visibility of the fallopian tubes. Conclusion: This case highlights the complexities of managing secondary amenorrhoea due to genital tuberculosis, which disrupts endometrial function and results in significant intrauterine adhesions. A multidisciplinary approach, involving hysteroscopic adhesiolysis, anti-tubercular therapy, and postoperative hormonal interventions, is crucial for effective treatment. Despite the restoration of menstrual cycles, ongoing fertility risks and pregnancy complications necessitate thorough preconception counselling and long-term monitoring.
Exploring The Effect of Testosterone Hormonal Therapy on Sexual Problems in Postmenopausal Women: A Comprehensive Systematic Review on Clinical Trials Amri, Zidan Dzulyadain; Putri, Annisa Reanimasi Asmoro; Amanda, Nasyabila Anryandi; Torrences, Theodorica; Shadiq, Raihan; Farida, Leny Silviana
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.234

Abstract

Introduction: Sexual dysfunction is a common concern among postmenopausal women. Testosterone therapy has been proposed as a treatment option, yet evidence remains inconsistent.    Material and Methods: We searched PubMed, ScienceDirect, and EBSCOhost (January 2010–December 2024). Randomized controlled trials (RCTs) assessing testosterone versus placebo or control in postmenopausal women were included. Data extraction and synthesis were performed independently by two reviewers. Risk of bias was assessed using the Cochrane RoB 2 tool. RevMan 5.4 was used for meta-analysis.    Results: Seven articles were considered relevant for assessing the effect of testosterone or androgen therapy on sexual function and desire of postmenopausal women (n = 711). The testosterone group showed significant improvement in sexual activity or desire (OD: 3.18, 95% CI: 2.53 - 3.98, p< 0.00001). This result shows that testosterone therapy has the potential to improve sexual activity and desire in postmenopausal women.    Conclusion: Testosterone therapy may improve sexual function in postmenopausal women, but heterogeneity and limited long-term safety data warrant caution. Further high-quality RCTs are needed. 
Socio-Economic and Demographic Determinants of Food Poverty among Household Heads: Evidence from a Zanzibar Household Budget Survey Balan, Ramkumar T
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.238

Abstract

Introduction: Food poverty and insecurity among household members have negative consequences on nutritional quality and may result in inadequate nutrition, endangering the physical, emotional, and financial well-being of household members. In 2024, Zanzibar was classified as IPC Phase 3 (Food Crisis) in five regions of the island. Previous studies in Tanzania often used food consumption score and food insecurity experience as measure of food consumption and hence food poverty. It was inadequate, and food consumption for an adult per month or per day (in kilocalories) was used. Material and Methods: 2788 household heads of HB Survey were used. Objective of the study was to investigate the socio-economic and demographic variables that affect household heads' access to food in Zanzibar. Fixing 2200kc as baseline consumption (equal to 1571.1091 TSH), food poverty was estimated among adults in Zanzibar.  Stratum was based on areas and weighted with occupancy. Two stage stratified design binary logistic model was executed, and AUC under ROC curve was used to evaluate the exactness of the model. Results: Descriptive statistics on covariates of poverty were determined, and food poverty and non-food poverty were estimated. There are significant differences in employment status, food poverty, pre-primary schooling, and age groups in the data, but no significant difference was found between rural and urban areas in terms of food poverty. Conclusion: Household size, educational level of householder, total monthly expenditure, and location were the significant correlates found influencing poverty.
Comprehensive Analysis of Phytoestrogens Intervention to Improve Cognitive Function in Menopausal Women: A Systematic Review of Randomized Controlled Trials Rosinta, Febi Ainnur Deavena; Deanita, Teresa Wynne; Ariyono, Muhammad Ilham Danny Wahyu; Silitonga, Thalita Kanaya
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.239

