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The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

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Published by The Indonesian Society for Digestive Endoscopy

ISSN : 14114801 EISSN : 23028181 DOI : -

Core Subject : Health,

Medicine & Pharmacology

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.

Arjuna Subject : Kedokteran - Ilmu Pencernaan

Articles 771 Documents

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Correlation Between Serum Thrombopoietin Level and Cirrhosis Clinical Stage in Liver Cirrhosis Patients in Mohammad Hoesin Palembang Hospital and Palembang BARI Hospital Muhamad Ayus Astoni; Fuad Bakry; Irsan Saleh
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 16, No 3 (2015): VOLUME 16, NUMBER 3, December 2015
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Thrombopoietin (TPO) is a cytokine mainly produced in the liver that regulate humoral control mechanism of thrombopoesis. Presumably, TPO production is decrease in patients with liver cirrhosis which interfere platelet production. The aim of this study was to identify the correlation between serum TPO levels and the clinical stage of liver cirrhosis.Method: With analytical cross sectional design, this sudy analyzed the correlation between the serum TPO level and the clinical stage of liver cirrhosis according to Child-Pugh classification in 32 liver cirrhosis patients and 30 healthy subjects from March 2015 to August 2015. The serum level of TPO was examined using the Quantikine human TPO immunoassay.Results: There were 13 females and 19 males patients aged 19 to 67 years old. Serum TPO level were lower in patients with liver cirrhosis (65.65 ± 28.97 pg/mL) than in healthy subjects (98.16 ± 41.25 pg/mL, p 0.005). Serum TPO levels were negatively correlated with clinical stage of liver cirrhosis in a moderate strength of correlation (r = -0.516, p = 0.002). There were no correlation between serum TPO level and platelet count (r = 0.186; p = 0.309), but a significant negative correlation between the clinical stage of liver cirrhosis and platelet counts (r = - 0.361; p = 0.042).Conclusion: There was a significant negative correlation between serum TPO levels and the clinical stage of liver cirrhosis according to Child-Pugh classification.

National Consensus on the Use of Sedation Drugs in the Gastrointestinal Endoscopic Procedures Daldiyono Daldiyono; Abdul Aziz Rani; Marcellus Simadibrata; Ari Fahrial Syam; Achmad Fauzi; Dadang Makmun; Murdani Abdullah; Indra Marki; Kaka Renaldi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 2 (2017): VOLUME 18, NUMBER 2, AUGUST 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Gastrointestinal endoscopy is rapidly developing and several gastrointestinal endoscopy equipment are available for both diagnostic and therapeutic purposes. Proper sedation is critical in performing endoscopic procedures, both for patients and physicians. This consensus is used as a guideline and not as a legal standard in performing endoscopic services. This consensus explained the definition, indication, contraindication, and complication prevention during sedation. Factors affecting the need of sedation is patient factors, procedure factors, and sedation level. Diagnostic or therapeutic upper gastrointestinal tract endoscopy which not complicated can be performed with minimal sedation or moderate sedation, while deep sedation can be considered for longer and more complex procedures. Furthermore, assessment and selection of sedation was explained, followed by the guide to choose pharmacological sedation and analgesics. Currently, diazepam, midazolam, propofol, fentanyl, and pethidine is the most likely used sedation during gastrointestinal endoscopy, with midazolam as the preferred medication of choice. This consensus also explained the antidote of each drug and the recovery after procedure. This consensus aimed to improve gastrointestinal endoscopic procedure services in Indonesia.

