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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Inflammatory Response of Annona Muricata Linn Leaves Extract in Colorectal Cancer Patients Ingrid Suryanti Surono
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
Publisher : Journal of Global Pharma Technology

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Abstract

Annona muricata L (AML) is a member of Annonaceae with antioxidant, anti-inflammatory and anticancer properties.  A randomized double blind placebo controlled pre post-trial on twenty colorectal cancer patients who had undergone primary tumor resection were conducted in two groups, each group was supplemented with A. muricata leaves extract, and maltose as placebo. Inflammatory responses were assessed using ELISA method. There is no significant difference between pre and post on cytokine and cyclooxygenase serum level, also between two groups. A strong significant correlation between serum level of TNF-α and IL-10 cytokine (coefficient correlation = 0.64, p = 0.01) and significant correlation between IFN-g and IL-10 (coefficient correlation = 0.47, p = 0.05) was found after 8 weeks AML supplementation, as shown by increasing of IL-10 production, in response to  TNF-α and IFN-γ in an inflammatory condition. This study  is  registered  in Clinical Trials.gov ID:  NCT02439580Keywords: Annona muricata L, inflammatory response, colorectal cancer, cytokine, cyclooxygenase, TNF-α, Interleukin-10, Acetogenin. 
The Association Between Brachial Ankle Pulse Wave Velocity and Left Ventric Mass Index In Patients With Hypertension Budi Susetyo Pikir
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: Arterial stiffness has been considered as a modest method in detecting the arterial burden that can trigger left ventricular hypertrophy in the heart. Increased left ventricle hypertrophy in hypertension patients is a predictor which has impact in the increase of morbidity and mortality. Objectives: We aimed to investigate the association between brachial ankle pulse wave velocity (BaPWV) and left ventricle mass index (LVMI) in patients with hypertension. Material and Methods: This study was conducted by collecting secondary data of 40 hypertension patients aged >40 years old, suffered from hypertension >1 year and have encountered brachial ankle pulse wave velocity test and echocardiography test. Results: There was a significant positive correlation between brachial ankle pulse wave velocity and left ventricle mass index in hypertension patients with r = 0.493 dan p = 0.001. Also, there was a significant correlation between BaPWV and Relative Wall Thickness with r = 0.404 and p = 0.01. There was a significant difference of LVMI value in males and females with the result of (117.78+22.70 and 100.15+16.82, p = 0.008). In contrast, there was no significant difference in BaPWV value in males and females (1865.63+322.29 and 1811.08+350.28). It was also obtained a significant correlation between age factor and systolic blood pressure with LVMI and BaPWV (r = 0.493, p = 0.001). Conclusions: There was significant positive correlation between BaPWV and LVMI in hypertension patients. The arterial stiffness was an indicator of increased left ventricle mass index in hypertension patients.Keywords: Brachial ankle pulse wave velocity, Left ventricle mass index, Hypertension, Heart.
Microencapsulation in Food Science and Biotechnology in Iraq Marwah Ali Oudah
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

microcapsules can release their contents at controlled speeds under specific conditions, and can protect the encapsulated product from light and oxygen. The microencapsulation consists of microparticles formed by a porous polymeric membrane containing an active substance. The material or mixtures of materials to be encapsulated can be covered or trapped within another material or system. A microcapsule consists of a semi-permeable, spherical, thin and strong membrane around a solid / liquid center. The materials used for encapsulation can be gelatin, fats, oils, gum arabic, calcium alginate, waxes, wheat starch, corn, rice, potatoes, nylon, cyclodextrin, maltodextrin, sodium caseinate, whey protein or protein of soy. The applications of microencapsulation are directed to the industry, it is given to the textile, metallurgical, chemical, food, cosmetics, pharmaceutical and medical industries. Among the techniques used to microencapsulate are spray drying, cooling drying, freeze drying, coacervation and extrusion. The substances that are microencapsulated can be vitamins, minerals, dyes, prebiotics, probiotics, nutraceutical flavors, antioxidants, odors, oils, enzymes, bacteria, perfumes, drugs and even fertilizers.Keywords: Encapsulation techniques in food, Encapsulation theory.
Study Some of the Risk Factors on Total Antioxidant Capacity in Iraqi Patients with Sporadic Colorectal Cancer Moaed E. Al-Gazally
Journal of Global Pharma Technology .
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Abstract