Abstract

Introduction: Dementia is marked by cognitive deficits that hinder daily functioning, with menopausal changes potentially impacting women's cognitive health and increasing dementia risk up to 70%. Studies suggest that hormone replacement therapy (HRT) can lower the risk of Alzheimer's disease in postmenopausal women, although the topic remains contentious. Phytoestrogens, which mimic estrogen, have shown promise in some trials for improving cognitive function in postmenopausal women. Consequently, the aim of this systematic review is to explore the efficacy of phytoestrogens for treating dementia and cognitive impairment in menopausal women.    Material and Methods: The literature search was conducted in five databases. The outcome of interest measures the improvement of cognitive function in each included study. Different types of phytoestrogen interventions were utilized, such as isoflavone extracts with specified dosages, resveratrol, and either isolated soy protein (ISP) or soy-based products.  The Cochrane Risk of Bias Tool 2 was used to assess the quality of the studies. The systematic review included a total of eight studies.    Results: The review included eight studies examining phytoestrogen interventions on cognitive function in 1,464 participants aged 45 to 92. While some studies showed no significant cognitive improvements, those using resveratrol and Ginkgo biloba reported notable enhancements, particularly in memory and executive function. Given that dementia and cognitive decline are common in postmenopausal women due to lower estrogen levels, phytoestrogens may offer potential benefits.    Conclusion: Phytoestrogens may improve cognitive function in menopausal women at risk of decline. However, further research is needed with more uniform populations, consistent interventions, and standardized assessments. 
Comprehensive Management of Peripartum Cardiomyopathy with Acute Renal Failure: From Prepartum to Renal Replacement Therapy – A Case Report Niazta, Nisa Amnifolia; Putri, Valerinna Yogibuana Swastika
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.240

Abstract

Introduction: Peripartum cardiomyopathy (PPCM) is a rare but potentially serious that poses significant diagnostic and therapeutic challenges, particularly in previously healthy women. We report a complex case of severe PPCM in a primigravida patient who needed intensive multidisciplinary care due to respiratory failure and acute renal failure. Case Presentation: A 21-year-old primigravida in 34 weeks of gestation presented with progressive dyspnea and signs of acute heart failure. Despite an unremarkable medical history, she exhibited severe left ventricular dysfunction (LVEF of 28%), cardiomegaly, and pulmonary congestion. Rapid deterioration necessitated urgent caesarean delivery under general anesthesia due to maternal and fetal distress. Postoperatively, the patient developed cardiogenic shock and acute kidney injury (AKI) necessitating vasopressor and continuous renal replacement therapy (CRRT). Intensive heart failure management, including bromocriptine therapy and guideline-directed medical treatment, led to gradual hemodynamic stabilization. She was successfully weaned off mechanical ventilation and CRRT within days, ultimately being discharged after 12 days of treatment with improved cardiac function. Conclusion: This case underscores the unpredictable nature and rapid progression of PPCM, even in the absence of traditional risk factors. Early recognition, prompt multidisciplinary intervention, and individualized therapy are critical to improving maternal and neonatal outcomes.
Retrospective Analysis: Infant Health Outcomes Born to Mother with Systemic Lupus Erythematosus Nooryanto, Mukhammad; Wulandari
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.241

Abstract

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects young women and presents risks during pregnancy, potentially impacting infant health. This study analyzes infant health outcomes such as birth weight, APGAR score (AS), preterm birth, NICU admission, and mortality in infants born to mothers with SLE. Material and Methods: A retrospective analysis was performed on data from infants born to mothers with SLE between 2023–2025. Data were analyzed using descriptive, bivariate, and multivariate tests with p < 0.05 considered significant. The study was conducted at General Hospital Dr. Saiful Anwar. Results: Of the subjects, 78.57% had mild SLE, 14.28% had moderate SLE, and 7.15% had severe SLE. Significant associations were found between pregnancy status and SLE severity (p = 0.000), delivery method (p = 0.005), blood loss (p = 0.035), birth weight (p = 0.022), and APGAR score (p = 0.005). Cesarean sections were more common in mild to moderate SLE cases. NICU admission was significantly associated with SLE severity (p = 0.002), and fetal mortality was higher in severe SLE cases (p = 0.001). The R-square values for the variables showed that 61.9% of the variation in Apgar score, 73.3% in blood loss, and 73.6% in mortality were explained by factors such as blood loss, grade of SLE, gravida, MEX SLEDAI, maternal age, and mode of delivery. Conclusion: SLE severity significantly influences maternal and neonatal outcomes, including delivery method, blood loss, birth weight, and APGAR score.
Therapeutic Strategies in the Treatment and Prevention of Preterm Labor: A Systematic Review Alim, Fathi Nabila; Hariyati, Suheni Ninik
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.242

