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I Wayan Sudarsa
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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Synthesis and Characterization of Some Capsaicin Derivatives and Study their Pharmacological Hydrolysis Faris Hamood Mohammed
Journal of Global Pharma Technology .
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Abstract

One of the alkaloid compounds that were found in the fruit of the Capsicum genus is a Capsaicin, which provides its spicy flavor. Capsaicin extracted directly from fruit and limited use in clinical trials to support the biological activity. In this research, using cationic polymerization were  carried out to the synthesis of drug-spacer polymer to obtain more able as hydrolysis proceeded and more convenient for hydrolysis of attachment of the appropriate pendant drugs, through increases the distance between drugs as a bioactive and backbone of the polymer chains. All prepared drug polymers were characterized by FTIR, UV-visible, TGA and 1HNMR techniques.
Study the Effect of Some Growth Factors on the Production of L-Asparaginase Enzyme by Fungal Isolate Aspergillus flavus Walla H. Shuker
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Nine filamentous fungi from infection fruits and vegetables .Seven isolated were of high productivity for L-Asparaginase enzyme compared with other isolates, this isolates were Aspergillus flavus, A.niger, Pencillium sp., Fusarium sp., Aspergillus flavus was the best isolate for Asparaginase production, depending on diameteron pink colour on the medium plates. Studied the effect of nitrogen and carbon sources, and PH the resulted revealed that the maximum Asparginase production was the following condition: PH 6.0, Glocose as a carbon source, Ammonium sulphate was (121.28) U/100ml.
Synthesis, Analytical, Thermodynamic Studies and Uptake Behavior of: Copper and Cadmium by New Schiff-base Chelating Resins W.S. Hanoosh
Journal of Global Pharma Technology .
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Abstract

The present work carried out a study on new Schiff-bases ligand derived from (P-phenyl amine and O-amino phenol) with 3-hydroxy benzaldehyde, which has been successfully prepared in warm alcoholic medium. These ligands were characterized by FTIR spectroscopy, CHN analysis & Uv-Visible spectra. From the UV –Vis spectra show that both heavy metal [Cu2+, Cd2+] form complexes with both schiff-bases in the ratio (1:2) [M: L]. Thermodynamic parameters were evaluated at different temperature using vant-hoff equation. Finally polyurethane foam from these ligand were prepared through the reaction with diisocyanate compound (MDI) and thermal study of these prepared polymers were evaluated by using thermogravemetric analysis (TGA)Keywords: Schiff-base, Polyurethane foam, TGA analysis.
Effect of Frying And Storage on the Quality and Shelf Life of Fried Sweet Potato (Ipomoea Batatas) Chip Nguyen Phuoc Minh
Journal of Global Pharma Technology .
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Abstract

Sweet potato is the seventh most important crop in terms of global production. Sweet potatoes are rich in antioxidants, such as phytophenolics and carotenoids which also provide distinct flesh colours. The high perishability of sweet potato roots during storage remains a major constraint. It is widely cooked by deep frying and consumed in forms of French fries and chips. Consumers are increasingly health conscious and trends are moving toward foods with low oil content. This research has been focused on different parameters of drying for minimum oil absorption and sensory palatability while maintaining the most phytochemical components such as total phenolic, total flavonoid and carotenoid; extending product shelf life during packaging and preservation. Results revealed that frying 2.0 cm of sweet potato chip in soybean oil heating at 150oC in 2 minutes was appropriated. Fried sweet potato chip could be preserved for 12 weeks under vaccum at 4oC. Moisture and oil content, as well as colour and texture are important quality attributes of fried sweet potato products. Frying of sweet potato bars is carried out to convert the roots to value added products. Frying method brings out unique flavor and texture to the products that improve their overall acceptability.Keywords: Sweet potato chip, Frying, Shelf life, Carotenoid, Flavonoid, Vaccum.
Inverse Correlation between Combination of Antiretroviral Therapy with the level of Serum Interleukin-6, Ferritin, and Hepcidin in HIV Patients with Anemia Chronic Disease I Ketut Agus Somia; Ketut Tuti Parwati Merati; I Made Bakta; Ida Bagus Putra Manuaba; Wayan Putu Sutirta Yasa; I Dewa Made Sukrama; Ketut Suryana; Rudi Wisaksana
Journal of Global Pharma Technology .
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Abstract

