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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 11 Documents
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Search results for , issue "Vol. 3, No. 1" : 11 Documents clear
Pemanfaatan Obat Tradisional Dengan Pertimbangan Manfaat Dan Keamanannya Kumala Sari, Lusia Oktora Ruma
Majalah Ilmu Kefarmasian Vol. 3, No. 1
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Abstract

Herbal medicines in general are safer than modern drug. This matter is caused by the less side effect of herbal medicines than modern drug. Side effects of herbal medicines can be reduced with the used of right materials, accurat dose, accurat usage time, accurat way of usage, accurat analyze information, and without abusing of herbal medicines itself. Accuracy of materials determine the effect of herbal medicines. Dose measuring in set of gram can lessen possibility the happening of effect which do not be expected. Information which is not supported by adequate basic knowledges and enough study can make traditional drug return to endangering.
Amankah Pengawet Makanan Bagi Manusia ? Harmita, Harmita
Majalah Ilmu Kefarmasian Vol. 3, No. 1
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Abstract

Uji Stabilitas Sediaan Mikroemulsi Menggunakan Hidrolisat Pati (DE 35–40) Sebagai Stabilizer Jufri, Mahdi; Anwar, Effionora; Utami, Putri Margaining
Majalah Ilmu Kefarmasian Vol. 3, No. 1
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Abstract

Various solubilization techniques have been developed to enhance the bioavailability of hydrophobic drugs. One of the solubilization techniques is preparation of microemulsion. Microemulsion is a potential carrier in drug delivery system because it has many advantageous characteristics. In this research, hydrophobic drug was made in a dosage form of oil in water (O/W) microemulsion using ketoprofen as a model and investigated the influence of adding starch hydrolisates with dextrose equivalent (DE) 35-40 in variety concentrations (0,0%; 1,5%; 2,0%; 2,5%) to the stability of this microemulsion system. This microemulsion consisted of isopropyl miritate as oil phase, tween 80 and lechitin as surfactants, ethanol as cosurfactant, propylene glycol as cosolvent, starch hydrolisates DE 35–40 as stabilizer, and water as external phase. The evaluation was stability test both phisically and chemically. The result showed that the stability of microemulsion system increased significantly by adding starch hydrolisates DE 35-40 at 2,5%.
Analisis Glimepirida Dalam Plasma Tikus Harahap, Yahdiana; Mansur, Umar; Sinandang, Theresia
Majalah Ilmu Kefarmasian Vol. 3, No. 1
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Abstract

The aim of this research is to find the method for analyze glimepiride and itÂ’s metabolite. Glimepiride is the second generation of antidiabetic oral from the sulphonyl urea that works by stimulating the insulin secretion from beta cells of pancreas. Glimepiride is isolated from plasma the using chloroform. Using the high performance liquid chromatography method which include C18 reversed phase column, using mixture of methanol:water (50:50, v/v) as a mobile phase, flow rate 1.0 ml/minutes, detection at wavelenght 228 nm with photo diode array detector gives retention times of glimepiride in 17 minutes without any interference from endogen component of plasma and from itÂ’s metabolite. Linearity with added internal standard gliclazide was established for the range concentration 100-1000 ng/ml with coefficient of correlation (r) is 0.9977 and give the limit of quantitation of glimepiride in 50 ng/ml. The results of validation method fulfilled for the given criterias.
Eksplorasi Pelayanan Informasi Yang Dibutuhkan Konsumen Apotek Dan Kesiapan Apoteker Memberi Informasi Terutama Untuk Penyakit Kronik Dan Degeneratif Handayani, Rini Sasanti; Gitawati, Retno; Muktiningsih, S.R; Raharni, Raharni
Majalah Ilmu Kefarmasian Vol. 3, No. 1
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Abstract

