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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Electrical Stimulation Type (Body Relax) in the Treatment of Chronic Lower Back Pain for the Players Physical Strength Isam Talib Abbas
Journal of Global Pharma Technology .
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Abstract

Chronic back pain is one of the most common injuries in physical strength players. The importance of research is to relieve pain in the lower back muscles and reduce the complications that result from chronic pain reduction using a type of electrical stimulation with frequencies dedicated to muscle relaxation. The problem of research lies in the lack of use of technical means of effective and direct impact in the rehabilitation of lower back injuries of physical strength players, especially that this group of players need special care in the process of rehabilitation. The aim of the research was to use the electromyostimulate (EMS) type body relax in the treatment of chronic low back pain and to know its effect on those with the pain. The researchers used the electrical stimulation used by the researchers to have a positive effect in reducing chronic pain and rehabilitation of the lower back muscles of the physical strength players in question. The research method used the experimental method of one group and identified the research community of players with low back pain in the physical strength of the successors in Najaf, and the sample of the study (6) injured players were chosen by deliberate method, and used the form of measuring the degree of pain according to the test Shopper and physical tests The training program included the use of EMS for muscle relaxation. The researchers used the statistical program (SPSS) and used the following statistical means (median, spring deviation, and toxin).The most important conclusions reached by the researchers are:1. The electrical stimulation of the body relax is a major role in reducing the level of chronic low back pain and improve the physical flexibility of the muscles of the lower back of the players of physical strength.Keywords: Electrical stimulation, Chronic, Lower back pain and Physical strength.
Vitamin D3 Level and Its Receptor of Patients with Psoriasis: A Case Control Study Abdulsamie Hassan Altaee
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Abstract

Psoriasis is multi-factorial disease resulted in response to increase secretion of inflammatory cytokines or deficiency in certain vitamins such as vitamin D3. This study aims to evaluate the levels of vitamin D3 and its receptor (VDR) in psoriatic patients and healthy control, additionally to determine the ratio between vitamin/receptor and their relative risk in the pathogenesis of psoriasis. This study was design as a case-control study and includes 45 psoriatic subjects and 45 healthy controls. The results of currents study were found a significant decrease in vitamin D3, VDR levels and vitamin D3/ VDR ratio when compared with the healthy control group. The relative risk for VDR levels with psoriasis found to be positively significantly associated, whereas those for vitamin D3 levels with psoriasis were insignificant. In conclusion, the relative risk for VDR is more than that for calicitriol and this support the pathogenic role of VDR abnormality in psoriasis.Key words: Vitamin D, Vitamin D receptor, Psoriasis, Keratinocyte, Babylon.
Assessment of the Effectiveness of Simulation and Recitation Training for Traffic Control Volunteers (Supeltas) on Cervical Spinal In-Line Position Stabilization with Helmet Removal Maneuvers Ferry Efendi
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Motor vehicle traffic accidents are a leading cause of death for an individual in Indonesia. This study aimed to evaluate the effectiveness of training using simulation and recitation models focusing on the achievement of the pre-hospital performance of traffic-control volunteers (Supeltas) in stabilizing cervical spinal in-line position in helmet removal maneuver. This study applied pre-test and post-test design with 248 respondents. Data were collected using questionnaires and evaluation papers to assess volunteers during practical tests. Data statistical analysis procedures included One-Way ANOVA, Wilcoxon-signed rank test, and N-gain score test. Differences were noted in the demographic data with significant findings and effects associated with age (p= 0.041) and education (p= 0.046) of Supeltas in stabilizing the cervical spine. The intervention group exposed to SMT training model showed a difference in the average scores of knowledge (mean 60.85 to 85.67; p= 0.010) and skills (mean 59.80 to 86.81; 0.002), which were greater than the scores of the group receiving RMT (mean 53.65 to 65.06; p = 0.028) and skills (mean 59.20 to 84.73; p= 0.043). The knowledge (N-gain score = 61.35%) and skills (N-gain score= 61.41%) of the group receiving a role-playing model (SMT) increased more effectively, compared to the increase experienced by the group receiving an assignment (RMT) (N-gain score knowledge= 23.57%; skills= 17.29%). This study suggests that the simulation model is more effective than the recitation model in improving the ability of Supeltas in stabilizing the cervical spinal in-line position for helmet removal in trauma situations. Keywords: Recitation, Simulation, Stabilization, Training.
