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All Journal Media Penelitian dan Pengembangan Kesehatan Pharmaciana: Jurnal Kefarmasian Jurnal Studi Sosial Program Pascasarjana P-IPS JGE (Jurnal Geofisika Eksplorasi) Jurnal Terapan Abdimas Jurnal Ilmiah Mahasiswa Ekonomi Manajemen Al Qalam: Jurnal Ilmiah Keagamaan dan Kemasyarakatan JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Sains dan Teknologi Reaksi Edu Masda Journal PESAGI (Jurnal Pendidikan dan Penelitian Sejarah) Industrial Research Workshop and National Seminar Pharmaceutical Sciences and Research (PSR)
. Iskandarsyah
Departemen Farmasi Universitas Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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UJI IRITASI DAN AKTIVITAS PERTUMBUHAN RAMBUT TIKUS PUTIH: EFEK SEDIAAN GEL APIGENIN DAN PERASAN HERBA SELEDRI (Apium graveolens L.) Kuncari, Emma Sri; Iskandarsyah, Iskandarsyah; Praptiwi, Praptiwi
Media Penelitian dan Pengembangan Kesehatan Vol 25, No 1 Mar (2015)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Abstract

AbstrakPerasan seledri (Apium graveolens L.) biasa dipergunakan untuk memacu pertumbuhan rambut. Salah satu senyawa utama yang terkandung di dalam seledri adalah apigenin. Penelitian ini membahas tentang pengaruh pemakaian gel yang mengandung apigenin dan perasan herba seledri sebagai penumbuh rambut, meliputi uji iritasi dan aktivitas pertumbuhan rambut pada tikus putih jantan galur Spraque-Dawley. Uji iritasi menggunakan metode Kamkaen dan Rao, sedangkan uji aktivitas penumbuh rambut menggunakan metode Hattori-Ogawa dan Suzuki-Hamada. Berdasarkan indeks iritasi primer, semua formulasi gel tidak potensial menyebabkan iritasi pada kulit tikus putih (p>0,05). Gel yang mengandung apigenin dan perasan herba seledri menunjukkan aktivitas lebih baik dalam memacu pertumbuhan rambut (p<0,05) dibandingkan kontrol tanpa perlakuan. Apigenin menunjukkan aktivitas lebih baik (p<0,05) dalam meningkatkan ketebalan rambut dibandingkan kontrol tanpa perlakuan.Namun perlakuan perasan herba seledri tidak nyata (p>0,05) meningkatkan ketebalan rambut. Dapat disimpulkan bahwa gel yang mengandung apigenin dan perasan herba seledri dapat meningkatkan pertumbuhan rambut pada tikus putih dibandingkan kontrol tanpa perlakuan.Kata kunci : seledri, apigenin, gel, iritasi kulit, penumbuh rambutAbstractCelery (Apium graveolens L.) juice is widely used for promoting hair growth. One of the main compounds in celery is apigenin. This research discusses about the effect of gel containing apigenin and celery juice application as hair growth in term of skin irritation and its hair growth activity on Spraque-Dawley male mice. The irritation test was Kamkaen and Rao methods, while hair growth activity was HattoriOgawa and Suzuki-Hamada methods. Based on primary index irritation, all of the gel formulations did not signifiantly potential in resulting skin irritation on the mice (p>0,05). Gel containing apigenin andcelery juice showed better activity in promoting hair growth (p<0,05) than control without treatment. Apigenin showed better activity (p<0,05) in increasing hair thickness as well than control without treatment. However treatment of celery juice did not signifiantly (p>0,05) increase hair thickness. Itcan be concluded that gel containing apigenin and celery juice may result in better hair growth on mice compared to control without treatment.Keywords : celery, apigenin, gel, skin irritation, hair growth
Koproses Karagenan-Pragelatinasi Pati Singkong Propionat sebagai Eksipien Sediaan Tablet Mengapung Junaedi, .; Iskandarsyah, .; Anwar, Effionora
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 4 (2013)
Publisher : Indonesian Research Gateway

