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Murdani Abdullah
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Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia
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INDONESIA
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Published by The Indonesian Society for Digestive Endoscopy
ISSN : 14114801     EISSN : 23028181     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.
Arjuna Subject : Kedokteran - Ilmu Pencernaan
Articles 785 Documents
 75   76   77   78   79 
Effectiveness of Combination Therapy of Stereotactic Body Radiation Therapy with Lenvatinib in Advanced Hepatocellular Carcinoma Putri, Alifia Sabira; Nuriasti, Rovera; Pambudi, Balqis Prudena Kurnia; Fauzan, Naufal Revaldy; Maudina, Baiq Zaskia; Prawira, Yoga; Larasati, Anak Agung Ayu Regina; Budyono, Catarina
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, August, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025168-175

Abstract

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a high mortality rate, especially in advanced stages. Treatment of advanced HCC remains a significant challenge due to limited effective therapeutic options. This study examines the effectiveness of combining Stereotactic Body Radiation Therapy (SBRT) and Lenvatinib in advanced HCC patients. SBRT is a high-precision radiation technique that allows high-dose irradiation of tumor targets with minimal damage to surrounding healthy tissues. At the same time, Lenvatinib is a multikinase inhibitor that inhibits several critical molecular pathways in angiogenesis and tumor cell proliferation. The results showed that the combination of SBRT and Lenvatinib significantly improved overall survival (OS) by reducing the risk of death by 63%, progression-free survival (PFS) reduced the risk of tumor progression by 67%, intrahepatic tumor progression-free survival (IHPFS) showed a decrease of 71%, objective remission rate (ORR) was also higher in the combination group (56.8%), and disease control rate (DCR) of 91.9% which was higher than the use of Lenvatinib alone. However, this combination therapy also carries a higher risk of side effects, including hypertension and diarrhea, which require close monitoring and dose adjustment. This study suggests combining SBRT and Lenvatinib may be a more practical approach to treating advanced HCC. However, the treatment strategy needs to be tailored to the patient's condition to minimize the risk of toxicity.
CTC or CEA: Choosing Reliable Markers for Metastatic Colorectal Cancer Miftahussurur, Prof. Dr. dr. Muhammad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025201-203

Abstract

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Hepatogenous Diabetes: A Comprehensive Overview Prasetya, Ignatius Bima; Sandra, Sharon
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025268-273

Abstract

Cirrhosis is the advanced stage of liver disease, marked by the presence of liver fibrosis. Cirrhosis serves as a risk factor for various metabolic conditions, including hypoglycemia and hyperglycemia. Although the pathophysiology remains unclear, hyperglycemia can occur due to the interaction of various factors, such as insulin resistance. The prevalence of both diabetes mellitus and cirrhosis is increasing, and their interaction influences each other’s outcomes. Hepatogenous diabetes (HD) refers to diabetes mellitus that develops in patients with cirrhosis. HD is diagnosed using an oral glucose tolerance test, which typically reveals elevated postprandial blood glucose levels. The management of HD follows the same principles as diabetes mellitus treatment; however, pharmacological therapy should be individualized based on the patient’s liver function to ensure optimal outcome. The objective of this review is to provide a comprehensive discussion of HD, encompassing its pathophysiology, clinical implications, diagnostic approaches, and management strategies. 
Remdesivir-Induced Hepatotoxicity: A Systematic Review of Clinical Evidence, Pharmacokinetics, and Safety Concerns Hamdan, Angkasa Ramatuan; Bestari, Muhamad Begawan; Girawan, Dolvy; Agustanti, Nenny; Husain, Okky; Hasan, Nadeem S.
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025228-236

Abstract

Background: Remdesivir is widely used for the treatment of COVID-19, with its potential benefits currently under investigation. Concerns remain regarding its potential hepatotoxic side effects. Drug-drug interactions, specifically with CYP3A4 and P-glycoprotein inhibitors, may worsen hepatotoxicity. In this context, dexamethasone has been suggested to mitigate liver injury, but the role remains unclear. Therefore, this study aimed to explore the characteristics, mechanisms, and risk factors of remdesivir-induced hepatotoxicity through a systematic review of case reports.Methods: A systematic review was conducted using databases such as PubMed, Scopus, EBSCO, and BMJ Case Reports for cases published from 2020 to 2024. The keywords used were “remdesivir,” “hepatotoxicity,” “COVID-19,” and “liver failure.” Relevant case reports were selected based on predefined inclusion and exclusion criteria. Furthermore, data were extracted following the Joanna Briggs Institute (JBI) checklist for case reports.Results: Among 46 individual articles screened after the removal of duplicates, five that detailed a total of six patients were eligible for inclusion. Hepatotoxicity was frequently reported in elderly patients and those with chronic liver disease. Drug-drug interactions that include remdesivir and CYP3A4 inhibitors increased the risk of liver injury. Based on observation, dexamethasone was associated with reduced hepatotoxicity, primarily due to its anti-inflammatory effects. In patients with ALT 5× ULN, remdesivir administration was controversial. Some cases showed improvement, and others required discontinuation due to severe liver dysfunction.Conclusion: This study emphasized the necessity for safety evaluations and standardized liver function monitoring in patients receiving remdesivir. Further investigation is essential to define clinical guidelines and improve patient safety in antiviral treatments.
Capsule Endoscopy as a Diagnostic Tool for Inflammatory Bowel Disease in a Patient with Multiple Myeloma Rizkiawan, Naufali; Mahmudah, Isna; Miftahussurur, Muhammad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025280-286