Background: The purpose of this study was to determine whether the cARV therapy correlates with the serum level of IL-6, ferritin, and hepcidin in HIV infected patients with ACD.Methods: A cross-sectional study conducted in HIV patients with ACD, aged 15-65 years with exclusion criteria such as chronic renal disease, chronic liver disease, treated for anemia in the last 3 months, taking iron supplements in the last 3 months, history of blood transfusion in the last 1 year, suffering from acute infection, tuberculosis infection, malignancy, hepatitis C virus infection, acute hypersensitivity reaction and pregnancy. Blood specimen examined by high sensitivity human IL-6 In vitro ELISA, DRG Hepcidin- 25 ELISA, serum ferritin by agglutination method and CD4 cell count by flow cytometry. Results: A total of 86 HIV patients with ACD consist of 42 subjects with experienced cARV and 44 subjects with naive cARV. There are several differences between cARV naïve and experienced cARV including: Hb (g/dl) [ 10.8 ( 9.88 – 11.75) Vs. 11.60 (11.00 – 12.34) p: 0.058 ], serum iron (mg/dl) [ 50.00 (31 – 66.8) Vs. 71.40 (56.00 – 108.00) p: 0.121 ), serum ferritin (ug/dl) [ 630 ( 194 – 1101) Vs. 195.40 (128.25 – 589.47) p: 0.008 ], IL-6 (pg/mL) [7.20 (3.88 – 10.76) Vs. 4.03 (1.69 – 8.49) p: 0.009), serum hepcidin (ng/mL) [45.54 (16.74 – 95.31) Vs. 23.35 (6.58 – 49.99) p: 0.007] , CD4 cell count (cell/uL) [31.5 (14.25 – 90.75) Vs. 307 (168.5 – 458.75) p : < 0.001)] There is a significant inverse correlation between the cARV therapy with level of serum IL-6 ( r: - 0. 285, p: 0.008), ferritin (r: - 0.321, p: 0.007) and hepcidin (r: - 0.293, p: 0.006). While there was a significant positive correlation between the cARV therapy with CD4 cell count (r: 0.676, p: 0.001). There was no correlation between the cARV therapy with serum iron levels ( r: 0.176, p: 0.121).Conclusion: There is an inverse correlation between the cARV therapy with serum level of IL-6, ferritin, and hepcidin in HIV patients with ACD.  Keywords: cARV, ACD, IL-6, Ferritin, Hepcidin.
The Effect of Bay Leaves (Syzygium Polyanthum) Administration Towards the Final Weight and Carcass Percentage of Laserpuncture-Induced Male Hybrid Ducks Lucia Tri Suwant
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

The carcass weight of laserpuncture-induced male hybrid ducks is not maximum yet. Nevertheless, it can be resolved by using bay leaves (Syzygium polyanthum) as a supplementary feeding to support the optimal work of laserpuncture technology. This research aims to evaluate the impact of bay leaves (Syzygium polyanthum) towards final weight and carcass percentage of laserpuncture-induced male hybrid ducks. This research applied Completely Randomized Design (CRD) with three treatments. Each treatment consisted of six replications, and each replicate consisted of six male hybrid ducks with homogenous age and weight. The three treatments were P0 (Control), P1 (Laserpuncture), and P2 (Laserpuncture and bay leaves). The data were analyzed by using Analysis of Variance (ANOVA) and continued by Least Significant Difference (LSD). The results suggested that the bay leave administration on laserpuncture-induced male hybrid ducks (P2) provided a significant effect (P<0.05) in comparison with (P0) & (P1) on the final weight. However, an insignificant effect (P>0.05) was identified on the carcass percentage of male hybrid ducks. The bay leaves administration on laserpuncture-induced male hybrid ducks can intensify the final weight gained, but it does not affect the carcass percentage.Keywords: Hybrid Duck, Laserpuncture, Bay Leaves (Syzygium Polyanthum).
Gypsiferous Soil Analysis of Samara-Tikrit Area-Iraq Weam H. Kadum
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The soil properties are an important parameter for architectural and structural design of structures. Samara-Tikrit area in Iraq is a tourist destination, so in the last decade a number of multistory buildings, roads, etc. have been constructed. This study investigates the properties of the soil to give a base data, which can be used for the future construction design. This work aims investigating the gypsiferous soils texture, mineralogy and to interpret their geotechnical characteristics in Samara-Tikrit area, Iraq. A total of thirteen (13) soil samples were taken of gypsiferous soils distributed on three (3) sites. The results of grain-size analysis show that mixture of sand with variable percentages of clay and the silt fractions. The soil profile in site 1 reflect that the upper (0.9) m. is of sandy clayey silt, whereas the lower (2) m. is of silty sandy clay. The deep soil is of silty and clayey sand that reach 4.5 in depth. Concerning the soil profiles in site 2 and 3 representing silty sandy clayin general and silt beds occur at site 3. The soils within the three sites are fine-grained, yellowish light brown, moderately to highly gypsum, ranging from friable to very hard gypsiferous soil. The results of thin section are indicating that gypsum ranges from 12.3-35.4 %; clay comprise 12.0-26.2 %, while calcite and dolomite are from 9.6- 23.2 %. Quartz and Chert grains are ranging from 11.3- 26.0 %. Feldspar is ranging between 9.3- 19.0 %, while rock fragments is ranging from 7.2-15.7%, with heavy minerals ranging from 0.8 -1.9%.  The X-ray diffraction analysis reflects that non-clay type minerals are quartz, calcite, dolomite, gypsum and feldspar; while the clay minerals are chlorite, smectite, kaolinite, illite and palygorskite. The geotechnical properties results reflect that six samples (1a, 1c, 1d,2c, 2d, 3b) are classified as gypsiferous soil with  less  than 25% gypsum content and with less values of initial void ratio, coefficient of curvature, uniformity coefficient, collapse potential %, compression strength, cohesion, and plasticity index %  while the other seven samples (1b,1e,2a,2b,2e,3a,3c ) are classified as highly gypsiferous soil with more than 25% gypsum content and with relatively higher values of initial void ratio, coefficient of curvature, uniformity coefficient, collapse potential %, compression strength, cohesion and plasticity  index%  .Keywords: Gypsiferous soil, Texture, Mineralogy, Samara-Tikrit area, Iraq.
Early Detection of Prostate Cancer by Tumour Marker PSA, CEA and CA19.9 Sahira H. Kareem
Journal of Global Pharma Technology .
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Abstract