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Abstract

The aim of this study was to prepare floating tablet dosage forms using coprocessed of kappa and iota carrageenan and pregelatinized cassava starch propionate (PPSP) as excipients. In this study, tablets were made by wet granulation method and using famotidine as a model drug. Several formulations of floating tablets were prepared using varying composition of the excipients coprossed carragenan with a certain ratio. The swelling and bupyancy of the floating tablets were evaluated. Furthermore, the drug release from the floating tablets were studied and analyzed using several models of kinetic equations. The result showed that formula A with excipients coprocessed carragenan (1:1) as much as 60% with 10% HPMC produce the best formula with floating lag time 11.42±1.53 minutes and total floating time for 22 hours. The formula also revealed a profile of controlled drug release and approached to Higuchi kinetics model and the non Fickian diffusion mechanism.Keywords : carragenan, PCSP, coprocess exipients, floating tablets.
APLIKASI INTEGRASI METODE SERVQUAL, QUALITY FUNCTION DEPLOYMENT (QFD), DAN KAIZEN UNTUK MENINGKATKAN KUALITAS LAYANAN OPERASIONAL (STUDI KASUS: PT. BANK CENTRAL ASIA, TBK - CABANG BANDA ACEH) Munira Oviyatama; Iskandarsyah Iskandarsyah; Hasan Yudie Sastra
Jurnal Sains dan Teknologi Reaksi Vol 16, No 2 (2018): JURNAL SAINS DAN TEKNOLOGI REAKSI
Publisher : Politeknik Negeri Lhokseumawe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30811/jstr.v16i2.1007

Abstract

Kualitas layanan operasional BCA Banda Aceh akan menuju kepada layanan yang lebih baik dalam rangka menjaga konsistensi dan peningkatan kualitas layanannya. Berdasarkan urgensi diatas penelitian ini bertujuan untuk mengukur kualitas layanan serta melakukan perbaikan kualitas layanan yang optimal sehingga akan menjadi salah satu bank dengan kualitas layanan yang terbaik. Untuk meningkatkan dan menstabilkan kualitas layanan yang dimaksud tersebut, maka peneliti memilih konsep mengintegrasikan 3 (tiga) metode, yaitu: (i) SERVQUAL, pada metode ini penelitian melakukan penyebaran kuesioner sebanyak 118 responden kepada nasabah-nasabah dengan kriteria-kriterianya berdasarkan; jenis kelamin, jenis transakasi, dan lain-lain yang berkaitan dimana, indikator-indikator pada kuesioner yang dirancangkan tersebut berdasarkan dimensi kualitas layanan yang sesuai dengan metode SERVQUAL yang meliputi: tangible, reliability, responsiveness, assurance, dan empathy. Kemudian dilanjutkan dengan analisa kuadran Importance Performance Analysis (IPA) untuk mengidentifikasi atribut-atribut yang menjadi prioritas pada peningkatan kualitas. (ii) Penerapan metode Quality Function Deployment (QFD), QFD dengan menggunakan matriks House of Quality (HoQ), hal ini akan memberikan rekomendasi perbaikan dari hasil analisa QFD dengan cara memberikan nilai persentase normalized contribution tertinggi yang menjadi prioritas rekomendasi dari objek tersebut melalui konsep Kaizen; (iii) Pemilihan metode Kaizen pada objek penelitian ini merupakan metode yang sesuai diterapkan untuk tujuan peningkatan kualitas layanan terutama pada bagian operasional dimana, metode ini dapat mengurangi waste (pemborosan) pada proses kerja Teller dan CSO sehingga layanan menjadi lebih cepat dan tepat. Penerapan ketiga metode ini akan menberikan hasil yang optimal terhadap peningkatan nilai kualitas layanan operasional pada BCA Banda Aceh.
PEMBELAJARAN IPS DENGAN METODE LIFE SKILL OF PORTOFOLIO UNTUK SMP Sribudi Karyadi; R Gunawan Sudarmanto; Iskandarsyah Iskandarsyah
Jurnal Studi Sosial / Journal of Social Studies Vol 1, No 2 (2013): Jurnal Studi Sosial
Publisher : Faculty of Teacher Training and Education, University of Lampung