Abstract

Introduction: Prematurity remains the leading cause of prenatal and newborn mortality and morbidity worldwide. Numerous trials with varying degrees of efficacy have been carried out to identify therapies to prevent premature birth. Therefore, the purpose of this study is to analyze the efficacy of medications with different dosages that have been previously studied in terms of their ability to delay premature labor.    Material and Methods: The authors searched for randomized-controlled trials (RCTs) that addressed the use of therapy to prevent or treat preterm birth in pregnant patients who were either diagnosed with or at risk for preterm birth. The PRISMA approach was used to conduct the search using electronic databases, including Embase, ProQuest, PubMed, and Cochrane.    Results: We obtained 34 RCTs that met the inclusion criteria. We discovered that 400 mg of progesterone administered intravaginally consistently had a substantial effect in postponing preterm birth. Other kinds of aspirin, such as 60 mg and 81 mg, are effective in postponing premature birth. In addition, taking supplements of docosahexaenoic acid (omega-3 fatty acid) throughout pregnancy considerably delays premature birth. Preterm labor is also markedly delayed in pregnant women with HIV when selenium supplements are taken.    Conclusion: Intravaginal progesterone, oral low dose aspirin, and docosahexaenoic acid supplementation have the potential to be therapies to prevent preterm labor.
Maternal and Fetal Outcome Differences in Pregnant Women with Preeclampsia and Severe Preeclampsia at Dr. Saiful Anwar General Hospital Daniati, Lidya; Rahardjo, Bambang
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.243

Abstract

Introduction: Preeclampsia is a major factor leading to complications for both mothers and infants, significantly raising maternal mortality rates in Indonesia, where severe instances result in approximately 1.5% of maternal deaths. It also heightens the chance of perinatal loss, with severe preeclampsia having a rate of around 4.6%. Frequent complications related to this condition are low birth weight, intrauterine growth restriction, asphyxia, and preterm delivery. The objective of this research was to evaluate the differences in outcomes for mothers and infants between those experiencing preeclampsia and those suffering from severe preeclampsia at Dr. Saiful Anwar General Hospital. Material and Methods: A retrospective analytical observational design was used, analyzing data from pregnant women treated at HKFM Education Center and Dr. Saiful Anwar General Hospital between January 2022 and December 2023. Statistical analysis involved the t-test or the Mann-Whitney test. Results: Findings revealed considerable variations in maternal results, such as eclampsia, elevated hypertension, and alterations in systolic blood pressure the day after delivery, among women diagnosed with preeclampsia versus those with severe preeclampsia. Distinct variations were observed in maternal well-being throughout pregnancy, during delivery, and in postpartum care. Nevertheless, fetal outcomes showed no significant disparities between the two categories, implying that the conditions for the infants during gestation and post-delivery were comparable. Conclusion: Women suffering from intense preeclampsia encountered various maternal outcomes in contrast to those without the condition, although fetal results were similar in both categories at the hospital that was examined.
Elevated Blood Pressure in Rat Offspring with Induced Intrauterine Growth Restriction: A Systematic Review Patridina, Geneung; Prasetyorini, Nugrahanti
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.244

Abstract

Introduction: Intrauterine growth restriction (IUGR), often caused by placental insufficiency, is a significant obstetric issue associated with adverse long-term health outcomes, including hypertension. This systematic review investigates the association between induced IUGR and elevated blood pressure in rat offspring.    Material and Methods: A systematic search of PubMed, SpringerLink, and the Cochrane Library was conducted on February 10, 2023, following PRISMA guidelines. Studies were included if they involved rat models of placental insufficiency-induced IUGR with documented birth weight reduction and blood pressure measurements compared to a control group. Data were extracted for meta-analysis using Review Manager 5.    Results: Eight studies met the inclusion criteria. Meta-analysis revealed a significant increase in both mean arterial pressure (MAP) (Mean Difference: 9.84, 95% CI: 2.69–16.99, p = 0.007) and systolic blood pressure (SBP) (Mean Difference: 13.09, 95% CI: 7.87–18.32, p < 0.00001) in IUGR offspring compared to controls. The increase in SBP was more pronounced in male offspring than in females.    Conclusion: Induced IUGR in rats leads to significantly elevated blood pressure, with a greater effect observed in males. Rat models provide valuable insights into the developmental origins of hypertension, though they may overestimate the effect and not fully replicate the human condition. The endothelin system and sex hormones are implicated in this sexually dimorphic response.

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