cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
 10   11   12   13   14 
Search results for , issue "." : 1,092 Documents clear
Current Status of mTOR Inhibitors as Novel Therapeutic Agents Laxmianarayana Bairy Kurady
Journal of Global Pharma Technology Volume. 9 Issue 6
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Mammalian target of rapamycin (mTOR) is a PI3K (phosphatidylinositol-3-kinase)-related kinase, via two distinct forms – mTOR complex 1 (mTORC1) and mTORC2 coordinates various extracellular and intracellular signals like growth factors, nutrients, amino acids, energy levels in order to achieve optimum cell growth. mTORC1 regulates protein synthesis, lipid biogenesis, oxygen homeostasis, proliferation, autophagy; mTORC2 plays role in cell survival. Since this pathway controls major cellular processes, its dysregulation is associated with pathological conditions like cancer, obesity, type 2 diabetes mellitus. Rapamycin, a naturally occurring mTOR inhibitor, along with synthetically derived compounds of rapamycin – rapamycin analogs (rapalogs), produced by chemical modification of parent drug have achieved clinical success in certain tumor subtypes. Rapalogs have shown their own limitations due to development of resistance and activation of feedback pathways, focusing on the need for efficient mTOR inhibition. In this regard, mTORC1/mTORC2 (mTOR Kinase) inhibitors and dual mTOR/PI3K inhibitors have shown promising results in various in-vitro tumor models, and are currently in phase I/II of clinical trials. With the better understanding of dynamics of mTOR signaling pathway and its function in tumor microenvironment, mTOR inhibitors may provide a good alternative against advanced and refractory cancers.Keywords: Rapamycin, mTOR, Tuberous sclerosis complex, PI3K, AKT, Rapalogs, Everolimus.
Perioperative outcome between open renal stone-removal surgery and PCNL in patients with staghorn stones Gede Wirya Kusuma Duarsa
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.381 KB)

Abstract

Background: Percutaneous nephrolithotomy (PCNL) has become the treatment of choice for staghorn stones, replacing open stone surgery. However, in a developing country, open stone surgery is still the treatment of choice due to its nature for not requiring endourology devices, it can be performed by a general surgeon, and it is financially acceptable.Objective: This study aims to compare the cost-related outcome between PCNL and open renal stone surgery in patients with staghorn stones.Method: Data were collected retrospectively, taken from patients’ medical records who underwent PCNL and open stone surgery in three hospitals from 2016-2017. Seventy-eight patients were divided equally into PCNL group and open surgery group. Data of the hospital length of stay, the volume of blood loss during surgery, stone-free rate, and post-operative additional procedures were recorded.Outcome Measurements and Statistical Analysis: The data were analyzed using SPSS version 23.0 for Windows.Results: The hospital length of stay was shorter in PCNL compared to open stone surgery (3 vs. 4 days, p<0.001). The post-operative stone-free rate was lower in PCNL compared to open stone surgery (48.7 vs. 92.3%, p<0.001). More post-operative additional procedures were found in PCNL compared to open stone surgery (p<0.001). There was no significant difference in the amount of blood loss during surgery in both groups (p=0.102).Conclusions: PCNL is a minimally invasive procedure that is effective and safe for treating staghorn stones. Nevertheless, in places where PCNL is unavailable, open stone surgery can still be a choice for treatment. 
Effect of Exam Stress of 1-4 Year Student on the Human Body Aminet Askerovna Pseunok
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (489.607 KB)

Abstract

The research was performed by the authors to study the effect of exam stress on the respiratory system of 1-4 year students. The experiment was carried out in the longitudinal regime for two years with the participation of the same students. Healthy students participated in the experiment voluntarily. We surveyed 89 1-4 year students, of which were 30 boys and 59 were young females aged 18-22 years. The survey was conducted during the intersessional period and on the day of the exam. To study the functional state of external respiration in the examined students, a pneumotachometric type spirometer with a SPIRO-SPECTR calibration syringe was used. The measurements were carried out from 9 to noon since during this period of the day the studied parameters are the most stable. The experiment took into account gender characteristics. Two age groups were formed: 18-19 years old (1-2 years of education) and 20-22 years old (3-4 years of education). Analysis of the research results showed that in the time course of learning from 1 to 4 years, students' adaptive capacity of the respiratory system increases, resulting in increased efficiency and effectiveness of regulatory mechanisms.Keywords: Longitudinal studies, Psycho-emotional stress, Examination stress, Functionality, Respiratory system.
Fabrication and Study the Structure, Optical and Dispersion Parameters of PMMA with InCl3 Additive Nadir Fadhil Habubi
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (767.386 KB)

