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High Serum Prostate Specific Antigen as A Risk Factor for Moderate-Severe Prostate Inflammation in Patient with Benign Prostatic Hyperplasia Duarsa, Gede Wirya K.; Lesmana, Rika; Mahadewa, Tjokorda G. B.
BALI MEDICAL JOURNAL Vol 4 No 3 (2015)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Benign Prostatic Hyperplasia (BPH) is one of the most common degenerative disease found in men. Theories have been delivered to elucidate etiology, one of them is the theory of inflammation, and PSA is considered as one of risk factor for prostate inflammation. Undetected chronic inflammation could be a problem in BPH due to the obstructive and irritative symptoms it causes. Assessing risk factor could provide a better treatment outcome. Methods: A retrospective case control study in Sanglah Hospital, Indonesia. 70 men with BPH who underwent TURP in 2014, prostate inflammation is evaluated histologically from prostate specimens by one pathologist to avoid subjectivity. Those without inflammations and with mild inflammations are categorized as control group (n=35), and those with moderate and severe inflammations are categorized as case group (n=35). Preoperative total serum PSA retrieved from medical record Results: Median PSA is higher in case group, 2,83 compared to 14,12, with odd ratio 1,18 (p
CHARACTERISTICS OF HYPOSPADIAS CASES IN SANGLAH GENERAL HOSPITAL, BALI-INDONESIA: A DESCRIPTIVE STUDY Duarsa, Gede Wirya Kusuma; Nugroho, Teguh Dwi
BALI MEDICAL JOURNAL Vol 5 No 1 (2016)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Hypospadias is one of the most common congenital anomalies. The purpose of this study is to assess the characteristics of hypospadias patients in Sanglah General Hospital, and the type of hypospadias repair and the outcome. Methods: The data is collected retrospectively from the hypospadias patients’ medical records who undergone a hypospadias repair between January 2009 to April 2012. The data is analyzed descriptively to describe the characteristics of hypospadias patients, the procedures taken, and the outcomes. Results: From 42 patients, type of hypospadias are 33.3% (n=14) penoscrotal; 21.4% (n=9) scrotal; 14.3% (n=6) corona; 26.2% (n=11) penile; 2.4% (n=1) subcoronal; 2.4% (n=1) and perineal. Chordee was present in 67.9% cases (n=36), and cryptorchidism present in 3.7 % case (n=2). The urethroplasty techniques applied: TIP 55.6% (n=15); Duckett Preputial Island Flap 14.8% (n=4); MAGPI 14.8% (n=4); 14.8% (n=4) two stages urethroplasty. Complication rate of Duckett is 50% (n=2) urethra cutaneous fistula; MAGPI 25% (n=1) meatal stenosis; TIP 20% (n=3), 2 urethrocutaneous fistula, 1 urethral stricture; 2 stages urethroplasty 0% (n=0). Conclusion: The findings suggest a different frequency of the proportion of the type of hypospadias in this study when compare to the readily available literature. The age of the patients undergone hipospadias repair was higher compare to other studies. TIP technique was the most preferred in Sanglah Hospital.
THE EFFECTIVENESS OF NETILMICIN SULPHATE INSTILATION ON THE URETHRA CATHETER REMOVAL PROCEDURE IN REDUCING THE INCIDENCE OF CATHETER ASSOCIATED URINARY TRACT INFECTION Darma-Kusuma, I.G.; Duarsa, G.W.K.; Golden, N.
BALI MEDICAL JOURNAL Volume 1, Number 3, September-December 2012
Publisher : BALI MEDICAL JOURNAL

