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UPT Publikasi Ilmiah, Universitas Islam Bandung. Jl. Tamansari No. 20, Bandung 40116, Indonesia, Tlp +62 22 420 3368, +62 22 426 3895 ext. 6891
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Bandung Conference Series: Pharmacy
Published by Universitas Islam Bandung
ISSN : -     EISSN : 28282116     DOI : https://doi.org/10.29313/bcsp.v2i2
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology Public Health
Bandung Conference Series: Pharmacy (BCSP) menerbitkan artikel penelitian akademik tentang kajian teoritis dan terapan serta berfokus pada Farmasi dengan ruang lingkup Airlock system Kanker, Alcohol, Antelmintik, Antigastritis drugs, Antioksidan, Artemia franciscana, Ascaris suum, Cacing babi (Ascaris suum Goeze), Contact Bioautography TLC, Daun cincau hijau (Cyclea barbata Miers), Daun kelor (Moringa oleifera Lam), Diabetes mellitus, DPPH Flavonoid, Fenilpropanolamin, Fermentasi, Flavonoid, Flavonol,Iles-iles, Isolasi, Lichen, Malassezia furfur, Metode Brine Shrimp Lethality Test (BSLT), Obat antidiabetes (OAD) Propionibacterium acnes, Obat tradisional, Parkia Speciosa Antibakteri, Pektin, Propionibacterium Acnes, Pseudoefedrin, Saccharomyces Cerevisiae, Spektrofotometri uv sinar tampak, Staphylococcus epidermidis, uji aktivitas antibakteri, Uji sitotoksik, Usnea baileyi. Prosiding ini diterbitkan oleh UPT Publikasi Ilmiah Unisba. Artikel yang dikirimkan ke prosiding ini akan diproses secara online dan menggunakan double blind review minimal oleh dua orang mitra bebestari.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 1 Documents
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Sintesis Tripeptida (Asp–His–Gly) Menggunakan Metode (SPPS) sebagai Kandidat Aktivitas Antioksidan Muhamad Adziana Ramadhan; Nety Kurniaty; Farendina Suarantika
Bandung Conference Series: Pharmacy 113 - 120
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.24563

Abstract

Abstract. Bioactive peptides have attracted considerable attention due to their potential antioxidant activity. This study aimed to synthesize the Asp–His–Gly tripeptide using the Solid Phase Peptide Synthesis (SPPS) method, characterize the synthesized product, and evaluate its antioxidant activity. The tripeptide was synthesized on 2-chlorotrityl chloride (2-CTC) resin using the Fmoc strategy through coupling, deprotection, capping, and cleavage steps. The crude peptide was characterized by High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS), while antioxidant activity was determined using the DPPH radical scavenging assay at 517 nm. HPLC analysis indicated that the synthesized product still contained several impurity peaks. The mass spectrum exhibited a dominant peak at m/z 385. The synthesized tripeptide showed weak antioxidant activity with an IC₅₀ value of 421.783 ppm, which was lower than that reported for the Asp–His–Gly peptide obtained from enzymatic hydrolysis of chickpea protein. The SPPS method successfully synthesized the Asp–His–Gly tripeptide; however, further optimization of coupling, deprotection, and purification is required to improve product purity and antioxidant activity. Abstrak. Peptida bioaktif merupakan senyawa yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mensintesis tripeptida Asp–His–Gly menggunakan metode Solid Phase Peptide Synthesis (SPPS), mengkarakterisasi produk sintesis, serta mengevaluasi aktivitas antioksidannya. Sintesis dilakukan pada resin 2-klorotritil klorida (2-CTC) dengan strategi Fmoc melalui tahapan pengkoplingan, deproteksi, capping, dan cleavage. Produk sintesis dikarakterisasi menggunakan Kromatografi Cair Kinerja Tinggi (KCKT) dan spektrometri massa (MS), sedangkan aktivitas antioksidan diuji menggunakan metode DPPH pada panjang gelombang 517 nm. Kromatogram KCKT menunjukkan masih adanya beberapa puncak pengotor, sedangkan spektrometri massa menghasilkan puncak dominan pada m/z 385. Tripeptida hasil sintesis memiliki aktivitas antioksidan lemah dengan nilai IC₅₀ sebesar 421,783 ppm, lebih rendah dibandingkan dengan peptida Asp–His–Gly hasil hidrolisis enzimatik protein kacang arab. Metode SPPS berhasil menghasilkan tripeptida Asp–His–Gly, namun diperlukan optimasi tahap pengkoplingan, deproteksi, dan pemurnian untuk meningkatkan kemurnian serta aktivitas antioksidan.

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