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Abstract

This research was held to construct IPS learning with life skill of portofolio method at class IX of SMPN 22 in 2012-2013.  This learning research was planned and drawn up based on IXA and IXB SMPN 22 student’s  life skills in 2012-2013.  The type of this research is qualitative descriptive, based on SMPN 22 student’s  life skills in class IX, through stages of exploration, colaboration, documentation and presentation.  There are two kind of life skills were used in this reserach, they are common life skill and special life skill.  Common life skill consist of individual skill, information quarry skill, social skill and group skill.  As for special skill consist of documentation skill and appearance skill.  The construction stages of IPS learning with life skill of portofolio method starts from mapping standard competetion and basic competetion, planning the IPS learning with life skill of portofolio method, planning of IPS learning, the erly stage of learning and IPS learning with life skill of portofolio method grouping, and last but not least is the stages of documentation.  Thereform, IPS learning with life skill of portofolio method at class ix of SMPN 22 in 2012-2013 can increase the level of cognitive, affective, psycomotor and social skill.Keywords : Learning life skill of portofolio method and life skills
INTERPRETASI STRUKTUR GEOLOGI PADA AREA GEOPARK CILETUH DENGAN ANALISIS DERIVATIF DATA GAYABERAT GGMPLUS Adib Ihsan Panggabean; Iskandarsyah Iskandarsyah; William Jhanesta
Jurnal Geofisika Eksplorasi Vol 7, No 3 (2021)
Publisher : Engineering Faculty Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jge.v7i3.155

Abstract

Geopark Ciletuh terletak di Kecamatan Ciemas sebelah barat Kabupaten Sukabumi, Jawa Barat, Indonesia. Pada Geopark Ciletuh terdapat adanya batuan Pra-Tersier yang tersingkap di permukaan dan juga terdapat berbagai macam struktur yang terbentuk akibat terjadinya pergerakan tektonik di sebelah barat daya Geopark Ciletuh. Penelitian ini dilakukan bertujuan mendelineasi struktur pada Geopark Ciletuh yang timbul oleh adanya perbedaan densitas dengan metode gaya berat. Pada penelitian ini digunakan analisis derivatif first horizontal derivative (FHD) untuk mengetahui keberadaan struktur dan second vertical derivative (SVD) untuk menentukan jenis patahan. Pada penelitian ini juga dilakukan dip estimation dengan metode multi-level second vertical derivative (ML-SVD). Setelah didapatkan data FHD, SVD, dan ML-SVD selanjutnya diintegrasikan dengan data geological section dari peta geologi Lembar Jampang Balekembang untuk dibuat penampang geologi. Interpretasi dugaan patahan memiliki arah orientasi NW-SE dan NE-SW. Hasil penelitian menujukkan adanya indikasi dugaan patahan naik dan patahan turun. Pada analisis terpadu, didapatkan adanya kesesuaian maupun ketidakkesesuaian antara data peta geologi dengan data geofisika.
Camellia sinensis extract phytosomes inhibit body weight gain in Sprague-Dawley rats Dwi Kurnia Putri; Iskandarsyah Iskandarsyah; Effionora Anwar
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (61.406 KB) | DOI: 10.12928/pharmaciana.v10i2.16427