Abstract

Polymethyl methacrylate films are prepared by casting method with various content of InCl3 (2, 4%). X-ray diffraction (XRD) and optical microscope are used to determine the structural properties. Transmittance that determined using UV-Visible spectrophotometer and optical parameters also calculated. Urbach energy values increase with the increasing of InCl3 and energy gap decreased from 3.849 eV of pure PMMA films to 3.230 eV of PMMA-4% InCl3. Dispersion parameters are determined using Wemple-DiDomenico model. Refractive index data at infinite wavelength was found to obey single oscillator model.Keywords: PMMA, Dispersion parameters, Composite, Optical properties.
The Correlation between Masculinity and Smoking Behavior among Adolescent in Surabaya Setho Hadisuyatmana
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (472.942 KB)

Abstract

Smoking behavior is one of the risky health behaviors adopted by adolescents in Indonesia. The behavior was commonly recognized as a masculine among male adolescents. The label of man identity called masculinity influences this condition. This study investigated the association of masculinity as ideology, masculinity norms, and gender role conflict and its correlation with smoking behavior in male adolescents who lived in Surabaya. This study used a descriptive correlative method and involved 314 adolescent males aged 15-18 years old in Surabaya as participants. We employed univariate analysis to identify predictors, including the ideology of masculinity (MNRI-SF), masculinity norms (CMNI-46), and gender role conflict (GRCS-I); and a dependent variable: male adolescents’ smoking behavior. The data were collected electronically, following waived written consents. Bivariate analyses were conducted to investigate each of the predictor's questionnaires and dependent variables using chi-square with the level of significance of p<0.05. Adolescents as participants in this study have low levels of ideological masculinity, high norms of masculinity and gender role conflict in the moderate category. The results indicated that ideology masculinity, masculinity norms, and gender role conflicts are positively associated with smoking behavior (p=0,001, p=0,029, and p=0,001 respectively). The findings of this study suggested that smoking behavior was constructed as an element to the idea of masculinity in the perspective of male adolescents in Surabaya, despite the available warning to prevent the circulation of tobacco products to adolescents. Thus, this study recommends the need for reinvention around tobacco-products circulation as not to involve the youth. Keywords: Adolescent, Gender role conflict, Masculinity, Smoking behavior.
Novel Unsaturated Intermediates (Aldehyde, Polyolefin, Pheromone and Fatty Acid) Synthesized using Wittig Reaction Hussein Habeeb Mustafa
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In this study novel unsaturated compounds could be prepared with the required skip-conjugated (Z,Z)-double bonds configuration using  a traditional Wittig reaction. This reaction depends on a coupling of aldehydes with phosphonium salt. Must products do not appear to have been prepared before, and these products were diagnosed by using NMR spectrum, infrared (IR) and mass spectrometer techniques. It is concluded that these products could widely be used as a fatty acid and a useful intermediates in the synthesis of pheromones instead of insecticides, and several chemical reactions.Keywords: Witting reaction, Unsaturated fatty acid, Skip-conjugated alkenes, Pheromone.
The Effectiveness of Using Pre-Screening Questionnaires to Improve Mother's Knowledge and Skills in Implementing Early Detection of Early Childhood Development Ningsih Jaya; Ambo Dalle; Bahtiar Bahtiar
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.128 KB)

Abstract

Early childhood development can be detected through developmental pre-screening, with the aim of detecting early developmental disorders. The research objective was to analyze the effectiveness of the use of pre-screening questionnaires to improve the knowledge and skills of mothers in detecting early childhood development. The design of this study was a pre test - post test, involving 60 mothers of children under five. Observations were made before and after the intervention. Data were analyzed using the Wilcoxon test. The results showed that there was an increase in maternal knowledge and skills after being given the intervention. Thus, it can be concluded that the use of developmental pre-screening questionnaires is effective in increasing the knowledge and skills of mothers under five in early detection of child development. Keywords: Child Development, Child Development Pre-Screening Questionnaire, Knowledge, Skills
The Survey of the Relationship between the Social Support and the Mental Health among the City of Tabriz Citizens in 2014 Mohsen Hojat
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective the citizens are the focal point of the emotions and excitement, center if the joy and health, the pounding heart and the capitals of a nation and this is why the states pay a great deal of their attention to the citizens’ psychological health in the cultural and social planning and policy-making. The present study aims at the determination of the relationship between the social support and the citizens’ psychological health in the city of Tabriz in 2013. Methods The current study is an analytical-descriptive research. The study sample volume has been selected from an above-15-year old 398 individuals (200 women and 198 men) population based on a multistage clustering method in the city of Tabriz. The information collecting tools were the social support questionnaire and general psychological health questionnaire (GHQ-28). To analyze the data, there was made use of SPSS program ver.16 and the statistical tests such as linear regression tests and independent t-test. Findings According to the findings obtained through the data analyses performed in the current study it was found out that there is a significant relationship between social support and psychological health (P<0.001). The women social support is directly associated with their mental health (P=0.02). Also, there is an inverse relationship between social support with the women’s anxiety-sleep disorders symptoms (P=0.02) and the women’s intensive depression symptoms (p=0.04). Conclusion Social support is in a direct and significant relationship with the women and men’s mental health. Changing the policy making goals with the objective of enhancing the quality and the quantity of the supportive networks, particularly for the susceptible women, can cause the social supports protective effects to be corroborated.Keywords: Mental health, Social support, Gender.
Amikacin Induced Ototoxicity in an 8 Year Old Patient with UTI: A Case Report Lisa Mathew Adackapara; Keerthana Chandrasekar
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.53 KB)

Abstract

Ototoxicity is an adverse drug reaction of Amikacin and involves mainly bilateral high-frequency sensorineural hearing loss and tinnitus. This case report is essential to identify, resolve and create awareness of the predisposing factors which can lead to ototoxicity. It elaborates the rare adverse effect caused due to Amikacin induced ototoxicity and the treatment strategies adopted at a secondary care hospital in an 8 year old male child. Treatment for Urinary Tract Infection (UTI) included Amikacin for 1 day following which the next day he developed blocked ears and diminished hearing as an adverse reaction to the aminoglycoside antibiotic. Management emphasis is on prevention, as most hearing loss is irreversible. After 3 days of treatment, the patient’s condition improved and was discharged with advice to continue liquid paraffin 3drops-0-3drops in both ears for 3 days. Appropriate measures must be put into place to manage aminoglycoside-induced cochleotoxicity effectively, in order to maximize the affected individual’s quality of life.
Evaluating Bactericidal Effect of the Antibiotics on the European Foulbrood Disease in Honeybees Varis Tuktarov
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (553.688 KB)

Abstract

The paper discusses the results of testing the bactericidal and bacteriostatic effect of various concentrations of pefloxacin and enrofloxacin on European foulbrood pathogens in contrast to oxytetracycline. The work presents the therapeutic efficacy of pefloxacin in treating bee colonies affected by European foulbrood disease. The study tested different methods of introducing medicine in the field experiment. European foulbrood disease revealed at the studied apiaries is caused by Melisococcus plutonium, Bacillus alvei, and Enterococcus faecalis; Brevibacillus laterosporus. In Nurimanovsky and Baimaksky districts (Republic of Bashkortostan, Russia), Melisococcus plutonium, which is the primary causative agent of EFB, has not been detected. The minimum bactericidal concentration of pefloxacin is 0.001% for Enterococcus faecalis, while the minimum level for Brevibacillus laterosporus and Bacillus alvei is 0.01%. Oxytetracycline exceeds the index 10fold, and it is 0.01 % for Enterococcus faecalis and 0.1 % for Brevibacillus laterosporus and Bacillus alvei. The minimum bactericidal concentration of pefloxacin is 0.01% for Melisococcus plutonium, which is 100 times lower than the minimum concentration of oxytetracycline (1.0%). High therapeutic efficacy is achieved (93.8...95.9%) in treating bee colonies affected by European foulbrood disease with pefloxacin by adding the antibiotic to the feed syrup (1:1) at a dose of 0.01%. The value is significantly higher than the effect of oxytetracycline applied at a dose of 0.05% (87.4...88.2%).Keywords: Apis mellifera mellifera L, European foulbrood disease, Bactericidal activity, Fluoroquinolones, pefloxacin.

Page 12 of 110 | Total Record : 1092

 10   11   12   13   14 

Filter by Year

2010 2025


Reset
Filter By Issues
All Issue Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue