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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 13 Documents
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Search results for , issue "Vol. 6, No. 3" : 13 Documents clear
Chemical Components of Ocimum basilicum L. and Ocimum tenuiflorum L. Stem Essential Oils and Evaluation of Their Antioxidant Activities Using DPPH Method Hikmawanti, Ni Putu Ermi; Hariyanti,; Nurkamalia,; Nurhidayah, Sahera
Pharmaceutical Sciences and Research Vol. 6, No. 3
Publisher : UI Scholars Hub

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Abstract

Ocimum basilicum L. and Ocimum tenuiflorum L. are two types of plants from Ocimum (Lamiaceae). One of their chemical compounds is essential oil. Essential oil might have an antioxidant activities. The part of the plants which are often wasted and never used are stem. This study aimed to analyze the chemical components of O. basilicum L. and O. tenuiflorum L. stem essential oils and evaluate their antioxidant activities. Essential oils were obtained by steam-water distillation. Analysis of chemical component of essential oil was performed using Gas Chromatography-Mass Spectroscopy (GC-MS). Antioxidant activities were evaluated with DPPH method and then the IC50 value was determined as 50% inhibition concentration of free radical. The results showed that O. basilicum L. stem essential oil had 13 components with the major compounds were methyl eugenol (52.60%), caryophyllene (18.75%), and germacrene-D (9.19%). Whereas, O. tenuiflorum L. stem essential oil had 11 components with the major compounds were α-copaene (5.56%), caryophyllene (17.28%), germacrene-D (9.29%) and methyl eugenol (56.72%). IC50 value of O. basilicum L. stem essential oil was 17.50 µg/mL, whereas IC50 value of O. tenuiflorum L. stem essential oil was 14.17 µg/mL. It was concluded that both oils might be good natural antioxidant agents.
Cytotoxic Activity of Stem of Pycnarrhena cauliflora through Apoptosis Induction on Human Breast Cancer Cell Line T47D Masriani,; Rudiyansyah,; Muharini, Rini; Enawaty, Eny
Pharmaceutical Sciences and Research Vol. 6, No. 3
Publisher : UI Scholars Hub

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Abstract

Cytotoxic activities of extracts of Pycnarrhena cauliflora leaves, stems and roots on some human cancer cells have been known. However, the cytotoxicity of stem of Pycnarrhena cauliflora on human breast cancer cell line T47D through an apoptosis induction has not been proven yet. This study was an effort in understanding the cytotoxic activity of stem of Pycnarrhena cauliflora through apoptosis induction. The crude ethanol extract was partitioned between n-hexane and dichloromethane at pH 3, 7 and 9, which was subsequently tested for their cytotoxic activity against human breast cancer cell line T47D by using 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT). Flow cytometric analysis with Annexin V-FLUOS/ propidium iodide (PI) double staining was used for apoptosis analysis. The dichloromethane fraction at pH 7 was considered the most potent with an IC50 value of 59.30 µg/mL and induced apoptosis on the T47D cell line. The result indicated the potential of dichloromethane fraction of the stem of P.cauliflora as a source of bioactiv
Efek Xilooligosakarida (XOS) dalam Mencegah Diabetes Mellitus Tipe 2 Dwita, Lusi Putri; Rahmi, Hanifah
Pharmaceutical Sciences and Research Vol. 6, No. 3
Publisher : UI Scholars Hub

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Abstract

Type 2 diabetes mellitus (T2DM) is one of the leading causes of death in Indonesia. Early intervention is very important to delay the development of this disease. This study aimed to determine the effect of XOS (Xylo-oligosaccharide) as prebiotic in preventing insulin resistance. The rats were divided into 5 groups: XOS 2 gr/kg, XOS 1 gr/kg, XOS 0.5 gr/kg, diabetic control, and non-diabetic control. Animals were given the test substances and standard feed for 2 weeks then induced with STZ (streptozotocin) except for non-diabetic control. On the 19th day, the data was collected. The results showed that XOS 2 gr/kg BW could prevent blood sugar elevation which is 57.84% lower than diabetic control and show a comparable cholesterol level to normal control. It can be concluded that administration of XOS showed a significant effect in preventing T2DM.

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