Abstract

A phytosome is a kind of nanovesicle lipids to increase the absorption of active substances. Green tea extract was formulated into phytosome to find out its ability to inhibit weight gain. There were three formulas with thin layer hydration. Furthermore, phytosome complex formation, morphology, particle size, zeta potential, and polydispersity index, and absorption efficiency test were characterized. Phytosomes and green tea extracts were tested for absorption in vitro. A total of 25 rats were divided into five test groups, which were the normal group, placebo group, orlistat group, green tea extract group, and phytosome group. For 8 weeks they were orally induced using 10% of fructose + 2% of cholesterol, and test treatment. The best characteristics of FIII were formed complex, spherical morphology, Dv90 782.67 ± 39.7 nm, polydispersity index of 56 ± 0.11, zeta potential of -70.83 ± 1.67 mV, and adsorption efficiency of 97.77 ± 2.66 %. The test on the animals at week 8 resulted in percentage of weight gain in normal treatment of 46.47 ± 17.48%, placebo of 101.17 ± 10.37%, orlistat of 42.51 ± 25.13%, green tea extract of 92.73 ± 36.43%, and phytosomes of 45.09 ± 15.56%. Green tea extract flux was 2316.2 ± 1309.8 μg/cm2/hour, while phytosome flux was 3125.3 ± 2071.8 μg /cm2/hour. To sum up, phytosomes can inhibit weight gain and are better than to green tea extracts (p < 0.05).
PENGARUH EKSPEKTASI, PERSEPSI KUALITAS, PERSEPSI NILAI DAN CITRA TUJUAN WISATA TERHADAP KEPUASAN WISATAWAN PADA PULAU WEH SABANG Amirul Azhar; Iskandarsyah Iskandarsyah
Jurnal Ilmiah Mahasiswa Ekonomi Manajemen Vol 4, No 4 (2019): November
Publisher : Departemen Manajemen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jimen.v4i4.11444

Abstract

Abstract: This study aims to measure the influence of expectations, perceived quality, perceived value and destination image on tourist satisfaction at Weh Island of Sabang. The sample used in this study is tourist visiting Weh Island of Sabang totaling 100 respondents. Data collection equipment used in this study was a questionnaire. The sampling technique used is Nonprobability Sampling. Multiple regression analysis was used as a method of analysis to determine the effect of all the variables involved. Based on the result analysis, indicating that expectation and destination image have an effect on tourist satisfaction. While, perceived quality and value do not havenot an effect on tourist satisfaction, Keywords: Expectations, Perceived Quality, Perceived Value, Destination Image, Tourist Satisfaction
(Formulation and In Vitro Penetration Evaluation of Transfersome Gel Preparation Contains Caffeine as an Anticellulite) RINI SUGIYATI; ISKANDARSYAH ISKANDARSYAH; JOSHITA DJAJADISASTRA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Transfersom merupakan vesikel nano yang bersifat deformabel sehingga mampu berpenetrasi sampai ke lapisan kulit yang lebih dalam. Kofein memiliki khasiat sebagai antiselulit. Penelitian ini bertujuan untuk formulasi dan mengetahui kemampuan daya penetrasi gel transfersom kofein dibandingkan dengan gel kofein tanpa transfersom. Empat formula transfersom dibuat dengan konsentrasi kofein yang berbeda (1; 2; 3; 5%) menggunakan metode hidrasi lapis tipis. Suspensi formula 4 dengan ukuran partikel 202,35 nm, indeks polidipersitas 0,1090 dan efisiensi jerapan 58,91% dipilih untuk sediaan gel. Uji penetrasi dilakukan secara in vitro dengan sel difusi Franz. Hasil yang diperoleh adalah jumlah kumulatif kofein yang terpenetrasi dari gel transfersom lebih tinggi yaitu 1218,34+358,71 μg cm-2, persentase jumlah kumulatif 8,53+2,55% dan fluks 360,91+86,50 μg cm-2 jam-1. Sementara gel kofein tanpa transfersom memiliki jumlah kumulatif terpenetrasi 369,29+231,57 μg cm-2, persentase jumlah kumulatif 2,61+1,37% dan fluks 70,96+73,39 μg cm-2 jam-1. Dapat disimpulkan bahwa gel transfersom kofein menghasilkan daya penetrasi yang lebih baik dibandingkan gel kofein tanpa transfersom.
Pengaruh Polimer dan Peningkat Penetrasi Terhadap Karakter Penetrasi Matriks Sediaan Patch Transdermal Karvedilol Untia Kartika Sari Ramadhani; Joshita Djajadisastra; Iskandarsyah Iskandarsyah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (673.545 KB) | DOI: 10.35814/jifi.v15i2.501