A PARAMETRIC APPROACH ON ACCELERATED FAILURE TIME MODEL sujatha - vishnumoorthy; Dharanidharan vishnumoorthy
Journal of Global Pharma Technology .
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Abstract

Survival analysis techniques have become standard tools for statistician in controlled clinical trial. The application of survival models to clinical trial data is valid when the endpoint of interest is the “time to the occurrence of a particular event”. The Cox’s proportional hazard model and its extension are used comprehensively for the past two decades. The Accelerated failure time(AFT) model is also presented and competing to proportional hazards model in the analysis of clinical trial data where the effect of treatments are to accelerate the event of interest in a tuberculosis controlled clinical trial over a treatment period of six months. It is concluded that the proportional hazards models demonstrate significant lack of fit while the accelerated failure time model in this and an illustration about the added advantages of AFT model
Effects of coal dust particulate matter exposure on H2O2, MDA, IL-13, TGF-β3 level and bronchioles sub-epithelial fibrosis in allergic asthma mice model Fujiati .
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: Pulmonary fibrosis in asthma is marked by a rapid decline in lung function. Unfortunately, the environmental factors aggravating this condition are still poorly understood. To date, the pathomechanism of exposure to coal dust affecting the subepithelial fibrosis in asthma remains unclear. Methods: Twenty-fourth female BALB/C mice were divided into four group. The first group was control, the second was mice exposed to coal dust particulate matter (PM) (days 46-75), the third was OVA sensitized mice  (Initial sensitization on day 0 and 14, re-sensitization days 21-75), and the fourth was made of OVA-sensitized mice and exposed coal dust PM. Results: The results showed coal dust PM significantly decreased levels of IL-13 BAL (p-value=0.001) but significantly elevated H2O2 BAL levels (p-value=0.001) and increased sub-epithelial bronchial fibrosis thickness (p-value= 0.000). This was based on the scale of fibrosis (0=<5 μm, 1=5-10 μm; 2=11-15 μm; 3=>15 μm; score 0-1=mild; 1-2=moderate; and 3= severe). The combination of ovalbumin sensitization and PM coal dust caused severe fibrosis (score 3).There was no significant association between IL-13, TGF-β3, H2O2, and MDA BAL with sub-epithelial fibrosis thickness. Conclusions:  PM exposure to coal dust may increase sub-epithelial fibrosis of the bronchioles by a mechanism independent of inflammation and oxidative stress.Objective:Pulmonary fibrosis in asthma is marked by a rapid decline in lung function. Unfortunately, the environmental factors aggravating this condition are still poorly understood. To date, the pathomechanism of exposure to coal dust affecting the subepithelial fibrosis in asthma remains unclear. Methods: Twenty-fourth female BALB/C micewere divided into four group. The first group was control, the second was mice exposed to coal dust particulate matter (PM) (days 46-75), the third was OVA sensitized mice (Initial sensitization on day 0 and 14, re-sensitization days 21-75), and the fourth was made of OVA-sensitized mice and exposed coal dust PM. Results: The results showed coal dust PM significantly decreased levels of IL-13 BAL (p-value=0.001) but significantly elevated H2O2 BAL levels (p-value=0.001) and increased sub-epithelial bronchial fibrosis thickness (p-value=0.000). This was based on the scale of fibrosis (0=<5μm, 1=5-10μm; 2=11-15μm; 3=>15μm; score 0-1=mild; 1-2=moderate; and 3= severe). The combination of ovalbumin sensitization and PM coal dust caused severe fibrosis (score 3).There was no significant association between IL-13, TGF-β3, H2O2, and MDA BAL with sub-epithelial fibrosis thickness.Conclusions:  PM exposure to coal dust may increase sub-epithelial fibrosis of the bronchioles by a mechanism independent of inflammation and oxidative stress.