Currently, the prevalence of degenerative diseases in Indonesia is increased. The degenerative and chronic diseases need life-long treatment as well as changes in life style. On the other hand, long-life treatment using drugs will develop risks of adverse drug reactions or the possibilities of drug-drug interactions. In these circumstances, the role of a pharmacist is important to providing drug information and counselling, and patient education. However, there is evidence that pharmaceutical care in almost all pharmacies (drug dispensaries) in Indonesia is still “drug-oriented”. Drug information is not adequate and is provided by pharmacy assistants (technicians). In order to implement pharmaceutical care practice that meets the “Standard Competence for Pharmacy Practice” as well as consumer’s expectation, we need to know what is the exactly consumer’s expect in pharmaceutical care, particularly in drug information, and how is the commitment of the pharmacists to provide drug information of degenerative and chronic diseases in pharmaceutical care. For those reasons, a field survey has been carried out in Jakarta, Yogyakarta and Makassar to explore the consumer/patient’s opinions and needs for pharmaceutical care. A focus group discussion has also been done to explore the pharmacist commitment to provide drug information in pharmaceutical care practice. As a result, there is an indication of a discrepancy between the consumer/patient’s need for drug information and the commitment of pharmacists to provide drug information. Consumers have need for more drug information for all aspects including adverse drug reactions, drug interaction, what to do if adverse reaction occurred, duration of any treatments etc., not only drug indication and administration. On the other hand, pharmacists still need more knowledge and continuing education, particularly in pharmacotherapy and pharmacology of drugs used for degenerative and chronic diseases.
Uji Larvasida Dan Repelansia Beberapa Ekstrak Tumbuhan Pada Nyamuk Culex SP Mahdy A, Al
Majalah Ilmu Kefarmasian Vol. 3, No. 1
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Abstract

There is a plethora of evidence to suggest that host seeking in mosquitoes is medicated by infochemicals or semichemicals emanating from the host and visual clues that the mosquitoes recognize. The objectives of this research was to evaluate larvacidal and repellant effect of several herbal extracts that repell the mosquitoes. The result shown that ethanolic extract of Piper aduncum effective as larvacide for the first instar of Culex sp, while extract of Canangium odoratum repelled almost all of the female mosquitoes treated.
Uji Aktivitas Penghambatan Xantin Oksidase secara In-Vitro oleh Isolat 6,4’-Dihidroksi-4-Metoksibenzofenon-2-O-β-D Glukopiranosida(C20H22O10) yang Diisolasi dari Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) Rina Yanti Eff, Aprilita; Rahayu, Sri Teguh; Syachfitri, Resta Dwi
Pharmaceutical Sciences and Research Vol. 3, No. 1
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Abstract

Hyperuricemia is a condition in which an increasing in uric acid levels abovenormal. Hyperuricemia is a major factor in the development of gout. Gout is adisease caused by the accumulation of monosodium urate crystals in the tissues dueto elevated levels of uric acid. Crown gods (Phaleria macrocarpa (Scheff.) Boerl) is Indonesia native medicinal that has effect such as lowering blood pressure, diabetes mellitus drugand lowering uric acid levels. One of the chemical constituents of this plant is abenzopheneon compound that is 6,4’-dihydroxy-4-metoksi benzofenon-2-O-β-D-glukopiranosida (C20H22O10). Research was conducted to determine the activity of 6,4’-dihydroxy -4-metoksi benzofenon-2-O-β-D-glukopiranosida (C20H22O10) that isolated from Crown gods in inhibiting xanthine oxidase by in-vitro method using spechtrofotometer with allopurinol as a positive control.The results showed that isolates 6,4’-dihydroxy-4-metoksi benzofenon-2-O-β-D-glukopiranosida (C20H22O10) has inhibitory activity against xanthine oxidase with IC50 values 15.705 mg / mL. However, allopurinol has xanthine oxidase inhibitory activity higher than isolates with IC50value of 0.091 mg/mL. Lineweaver-Burk plot showed that isolates 6,4’-dihydroxy-4-metoksi benzofenon-2-O-β-D-glukopiranosida(C20H22O10) has a competitive inhibitory activity.
Pengaruh Pemberian Minyak Atsiri Daun Kemangi (Ocimum americanum L.) Terhadap ~ Motilitas Usus Mencit Putih Jantan Sriyani, Dewi; Saputri, Fadlina Chany
Pharmaceutical Sciences and Research Vol. 3, No. 1
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Kemangi (Ocimum americanum L.) is a well known plant that contains essential oils with citral as a major compound. Citral is reported to have beneficial effect on intestinal motility. In the present study, we investigated the effect of essential oil of kemangi leaves (Ocimum americanum L.) on male DDY mices intestinal motility. Thirty mices were divided into six groups and each group was pretreated with 0,2 ml of 0,5% CMC (negative control), 1 mg/kg BW of atropine sulfate (positive control), 5 mg/kg BW of citral (comparative control), and three dose variation of volatile oil of kemangi leaves (25 mg/kg BW; 50 mg/kg BW; 100 mg/kg BW) orally. All mices were given charcoal meal suspension 0,2 ml orally, and the animals were sacrificed. The percentage ratio and inhibition were analysed by measure the intestinal transit of charcoal. The results showed that the essential oil of kemangi leaves dose 100 mg/kg BW significantly (p < 0.05) reduced intestinal transit in mice with the percentage ihibition value of 59,79%. This value is not significant different (p > 0.05) compared with citral and atropine sulfate. It is concluded that the essential oil of kemangi leaves has potential effect as antispasmodic agent.
Uji Aktivitas Antiproliferasi Formula Liposom Ekstrak Etanol Kunyit (Curcuma domestica) Terhadap Sel Kanker Payudara T47D Pasaribu, Gabriella; Iskandarsyah, Iskandarsyah; Sagita, Erny
Pharmaceutical Sciences and Research Vol. 3, No. 1
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Abstract