Abstract

Carvedilol is β-blocker antihypertensive drug with low oral bioavaibility and short half time which causes the frequency of oral drug used more often or the oral dose might be increased. Transdermal patch with the matrix system can deliver drug through skin in controlled within specifi c time period and hopefully it can improve carvedilol bioavaibility and convenience for patients.The aim of research was to fi nd out the effect of polymer and penetration enhancer toward penetration characteristic of carvedilol transdermal patch matrix seen from kinetics release data and penetration data of carvedilol. The polymer ratio of Polyvinyl Alcohol (PVA) : Ethyl cellulose (ES) polymers and Sorbitan Monolaurate (SM) as penetration enhancer concentrations used were F1 (1:1) / 8%, F2 (1: 1) /10%, F3 (2:1) /8%, F4 (2:1)/10%. Formula F1 did not pass in the organoleptictes so next test only carried out for formula F2, F3 and F4. The in vitro release of carvedilol showed formula F2, F3 and F4 lasted for 24 hours and the released kinetics of carvedilol followed the order of 0 and Higuchi. Carvedilol % cumulative from penetration test in vitro showed for F2, F3 and F4 formulas respectively were 15,384%, 16,495% and 18,287%.
PENGARUH PENGGUNAAN MEDIA BLOG UNTUK MENINGKATKANMOTIVASI BELAJAR SISWA Rahmawati Rahmawati; Iskandarsyah Iskandarsyah; Suparman Arif
PESAGI (Jurnal Pendidikan dan Penelitian Sejarah) Vol 3, No 4 (2015): PESAGI (Jurnal Pendidikan dan Penelitian Sejarah)
Publisher : FKIP UNIVERSITAS LAMPUNG

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Abstract

The purpose ofthis study was to determine whether there is a significant effect and the magnitude of the effect of the media use blogs to increase students' motivation in Class XI History Lesson Social Sciences Way Jepara high school academic year 2014/2015 . The method used is experimental with a single experimental design. Based on the analysis of quantitative data can be concluded that there is significant influence and magnitude of the effect of the media use blogs to increase students' motivation is equal to 0.54.Tujuan penelitian ini adalah untuk mengetahui ada tidaknya pengaruh yang signifikan dan besarnya taraf signifikansi pengaruh penggunaan media blog untuk meningkatkan motivasi belajar siswa Pada Mata Pelajaran Sejarah Kelas XI IPS SMA Negeri 1 Way Jepara Tahun Ajaran 2014/2015.Metode yang digunakan adalah eksperimen dengan desain eksperimen tunggal.Berdasarkan analisis data secara kuantitatif dapat disimpulkan bahwa ada pengaruh yang signifikan dan besarnya taraf signifikansi pengaruh penggunaan media blog untuk meningkatkan motivasi belajar siswa adalah sebesar 0.54.Kata kunci:blog, media,motivasi belajar
Co-Authors . Jenny . Juheini . Sutrio . Sutriyo Adib Ihsan Panggabean Ahmad Aulia Alip Mutakim Alip Mutakim, Alip Amirul Azhar Animar J A Animar J.A. BZ, Fazli Syam Cut Afrianandra, Cut Devi Octarina Devi Octarina Devi Octarina, Devi Dian Hayati Dian Hayati Dwi Kurnia Putri Effionora Anwar Effionora Anwar Emma Sri Kuncari Erny Sagita Erny Sagita, Erny Esadini, Ayu Rana Evayani, Evayani Gabriella Pasaribu Gabriella Pasaribu, Gabriella Harmita Harmita, Harmita Hasan Yudie Sastra Ilmi Zajuli Ichsan Imam Prabowo Imam Prabowo, Imam J.A, Animar Jenny Jenny Jenny, Jenny JOSHITA DJAJADISASTRA Juheini Amin Juheini, Juheini Junaedi, . Lestari, Novi Mudinillah, Adam Munira Oviyatama Nurleni, Novi Praditya Ardi Putranto Praptiwi Praptiwi R Gunawan Sudarmanto Rahmawati, Rahmawati RINI SUGIYATI Rosmala Dewi Rosmala Dewi Sribudi Karyadi Suparman Arif Sutriyo Sutriyo, Sutriyo Untia Kartika Sari Ramadhani William Jhanesta