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Abstract

Objective: Catheter associated urinary tract infection (CAUTI) is the most common complication of short-term indwelling catheters. The risk of this complication is increase along with the length of catheter insertion. There is no complete agreement of intravenous administration of prophylaxis antibiotic in reducing the incidence of CAUTI. Currently, antibiotic instilation into bladder was developed, however it is still a controversial issue. Therefore in this study we would like to see the effectiveness of this procedure in reducing the risk of CAUTI. Method: Single blind randomized controle trial was conducted on 40 eligible male patients treated at surgical ward, Sanglah Hospital between  March and August 2012. Twenty patients had  netilmicin sulfate instilation and anathor 20 patients treated without instilation procedure. Urine culture was taken before and after catheter removal. The  number of colonies were analyzed according to the WHO criteria. In this study WHO critirion 3 was used with a significant bacteriuria of more 10 5 CFU / mL. Data were analyzed with Chi-square table and processed statistically with SPSS. Significance was set at p value <0.05 with 95% CI. Results: The mean age was 50.07 (SD 15.49) years. The avarage length of urinary catheterization was 5 days (range from 4 to 14 days). CAUTI was observed in 18 patients (45%); symptomatic was 11 patients (61.1%) and asymptomatic was 7 patients (38.9%). Statistic analysis showed that netilmicin sulfate insilation significantly reduced the risk of CAUTI (OR 0.028 ; CI 0.004 - 0.172). Conclusion: Netilmicin sulfate instilation prior to catheter removal significantly reduced the risk of CAUTI after short-term indwelling catheter.
The Role of Multiplex Polymerase Chain Reaction in Detecting Etiological Causes of Bacterial Prostatitis Associated Benign Prostatic Hyperplasia Rosadi, Bramastha A; Mahadewa, Tjokorda G. B.; Duarsa, Gede Wirya K.
BALI MEDICAL JOURNAL Vol 4 No 1 (2015)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Benign Prostatic Hyperplasia (BPH) has been correlated with chronic prostatitis according recent study. Chronic pelvic pain is the chief complain of BPH followed by prostatitis. The gold standard of the etiological diagnosis is urine culture, but the negativity rate is still high. Multiplex polymerase chain reaction (PCR) as a diagnostic tool in search of etiological causes could identify microorganism on DNA level. This research aims to find out the role of multiplex polymerase chain reaction as diagnostic tools on prostatitis patients. Material and Method: A total of 12 samples collected during the TURP procedure in Sanglah General Hospital Denpasar – Bali from February until May 2015. All of the samples has been diagnosed prostatitis clinically and perform urine culture test. The prostate specimen taken was sent to the Pathological anatomy for histopathology diagnostic and underwent multiplex PCR for etiologic diagnostic. Result: 12 samples have been declared as prostatitis based on histopathology examination, and then were analyzed using multiplex PCR. 10 samples were positive (6 were E. coli, 2 were C. trachomatis, the rest were N. gonorrhea and P. aeruginosa). The urine culture revealed 9 positive, within the result 6 were E. coli, and the others were P. aeruginosa, M. morganii and A. haemolyticus. Conclusion: In prostatitis patient, the etiological diagnostic was important. Multiplex PCR as diagnostic tools could detect the microorganism on a negative urine culture. The combination of the urine culture test and multiplex PCR revealed a better result on etiologic diagnosis which leads to a better management of the disease.
CORRELATION OF CYSTOSTOMY TO LOW URETHROCUTANEOUS FISTULA INCIDENT IN HYPOSPADIA SURGERY Laura, S. F.; Duarsa, G. W. K.; Mahadewa, T. G.
BALI MEDICAL JOURNAL Vol 3 No 3 (2014)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Hypospadia is the most common congenital abnormalities to the penis. The most common post-operative complications and hypospadias is uretherocutan fistula. Uretherocutan fistula is arising from an infected wound, hematoma, urinary extravasations, ischemic necrosis of the flap or graft, technical errors, and postoperative care. Although, reconstruction of the urethra without cystostomy results in patients discharged quickly, some sources still recommend the use of cystostomy in hypospadias surgery. This is because of lower complication rate and more comfortable for the children during the postoperative period. The purpose of this study was to determine the incidence of fistula uretherocutan correlation with cystostomy using hypospadia operation. Methods: This study was carried out with cross-sectional design involving 68 patients, comprising 34 people with operating groups and 34 other people of hypospadias surgery without cystostomy. This is a retrospective study by observing medical record of the patients at Sanglah General Hospital from December 2013 until May 2014. All data obtained were assayed with Chi-square and Person Correlation and considered significant at p < 0.05. Results: This Study reports that the value of r = -0.364, p = 0.034, and PR = 0.16. However, there is a correlation in the use of cystostomy to a lower incidence of fistula in operation uretherocutan hypospadia. In cystostomy surgery, fistula incidence was 2.9% and operating without cystostomy was 17.6%. In operation hypospadia using cystostomy is expected to reduce the incidence of fistula.
SIMPLE VIRILIZING CONGENITAL ADRENAL HYPERPLASIA: Presentation in a Female Child with Genital Ambiguity undergoing Genitoplasty (A Case Report) -, Nurhaen; Duarsa, G. W. K.
BALI MEDICAL JOURNAL Volume 1, Number 3, September-December 2012
Publisher : BALI MEDICAL JOURNAL