Breast cancer is one of deadliest diseases in world. Turmeric extract was known to have antiproliferative activity. To minimize its toxicity, turmeric extract was encapsulated with liposome, a vesicle lipid bilayer functioned as cancer drug carrier in body. This research aimed to determine encapsulation effect of turmeric ethanol extract against antiproliferative activity in T47D breast cancer cells through in vitro assay. Liposomes was made using thin layer method and particle size was reduced by extrusion. Materials used are phosphatidylcholine, cholesterol, and turmeric extract. Optimization of liposomes was made in three formulations with different concentrations of extract. Most optimal formulation was formulation with minimum amount of extract, judging from physical parameters which have smallest precipitates and longest settling time. Evaluation liposome particle size and zeta potential was used DLS, morphology was used TEM, and entrapment efficiency was used dialysis. Most optimal formulation was tested their antiproliferative activity compared with not encapsulated extracts used 3-(4,5-dimethylazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. There was decrease antiproliferative activity of encapsulated extracts. IC50 encapsulated extracts was 45.762 μg/ml and IC50 extracts was 36.399 μg/ml. Liposome particle size was below 445 nm. Zeta potential was -7.51 mV. Morphology was LUV and MVV. Entrapment efficiency was 63.80%. It could be concluded that encapsulation of turmeric extract into liposome could reduce its toxicity against cancer cells.
Uji Penghambatan Xantin Oksidase secara In Vitro Ekstrak Kulit Rambutan Putri, Nurul Eka; Rissyelly, Rissyelly; Mauldina, Marista Gilang
Pharmaceutical Sciences and Research Vol. 3, No. 1
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Abstract

Hyperuricemia is a condition have higher uric acid levels that can cause a cumulation uric acid crystals in the tissues. Xanthine oxidase is an enzyme which catalyze the oxidation of hypoxanthine into xanthine and into uric acid.Therefore, the inhibition of xanthine oxidase will reduce ammount of uric acid. This research aims to determine xanthine oxidase inhibition activity and also to identify chemical constituent group of extract rambutan (Nephelium lappaceum Linn.) skin. Rambutan fruit skin was extracted by graded maceration using a three solvent, based on polarity the solvent are n-hexane, ethyl acetate and methanol. The test of inhibition xanthine oxidase activity was using a spectrophotometer at λ = 274.79 nm, pH 7.8, substrate concentration of xanthine 0.15 mM and an incubation temperature of 30°C. Inhibition on Allopurinol as positive control has IC50 0.15 μg/mL. The result showed that methanol extract of rambutan skin had the highest inhibition percentage with IC50 3.71 μg/mL. Phytochemical screening showed that the most active extract methanol of rambutan fruit skin contain flavonoids, saponins, tannins and terpenoids.

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