Colorectal cancer is one of the most frequent malignant diseases in the developed countries. It was reported that total antioxidant status is being play a very important roles in development of carcinogenesis. The aim of  this study to assess of some risk factors such as age, gender, obesity, and smoking status on total antioxidant status in patients with sporadic colorectal cancer in Iraq. This investigate was completed by using colorimetric method to measure of total antioxidant capacity (T-AOC) and assess the risk factors depending on the levels of T-AOC. All patients included in the present study were getting adjuvant chemotherapy regimen  and subdivided into two groups according to Duke´s classification of malignant into early stages A+B and advance stages C+D, cancer site (colon or  rectum), and according to the number of dose of chemotherapy regimen (half dose or total dose). The present study showed negatively correlation (r = -0.567) (p<0.05) between T-AOC and ages of patients with sporadic CRC (p< 0.001). The levels of T-AOC decreased in both ever and never smoking compared to control group (p< 0.05). The results showed highly significant difference (p< 0.001) of T-AOC levels between A+B and C+D groups depending on age. The levels of T-AOC was decreased markedly in patients with ages less than 50 years compared to ages more or equal 50 years in both combination stages A+B and C+D (the higher difference was observed in same age and different state). In conclusion the risk factors that studied in this work may be have the main role to decrease levels of T-AOC and in result will increase the probability of injury with colon and rectal cancer in Iraqi population.Keywords: Total antioxidant capacity, Smoking status, Sporadic Colorectal cancer, Adjuvant chemotherapy, Obesity status
Expression of α TNF in Some Organs of Rabbits Treated with Aflatoxin B1 Fadia Falah Hassan
Journal of Global Pharma Technology .
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Abstract

Our study was designed to detect the effect of aflatoxin B1 in liver, kidney and spleen of New Zealand White rabbits and investigate the role of α TNF in aflatoxin B1-induced the same organs toxicity. Histopathological study showed various pathological effects of rabbit’s organs treated with 0.3 mg/kg body weight intraperitoneally with aflatoxin B1 in comparing with control animals. Alpha TNF was used as a marker for immunohistochemically study, results clarified that it was no expression in control animals (score =0) while results of animals treated with 0.3 mg/kg body weight intraperitoneally showed that liver was the most susceptible organs whereas the expression was severe (score =4), strong (score =3) and moderate (score =2) in liver, kidney and spleen respectively.Keywords: Aflatoxin B1, Histopathology, Immunohistochemistry, α TNF.
Study of the Border Adjustment of Indirect and Direct Restorations by Thermo cycling Method with Following Staying Yulianna Enina
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

According to modern concepts, the marginal permeability of restorations, the presence or absence of micro leaks, are the main factors determining the service life of the restoration. The restoration of teeth is subjected to several different types of stress - one of which is temperature fluctuations in the oral cavity. It is known that when eating food, brushing teeth, etc. the temperature in the oral cavity changes and affects the physical and mechanical properties of the hard tissues of the teeth, as well as of the restorative material, and in some cases leads to deformation of the zone of connection of the restorative material with the tooth surface up to its destruction. The thermal cycling procedure makes it possible to simulate the influence of this factor on the conditions of functioning of the reducing material; this is achieved by exposing the sample to a limited number of thermal cycles, which means of an artificial "aging" of the sample in laboratory conditions. Keywords: Direct restoration, Indirect restoration, Inlay, Thermal cycling, Micro leakage, Marginal fit.
The Effect of Physiotherapy of Spine Deviations According to Anatomical and Kinematic Analysis Mohammed Jasim Mohammed Al-Khalidi
Journal of Global Pharma Technology .
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Abstract

