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The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

jghe
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Published by The Indonesian Society for Digestive Endoscopy

ISSN : 14114801 EISSN : 23028181 DOI : -

Core Subject : Health,

Medicine & Pharmacology

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.

Arjuna Subject : Kedokteran - Ilmu Pencernaan

Articles 11 Documents

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Search results for , issue "VOLUME 12, NUMBER 3, December 2011" : 11 Documents clear

Biliary Atresia in Infants with Cholestasis Budi Purnomo; Badriul Hegar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Cholestasis is a pathological condition due to impaired secretion and excretion of bile into the duodenum. The etiology should be found within golden period age ( 10 weeks of life) in order to get better outcome. Biliary atresia is characterized by total obstruction of extrahepatic biliary system. The cause is unknown. The only effective treatment is Kasai procedure, which should be done at 8 weeks age or less. The aim of this study was to observe the pattern of cholestasis cases in infants. Method: A descriptive study was conducted on 63 patients with cholestasis at the Harapan Kita Woman and Children Hospital, Jakarta between January 2008 and December 2009. Data was obtained from the computerized medical record database system. Statistical analysis was performed using SPSS program. Results: There were 63 infants, include of 40 (63.5%) boys. Age at admission were 80.2 (30-207) days. The laboratory findings included mean serum levels of hemoglobin 8.9 g/dL, conjugated bilirubin 12 mg/dL, alanine transaminase 149 u/L, aspartate transaminase 236 u/L, alkaline phospatase 582 u/L and gamma-glutamyl transpeptidase level 326 u/L. Biliary atresia was diagnosed in 8 (12.7%) infants by abdominal ultrasonography examination, cholangiography and liver biopsy. Kasai procedure (portoenterostomy) was performed to all those infants. Two of those infants died. Conclusion: Cholestasis has become one of the most common problem found in infants. Biliary atresia should always be considered as one of the cause, since early diagnosis and immediate treatment are needed to provide a good outcome. Keywords: cholestasis, biliary atresia, Kasai procedure

Clinical Effects of an Amino Acid and Glucose Solution in Non-surgical Gastrointestinal Patients of Internal Medicine Ari Fahrial Syam; Achmad Fauzi; Murdani Abdullah; Marcellus Simadibrata; Chudahman Manan; Abdul Aziz Rani; Daldiyono Daldiyono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: This study was performed to assess the efficacy and safety of intravenous amino acid and glucose solution with electrolytes in non-surgical gastrointestinal patients. Method: This single, open, and pre-post study was conducted in the internal medicine ward at Cipto Mangunkusumo Hospital between June 2007 and March 2008. Patients were administered solution of amino acid, glucose, and electrolytes via peripheral vein at a dose of 1000 mL/day for one week period. Non-operative gastroenterology patients with age between 16 and 65 years were eligible in this study; patients were excluded if they had diabetes mellitus, severe hepatic or renal dysfunction, electrolyte disturbance, and obesity. The data were analyzed by paired t-test and McNemar test using SPSS version 16. Results: Fifteen patients consisted of 8 (53.5%) female, mean age was 38.47 ± 14.73 years. The body mass index (BMI) at screening was 14.50 ± 2.11 kg/m2. Patients’ BMI increased in day-1, day-3, and day- 7 into 14.5; 14.58; 14.80 kg/m2, respectively (p 0.05). The increasing of prealbumin, albumin, transferin, and total protein were 7.30 mg/dL vs 11.16 mg/dL; p = 0.018; 2.71 g/dL vs 3.12 g/dL; p = 0.024; 102.37 mg/dL vs 141.95 mg/dL; p = 0.016; 6.24 g/dL vs 6.85 g/dL; p = 0.019, respectively. The clinical symptoms of nausea and weakness in patients decreased from 53.3% to 6.7%; p = 0.016, and 66.7% to 6.7%; p = 0.004. Conclusion: This parenteral nutrition solution was effective to improve clinical nutrition parameters. Keywords: amino acid and glucose solution, non-surgical gastrointestinal patients, peripheral parenteral nutrition

