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UPT Publikasi Ilmiah, Universitas Islam Bandung. Jl. Tamansari No. 20, Bandung 40116, Indonesia, Tlp +62 22 420 3368, +62 22 426 3895 ext. 6891
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Bandung Conference Series: Pharmacy
Published by Universitas Islam Bandung
ISSN : -     EISSN : 28282116     DOI : https://doi.org/10.29313/bcsp.v2i2
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology Public Health
Bandung Conference Series: Pharmacy (BCSP) menerbitkan artikel penelitian akademik tentang kajian teoritis dan terapan serta berfokus pada Farmasi dengan ruang lingkup Airlock system Kanker, Alcohol, Antelmintik, Antigastritis drugs, Antioksidan, Artemia franciscana, Ascaris suum, Cacing babi (Ascaris suum Goeze), Contact Bioautography TLC, Daun cincau hijau (Cyclea barbata Miers), Daun kelor (Moringa oleifera Lam), Diabetes mellitus, DPPH Flavonoid, Fenilpropanolamin, Fermentasi, Flavonoid, Flavonol,Iles-iles, Isolasi, Lichen, Malassezia furfur, Metode Brine Shrimp Lethality Test (BSLT), Obat antidiabetes (OAD) Propionibacterium acnes, Obat tradisional, Parkia Speciosa Antibakteri, Pektin, Propionibacterium Acnes, Pseudoefedrin, Saccharomyces Cerevisiae, Spektrofotometri uv sinar tampak, Staphylococcus epidermidis, uji aktivitas antibakteri, Uji sitotoksik, Usnea baileyi. Prosiding ini diterbitkan oleh UPT Publikasi Ilmiah Unisba. Artikel yang dikirimkan ke prosiding ini akan diproses secara online dan menggunakan double blind review minimal oleh dua orang mitra bebestari.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 1 Documents
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Search results for , issue "217-226" : 1 Documents clear
Formulasi dan Evaluasi Patch Antijerawat Mengandung Nanoemulsi Tea Tree Oil Berbasis Kitosan Fanny Handayani; Purwaeni Purwaeni; Hanifa Rahma
Bandung Conference Series: Pharmacy 217-226
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.24483

Abstract

Abstract. Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit associated with the proliferation of Cutibacterium acnes. Tea tree oil (TTO) derived from Melaleuca alternifolia exhibits antibacterial and anti-inflammatory properties; however, its application is limited due to volatility and poor stability. This study aimed to develop a chitosan-based TTO nanoemulsion patch and evaluate its physicochemical properties, stability, and antibacterial activity against C. acnes. The research was conducted experimentally through TTO characterization using GC-MS, nanoemulsion preparation with Tween 80 and propylene glycol, optimization using a 2² factorial design, and patch preparation using the solvent casting method. The optimized nanoemulsion was obtained using 25% Tween 80 and 25% propylene glycol, resulting in a transmittance value of 99.629%. The nanoemulsion showed favorable characteristics, including a particle size of 11.6 ± 0.265 nm, PDI of 0.048 ± 0.039, pH of 6.44 ± 0.0794, viscosity of 79.167 ± 0.971 cPs, pseudoplastic flow behavior, and good thermodynamic stability. The best patch formulation was Formula 3 containing 10% gelatin, based on physical evaluation and stability assessment. However, the TTO nanoemulsion patch did not exhibit antibacterial activity against C. acnes, indicating that the active compound release from the patch matrix was not yet optimal. Further studies on drug release profiles are required to improve the effectiveness of the topical delivery system. Abstrak. Jerawat (Acne vulgaris) merupakan penyakit inflamasi kronis pada unit pilosebasea yang melibatkan proliferasi Cutibacterium acnes. Tea tree oil (TTO) dari Melaleuca alternifolia memiliki potensi sebagai antibakteri dan antiinflamasi, tetapi penggunaannya terbatas karena sifat volatil dan stabilitas yang rendah. Penelitian ini bertujuan untuk mengembangkan patch nanoemulsi TTO berbasis kitosan serta mengevaluasi karakteristik fisik, stabilitas, dan aktivitas antibakterinya terhadap C. acnes. Penelitian dilakukan secara eksperimental melalui karakterisasi TTO menggunakan GC-MS, formulasi nanoemulsi dengan Tween 80 dan propilen glikol, optimasi menggunakan desain faktorial 2², serta pembuatan patch dengan metode solvent casting. Hasil penelitian menunjukkan formula optimum nanoemulsi diperoleh pada konsentrasi Tween 80 25% dan propilen glikol 25% dengan nilai transmitan 99,629%. Nanoemulsi memiliki karakteristik fisik yang baik dengan ukuran partikel 11,6 ± 0,265 nm, PDI 0,048 ± 0,039, pH 6,44 ± 0,0794, viskositas 79,167 ± 0,971 cPs, sifat alir pseudoplastis, serta stabil secara termodinamika. Formula terbaik patch diperoleh pada Formula 3 dengan kandungan gelatin 10% berdasarkan evaluasi mutu fisik dan stabilitas. Namun, patch nanoemulsi TTO belum menunjukkan aktivitas antibakteri terhadap C. acnes karena belum terjadi pelepasan zat aktif yang optimal dari matriks patch. Penelitian lanjutan mengenai profil pelepasan zat aktif diperlukan untuk meningkatkan efektivitas sistem penghantaran.

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