Treatment for Patients with Primary Immunodeficiency Diseases Anastasia Gradskaya
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Primary immunodeficiency diseases occur with a frequency of 1: 10,000 pp. among population. The purpose of this study is to evaluate the most common forms of primary immunodeficiency among patients in Moscow based on the Russian registry for primary immunodeficiency, as well as to analyse the treatment tactics of three patients. The studies were conducted in 2016-2018 among 73 patients aged 5-12 from Russian Children's Clinical Hospital (RCCH), all diagnosed with primary immunodeficiency. The classification of patients was carried out according to the Russian registry by type of primary immunodeficiency. Lethal cases, gender and age distribution were considered. The treatment tactics of three patients were analysed. The number of boys exceeds the number of girls by 7.2 times (p ≤ 0.001) for defects in antibody production, by 6.0 times (p ≤ 0.001) for combined immunodeficiency, by 1.4 times (p ≤ 0.05) for phagocytic defects, and by 2.5 times (p ≤ 0.01) for other types of immunodeficiency. The patients with defects in antibody production predominated, namely by 1.5 times - patients with combined immunodeficiency (p ≤ 0.05), by 2.8 times - patients with phagocyte defects (p ≤ 0.01), by 4.7 times - patients with other types of immunodeficiency (p ≤ 0.001). 73 patient patients under the age of 12 years with primary immunodeficiency had their anamnesis analysed that helped to identify 4 main forms. Boys prevailed in gender composition (80.8%), and there were no significant differences between boys and girls in age. The lethality prevailed among patients with combined type immunodeficiency. Thus, there were 1.3 times less lethal cases among patients with phagocyte defects comparing to the combined type (p ≤ 0.05), but 2.4 times more compering to the other types of immunodeficiency (p ≤ 0.01).Keywords: Primary immunodeficiency diseases, Patient registry, Combined immunodeficiency, Defects in antibody production.
Some of the Biomechanical Variables and Their Correlation in the Performance of the Cartwheel Skill on the Surface of Movements in the Gymnastics for Women Ruaa Ali Hussein
Journal of Global Pharma Technology .
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Abstract

The importance of research in the knowledge of the relationship between some of the biomechanical variables and the performance of human wheel skill on the ground movements of women in the players of the team of the Faculty of Education for Girls / University of Kufa, which can be invested correctly and in a scientific way to achieve good performance and through the researchers to the nature of the educational process of basic skills In the gymnasium and their teaching and training experience, the following question is answered in this study:What are the biomechanical variables that are related to the performance of cartwheel skill on the surface of movement for women in the gymnastics?The researcher used the descriptive approach in the method of correlative relations to suit the nature of the research problem. The descriptive approach is one of the best approaches to achieve the research objectives. The research society was (10) players of the team of the Faculty of Education for Girls in gymnastic / University of Kufa. The experiment was conducted first, Field research through video imaging and analysis of biomechanical variables and reaching the results identified by the power platform device, which dealt with statistics using the statistical file (SPSS), which enabled the researchers to reach conclusions:There is a significant correlation between positive biomechanical variables and the cartwheel. Biomechanical variables are important in the performance of the gymnastic skills, where the correct performance paths of the skill are shown. The recommendations are the need to focus on the biomechanical variables examined for possible development through exercises to help them achieve the best achievement. This is the desired goal.Keywords: Biomechanical variables, Cartwheel skill, Surface of movements and gymnastics.
The Effect of Ethanolic Extract of Mangosteen Peel As Adjuvant Therapy to TNF-Α And IL-10 in Wistar Rats Infected with M.tuberculosis H37rv Indah Widyaningsih
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Objective: This study was an experimental study of wistar rats infected with M. tuberculosis H37 Rv and then given isoniazid  INH as an anti-tuberculosis drug and ethanolic extract of mangosteen peel as adjuvant therapy. Method: Rats infected with M tuberculosis H37rv 106 Mc Farland, as 100µl intratracheal. Rats were randomly divided into six groups control (K1), rats infected with M tuberculosis H37rv  only (K2), and rats infected with M tuberculosis H37rv and then treated with INH 100,200, 300 and 400 mg/kg body weight/ day (P1, P2, P3 and P4, respectivelyAfter administration of 4 weeks of therapy, the rats were sacrificed and the right lung  tissue was  collected to measured the levels of TNF α and IL 10 by using  ELISA. Results  The mean level of TNF α was found in the lowest P2 group compared to the treatment group (P1, P3 and P4) and the control was 24.16pg/ml. The  level of  IL 10 was found in the lowest P2 group compared to the treatment group (P1, P3 and P4) and the control was 232.75pg/ml. Ethanolic extract of mangosteen peel has a significant effect on decreasing levels of TNF α with a value of P = 0.000 <0.005 and IL 10 with a value of p = 0.001 <0.005.  Conclusion  Ethanolic extract of mangosteen peel is effective in reducing levels of TNF α and IL10 in adjuvant tuberculosis therapy, especially at doses of 200mg/kgbw/day, in smaller or larger doses there is an increased possibility of interaction between INH  and the active substances in the extract. Therefore further studies are needed to find the cause.Keywords: M.tuberculosis, Mangosten, TNFα, IL10.
The Effects of Hydroalcoholic Extract of Devil's Claw on Serum Levels of Obestatin and Body Weight in Male Rats Hossein Kargar Jahromi
Journal of Global Pharma Technology .
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Introduction previous studies have referred to the moderating effect of devil's claw on appetite process. Obestatin is a peptide with 23 amino acids secreted from parietal cells of gastric mucosa. This hormone inhibits food intake and body weight reduces. This study was conducted to study the effects of hydroalcoholic extract of devil's claw on serum levels of obestatin and body weight in male ratsMethod In this experimental study, 40 male Wistar rats with an average weight of 180-200 g were randomly divided into 5 groups of 8 animals (control, testator, and the experimental groups receiving the hydroalcoholic extract of devil's claw in concentrations of 150, 300 and 600 mm g per kg of body weight). Hydroalcoholic extract of devil's claw (HAEDC) was administered to animals in gavage for 28 consecutive days. One day after the last injection, the rats were weighed, and after getting blood samples and separation of serum, obestatin concentration was measured using ELISA kits for rats. Data analysis was performed using ANOVA with SPSS 21 and Duncan's test.Results 300 and 600 mg/kg of HAEDC significantly increase serum levels of obestatin and reduce body weight compared to the control group (p<0.05).Conclusion HAEDC reduces body weight by increasing secretion of obestatin that restrains the appetite.Keywords: devil's claw, Obestatin, Body weight, Rat.
Modeling of the Effect of Socio-Economic Factors on the Accessibility of Medical and Pharmaceutical Care to the Population (on the Example of Sudan) Ievtushenko Olena M
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Introduction. The availability of pharmaceutical care is closely connected with the health care system and may be influenced by many factors. The heterogeneity of factors determines the need for their ranking and selection, determining the degree of their mutual influence on each other and on the level of morbidity in the country. The purpose. The aim of the study was the modeling of the availability of medical and pharmaceutical care (for example, Sudan). Materials & Methods. For the analysis, the following factors were selected: share of the state’s population in the total population of Sudan, share of the state’s area, share of doctors in the total employed population of Sudan, territorial accessibility of medical care, growth rates of the pharmacy network in the state, territorial accessibility of pharmaceutical care, share of expenditures on medicines in the subsistence minimum of Sudanese. To determine the degree of influence of these factors on the incidence rate, correlation and regression analysis was used; the models obtained were tested for adequacy, including the normal distribution of residuals. Research results and discussion. As a result of the study, a number of models were obtained, of which the optimal one was chosen according to the corrected coefficient of determination. It was revealed that the main accessibility factors affecting the incidence of infectious diseases are the territorial accessibility of pharmaceutical care, the share of drug costs in the subsistence minimum of Sudanese, and the growth rate of the pharmacy chain. Conclusions. In accordance with the proposed model, it is possible to determine not only the level of morbidity, but also to simulate the level of accessibility of pharmaceutical care to the population of a separate municipality, to develop, based on the analysis performed, certain organizational, administrative or legislative measures.Keywords: Pharmacy, Accessibility, Medical care, Pharmaceutical care, Modeling, African countries, Sudan.

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