This research includes several axes through the use of physiotherapy by utilizing therapeutic exercises to correct the Students' curvatures of the spine as those exercises are working on the treatment of curvatures and improving the body texture for students. This study aims at recognition of training program impact that is suggested for correction of spine curvature, the study was conducted on two groups of school boys and girls by the age of (8-11) years numbered (20) students. The experimental method has been used of two equivalent partial groups that is applied therapeutic units that included therapeutic exercises for (16) weeks by a fact of (32) therapeutic units and a time of (40) minutes a unit, kinematic analysis has been used to determine the angles of curvature of the spine for students (boys and girls). The Study results signified improvement of straightness of spine for both groups; the study also recommended using of the suggested therapeutic program for individuals suffering curvatures of the spine.
Modeling and Optimization of Extraction of Gallic Acid from Chenopodium Murale using Response Surface Methodology Marwa Abdul Hussain Qassim
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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In this work, the investigation of recovery of gallic acid from chenopodium mural by leaching process was conducted. 99% of ethanol was used as a solvent.  Five parameters were investigated namely time (20 - 90) min, speed of mixing (200-1000) rpm, temperature (25˚C-70˚C), particle size (100-500) µm, solid/liquid ratio 1/50 gm/gm to 1/20 gm/gm. To design the experiments, Response Surface Methodology was used using Minitab 17 software. The model equation for optimization of the extraction process was found. The best conditions for the process were extraction temperature of 70 ˚C, the liquid-solid ratio of 0.05 gm/ml, extraction time of 90 min, agitation speed of 200 rpm and particle size of 100 microns. HPLC instrument equipped with UV detector UV-20A with wavelength Range 190-700nm was used for the analysis of samples. The aim of this study is to obtain a model equation for optimization of extraction of gallic acid from Chenopodium murale using response surface methodology. The influence of temperature, solid/liquid ratio, agitation speed, particle size and time on extraction yields will analyze.Keywords: Antioxidant, Gallic acid, Chenopodium mural, Leaching and Response Surface Methodology.
Incidence and Sensitivity Pattern of Klebsiella Pneumoniae, Escherichia Coli and Pseudomonas Aeruginosa in a Tertiary Care Hospital Rahul Radhakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
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Abstract

Objective: Antimicrobial resistance is a serious problem worldwide and differs from region to region. This study was carried out to determine the incidence and sensitivity pattern of gram negative bacteria mainly Klebsiella pneumoniae (K. pneumoniae), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) in our region and discuss the general issues related to antimicrobial resistance. Methods: Retrospective study was carried out in 6 months. Samples of urine, blood, pus, CSF and miscellaneous samples (fluids, swabs, sputum and stool) were collected from indoor and outdoor patients for isolation and antimicrobial susceptibility of K. pneumoniae, E. coli and P. aeruginosa were carried out in the Department of Microbiology in a Tertiary care Hospital.Results: Out of the 800 samples analyzed 618 showed growth,where 427 samples were isolated and it constitutes E.coli (43.32%), K. pneumoniae (33.02%) and P. aeruginosa (23.65%). Both E.coli and K. pneumoniae showed highest sensitivity for doxycycline (73%; 65% resp.) and second highest for levofloxacin (68%; 62% resp.), whereas, P. aeruginosa showed highest 55% sensitivity for amikacin followed by 46% for levofloxacin. β-lactam antibiotics and aminoglycosides showed high mean resistance (K.pneumoniae-81%, E.coli-77%, P. aeruginosa-84.4%) and (K. pneumoniae-73%, E. coli-59%, P. aeruginosa-68%) respectively.Conclusion: The data indicates high resistance among the gram-negative bacteria for β-lactam and aminoglycoside antibiotics. This study concludes that a proper awareness about antibiotics is essential as well as proper measures is to be implemented to control irrational use of antibiotics in this region. Keywords: Antibiotics;  Antimicrobial sensitivity; Gram-negative bacteria; Resistance
The Effect of Type II Diabetes Mellitus on Some Prostate Markers in Iraqi Men Khalid Maseer Rmaidh
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Aim: Diabetes mellitus is a spread disease in the whole world and this study was conducted on Iraqi diabetic men to know the relation between type II diabetic and some prostate related markers including (prostate size, total prostate antigen, random blood sugar and zinc). Material and methods: This study included one hundred men their age ranges between (40-60 year), fifty males were suffering from type II diabetes mellitus, and other fifty men were non-diabetics. Some parameters such as (Prostate size, total prostate specific antigen (tPSA), random blood sugar (RBS) and Zinc (Zn+2) were studied. Results: The results have showed significant increase in prostate size 50.5000 ± 3.748 and random blood sugar 203.55 ± 13.629 mg/dl compared with non-diabetic group 39.650 ± 2.484 and 125.750 ± 5.396 mg/dl, respectively but there is non-significant difference in total prostate specific antigen 1.543 ± 0.087 ng/ml and zinc 9.725 ± 0.344 µmol/l in diabetic group compared with non-diabetic group 1.612 ± 0.152 ng/ml and 11.025 ± 0.582 µmol/l respectively at P≤0.05.Conclusions: Patients with type II diabetes mellitus are more liable to suffer from increase in prostate size and increase in RBS levels in Iraqi men under study.Keywords: Diabetic patient, Prostate size, RBS, Zinc and tPSA.

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