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Farmasains : Jurnal Farmasi dan Ilmu Kesehatan
Published by Universitas Muhammadiyah Malang
ISSN : 20863373     EISSN : 2620987X     DOI : 10.22219
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Farmasains publishes articles that cover textual and fieldwork studies with various perspectives of pharmacy science including: Pharmaceutical Technology Pharmaceutical Chemistry Biology Pharmacy and Natural Products Pharmacology and Toxicology Clinical Pharmacy Community Pharmacy Pharmacoepidemiology Pharmacogenomic and Pharmacogenetic Pharmacoeconomic Health-related topics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 8 Documents
 1 
Search results for , issue "Vol 4, No 2 (2019): November" : 8 Documents clear
Factors affecting in the use of antihipertension drugs with the health belief model approach in Puskesmas Pandanwangi Malang Hidayati, Ika Ratna; Putri, Cikita
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (481.893 KB) | DOI: 10.22219/farmasains.v4i2.10071

Abstract

Hypertension is a condition where systolic blood pressure is 140 mmHg or higher, and diastolic blood pressure is 90 mmHg or higher. Generally, hypertension patients use captopril and Amlodipin as treatment of hypertension. It is necessary to take various efforts to improve the obedience of hypertensive patients during drug therapy. One theory studies that obedience behavior is the Health Belief Model. The HBM theory covers perceived susceptibility, severity, benefits, and barrier, along with self-efficacy. To investigate factors affecting the obedience of hypertensive patients during the antihypertensive captopril and amlodipine medications treatment in the Puskesmas Pandanwangi, Malang, this study using the approach of HBM theory and instrument. Sampling was done through a purposive and accidental sampling method. The data analysis was done through multivariate analysis, which used multiple regression to determine the effecting factors based on the HBM theory on the obedience of hypertensive patients during the antihypertensive captopril and amlodipine medications therapy. Factors of HBM theory that affect the obedience of hypertensive patients are self-efficacy, perceived severity, and perceived barrier. Whereas, the unaffected factor are perceived suspectibility and perceived benefits. Overall, factors of HBM theory affect obedience.
Isolation of terpenoid compound of n-hexane extract of Marsilea crenata Presl.. Ma'arif, Burhan; Agil, Mangestuti; Widyowati, Retno
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1419.172 KB) | DOI: 10.22219/farmasains.v4i2.10717

Abstract

Isolation, identification, and structure elucidation of terpenoid compounds from an n-hexane extract of Marsilea crenata Presl., had been done. The leaves of M. crenata was extracted using n-hexane solvent. The extract then separated with vacuum column chromatography and open column chromatography to obtain the isolate. Furthermore, the isolate was identified and elucidated using UV-Vis, FT-IR, 1H-NMR, 13C- NMR, and 2D-NMR (COSY, HMQC, and HMBC). The identification and elucidation of the isolated structure from an n-hexane extract of M. crenata leaves indicate the isolate was a pentacyclic triterpenoid. 
Benefit administration of vitamin B1, B6, and B12 on the depression symptom in hemodialysis patients Pinzon, Rizaldy Taslim; Ardiani, Birgitta Lisbethiara
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1279.788 KB) | DOI: 10.22219/farmasains.v4i2.8919

Abstract

Chronic kidney disease (CKD) is a disease that causes a decrease in kidney function, which can be seen from GFR (Glomerulus Filtration Rate) value, which is less than 60 ml/minute/1.73 m2 in minimum three months. Depression is a psychological problem in a patient with chronic kidney disease undergoing hemodialysis. The previous study has shown that giving vitamin B combination can improve depression symptoms. To measure the benefit of vitamin B1, B6, B12 parenterally for depression symptoms in chronic kidney disease patients undergoing hemodialysis. This study used an experimental design (one group pre and post-test) in 117 patient that obtained using a consecutive sampling method. Depression score was measured by the HADS questionnaire before given vitamin B (pre-test) and after given vitamin B (post-test). Data were statistically analyzed using a licensed SPSS program with paired t-test/Non-Parametric Wilcoxon. The relationship between the history of the use of the antihypertensive, antidiabetic, folic acid drug, and depression scores were not showing significant results (p > 0.05). The relationship between administration of vitamins B1, B6, and B12 and the patient's depression score showed a decrease but not significant (p = 0.522). There was no significant difference after the administration of vitamin B1, B6, and B12 on the depression score of patients with chronic kidney disease undergoing hemodialysis at Bethesda and Panti Rapih Hospital in Yogyakarta.
Transdermal delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): a mini review Nugraheni, Raditya Weka
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (469.334 KB) | DOI: 10.22219/farmasains.v4i2.11369

Abstract

The transdermal route has several advantages over the oral route, especially for the drugs which significantly experience the first-pass effect in the liver. Another advantage of drug administration via the transdermal route is its non-invasive way and can be used by patients themselves. Also, it allows long-term use, thereby increasing patient compliance and is generally inexpensive. The development of transdermal preparation itself is not easy because of the permeability factor of drug ingredients through the skin is relatively low compared to the gastrointestinal route or mucous membrane because the skin is part of the body's defense system and prevents foreign materials to entering the body. The biggest challenge for drug administration via the transdermal route is that the limitations of drugs can be administrated through this route. NSAIDs are drugs that are widely used in chronic conditions and can cause serious gastrointestinal side effects. Therefore the transdermal route is expected to be a promising alternative in the future. The drug-loaded nanoparticle delivered using the iontophoresis method can improve the bioavailability of NSAIDs via the transdermal route.
Antidiabetic activities of 96% ethanol extract of Abelmoschus esculentus on Balb-C mice strain Aditama, Agnis Pondineka Ria
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1183.384 KB) | DOI: 10.22219/farmasains.v4i2.10718

