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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Methodology for Development of Pediatric Medicines for Complex Treatment of Diseases of Immune-Dependent Nature Olga Rukhmakova; Tatyana Yarnykh; Olexander Tykhonov; Galina Melnyk
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

The objective of the work – is to substantiate methodology for development of pediatric medicines for complex treatment of diseases of immune-dependent nature.Materials and Methods: at the first stage of research, their objective was set, its significance for science and practical pharmacy was shown. At the information search stage, the need for new children’s medicines was identified. The second stage of research involves determining the main directions of achieving the objective. The third stage is the choice and justification of means aimed at achieving the objective, namely, the objects and methods of research. The fourth stage is devoted to the complex of experimental studies on the development of pediatric medicines for complex treatment of diseases of immune-dependent nature. At the final stage of research technical conditions, relevant sections of registration dossier and projects of quality control methods for proposed medicines were developed.Results: based on the created general methodological concept of the development of pediatric medicines for complex treatment of diseases of immune-dependent nature, we have compiled a plan of experimental research, which is given in the article.Conclusion: methodology for development of pediatric medicines for complex treatment of diseases of immune-dependent nature has been substantiated.
Electronic Properties of Adsorption of CO, CO2, OH, and B2 on Nitrogen Doped Graphene Nanosheets as a Gas Sensor Application for Harmful Gases Rajaa K. Mohammad
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

In the present work, the sensitivity of hybrid nitrogen-graphene nanosheet (Ndoped graphene) toward a series of small gas molecules (CO, CO2, OH, and B2) has been calculated based on the first-principles calculations. The properties that have been investigated are the density of state, IR spectra, and the electronic and structural properties. Interestingly, we observed that the adsorptions of (CO, CO2, OH, and B2) on the N-doped graphene are small physisorption with adsorption energy (Ead) between 0.75 to 1.15 eV, whereas the adsorption of CO on N doped graphene is high chemisorptions. The adsorption of CO and CO2 on the electronic properties lead to a decreasing in the highest occupied molecular orbital (EHOMO) and lowest unoccupied molecular orbital (ELUMO) and Fermi energy (Ef), and increasing in the energy band gap (Eg). Our findings indicate the possibility of using this nanosheet as a gas sensor for harmful gases (CO, CO2).Keywords: Electronic properties, Nitrogen- graphene nanosheet, Gas sensor, Harmful gases.
16Sr RNA Gene and reca Gene as Taxonomic Tool for Detection of Burkholderia Cepacia Isolated from Patients from Baghdad / Iraq Zahraa Kareem Raheem
Journal of Global Pharma Technology .
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Abstract

Twenty two isolates of Burkholderia cepatia (B. cepacia) were isolated from clinical sources and  diagnostic using VITEK 2 system and GNB ID cards. Two molecular diagnostic methods have been used to confirm the identification., the first method is the polymerase chain reaction (PCR) by 16S rRNA gene (1400bp) amplification followed by sequencing the product by send it directly for DNA Sanger Sequencing to Macrogen Company / Soul, Korea, data were analyzed and edit using Geneious Program and the edited sequence were compare with data base using BLAST (Basic Local Alignment Search Tool) to find the closed relation with submitted sequences, the second method is Real-Time Polymerase Chain Reaction by recA gene (385 bp fragment) amplification. The VITEK 2 System identify all the B.cepacia isolates with confidence values (97-99) %, 16S rRNA gene amplification and sequencing results confirm the identification with percentages of identification ranging from (96-99) %, after sequencing analysis, one of the B.cepacia isolate had been submitted in Gen Bank ((National Centre Biotechnology Information NCBI) under the accession number (MF678807). These results highlight the advantage of using these PCR assay to detect B. cepacia from different clinical sources that confirm the identification of isolates which may be misidentified when biochemically tested.Keywords: Burkholderia cepacia, Molecular identification, PCR, 16S rRNA gene sequencing, Real-Time PCR, recA gene.
Effectiveness of an Educational Program on Nurses' Knowledge and Practices about Prevent Complication for Patients Undergoing Thyroidectomy at Al-Hussein Teaching Hospital in Al-Nasiriyah City Ali T. Hameed
Journal of Global Pharma Technology .
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Abstract