Preventing NSAID-induced Gastropathy: The Role of Mucus Cells to Prevent Aspirin-Induced Acute Gastric Mucosal Damage Chudahman Manan; Bambang Pontjo Priosoeryanto; Daldiyono Daldiyono; Sri Estuningsih; Min Rahminiwati
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Mucus is pre-epithelial gastric layer that may prevent damages due to direct contact between aspirin and gastric epithelial cells. The integrity of gastric mucosa and mucous cellular reaction may serve as primary and secondary prevention of extended aspirin-induced gastric mucosal damage. The aim of this study was to prove the function of mucus as defensive factor in rats. Method: The study was conducted in twenty white rats of the Sprague-Dawley strain at Department of Pathology and Clinical Reproduction, Bogor Agricultural University, between January and December 2008. The rat in the treatment group were given 400 mg aspirin diluted in aqua bidest through intra- gatric canules; while the control group received aqua bidest only once daily for 3 days. Necropsies, macroscopic and microscopic observation were performed by counting the number of Alcian blue- periodic acid Schiff-stained mucous cells at fundus/corpus and antrum/pylorus regions. Data analysis was performed using ANOVA and Duncan test. Results: The number of mucous cells with positive lesions in the treatment group was significantly different from the control group at both regions. There was no significant difference of negative lesions between treatment and control group at both regions. At antrum/pylorus region, there was no difference of negative lesions between treatment and control groups; however, both groups demonstrated significant difference of positive lesions in treatment group. Conclusion: In primary prevention for gastric mucosal lesions, there is no increasing number of mucous cells in normal mucosa. Increasing number of mucous cells is a secondary prevention against extended aspirin-induced gastric mucosal damage. Keywords: NSAIDs/ASA, mucus cells, gastric mucosal lesion, rat

Evaluation and Management of the Pediatric Patients with Suspected Gastroesophageal Reflux Diseases Badriul Hegar; Yvan Vandenplas
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Gastroesophageal reflux is a normal physiologic process occurring in healthy infants. Symptoms due to gastro-esophageal reflux diseases (GERD) are troublesome when they have adverse effects on the well- being of the patient. A thorough history and physical examination is generally sufficient to establish a clinical diagnosis of uncomplicated infant with gastroesophageal reflux. Poor weight gain is a warning sign. Irritability and regurgitation are associated with a wide range of physiologic and pathologic conditions. Heartburn or substernal burning is a reliable indicator for GERD in adolescents. Barrett esophagus does occur in children with severe chronic reflux. GERD is commonly cited as a cause of dysphagia; however, there are no strong pediatric data demonstrating this relationship. An etiologic role for reflux in reactive airways disease, such as asthma, has not been established. No test can determine whether reflux is causing recurrent pneumonia. Data showing the correlation between reflux and upper airway disease is weak, consisting mainly of case descriptions. Sandifer syndrome is an uncommon, but specific manifestation of GERD. Children with cerebral palsy are at particularly high risk of GERD. Similarly, children with certain genetic syndromes such as Cornelia de Lange and Down syndrome are prone to GERD. A higher prevalence of GERD and its complications has been reported in patients with a variety of chronic respiratory disorders including bronchopulmonary dysplasia and cystic fibrosis. GERD treatment is frequently administered to premature infants. However, the true prevalence of GERD is unknown. Keywords: gastroesophageal reflux diseases, infants, children

Non-invasive Markers for Diagnosis of Liver Cirrhosis in Chronic Hepatitis B Jeffry Beta Tenggara; Irsan Hasan; Andri Sanityoso; Murdani Abdullah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Indonesia is an endemic country for hepatitis B viral infection. Thus, early diagnosis of cirrhosis is important to be established with regard to prompt treatment and to determine the patients’ prognosis. Liver biopsy which is a gold standard in diagnosing liver cirrhosis has several limitations, such as expensive and invasive. The objective of this study was to identify the accuracy of non-invasive markers: aspartate/alanine transaminase ratio (AAR), age-platelet index (API), aspartate transaminase to platelet ratio index (APRI), spleen to platelet ratio index (SPRI), and age-spleen-platelet ratio index (ASPRI) in predicting cirrhosis in chronic hepatitis B patients. Methods: A diagnostic study was performed in Division of Hepatology and Hepatology Outpatient Clinic, Depatment of Internal Medicine, Cipto Mangunkusumo Hospital between January 2009 and July 2010, with the participation of 71 chronic hepatitis B patients who had undergone liver biopsy consecutively. Stage of fibrosis was determined based on the METAVIR scoring system. Five non-invasive markers: AAR, API, APRI, SPRI, and ASPRI were compared with liver biopsy Results. Statistical analysis was performed by using T-test and Spearman correlation test using SPSS version 13. Results: API, APRI, SPRI, and ASPRI had significant correlation with the incidence of liver cirrhosis in hepatitis B infection (p 0.05). However, AAR had no correlation with the incidence of cirrhosis. Using the cut-off point of 1.19, APRI was the best marker with area under curve (AUC) 0.91, sensitivity 83.3%, and specificity 89.2%. Conclusion: Non-invasive markers were suitable in predicting cirrhosis and have the potential to decrease the number of liver biopsy in chronic hepatitis B patients. Keywords: non-invasive markers, chronic hepatitis B, liver cirrhosis

Correlation between Apolipoprotein B (Apob) Level and Non Alcoholic Fatty Liver in Type 2 Diabetes Mellitus with Metabolic Syndrome Tejo Nugroho; Tantoro Harmono; Tri Yuli Pramana; Sugiarto Sugiarto
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Non-alcoholic fatty liver disease (NAFLD) is a liver disorder commonly found in the majority of patients with metabolic risk factors, such as obesity and type 2 diabetes. Apolipoprotein B (apoB) is the moiety of low density lipoprotein (LDL) and clinical interest that provides a relative accurate estimation of circulating LDL particle. The aim of this study was to know the relationship between apoB level and occurrence of fatty liver in type 2 diabetes mellitus (DM) with metabolic syndrome. Method: A cross sectional study was conducted in patients suffered from type 2 DM with metabolic syndrome at Internal Medicine Outpatient Clinic in Moewardi Hospital Surakarta between April and May 2011. Thirty two patients with type 2 DM and metabolic syndrome were enrolled to this study and categorized into two groups; consisting of 16 patients with fatty liver and 16 patients without fatty liver. Student t-test was used in the analysis of this study. Results: Of 32 patients who fulfilled this study criteria, patients type 2 diabetes mellitus and metabolic syndrome with non-alcoholic fatty liver diseases (NAFLD) had higher apoB level than patients type 2 diabetes mellitus and metabolic syndrome without NAFLD (p = 0.013). Conclusion: NAFLD group had significantly higher apoB level than without NAFLD group in type 2 DM with metabolic syndrome patients. Keywords: apolipoprotein B, non-alcoholic fatty liver disease, type 2 DM, metabolic syndrome

The Future of Acid Inhibition Guido NJ Tytgat
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

There are many unmet needs with current gastric acid suppression with proton pump inhibitors (PPIs). Recommended prescription of one standard morning dose for all patients and for all medical conditions must be scientifically inappropriate and far from individualized personal medicine. For several diseases, especially gastroesophageal reflux disease and Barrett esophagus, more intense, more prolonged diurnal acid suppression is indicated. Especially inhibition of nocturnal acid secretion with our current delayed-release PPIs turns out to be difficult. This overview summarizes the actual attempts to improve the control of acid secretion, which is necessary to adapt the degree of acid inhibition to the individual patient needs. To be discussed are: immediately release PPIs, extended PPI formulations, PPIs with a much longer half-life, potassium competitive acid blockers, gastrin antagonists, etc. Future studies have to proof that those novel drug approaches indeed contribute to reduce the unmet needs. Keywords: acid secretion, PPI, nocturnal acid secretion