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Abstract

Objective: our objective was to display the presentation of simple virilizing Congenital Adrenal Hyperplasia (CAH) with genital ambiguity and severe virilization of the external genitalia, influencing growth, height and weight, bone maturation, quality of life and hence undergoing genitoplasty. Surgical treatment was aimed to obtain a more natural psychological and sexual development and the type of surgical repair performed was tailored based on individual patient’s anatomy findings. Case: we report a case of a 3-year old female with simple virilizing CAH, diagnosed due to genital ambiguity, severe virilization, clitoromegaly, external genital pigmentation, precocious pubic hair, previously was under treatment with glucocorticoid replacement therapy for 2 years since newborn and neglected due to discontinuing the hormonal treatment for one year duration, underwent several clinical studies including chromosomal study for sex determining, pelvic ultrasonography for internal anatomical details and bone age study for skeletal maturation, given stress dose steroids pre-operatively and followed by genital reconstructive surgery (genitoplasty). A clitorectomy and labioplasty approach were performed. At time of surgery cystoscopy was carried out prior to the surgical repair. Results: Management of virilizing CAH child with ambiguous genitalia demands multidisciplinary and interdisciplinary approach. The team‘s major challenge is to use the feasible means to make the least bad choice in order to select a gender able to match the individual identity, social identity, and behavioral identity. Surgical option should be tailored, one stage surgery, at early age and performed according to the individual anatomy findings.
THE CORRELATION BETWEEN SERUM PSA LEVEL AND PROSTATE HISTOLOGIC AGGRESSIVENESS WITH PROSTATIC VOLUME IN BPH PATIENTS Duarsa, Gede Wirya Kusuma; Oka, AA Gde; Santosa, Kadek Budi; Yudiana, Wayan; Tirtayasa, Pande Wisnu; Udiyana, Nyoman Dwi Maha; Mahadewa, Tjok Gede Bagus
Indonesian Journal of Urology Vol 26 No 1 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i1.465

Abstract

Objective: Prostate inflammation is one of pathophysiology of prostate hyperplasia in benign prostatic hyperplasia (BPH). There are several factor that involved in prostatic inflammation, such as prostate specific antigen (PSA) that play a role as an autoantigen. The objective of this study was to assess the correlation between free PSA level with prostate histologic aggressiveness, and also the correlation between prostate histologic aggressiveness with prostatic volume in BPH patients. Material & Methods: The design of this study was cross-sectional analytic observational study to determine correlation between serum PSA level with prostatic aggressiveness, and prostatic volume with prostatic aggressiveness. This study was performed from June to November 2016 in Sanglah Public Hospital, Surya Husadha, Balimed, Bhakti Rahayu, and Ganesa Hospital. Eighty three patients with BPH undergoing transurethral resection of the prostate (TURP) were recruited. Results: The result of gamma correlation analysis using Chi-square of PSA level with aggressiveness (p=0.000) and aggressiveness with prostatic volume (p=0.012). Conclusion: Serum PSA level were correlated with prostatic aggressiveness. Prostatic aggressiveness also correlated with prostatic volume.
Infeksi saluran kemih berhubungan dengan peningkatan nilai prostate specific antigen pada pasien benign prostate hyperplasia di Rumah Sakit Sanglah Nyoman Khrisna Dharmawan; Gede Wirya Kusuma Duarsa
E-Jurnal Medika Udayana Vol 7 No 5 (2018): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Abstract

Increasing the value of Prostate Specific Antigen (PSA) is caused by various things related to abnormal enlargement of the prostate such as prostate cancer and benign prostate hyperplasia (BPH), urinary tract infection (UTI) can cause inflammation and irritation of the epithelial cells of the prostate that can cause swelling of the prostate. This study aims to determine whether UTI associated with increased PSA value in patients with BPH. This research was conducted by recording a patient who came to the urology clinic with a diagnosis of BPH between July and October 2015, then patients were evaluated with a urine sample taken for further cultured to determine if the patient has a UTI or not. Then also taken blood samples to determine levels of PSA values ??with a cut-off point of 4 ng / ml. The statistical analysis used is the test Shapiro Wilk normality test, and Chi-Square to determine the correlation between PSA and UTI. Obtained 24 BPH patients were divided into 2 groups: 12 patients with BPH with positive urine culture and 12 BPH patients with negative urine culture with a mean age of the sample in the study was 64 ± 2 years. The mean rank of PSA in BPH patient group with positive urine culture was 17.25, while in BPH patients with negative urine cultures of 7.75 (p = 0.001), In the test Chi Square correlation obtained 6 patients in this group of patients BPH with positive urine culture had a high PSA values ??and the rest have lower psa (p = 0.005). There can be concluded that the relationship between the PSA value by urine culture in patients with BPH Keywords: Benign Prostate Hyperplasia, Urinary Tract Infection, Prostate Specific Antigen
DIAGNOSIS DAN PENATALAKSANAAN KATUP URETRA POSTERIOR Putu Primeriana Nugiaswari; Gede Wirya Kusuma Duarsa; Sri Maliawan
E-Jurnal Medika Udayana Vol 1 No 1 (2012): e-jurnal Medika Udayana
Publisher : Universitas Udayana

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Abstract

Katup uretra posterior merupakan penyebab utama kesakitan, kematian, dan kerusakanginjal berkelanjutan pada anak-anak. Kelainan ini berupa lipatan mukosa abnormalkongenital pada uretra pars prostatika yang menyerupai membran tipis yangmenghambat drainase kandung kemih. Katup uretra posterior mayoritas didiagnosis saatprenatal melalui penggunaan ultrasonografi maternal. Tingkat keparahan dan derajatobstruksi yang disebabkan oleh kelainan ini tergantung pada konfigurasi dari membranobstruktif dalam uretra. Keputusan untuk mengintervensi saat prenatal didasarkan padausia kehamilan, volume cairan amnion, dan fungsi renal pada aspirasi urin fetus. Ablasikatup dengan endoskopi merupakan standar emas penanganan katup uretra posterior.
DAMPAK PANDEMI COVID-19 PADA PELAYANAN EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY (ESWL) DI RS SURYA HUSADHA DENPASAR Gede Wirya Kusuma Duarsa; Gede Wirya Diptanala Putra Duarsa; Pande Made Wisnu Tirtayasa
E-Jurnal Medika Udayana Vol 10 No 9 (2021): Vol 10 No 09(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i9.P03

Abstract

Pandemi COVID-19 telah membuat suatu gangguan pada sistem pelayanan kesehatan yang telah berjalan sekian lama. Hal ini bisa menjadi suatu hambatan namun dapat pula menjadi suatu tantangan, khususnya di bidang pelayanan kesehatan pasien dengan batu saluran kemih. Penyakit batu saluran kemih dapat terjadi di sepanjang traktus urinarius contohnya di ginjal. Terdapat beberapa metode penanganan batu ginjal, salah satunya adalah dengan tindakan extracorporeal shock wave lithotripsy (ESWL). Penelitian ini bertujuan untuk melihat apakah pandemi COVID-19 berdampak terhadap jumlah pelayanan ESWL di salah satu pelayanan kesehatan di Denpasar. Studi observasional deskriptif dilakukan di RS Surya Husadha Denpasar dengan menggunakan data sekunder yaitu data rekam medis pasien yang dilakukan tindakan ESWL. Data dibagi menjadi dua grup yaitu data sebelum pandemi COVID-19 (November 2019 – Januari 2020) dan data saat pandemi COVID-19 berlangsung (Februari 2020 – Mei 2020). Total data yang dikumpulkan sebanyak 1109 kasus yaitu terdiri dari 499 kasus sebelum pandemi dan 610 kasus saat pandemi COVID-19. Rerata jumlah pasien yang dilakukan ESWL sebelum dan saat pandemi adalah 166,3 kasus/bulan dan 152,5 kasus/bulan. Terdapat penurunan rerata jumlah pasien yang dilakukan ESWL saat pandemi yaitu sebanyak 8,2% dibandingkan sebelum pandemi COVID-19. Sebagian besar kasus adalah berjenis kelamin laki-laki pada kedua grup dan kelompok umur terbanyak pada kedua grup adalah kelompok umur >50 tahun. Penurunan angka tindakan ESWL saat pandemi pada studi ini dilatarbelakangi oleh faktor pada pelayanan kesehatan dan faktor dari pasien sendiri. Prioritas utama diberikan kepada pasien batu saluran kemih dengan potensi risiko yang lebih besar.