Thyroid surgery as any surgical procedure involves risks, which can cause life-threatening complications during the post-operative stage which includes (postoperative hemorrhage, respiratory obstruction, Infection, hypothyroidism, hypoparathyroidism, thyroid storm, and laryngeal nerve damage). So, educational programs concerning to prevent this complications is necessary to nurses to have practical skills and scientific knowledge to identify and detect early signs and symptoms of potential complications and take appropriate action, so early detection and fast response are vital to limiting damage and maintaining patient safety. For the purpose of evaluating effectiveness of an educational program on nurses' knowledge and practices about prevent complication for patients undergoing thyroidectomy in ICU and surgical wards at Al-Hussein teaching hospital in Al-Nasiriyah city; the researcher has constructed a questionnaire format in order to reach the objectives of the study. The questionnaire is consisting of (3) parts which are: Part I: demographic characteristics of the nurses such as (age, gender, and years of experience, educational level, and training courses). Part II: knowledge of nurses about prevent complication for patients undergoing thyroidectomy, it consists of (40) multiple choice questions in three Axes. Part III: The practices checklist for nurses (Observation checklist), is composed of (54) items divided into three part. Reliability of instrument was determined through the use intra examiner (test & retest), and inter examiners which is assessed by calculating alpha Cronbach, and the instrument validity was determined through a panel of (15) experts. The analysis of data was performed through the application of descriptive statistic (frequency, percentage, Mean of score (MS), Differences between pre-post Grand Mean of Score, Standard Deviation (SD), and (RS %) Relative Sufficiency) and Inferential statistical (Chi-Square test, Contingency Coefficients (C.C.) test, t-test, and (ANOVA) Analysis of Covariance). The results of the study showed that the effectiveness of an educational program on nurses' knowledge and practices about prevent complication for patients undergoing thyroidectomy in ICU and surgical wards are a positive. It also shows that there are highly significant differences in the study group between pre and post-tests in overall main domains related to nurses' knowledge and practice. The study concluded that the nurses working at ICU and surgical wards they really felt the gap in their knowledge and practices about prevent complication for patients undergoing thyroidectomy and they were aware of their lack of knowledge and their practices. So, this leads to conclusion that certainly in-service education should be provided for nursing staff to equip them to meet the new demands of nursing care based on latest technological advancement and knowledge explosion in the nursing. The study recommended that providing an educational programs should be ongoing for nurses to enhance their knowledge and skills about prevent complication for patients undergoing thyroidectomy. Also, Modern instructive facilities for nursing team at surgical wards should be provided to enhance nurse's knowledge and practices.Keywords: Effectiveness, Education Program, Nurses ꞌKnowledge &Practices, Prevent Complication, Thyroidectomy.
The Design of A Multi-Skills Appliance and Its Effect to Improve the Sum of Motor, Functional Abilities and Skills of Passing and Scoring for Female Students in the Futsal Mohammed Naji Shaker Abugneam
Journal of Global Pharma Technology .
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Abstract

Futsal is one of the basic lessons for female students in the College of Physical Education and SportsSciences in the first stage of study in Iraq, for the purpose of learning the basic skills in this game andsome functional and motor abilities and quickly, the researchers designed a multi-skills appliance thathelps in learning a number of skills including scoring, passing, quitting and rolling ball. The multi-skillsappliance consists of three parts, each measuring 2 meters, can be connected to each other according toneed and variety of skill. The exercises used on the appliance designed to improve the performance of theexperimental group compared to the control group according to the statistical results of the tests, wherethe allotted time was 90 minutes distributed on the three parts of the preparatory and main and finalcourses. The number of learning units for passing and scoring was two units per week for 6 weeks, with atotal of 12 units.Keywords: Skills, Educational appliance design, Futsal, Motor accuracy, Scoring, Motorlearning, Anaerobic ability and passing.
The Right for a Healthy Environment in Indonesia: Comparison of Global Laws Sigit Sapto Nugroho; Sarjiyati Sarjiyati; Anik Tri Haryani; Yuni Purwati; Susiani Tri Wahyuningsh; khudzaifah dimyati; Heru Santoso Wahito Nugroho
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Objective: The research purpose is to explains according the constitution every citizen has the right to obtain the constitutional guarantee to live and access the healthy environment. Method: The research methods is normative juridical method is conducted by examining literature material. Citizens also have the right to live in a good and healthy living environment for their growth and development. This is regulated in Article 28 on the Declaration of the Human Rights, the Stockholm Declaration, and the constitutions of countries in the international world. Results: Result of the research is the rights for a good and healthy environment brings a burden of responsibility for the state to protect and to sustain the living environment’s supporting power for the sake of the future generations. Conclusion: The conclusion from this research is that the efforts to uphold these rights may be guaranteed by the constitution. Thus, every citizen may file a lawsuit to the court if the state does not fulfil this right
Vinblastine Based Iron Oxide Nano Drug Delivery System Mohammed S. K. Albermani
Journal of Global Pharma Technology .
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Abstract

Magnetic nanoparticles are a class of nanoparticles with significant properties which make them a highly promising to contribute in a drug design. The size depend property is the key issue that nondrug delivery system relaying on as well as the size of these submicron nanoparticles compared with the volume ratio. Many researchers in the being time focusing on the use of the innovated property of Magnetic nanoparticles applications in drug delivery systems due to their stability and biosafety compared with the others nanoparticles. Hence  Iron Oxide have been chosen for this study and formulated by co-precipitation method with the size ranging between 50-100 nm in diameter the size and the morphology of the iron oxide were conformed using SEM. Vinblastine sulfate which is well known as a powerful chemotherapy against cancer have been incorporated with the iron oxide NPs and tested on MCF-7 a breast cancer cell line at different intervals of time 24hrs, 48hrs and 72hrs, a bright field and fluorescent  image was taken to show the health growing of the cells. MTT survival assay have been conducted to measure the cytotoxity of the iron oxide-vinblastine and compare it with the pure vinblastine. The entire Vin- Fe3O4have shown more efficiency to inhibit the growth of MCF-7 cell line compared with the pure vinblastine. This formulation can be considered as a useful functional drug to cure cancer.
Evaluation of In-Vitro Anticancer Activity of Hibiscus Rosa Sinensis against HeLa cell Line P. Sampath Kumar
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

            The antifungal activity of Hibiscus rosa sinensis was evaluated against the following pathogenic fungi such as Candida albicans, Aspergillus niger, Trichoderma viride and  Rhizopus microsporus. The acetone extract of Hibiscus rosa sinensis flower showed little antifungal activity.  The acetone extract of Hibiscus rosa sinensis flower showed higher activity against HeLa cell line using MTT assay. The results obtained from the study revealed that Hibiscus rosa sinensis flower  Possess anticancer  activity against HeLa cell line using MTT assay.  
Technical Variables Affecting to Production of Pickle Ficus (Ficus Racemosa) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

The plant Ficus racemosa occupies a vital place in the traditional system of medicines. It contains antioxidants which quenches free radical damage to cells and tissues. The short shelf life of ficus can be a major cause of postharvest losses especially during peak harvesting season. Fermentation is one of the most convenient technologies for the production of shelf stable food product. The objective of this study was to evaluate different variables influencing to the fermentation of ficus such as concentration of CaCl2, temperature and time for blanching; effect of ratio Lactobacilus acidophillus to the antioxidant of fermented ficus. Results showed that ficus should be blanched in hot water 95oC in 15 seconds with the present of 3.0% CaCl2. Moreover, the fermentation process for pickle ficus had the best antioxidant by addition of 15% sugar, Lactobacilus acidophillus at ratio 2.0 x 108 cells/ml. Blanching and fermentation had significantly affected to antioxidant capacity and firmness of pickle ficus. The pickle ficus had a high content of antioxidant as well as firmness. This plant holds a great prospective source for developing herbal products and thus a vital source of income for the pharmaceutical industry.Keywords: Ficus, pickle, fermentation, blanching, Lactobacilus acidophillus, antioxidant.
Evaluation of Narrow Band Ultraviolet B (NBUVB) Treatment in Patients with Lichen Planus Farah Saleh Abdul-Reda
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Background: In lichen planus, cutaneous lesions usually resolve within 2 years; however, treatment may be justified to reduce time till resolution and relieve the symptom of itching. Treatment may include a variety of agents that have been described as 1st line, second line and third line therapies. Oral lesions may resolve spontaneously within 5 years; but most cases are chronic, therefore treatment must be justified when ulcerative lesions interfere with normal feeding, otherwise treatment should be avoided because the burden of side effects is much more than the obtained benefit.  Aim of the study: to evaluate the response of patients with lichen planus to narrow band ultraviolet B phototherapy. Patients and methods: The present cohort study included 40 patients with lichen planus with and age range of 11 to 55. The study was carried out at the dermatology unit, Al-Diwaniyah Teaching Hospital located at Al-Diwaniyah province, Mid-Euphrates region of Iraq. The duration of study extended from January 2018 till March 2019.All patients were treated twice weekly (two sessions per a week).The starting dose was 150-200 mj/cm2, then the dose was increased 10-20% per session. All patients were followed for a period of 6 up to 12 months in order to record the quality of response and relapse and number of relapses if ever happened. Results: Patients received treatment sessions that ranged from 25 up to 50. Patients with excellent response accounted for 20 (50 %), patients with good response accounted for 10 (25 %), patients with fair response accounted for 7 (17.5 %) and patients with poor response accounted for 3 (7.5 %). Response to treatment showed no correlation to any of demographic characteristics. After 6 months of follow up only 5 patients developed relapse and after one year the number rises to 7 patients. Conclusion: In view of the available data obtained from the current study and previous reports it is obvious that NBUVB treatment in patients with lichen planus is associated with an acceptable complete and partial response rate with good patient satisfaction.Keywords: Lichen planus, Narrow band ultraviolet B therapy.

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