Clinical Profile and Outcome of Non-Variceal Upper Gastrointestinal Bleeding in Relation to Timing of Endoscopic Procedure in Patients Undergoing Elective Endoscopy Lianda Siregar; Abdul Aziz Rani; Chudahman Manan; Marcellus Simadibrata; Dadang Makmun
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Endoscopy is the most accurate method for diagnosing the source of upper gastrointestinal bleeding. This study was aimed to evaluate the correlation between the timing of elective endoscopy and the length of hospital stay, the amount of transfusion given and incidence of recurrent bleeding or patient mortality. Method: A retrospective study was conducted in all patients with non-variceal upper gastrointestinal bleeding who had experienced elective endoscopy at Cipto Mangunkusumo Hospital between January 2007 and August 2008. Identification of clinical risk using clinical Rockall score was performed at the emergency room. Persistent bleeding, recurrent bleeding, surgical treatment and death were the outcome variables. Statistical analysis was performed using Chi-square/fisher exact test and linear regression. Results: There were 40 eligible cases with mean age of 53 ± 13 years; the greatest occurrence was at the age group of 50-59 years (12%), male (52.5%) and those who had clinical symptom of melena (52.5%). Twenty seven (67.5%) patients had Rockall score of 1-3 points and 13 (32.5%) had 4-6 points. There was only one patient who had adherent clots (Forrest grade II B). Endoscopy results revealed that the most common cause of bleeding was gastric ulcer, which occurred in 12 (30%) patients. There was no correlation between the timing of endoscopic procedures and outcome variable; however the length of hospital stay had a significant correlation with timing of endoscopic procedures. Conclusion: Elective endoscopy does not affect the variables of mortality and recurrent bleeding; however, it affects the length of hospital stay. Further prospective studies are required to find causal relation between them. Keywords: non-variceal upper gastrointestinal bleeding, Rockall score, elective endoscopy, outcome variables

Urgent Versus Elective Endoscopy for Acute Non-variceal Upper Gastrointestinal Bleeding Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Characteristic Profiles of Parasitic and Fungal Infections in Acute Diarrhea Marcellus Simadibrata; Suzana Ndraha; Tjahjadi Robert Tedjasaputra; Ari Fahrial Syam; Achmad Fauzi; Murdani Abdullah; Abdul Aziz Rani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Diarrhea has been widely encountered in developing countries, including Indonesia. This study aimed to investigate the incidence of parasites and fungal infections, which also constitutes the etiologies of acute diarrhea. Method: A cross-sectional study was performed involving 93 patients. Patients with chief complaint of acute diarrhea were recruited at five hospitals in Jakarta, Indonesia during the period of November 2008 until May 2009. Acute diarrhea was defined as passing watery or soft stools with frequency of more than three times per day, weighted more 200 g per day, and occurred in less than 15 days duration. They were asked to collect their stool to the laboratory for further parasites and fungal detection. Results: This study showed that 41 out of 93 patients (44.09%) were found to be infected with parasites or fungi. The most common microorganism found was Candida albicans in 18 (19.35%) patients. Other parasites encountered in the stool samples were Blastocystis hominis, Entamoeba histolytica, Entamoeba coli, Giardia lamblia. The presenting clinical symptoms of the patients were fever (44.87%), bloating (41.03%), nausea (39.74%), oliguria (39.74%), cephalgia (35.90%), vomiting (24.36%), and tenesmus (19.23%). Conclusion: The incidence of parasitic and fungal infections in patients with acute diarrhea constitutes nearly half of all cases of infection-caused diarrhea. The most commonly encountered microorganism is Candida albicans. Keywords: parasites, fungi, acute diarrhea

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Reviewer

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Contact Name
Murdani Abdullah

Contact Email
ina.jghe@gmail.com

Phone
+6285891498517

Journal Mail Official
ina.jghe@gmail.com

Editorial Address
Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA

Abstract

Abstract

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Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Murdani Abdullah

Contact Email ina.jghe@gmail.com

Phone +6285891498517

Journal Mail Official ina.jghe@gmail.com

Editorial Address Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

Location Kota adm. jakarta pusat, Dki jakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Murdani Abdullah

Contact Email
ina.jghe@gmail.com

Phone
+6285891498517

Journal Mail Official
ina.jghe@gmail.com

Editorial Address
Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA