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Bandung Conference Series: Pharmacy
Published by Universitas Islam Bandung
ISSN : -     EISSN : 28282116     DOI : https://doi.org/10.29313/bcsp.v2i2
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology Public Health
Bandung Conference Series: Pharmacy (BCSP) menerbitkan artikel penelitian akademik tentang kajian teoritis dan terapan serta berfokus pada Farmasi dengan ruang lingkup Airlock system Kanker, Alcohol, Antelmintik, Antigastritis drugs, Antioksidan, Artemia franciscana, Ascaris suum, Cacing babi (Ascaris suum Goeze), Contact Bioautography TLC, Daun cincau hijau (Cyclea barbata Miers), Daun kelor (Moringa oleifera Lam), Diabetes mellitus, DPPH Flavonoid, Fenilpropanolamin, Fermentasi, Flavonoid, Flavonol,Iles-iles, Isolasi, Lichen, Malassezia furfur, Metode Brine Shrimp Lethality Test (BSLT), Obat antidiabetes (OAD) Propionibacterium acnes, Obat tradisional, Parkia Speciosa Antibakteri, Pektin, Propionibacterium Acnes, Pseudoefedrin, Saccharomyces Cerevisiae, Spektrofotometri uv sinar tampak, Staphylococcus epidermidis, uji aktivitas antibakteri, Uji sitotoksik, Usnea baileyi. Prosiding ini diterbitkan oleh UPT Publikasi Ilmiah Unisba. Artikel yang dikirimkan ke prosiding ini akan diproses secara online dan menggunakan double blind review minimal oleh dua orang mitra bebestari.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
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Search results for , issue "209 - 216" : 1 Documents clear
Kajian Strategi Formulasi SNEDDS dan SMEED Ekstrak Jahe dan Senyawa Bioaktifnya Tri Awalani sapa'ati Gusti; Ratih Aryani; Sani Ega Priani
Bandung Conference Series: Pharmacy 209 - 216
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.24718

Abstract

Abstract. Ginger (Zingiber officinale) extract and its bioactive compounds, such as 6-gingerol and 6-shogaol, have various pharmacological activities. However, their oral use is still hampered by low bioavailability. This study aims to analyze the formulation strategies of self-nanoemulsifying drug delivery systems (SNEDDS) and self-microemulsifying drug delivery systems (SMEDDS) to increase the bioavailability of ginger extract and its bioactive compounds. The study was conducted using a systematic literature review (SLR) method with secondary data sources obtained from PubMed, Scopus, Taylor & Francis, and Google Scholar for articles published in 2016-2026 according to inclusion and exclusion criteria. Data were analyzed descriptively through the extraction of formulation components, preparation characteristics, and pharmacokinetic profiles. The study results showed that formulations based on long- and medium-chain triglyceride oil, nonionic surfactants (Tween 80 and Cremophor), and PEG 400 or propanediol cosurfactants were able to produce droplet sizes of 13.10–73.06 nm with a polydispersity index value of less than 0.5. The SMEDDS formulation was proven to increase pharmacokinetic parameters, one of which was the area under the curve (AUC) by approximately 5.7 – 6,6  times compared to the compound without formulation, indicating increased bioavailability of the compound. Thus, the delivery of SNEDDS and SMEDDS is an effective formulation strategy to increase the bioavailability of ginger extract and its bioactive compounds. Abstrak. Ekstrak jahe (Zingiber officinale) dan senyawa bioaktifnya, seperti 6-gingerol dan 6-shogaol, memiliki berbagai aktivitas farmakologis. Namun, pemanfaatannya secara oral masih terkendala oleh bioavailabilitas yang rendah. Kajian ini bertujuan untuk menganalisis strategi formulasi self-nanoemulsifying drug delivery system (SNEDDS) dan self-microemulsifying drug delivery system (SMEDDS) dalam meningkatkan bioavailabilitas ekstrak jahe dan senyawa bioaktifnya. Penelitian dilakukan menggunakan metode systematic literature review (SLR) dengan sumber data sekunder yang diperoleh dari PubMed, Scopus, Taylor & Francis, dan Google Scholar terhadap artikel yang dipublikasikan pada tahun 2016–2026 sesuai dengan kriteria inklusi dan eksklusi. Data dianalisis secara deskriptif melalui ekstraksi komponen formulasi, karakteristik sediaan, serta profil farmakokinetika. Hasil kajian menunjukkan bahwa formulasi berbasis minyak trigliserida rantai panjang maupun rantai menengah, surfaktan nonionik (Tween 80 dan Cremophor), serta kosurfaktan PEG 400 atau propanadiol mampu menghasilkan ukuran droplet 13,10–73,06 nm dengan nilai indeks polidispersitas kurang dari 0,5. Formulasi SMEDDS terbukti meningkatkan parameter farmakokinetika, salah satunya area under the curve (AUC) hingga sekitar 5,7–6,6 kali dibandingkan dengan senyawa tanpa formulasi, yang menunjukkan peningkatan bioavailabilitas senyawa. Dengan demikian, penghantaran menggunakan SNEDDS dan SMEDDS merupakan strategi formulasi yang efektif untuk meningkatkan bioavailabilitas ekstrak jahe dan senyawa bioaktifnya.

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