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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Physical Factors in the Treatment of Chronic Venous Insufficiency of the Lower Extremities Aleksandr Derinov
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Trophic ulcers are one of the most severe complications of chronic venous diseases, leading to functional insufficiency of the lower extremities and a sharp decline in the life quality. Complex of preoperative preparation and combination with various methods of surgical correction are essential in this case. Higher results can be obtained with combined application of several techniques. Topical application of combined low-intensity laser radiation and micro dispersed drug irrigation is a pathogenetically substantiated non-invasive method of conservative treatment and preoperative preparation of trophic ulcers in patients of the C6 class.Keywords: Bactericidal therapy, Pain syndrome, Varicose veins, Trophic ulcers.
Effect of Cinnamon (Cinnamomum burmannii) Bark Oil on Testicular Histopathology in Streptozotocin Induced Diabetic Wistar Male Rats Mustofa Helmi Effendi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The purpose of this study was to determine the effect of cinnamon bark oil (CBO) on testicular histopathology. The variables taken were the diameter of the seminiferous tubules and the number of leydig cells in the testes of white male rats (Rattus norvegicus) which had been induced by streptozotocin. Twenty white male rats adult Wistar strains aged 2-3 months with an average weight of 150-250 grams were used in this study. The rats were divided into five experimental groups (4 rats each group) treated with a combination of streptozotocin and cinnamon bark oil (CBO) which were designed as follows: K(-), K(+), P1, P2, and P3. P is white rat injected with streptozotocin with a single dose of 45 mg / kg body weight intraperitonially, followed by therapy. K(-) without streptozotocin and only given drug solvent, K(+) given drug solvent, P1 treated with CBO 100 mg / kgBB orally, P2 treated with CBO 200 mg / kgBB orally, P3 treated orally with CBO 400 mg / kg orally for 14 days. White rat animals were then mutilated and testicular organs were taken for histopathological preparations using HE staining, then the diameter of the seminiferous tubules and the number of Leydig cells were calculated. Data were analyzed with One Way ANOVA and followed by Duncan's test. The results showed that streptozotocin had the potential to reduce the size of the seminiferous tubule diameter and the number of Leydig cells, while CBO at a dose of 400 mg / kgBW could increase the size of the seminiferous tubule diameter and the number of Leydig cells. It can be concluded that CBO can be used to reduce testicular dysfunction induced in diabetic rats.Key words: Cinnamon bark oil, Seminiferous tubule diameter, Leydig cells, Streptozotocin, Male rat.
Histological Effect of Androgenic Anabolic Steroide Dianabol in Heart and Some Blood Parameters of Male Albino Rats Ahmed Obaid Hossain
Journal of Global Pharma Technology .
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Abstract

Anabolic androgenic steroids (AAS) standup between the drugs most broadly ill-treated with the goalmouth of improving athletic ability, appearance or muscle mass. Androgenic anabolic steroid (AAS) the most widespread types of steroids in general and particularly between young people as it works to increase the body’s metabolism, The current study was performed to examine effect of androgenic anabolic steroid dianabol in heart and some blood parameters for male Albino rat . In this research the rats were divide in to three groups, ( 4 replicates for each) . The first group control was orally received normal saline for such period . while the second group (t2) and third (t3) treated groups orally received dianabol suspension at concentrations 30 and 50 mg/kg/day for 8 weeks respectively. The results in heart tissue (both groups) show mild hemorrhage and no singes of necrosis in the tissues. The results showed that significant increase`(P<0.05) in RBC count , platelets total , Hb , p.c.v and ratio of lymphocytes in treatmssents groups compared with control , while the WBCs count show significant decrease (p<0.05) in percentages of granulocytes and monocytes, furthermore
Effectiveness of Edible Coating to Preservation of Passion Fruit Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Passion fruit (Passiflora edulis) is considered an exotic species with attractive flavor and aroma. This is a rich source of bioactive compounds, as polyphenols. The interest in P. edulis has been increased because of its antioxidant compounds. Passion fruit is generally considered to have a short storage life, because it is a very delicate, perishable fruit. The main problem of postharvest losses associated with passion fruits is rapid loss of firmness. The objective of the present study was to identify the effect of different carrageenan concentrations (1.0%, 1.5%, 2.0%, 2.5%, 3.0%) and storage temperature (8 oC, 12 oC, 16 oC, 20 oC) to the weight loss, firmness, total soluble sugar and ascorbic acid in passion fruit (Passiflora edulis) fruits during preservation. Moreover, shelf life (0 day, 7 days, 14 days, 21 days and 28 days) of passion fruit (Passiflora edulis) fruit in storage also clarified. Results demonstrated that carrageenan 2.5% and storage temperature 8 oC could maintain passion fruit (Passiflora edulis) fruit quality for 28 days without any deterioration. This is an opportunity to develop value‐added products reducing the postharvest losses, improving nutritional value and generating additional revenue for passion fruit growers.Keywords: Passion fruit, Carrageen an, coating, Firmness, Shelf life, Preservation.
Safety, Health and Feasibility Local Wisdom and Regulation of Marine Products: Convergence and Case Study of Mare Island, Tidore Islands Husen Alting; Suwarti Suwarti; Irfan Ahmad
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Purpose: to finds a convergence between the local regulation and wisdom in Mare regarding the sustainability of resources and marine products and its safety, feasibility and health standards. Methods: this study is a descriptive qualitative study which describes regulations on the safety, feasibility and health standards of processing seafood and local wisdom regarding the preservation of marine resources. Result: Local wisdom in Mare has not been able to achieve regulations related to safety, feasibility and health standards of seafood but the local wisdom was able to maintain the sustainability of marine resources. Both of these things can be converged with technology so that the sustainability of marine resources can be achieved while realizing the safety, feasibility and health standards of marine produce. Conclusion: local wisdom is not a static thing so that between local wisdom and the preservation of marine resources and safety regulations, feasibility and health standards of seafood can be converged upon them.
Effectiveness of Edible Coating to Extend Shelf-Life of Dry Fermented Sausage N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

The manufacturing of rapid and shelf stable dry fermented sausages became an art and provided the market with a very diverse range of delicacies. Fermented sausages can be defined as a meat product made of a mixture of mainly pork meat pork fat, salt, curing agents, sugar, spices, and in many cases starter cultures are added. The mix, including as little oxygen as possible, is placed into steam - permeable casings and subjected to a fermentation and drying process. Fat is one of the important factors contributing to enhanced flavor, texture, juiciness, and mouth feel of dry fermented sausage. However, fat is easily rancid to create bad odor as well as lower product quality and shelf-life. Objective of the current research studied the feasibility of edible coating in extending shelf-life of dry fermented sausage. The dry fermented sausages were treated by different formulas (N0: control; N1: 2.0% wheat gluten; N2: 2.0% w/w chitosan; N3: 2.0% w/w sodium alginate; N4: 2.0% w/w collagen) and in different concentration of chitosan (2.0%, 2.5%, 3.0%, 3.5%, 4.0%). The effectiveness of edible coating was based on the physicochemical attributes such as pH, water activity (aw), TBARS value (mg/kg); biogenic amines such as tyramine (mg/kg), 2-phenylethylamine (mg/kg), tryptamine (mg/kg), cadaverine (mg/kg), putrescine (mg/kg) and histamine (mg/kg); antimicrobial capacities such as total plate count (cfu/g), Enterobacteriaceae (cfu/g), Coliform (cfu/g), E. coli (cfu/g), Staphylococus (cfu/g), Listeria (cfu/g), Salmonella (cfu/g), Vibrio (cfu/g), yeast (cfu/g), mold (cfu/g) and sensory characteristics of dry fermented sausage during storage. All treated samples were analyzed after 9 months of storage at ambient temperature under vaccum packing. Results revealed that the incorporation of 3.0% w/w chitosan could inhibit microbial spoilage and lipid oxidation and therefore maintain the sensory score of the dry fermented sausage for 9 months during storage. The study indicated that the combination treatment with edible coating could be commercially utilized to maintain the freshness and prolong the shelf‐life of the dry fermented sausage.Keywords: Dry fermented sausage, Wheat gluten, Chitosan, Sodium alginate, Collagen, Antimicrobial, biogenic amine, Sensory.
Factors Affecting Amputation in Patient with Diabetic Foot Ulcer at Sardjito General Hospital Andreas Wahyu Wicaksono
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Diabetic foot ulcer (DFU) can cause significant morbidity and need for surgical intervention due to the high prevalence of diabetic foot problems in general population. The incidence of DFU is 15% of all diabetic patients. Eighty-two percent (82 %) of DFU will lead to lower extremity amputation. Therefore, the factors that affecting the needs of distal limb amputation should be described for prevention and decrease the need of amputation and morbidity of the patients. Objective: The aim of this study is to determine factors affecting distal limb amputation in patient with DFU. Methods: The design of this study is retrospective cohort, using data of DFU patient treated surgically from January 2012 to September 2016. Socioeconomic factors, Blood profile, Diabetes Mellitus (DM) profile and Ankle Brachial Index (ABI) were collected. All the data were then analyzed using SPSS. Result: There were 119 patients were enrolled in this study. Thirty-nine patients (32.7%) had distal limb amputation. The amputation level was forefoot (34 patients, 87%), mid foot (2 patients, 5%), hind foot (2 patients, 5%) and Trans tibial (1 patient, 3%) amputation. This study showed that socioeconomics factors were not significantly correlated with distal limb amputations in patients with diabetic ulcer. The level of DLA was not affected by patient’s blood profile, DM profile and ABI. Conclusion: Decision to perform surgical intervention can not only rely on the laboratory profile and socioeconomic factors of the patients. Clinical judgement of the doctor and the patients' general conditions should also be considered.
Assessment of the Level of Motivation of Academic Achievement, Professional Orientation and Future Perceptions of Students of Physical Education Faculties in the Middle Euphrates Universities Ayman Hani Abed Al-Gburi
Journal of Global Pharma Technology .
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Abstract

The Study ObjectivesEstablish standard levels of motivation for academic achievement, professional orientation and future perceptions of students of physical education faculties in the middle Euphrates universities.To identify the drivers of academic achievement, professional orientation and future perceptions of students of physical Education colleges at the middle Euphrates universities.To identify the level of motivation of academic achievement, professional orientation and future perceptions of students of physical education faculties in the middle Euphrates universities.Researchers used the survey curriculum to identify the drivers of academic achievement, professional orientation, future perceptions and student assessment according to these variables, and the research community included the students of the fourth stage in the faculties of Physical Education and Sports sciences at the Middle Euphrates universities, after which it was applied Metrics for the purpose of conducting the assessment, and using the appropriate statistical means in order to process data using the statistical pouch (SPSS).In the light of the results of the present research, and of the interpretations that have been followed, we can draw some conclusions, the most important of which are the following:Standard standards of motivation for academic achievement, professional orientation and future perceptions have been established for students of Physical Education Colleges and Sports sciences at the Middle Euphrates universities.Students of the faculties of Physical Education and Sports sciences at the Middle Euphrates universities have an average level of motivation for academic achievement, professional orientation and future perceptions.There is a potential for developing the motivation for academic achievement, professional orientation and future perceptions of students of physical Education Colleges and Sports sciences at the Middle Euphrates universities.In the light of the findings and conclusions of the research, the current research has reached the most important recommendations, as follows:To take advantage of the benchmarks of academic achievement, professional orientation and future perceptions that researchers have applied and set standards for them to detect these variables for students of physical Education Colleges and Sports Sciences in Iraq.Use of standards in educational and psychological guidance to develop the motivation of academic achievement, professional orientation and future perceptions.The need to provide specific lectures to students during educational and teaching units by a psychologist and a psychologist.Keywords: Assessment, Academic achievement, Professional orientation and future perceptions.
Evidence-Based Dentistry Caries Risk Assessment and Disease Management Hanaa Raheem Fahad
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Dental caries is a multifactorial, dynamic disease process that results from a dysbiosis in the biofilm, driven by exposure to fermentable carbohydrates, which over time leads to demineralization of dental hard tissues. In spite of the significant reduction in caries prevalence in many parts of the world, dental caries remains a major public health problem affecting people of all ages. Furthermore, the disease is not equally distributed, with multiple population groups at increased risk. If allowed to progress, over time the disease will result in the development of detectable changes in the tooth structure, or caries lesions, which initially are noncavitated (i.e., macroscopically intact, sometimes referred to as “white spot” or “incipient” lesions), but that eventually might progress to cavitation. Modern caries management stresses a conservative and preventive evidencebased philosophy, with patient-centered risk-based disease management, early detection of caries lesions, and efforts to remineralize and/or arrest noncavitated lesions that aim to preserve tooth structure and maintain health. In support of this philosophy, numerous systems and guidelines have been developed. Furthermore, this caries management philosophy is the basis for current cardiology education frameworks worldwide.Keywords:  Dentistry, Fluorides, Risk Assessment Disease, Risk Assessment Management.
In Vitro Assessment of Total Phenolic, Total Flavonoid and Sunscreen Activities of Crude Ethanolic Extract of Belimbing wuluh (Averrhoa bilimbi) Fruits and Leaves Muhammad Ryan Radix Rahardhian
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Averrhoa bilimbi, namely belimbing wuluh in Indonesia. It’s the fruits used to food in vegetable dishes. Belimbing wuluh’s leaves and fruits are traditional herb in Indonesian. This study aim to determined total phenolic content, total phenolic content and sunscreen activity from ethanolic extract of Belimbing Wuluh fruits and leaves. Total phenolic content of fruits ethanolic extract is 19.8022 ± 1.6696 mg GAE/g more than leaves ethanolic extract 6.5886±0.0590 mg GAE/g. Both have significant differences after tested t test (sig<0.05). Total flavonoid content of fruits ethanolic extract 24.7458±0.3291 mg RE/g more than leaves ethanolic extract 13.3126±0.5695 mg RE/g. Both have significant differences after tested t test (sig<0.05). Sun Protecting Factor of leaves ethanolic extract better than fruits ethanolic extract. Only one leaves ethanolic extract concentration of 300 ppm can be drawn in the total block valuation category with ultra protection. The conclusion is leaves ethanolic extract has good potential as an active sunscreen ingredient although it has a total phenolic content and a lower total of flavonoids than fruits ethanolic extract of belimbing wuluh. These data indicate that the sunscreen active ingredients found on the leaves of belimbing wuluh are suspected of phenolic compounds and other components that have a conjugated double bond that can absorb UV light in the 290-320 nm range.Keywords:  Averrhoa bilimbi, Total Phenolic Content, Total Flavonoid Content, Sunscreen Activity.

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