Abstract

Diabetes mellitus (DM) is a progressive metabolic disease that continues to increase every year. Treatment therapy using oral hypoglycemic drugs to treat DM has side effects, and alternative approaches must be taken. Abelmoschus esculentus has been known to be used as an alternative to DM because it has antioxidant activity due to its high flavonoid content. The purpose of this study was to determine the antidiabetic activity of 96% ethanol extract of Okra leaves against male mice of balb-c strain. Male mice were acclimatized for seven days and divided into five test groups and then fasted for 18 hours. Then the mice were induced with 150 mg / 20 g BW alloxan and measured on the 3rd day. Ethanol extract 96% okra leaves were then given in a dose of 5.6 mg / 20g BW; 11.2 mg / 20g BW; 22.4 mg / 20g BW, CMC Na 0.5% as negative control and glibenclamide 0.026 mg / 20g BBs as positive control for 14 days. The results of therapy with 96% ethanol extract of okra leaves can reduce blood glucose levels in mice so that the okra leaves contain flavonoid compounds that have antioxidant activity and can reduce blood glucose levels.
Phytochemical screening and determination of total phenolic and total flavonoid contents of pear peel extracts Patricia, Vinda Maharani; Saputri, Fauzia Ningrum
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i2.10166

Abstract

The study was carried out to investigate the presence of different phytochemicals as well as to determine the total phenolic and flavonoid contents of green pear/european pear peels and yellow pear/asian pear peels. Phytochemical screening of the pear peels was carried out following standard protocols. Total phenolic content was determined by Folin-Ciocalteu method and total flavonoid contents was determined by Aluminum Chloride Colorimetric method, measured using n-hexane, etil acetate, and methanol. Phenolics, flavonoids, tannins, alkaloids, and saponins are present in green pear and yellow pear peels. The total phenol and flavonoid contents are highest in methanol extracts in which green pear peels have a higher concentration than yellow pear peels. In conclusion, the green and yellow pear peels are rich in phenolic compounds and have great potential as natural antioxidants. Therefore, the results of this research should be considered to provide the possibility for future developments of highly functional antioxidants.
The correlation of cough medicine advertisement in television on community self-medication in Krajan Sae Beji Village Junjero Batu City (Based on BPOM Head Regulation Number 8 in 2017) Titani, Mutiara; Hidayat, Rahmat; Hidayati, Ika Ratna
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i2.12505

Abstract

Self-medication is an action treat by taking its own actions from assessing complaints and symptoms and drug selection. In doing self-medication, the community must have knowledge of the symptoms and drugs obtained from several sources, for example in television advertising. So this research’s goals is to determine the relationship of cough medicine advertisements on television to self-medication attitudes in Krajan Sae Hamlet, Beji Village, Junrejo Subdistrict, Batu City. This research is a descriptive study with  quantitative approach. Using instrument validated questionnaires. The sampling technique used is incidental sampling. The number of samples used refers to the Slovin’s formula with 97 respondents. To process this research the researcher use SPSS and Ms. Excel to get the correlation between cough medicine advertisements on television with public self-medication actions, influential indicators and linear regression results. The indicator that give influence of self-medication is indicator that is not misleading because it has the largest t count value of 2,360 with t table value 1,988 (df = 95). Regression  obtained by the results of simple linear regression equations namely Y = 7.618 + 0.303x. It means that, self-medication for cough medicines advertised on television will increase by 0.303 (b) units for each addition of one drug  unit. The results of the correlation study were analyzed using Ms. Excel obtained the results of r count 0.298 (N = 97, alpha = 0.05), with r table 0.195 (N = 100, alpha = 0.05). So that the value of r count > r table so Ho is rejected and Ha is accepted. It can be concluded that there is a relationship between cough medicine self-medication and television cough drug advertisement in Krajan Sae Hamlet, Beji Village, Junrejo Subdistrict, Batu City. 
Lavender aromatherapy inhalation to reduce menstrual pain in teenagers Azizah, Nurul
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i2.12507

Abstract

One way to reduce the pain of dysmenorrhea with non-pharmacological therapy is lavender aromatherapy. The purpose of this research is to find out the picture of lavender aromatherapy inhalation in decreasing the intensity of primary dysmenorrhea pain. The research method uses quasi experiment with pre-post test non equivalent control group design. Analysis using independent sample T-test. The number of repondent 30 adolescents who experience dysmenorrhea pain on 1-2 days early menstruation according to inclusion criteria. pain measurement before and after lavender aromatherapy inhalation intervention using the VAS (Visual Analog Scale) pain scale then comparing the difference in the pretest and post test values.The results showed that prior to treatment, the intensity of dysmenorrhea pain was 8.53 and after being treated in the form of lavender aromatherapy inhalation there was a decrease in pain intensity with an average of 3.77. From the statistical results using the Independent Sample T Test, P values <0.002 with 95% C.I. -1,532 - (- 0.430). This shows that the decrease in pain intensity score of dysmenorrhea after inhalation of Lavender aromatherapy (Lavendula Augustifolia) is significant. Conclusion Most teenagers experience a decrease in pain after being given inhalation lavender aromatherapy. Suggestions for further researchers so that larger respondents so the results are more representative.

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