Changes in Tumor Nekrosis Factor Alpha and Interleukin 6 Levels in Patients with Obstructive Jaundice due to Pancreatobiliary Cancer Who Underwent Biliary Drainage Adang Sabarudin; Rino Alvani Gani; Murdani Abdullah; Cleopas Martin Rumende
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 2 (2016): VOLUME 17, NUMBER 2, August 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Obstructive jaundice represents the most common complication of biliary tract malignancy. Obstructive jaundice causes releases of proinflammatory cytokine. There has been controversy about effect of biliary drainage on the change in proinflammatory cytokine level in pancreatobiliary cancer patients. The present study was designed to determine levels of tumor necrosis factor alpha (TNF-alfa) and interleukin 6 (IL-6) in preprocedure of either endoscopic retrograde cholangio pancreatography (ERCP) or percutaneous transhepatic biliary drainage (PTBD) and postprocedure of them in obstructive jaundice patient caused by pancreatobiliary cancer.Method: The study method was before-and-after case study design with consecutive sampling. Blood was collected five days prior to either endoscopic retrograde cholangio pancreatography (ERCP) procedure or percutaneus transhepatic biliary drainage (PTBD) procedure and five days after either of them. Enzyme linked immunosorbed assay (ELISA) was used to determine TNF-alfa and IL-6.Results: Forty subjects were included in this study which consisted of 22 men and 18 women. The age was 55.3 (SD 13.7) years old. According to the results of imaging and endoscopy procedure, twenty-two people were diagnosed cholangicarcinoma, ten people were diagnosed ampulla vateri and eigth people were diagnosed pancreatic tumor. In preprocedure, the TNF-alfa concentration was 4.81 (SD 2.91) pg/mL, the IL-6 concentration was 7.79 (SD 1.57) pg/mL and the bilirubin concentration was 15.5 (SD 6,9) mg%. In postprocedure, the TNF-alfa concentration was 8.05 (SD 6.7) pg/mL, there was a significant increase in TNF-alfa concentration (p = 0.02). However, IL-6 concentration was 7.75 (SD 1.76) pg/mL, there was not any significant chance in IL-6 concentration (p = 0.52). The bilirubin concentration was 11.3 (SD 6,5) mg%.Conclusion: There was a significant increase in mean concentration value of TNF-alfa after biliary drainage procedure. On the other hand there was not any significant decrease in the mean concentration value of IL-6 after biliary drainage procedure.

Acute pancreatitis as a complication of dengue fever Ridho, Sayid
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 1, NUMBER 1, December 2000
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/112000%p

Acute pancreatitis is a rare complication of dengue fever that usually occurs without hyperglycemia. We report one patient of dengue fever with a complication of acute pancreatitis. A 28 year old male was referred from a private clinic to Dr. Cipto Mangunkusumo hospital, because of fever and abdominal pain since two days before admission. The physical examination showed slight fever and epigastric pain. The laboratory examination revealed leukocytosis, thrombocytopenia and increased levels of serum amylase and lypase. The diagnosis of dengue infection was made after the finding the IgM for dengue virus. After 12 days of hospitalization, the patient’s clinical signs and symptoms and laboratory findings were within normal limits. Key words: acute pancreatitis, dengue fever

Management of Gastric Motility Disorder Mustika Dian Permana; Kaka Renaldi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 19, No 1 (2018): VOLUME 19, NUMBER 1, April 2018
Publisher : The Indonesian Society for Digestive Endoscopy

Gastric motility disorder or gastroparesis is an objective slowing of gastrointestinal emptying syndrome, in the absence of mechanical obstruction, with cardinal symptoms such as rapid feeling of fullness, fullness sensation after eating, nausea, vomiting, bloating, and upper abdominal pain. Patients with gastroparesis are at risk of weight loss, malnutrition, and lack of vitamins and minerals, as well as increasing morbidity and mortality. The prevalence and incidence data of gastroparesis do not describe the true reality, because of the complexity of diagnosis. Beside Diabetes mellitus, many other causes should also be considered. Several studies have shown that nausea, vomiting and fullness sensation in abdominal are the most associated symptoms with gastroparesis. A 4-hour solid phase gastric emptying scintigraphy is the diagnostic standard for the slowing of gastric emptying. Lowest effective dose metoclopramide starting with a dose of 3 x 5 mg is the first line for pharmacological therapy. For persistent or refractory gastroparesis with pharmacologic therapy, gastric electrical stimulation (GES) and surgical therapy may be considered. The management should involve relevant medical team by not forget to consider patient comfort.

Endoscopic Features of Patients with Bronchial Asthma and Gastroesophageal Reflux Symptoms Syafruddin AR Lelosutan; Agus Dwi Susanto; Ruswhandi M
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 7, ISSUE 3, December 2006
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/73200667-71