Abstract

Capsule endoscopy is an important tool for minimally invasive evaluation of the small bowel, allowing improved diagnostic yield with low complication rates relative to traditional modalities. Here, we present the first case of inflammatory bowel disease (IBD) diagnosed by a capsule endoscopy in Surabaya. There was a case of a patient who suffered chronic diarrhea for four months. When the patient experienced persistent diarrhea, generalized weakness was then reported as a symptom. The patient then received a conventional endoscopy and was planned for a colonoscopy. However, the endoscopy was canceled due to the patient's respiratory distress. The patient underwent capsule endoscopy, where hyperemia and erosion from the small intestine to the colon were found. The diagnosis of IBD was established and the patient was given sulfasalazine 500 mg every 24 hours. In order to image the small intestine endoscopically, capsule endoscopy remains to be the preferred method. This case serves as an example of the advantages of capsule endoscopy, especially in terms of the diagnosis of inflammatory bowel disease.
Unraveling the Potential Role of Probiotics in Ameliorating Hyperuricemia Darmawan, Guntur
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025274-279

Abstract

Hyperuricemia has gained clinical interest due to emerging evidence of its association with various diseases, such as hypertension, diabetes mellitus, cardiovascular disease, chronic kidney disease, and fatty liver. Gut dysbiosis has been suggested to be linked to hyperuricemia, as the gastrointestinal tract is responsible for approximately one-third of the total human uric acid excretion. Alterations in gut microbiota composition have been observed in individuals with hyperuricemia.. Probiotics have regained popularity due to their beneficial health effects, and several studies have shown their potential as a dietary intervention for hyperuricemia. This review aims to examine the intestinal dysbiosis in individuals with hyperuricemia and explore the role of probiotics in ameliorating uric acid levels.
Spleen Stiffness Measurement as a Predictor of Advanced Liver Fibrosis in Chronic Hepatitis B Patients Hertanto, Carisa Irene; Maimunah, Ummi; -, Aryati; Miftahussurur, Muhammad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025237-244

Abstract

Background: Chronic hepatitis B is a viral infection that may progress to liver fibrosis. Progressive fibrosis increases portal pressure, leading to elevated spleen stiffness. Although inflammatory reactions and mechanical cholestasis affect liver stiffness, the effect is comparatively limited. Therefore, this study aims to analyze spleen stiffness as a noninvasive marker of liver fibrosis and evaluate the correlation between spleen and liver stiffness.Methods: A retrospective cross-sectional study was performed on chronic hepatitis B patients. Fibroscan was used to measure liver and spleen stiffness. Liver fibrosis was categorized as nonsignificant (F0–F1), significant (F2–F3), and advanced (F4). Correlations between spleen stiffness and liver fibrosis stages were assessed using Spearman’s test, with p 0.05 considered statistically significant. Results: The results showed that 127 patients were eligible for analysis, predominantly male (71.7%), with a mean age of 46.4 ± 9.8 years. The median spleen and liver stiffness were 25.5 kPa (range 5.6–100) and 9.4 kPa (range 2.4–75), respectively. Moreover, spleen stiffness had a positive correlation with liver stiffness (Spearman r = 0.503; p 0.001) and liver fibrosis stages (Spearman r = 0.479; p 0.001). The optimal cutoff for spleen stiffness in predicting advanced fibrosis was 28 kPa, with an area under the receiver operating characteristic curve(AUROC) of 0.816, sensitivity of 0.739, and specificity of 0.753.Conclusion: Spleen stiffness is significantly correlated with liver fibrosis severity. A cutoff of 28 kPa was identified for advanced fibrosis, suggesting spleen stiffness measurement serves as a promising alternative to biopsy.
A Case Study on Rare Occurance of Geriatric Intussusception with Lipoma as The Leading Point Risdiarta, Rosalia Septaviana; Guanawan, Jimmy Indarto; Nugroho, Daniel C.A.; Prastoatmodjo, Radityo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025287-292

Abstract

Intussusception is commonly found in the early years of infancy but is considered rare in adult patients. There are no specific symptoms for intussusception in adults, as it is typically seen in infants; hence, radiology imaging is a major key to determining the diagnosis. We presented a case where a 77-year-old male patient presented with persistent abdominal pain, distension, and bloody stool 4 days before an emergency department (ED) visit. The patient was referred from another healthcare facility after receiving a normal result of USG. A 3-view abdominal x-ray was performed, which revealed ileus with large bowel obstruction. The abdominal CT-scan later revealed a sausage-like sign, suggestive of a colo-colic intussusception with a large mass of fat as the leading point and pneumo-peritoneum. Abdominal CT-Scan showed the detailed imaging of how and where the intussusception is occurring and what seems to be the root problem. The laparotomy surgery report also confirmed the colo-colic intussusception with lipoma as the primary cause. Hence, radiology plays a crucial role in diagnosing the tumor leading to intussusception in the preoperative setting. Among the imaging techniques, abdominal CT scan has emerged as the preferred method due to its high sensitivity and ability to provide detailed information, which is essential for therapeutic management. This case report aimed to highlight the importance of radiological imaging, particularly abdominal CT scan, in diagnosing adult intussusception with a neoplastic leading point, and to present a rare case of colo-colic intussusception caused by a lipoma in an elderly patient.
The Potential of Alpha-Lipoic Acid Supplementation for Non-Alcoholic Fatty Liver Disease: A Systematic Review Prasetya, Alver; Tobian, Nikolaus; Tanjaya, Hendri; Tenggara, Riki; Loe, Luse
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025204-211

Abstract

Background: Insulin resistance, genetic susceptibility, oxidative stress, and inflammation lead to the development of non-alcoholic fatty liver disease (NAFLD). Alpha lipoic acid (ALA) has demonstrated benefits in enhancing insulin sensitivity and reducing inflammatory reactions in both human and animal studies. This study aims to determine the effectiveness of ALA against NAFLD.Methods: Detailed searches were conducted across several databases, including PubMed, CENTRAL, Europe PMC (medRxiv and bioRxiv), EBSCOhost (Medline), and ProQuest, using keywords such as lipoic acid, metabolic-associated fatty liver disease, steatohepatitis, and non-alcoholic fatty liver disease. Risk of bias was assessed using the Cochrane risk-of-bias tool for randomized trials.Result: Four studies were included in which the ALA effect was compared with placebo or no intervention. A significant reduction in BMI (p0.001), lipid profiles (p0.05), glycemic markers (p0.05), liver enzymes (p0.05), oxidative stress (p0.05), and fibrosis score (p0.05) was seen in NAFLD patients with ALA supplementation.Conclusion: This study shows that ALA may help manage NAFLD. However, further research is required to establish robust evidence.
The Role of Circulating Tumour Cells and Carcinoembryonic Antigen as Diagnostic Tool for Metastatic Colorectal Cancer in Indonesia Angraeni, Sri; Abdullah, Murdani; Hasan, Irsan; Rinaldi, Ikhwan; Fauzi, Achmad; Martin, Cleopas; Shatri, Hamzah; Irawan, Cosphiadi; Nursyirwan, Saskia Aziza; Ibrahim, Febiansyah; Siregar, Lianda; Loho, Imelda Maria; Waspodo, Agus Sudiro; Margaluta, Ariansah; Firsyada, Fajar; Darnindro, Nikko; Lutfiah, Evah; Tanadi, Caroline; Ilyas, Mohammad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025245-254

Abstract

Background: Patients with metastatic colorectal cancer (CRC) have a poor prognosis, with a 5-year survival rate of only 14%. Early detection and early intervention may improve outcome. Both circulating tumour cells (CTC) and serum carcinoembryonic antigen (CEA) have been suggested as diagnostic biomarkers for metastatic CRC. This study explored the performance of CTC and CEA as a tools for the detection of metastatic colorectal cancer in Indonesia.Methods: This study was conducted from December 2024 to April 2025 on metastatic colorectal cancer patients from three hospitals in Jakarta. CTC was analysed using the gradient density method and flow cytometry. CEA was analysed using chemiluminescent microparticle immunoassay.Results: This study recruited 160 patients with colorectal cancer patients of whom, 45% were known to have metastatic colorectal cancer. The median age was 57 (47—66) years and analysis was done at one time point only. The area under the curve (AUC) for CTC, CEA, and the combination of both CTC and CEA in diagnosing metastatic colorectal cancer was 0.579, 0.811, and 0.703, respectively. CTC showed 56.94% sensitivity and 50.00% specificity in detecting metastatic colorectal cancer. Meanwhile, CEA showed higher sensitivity (72.22%) and specificity (72.72%). Combination of both CTC and CEA increased sensitivity to 91.67%, but with a lower specificity of 37.50%. The optimal cut-off for CTC and CEA were 34.5 cells/3 ml and 18.31 ng/ml, respectively.Conclusion: CEA showed a better performance than CTC in diagnosing metastatic colorectal cancer. Combination of CTC and CEA showed promising potential as a valuable surveillance tool for detecting metastasis in colorectal cancers, but not as a primary diagnostic tool. 

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