Prostate cancer is the most common cancer and the second leading cause of cancer deaths in men. , tumor markers are substances that can be found in the body when cancer is present, Prostate-specific antigen (PSA) is well known as a specific tumor marker for prostate cancer Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) elevating adenocarcinomas originating in the prostate gland. In the present study have been investigated the levels of cancer antigen and some of trace element in fifty men, aged were 50 – 75 year they divided into two groups included prostate patients and control groups. This study showed significant increasing (P<0.05) in the level of PSA, CEA and CA19.9 concentration in forty cases of prostate patients and significant increasing (P<0.05) in CEA and CA19.9 concentration with a note that the concentration of PSA was low in ten cases of prostate cancer patients and significant difference in serum trace element concentration.Keywords: Prostate Cancer, PSA, CEA, CA19.9 and Trace Element.
The Effect of Different Surface Treatments of Cad/Cam Sub-Structures on Microleacage of Veneering Composite Resins Mustafa A. Zeinalabdeen
Journal of Global Pharma Technology .
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Abstract

Purpose: The aim of the study is to evaluate the effect of different surface treatments on the microleacage of hybrid composite resin to Lava Ultimate and Vita Enamic hybrid resin-nanoceramic CAD/CAM blocks. Materials and Methods: In this in-vitro study for each CAD/CAM block (4) samples were prepared and divided according to surface treatment to (4) groups as follows: control, 50 μm (Al2O3) airborne-particle, fem to second laser & combination of 50 μm (Al2O3) airborne-particle and femtosecond laser. One additional sample for each CAD/CAM block was prepared for each surface treatment group for SEM analysis. Filtek Z250 hybrid composite was adhered onto each sub group after application of universal single bond adhesive. Microleacage test for each sample was evaluated after (1000) thermal aging cycle. Dye penetration technique using a solution of 0.05% basic fluxin solution to evaluate microleacage between composite resin and CAD/CAM block.  Results: Examination revealed that there is no microleacage occurred in any of tested groups (0). Conclusions: As a result of this study using these methods of surface treatments is expected to increase clinical success of the restorations.Key words: Micro-tensile bond strength, Surface treatment, Fem to second laser, CAD/CAM.
Cytomorphological Monitoring of the Rate of Healing of Aft and Traumatic Injuries of the Oral Mucosa Anton Timoshin
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

The oral mucosa is an indicator that shows the state and functioning of internal organs and systems of the entire body. Inflammatory diseases of the oral mucosa are a pathology that affects patients of various ages. And it causes some discomfort to the patient and disrupts the usual rhythm of life. With a long course of this pathology, there is a violation of the endocrine glands, the immune system, and against the background of a painful symptom, psycho emotional tension may occur. The inflammatory process on the oral mucosa can be caused by factors such as bacterial, viral, fungal, and others. Regardless of the etiological factor, the inflammatory process itself does not pose a threat to the patient's life, even in spite of the etiological factor, although it complicates it. However, in the absence of treatment and prolonged course, it can lead to malignancy of the process. This is facilitated by the constant impact on the pathological focus of mechanical, chemical and thermal stimuli when eating. Also, if the patient has chronic somatic diseases that occur against the background of a decrease in immunological protection, the threat increases. Keywords: Oral mucosa, Inflammation, Pathology, Farmadont III.

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