Background: Studies evaluating endoscopic results in patients with bronchial asthma and Gastroesophageal Reflux Disease (GERD) in Gatot Soebroto hospital have never been undertaken. It leads an idea to further study, in order to find a more accurate and rapid management as solution for anticipating asthma attack and complications of bronchial asthma to upper gastrointestinal tract. Methods: A retrospective study was aimed to evaluate endoscopic result of upper gastrointestinal tract in bronchial asthma patients who had GERD symptoms as appropriate to the criteria of 4 major GERD symptoms of Talley 2002. Data was collected in one year period starting from November 2004 to October 2005. Results: Subject characteristics in this study indicated that there were more female patients compared to male with a ratio approaching 3:1 who had such symptoms. Mean age was 38.5 years and ratio of body weight to body height indicated normal weight result and the mean value for duration of asthma was 27 years. Clinical symptoms of GERD found in the present study was in accordance with four majors symptoms of GERD i.e. 32 (100.00%) cases of regurgitation, 29 (90.63%) cases for each of heartburn and non-cardiac chest pain symptom, and 7 (21.88%) cases of difficult / painful swallowing or dys/odinophagia. The endoscopic result of upper gastrointestinal tract had figured of: (1) 4 (12.50%) cases of normal esophagus, (2) 11 (34.40%) cases of non-erosive esophagitis known as Non Erosive Reflux Disease (NERD), and (3) erosive esophagitis which regarding to Los Angeles classification: 15 (46.90%) cases of grade A and 2 (6.20%) cases of grade B. Conclusion: The incidence of esophagitis in accordance with LA classification is extremely high although no severe damage (grade C and grade D) was found. Early anticipation of reflux associated respiratory symptoms and anti-reflux treatment should be considered in order to shorten or to discontinue the asthma attack cycle. Keywords: bronchial asthma, GERD, endoscopy, NERD

The Differences of T-Regulator Cells, Alanine Aminotransferase Serum and Aspartate Aminotranspherase Between Hepatitis B Chronic Patients with and without Liver Fibrosis Yostila Derosa; Nasrul Zubir; Raveinal Arnelis
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 2 (2021): VOLUME 22, NUMBER 2, August 2021
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Hepatitis B is acute or chronic liver inflammation caused by hepatitis B viral and can progress to hepatic chirrosis or liver cancer. Chronic hepatitis B has a high risk for liver fibrosis. Chronic inflammation and liver fibrosis are interrelated processes. This study aimed to determine the differences in T-regulator cells, Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) between chronic hepatitis B patients with and without liver fibrosis.Method: This study used a cross-sectional method for patients diagnosed with chronic hepatitis B in the Inpatient and Outpatient Department of the Internal Medicine Department DR. M. Djamil Padang and other hospitals in Padang city for 6 months. Samples were selected by consecutive sampling according to inclusion and exclusion criteria. Liver fibrosis is identified by fibroscan. Data were analyzed by SPSS 21.0.Results: thirty-two patients were diagnosed with chronic hepatitis B and 50% had liver fibrosis. The levels of T-regulator cells in chronic hepatitis B patients without liver fibrosis were 2.08% and liver fibrosis 2.25%, but this difference was not statistically significant (p 0.05). Mean ALT levels in the group without fibrosis were 19 IU/L (7IU/L-71IU/L) and liver fibrosis 61 IU / L (13IU/L-625IU/L). The mean AST level in the group without fibrosis were 15.5 IU/L (10IU/L-32IU/L) and liver fibrosis 35.5 IU/L (10IU/L-476IU/L). The difference between ALT and AST in the two groups was significant (p 0.05). Hepatitis B patients with liver fibrosis had higher ALT and AST levels than without fibrosis.Conclusion: There were differences levels of T-regulator cells in the two groups, but it was not statistically significant. ALT and AST levels were higher in the liver fibrosis group and statistically significant.

Aspartate Aminotransferase to Platelet Ratio Index and FibroScan for Predicting Liver Fibrosis with Chronic Hepatitis B Tarigan, Elias; Yusuf, Rustam Effendi; Dairy, Leonardo Basa; Sembiring, Juwita; Sihombing, Mabel HM; Siregar, Gontar Alamsyah; Zain, Lukman Hakim
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 3, December 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Non-invasive test have been constructed and evaluated mainly for binary diagnoses. The accuracy of non-invasive tests such as aspartate aminotransferase to platelet ratio index (APRI) and transientelastography/FibroScan should be evaluated especially in clinical practice. The aim of the study was to evaluate the accuracy of detailed fibrosis classification available for APRI and FibroScan to liver biopsy in chronichepatitis B patients.Method: A cross sectional study was conducted in 51 patients with chronic hepatitis B. The patients underwent laboratory test, FibroScan and liver biopsy between April 2011 and July 2013 at Adam Malik Hospital, Medan.Liver biopsy was assessed based on the METAVIR score. Area under receiver operating characteristic curve (AUROC) predictive value was used to evaluate the accuracy of APRI and FibroScan. All data were analyzedusing SPSS 20.0.Results: APRI versus METAVIR diagnosed severe fibrosis and cirrhosis with sensitivity 40% and specificity 83.9%, positive predictive value (PPV) 61.5%, negative predictive value (NPV) 68.4%, positive likelihood ratio(LR) 2.48 and negative LR 0.72 with diagnostic accuracy 66.7%. The AUROC value was 0.619 (95% CI = 0.446 – 0.715); kappa = 0.255; p 0.05. FibroScan versus METAVIR predictive value with sensitivity 75% andspecificity 67.6% were PPV 60%, NPV 67.7%, positive LR 2.31 and negative LR 0.36 with diagnostic accuracy 70.6%. The AUROC value was 0.714 (95% CI = 0.567–0.861); kappa 0.409; p 0.05.Conclusion: FibroScan has better accuracy than APRI for predicting severe fibrosis and cirrhosis in patientswith chronic hepatitis B.Keywords: APRI, FibroScan, liver biopsy, chronic hepatitis B

Treatment of Chronic Hepatitis C with High Dose Interferon Therapy Experience from Pertamina Central Hospital Jakarta Waldemar Simanjuntak
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 3, NUMBER 3, December 2002
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/33200282-85

Background: Until several years ago, interferon alfa was the only drug with proven benefit for the treatment of chronic Hepatitis C. Several therapy categories such as fixed-dose regimens, induction-dose regimens and escalation-dose regimens are already known. With standard dose interferon therapy of 3 MU, TIW for 6 months, a sustained response rate can ve achieved in only 10-20% of patients. This study reports the Results of treatment of chronic Hepatitis C with high dose interferon therapy of 6 MU, TIW for 6 months. Methods: From February 1996 to February 1998, 15 patients with Hepatitis C were treated with interferon alfa-2b 6 MU, TIW for 6 months. Ultrasound-guided liver-biopsy was performed using the Menghini-Technique (Hepafix). Virological and biochemical responses were assessed at the end of the treatment period at week 24 and at the end of follow-up period at week 48 and up to 2 years later. Virological and biochemical sustained responses were defined as the absence of HCV-RNA, and SGPT concentration within the normal range at both weeks 24 and 48. Histological response was assessed after the end of treatment. Side-effects were observed and noted. Results: Ten out of 15 patients (66.7%) were HCV-RNA negative and 11 out of 15 patients (73.3%) demonstrated ALT within the normal range at week 24. At the end of the follow-up, from week 48 until 2 years later, HCV-RNA negative and normal ALT were found in 6 patients (40%). Histological improvement was found in 4 out of 6 patients. Fever was the most common side-effect and was found in 13 patients, while fatigue was found in 12 patients, myalgia in 11, headache in 10, and anorexia in 11 patients. Conclusion: High dose interferon alfa-2b therapy for the treatment of chronic Hepatitis C can improve the rate of sustained response, but is associated with more side-effects. Key Words: Chronic hepatitis C, Interferon.

Prevalence of Hepatitis B Infection Among Male Prisoners in Malang Syifa Mustika; Daya Daryadijaya
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 1 (2019): VOLUME 20, NUMBER 1, April 2019
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Hepatitis B virus (HBV) infection is a global public health problem. Prison populations are at high risk for HBV transmission. In Prison, there is very rare to perfom screening for hepatitis B. This study aims to determine the prevalence of HBV infection among male prisoners in Malang, East Java Province of Indonesia.Method: In this cross sectional study, a total of 165 male prisoners were screened using rapid test (DiaSpot® test kit) for detection of HbsAg in serum samples.Results: The risk factors for HBV transmission were had permanent tattoo (11.32%), multiple sex partner (6.67%), injecting drug users (24.32%), history of blood tranfusion (4.76%), and family history of hepatitis (9.37%). There are 101 subjects (61.2%) for negative anti-HBs result. Positive result for HBsAg and anti-HBs were 7.8% and 30.9% respectively.Conclusion: The prevalence of HBV infection among male prisoners was 7.8%. It is suggested to perfom HBV infection screening on high risk population routinely.

Page 27 of 78 | Total Record : 771

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Murdani Abdullah

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ina.jghe@gmail.com

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Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

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Dki jakarta

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Abstract

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Murdani Abdullah

Contact Email ina.jghe@gmail.com

Phone +6285891498517

Journal Mail Official ina.jghe@gmail.com

Editorial Address Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

Location Kota adm. jakarta pusat, Dki jakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Murdani Abdullah

Contact Email
ina.jghe@gmail.com

Phone
+6285891498517

Journal Mail Official
ina.jghe@gmail.com

Editorial Address
Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA