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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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The Role of Mobile Phones in the Transmission of Methicillin-Resistant Staphylococcus aureus (MRSA) among the Students and Staff of the College of Health and Medical Technology/ Kufa in Najaf, Iraq Oday Mitib Hadi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Background: During every phone call the mobile phone, come into close contact with strongly contaminated human body areas with hands to hands, and hands to other areas like mouth, nose, and ears [10]. Mobile phones touch faces, ears, lips, and hands of different users thus they may be serves as reservoirs of different pathogens [11].  This study was designed to determine the role of the mobile phones in the transmission of methicillin-resistance Staph. aureus. Methodology: The cross-sectional study was done in the college of health and medical technology/ Kufa- Najaf- Iraq. Three hundred swab samples from mobile phones were collected from the students and staff of the college from November- 2015- February-2016 and divided into three groups categorized according to the site of collection (from the mobile phones) as follows: earpiece, keypad or touch screen, and mouthpiece. All samples were cultured, and the resulting isolates were identified and subjected to antimicrobial susceptibility test by standard procedures (Kirby-Bauer method).Methicillin-resistant Staph. aureus was detected by using polymerase chain reaction (PCR) based on mecA gene.   Results: Keypad or touch screen was occupied the highest percentage (58.74%) of bacterial contamination among other regions i. e. earpiece (26.7%) and mouthpiece (14.83%).Coagulase-negative Staph. aureus was predominant (41.83%) bacterial genus among other Gram-positive genera. Other Gram-positive bacteria had different ratios; there were 28.37%, 19.71%, 8.65%, 0.96% and 0.048 for Micrococcus spp., Bacillus spp. Methicillin-sensitive Staph. aureus (MSSA), Methicillin-resistant Staph. aureus (MRSA), and Enterococcus faecalis, respectively. On the other hand, Gram-negative bacteria gave different percentages, ranging from 53.57% for E. coli to 3.57% for Salmonella spp. Molecular detection was revealed the presence of mecA gene in only two isolates of Staph. aureus. Conclusion: Mobile phones may serve as vehicles of transmission of methicillin-resistance Staph. aureus.Keywords: Mobile phones, Methicillin Resistant Staph. aureus,  Meca gene.
Study the Optical Properties of Fluorescein Sodium Dye Doped in Polymer Polyvinyl Alcohol Khawla J. Tahir
Journal of Global Pharma Technology .
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In this research, the linear and non-linear optical properties for laser dye fluorescein sodium in solvent Ethanol doped with polymer polyvinyl alcohol (PVA) at different concentrations (1x10-4,5x10-4,1x10-3,5x10-3,1×10-2,5x10-2) M were studied. Z-scan technique was used to determine the nonlinear optical properties like the refractive index (n2) and the absorption coefficient (β) at wavelength 532nm CW frequency doubling Nd-YAG laser. The results showing the nonlinear absorption coefficient (β) changes between saturated absorption and two-photon absorption of certain concentration while the refractive non-linear coefficient (n2) of film samples changes between positive (self-focusing) and negative (self-defocusing). The quantum efficiency has been calculated for the same above concentrations (87%, 83%, 76%, 73%, 70%, 67%) respectively.Keywords: Linear and non-linear optical properties, Fluorescein Sodium dye, Z-scan technique, fluorescence quantum efficiency.
Molecular Identification of Tomato Yellow Leaf Curl Virus and its Whitefly Vector (Bemisiatabaci) Aqeel N. Al-Abedy
Journal of Global Pharma Technology .
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This study was conducted in the Plant Virology Laboratory of Plant Protection Department at College of Agriculture-Karbala University to isolate and identify three viral isolates, which isolated from diseased tomato (Solanumlycopersicum L.) plants grown in farms of the desert region in Najaf, Karbala, and AL-Muthanna provinces in Iraq. In addition, this study also aimed at identifying the biotype of whitefly (B. tabaci) in 10 different locations in Najaf, Babylon, and Karbala. Identification of TYLCV and white flies was done on the basis of the PCR technique and determining the nucleotide sequences of the PCR-amplified products.   Results, obtained from the PCR amplification and analysis of nucleotide sequences of the amplified products of the viral isolatesusing BLAST (Basic Local Alignment Search Tool), showed that the three isolates belong to Tomato yellow leaf curl virus (TYLCV). Comparison of the nucleotide sequences generated from the identified TYLCV isolates with the nucleotide sequences deposited at the National Center for Biotechnology Information (NCBl) revealed that the identified TYLCV isolates (A1MA, A2MA, and A3MA) were not previously recorded at NCBI. Therefore; these identified sequences have been deposited and recorded in GenBank database (NCBI) under the accession numbers: KT961703, KU145132, and KT961704, respectively. From the analysis of the mitochondrial cytochrome oxidize I (mtCO I) sequence of B. tabaci using BLAST program, results indicated that the biotype B whitefly is the only biotype prevalent in sampling region and none of the collected whitefly samples contains either the Q biotype or any other whitefly biotype. 
The Effect of the Micro -Teaching Method on the Physiological Level of Testosterone and Learning the Most Important Basic Skills in Fencing Aqeel Yahya Hashim Abdulaziz
Journal of Global Pharma Technology .
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The -teaching method is one of the modern methods in which all curricula have been taken ,It is one of the methods of teaching that has emerged in the field of modern teaching, which is a method of developing student XSTAP teaching skills, because it is a real teaching is not much different from full teaching training, it contains all the elements of teaching known .The fencing sport is one of the oldest known sports in the world, which has gradually expanded its attention to the increasing interest in its education and training. The researchers used the experimental approach on the students of the third stage in the Faculty of Physical Education and Sports Science University of Kufa (61) students, the tests were used to measure the physiological level of testosterone and to measure the level of performance of the most important skills in the duel. The researchers performed tribal tests and measurements on 27/11/2016, which included the withdrawal of a blood sample to measure the physiological level Testosterone, and then test the performance of basic skills in dueling and the preparation of units for teaching the method of -teaching and conduct post-tests. The researchers concluded that the use of the method of teaching micro-give the results of learning better, helping to achieve the objectives of educational exercises, the use of micro-teaching impact on the secretion of testosterone level, which reflects the strength of personality, and recommended the use of the method of teaching -achieving the objectives of educational exercises ,the use of micro-teaching in the development of personality traits, because the method of teaching -works to develop personal aspects ,and the use of the micro-teaching method with other samples of beginners in learning and with learners in the development of the skillful performance of the fencing .Keyword: Micro -teaching method, Testosterone, Learning , Basic skills and fencing .
The Effects of Socio-Demographical Factors and Perceived Seriousness Upon Motherly Skill of Managing Eating Disorder on Children with Avoidant Restrictive Food Intake Disorder (ARFID) Yoyok Bekti Prasetyo
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Objective: Perceived seriousness is considered to mothers in making decisions for the sake of protective attempts upon children suffering from avoidant restrictive food intake disorder (ARFID). This study aimed to identifyy the predictor factors of motherly skill in managing eating disorder on children with ARFID. Method: A cross-sectional descriptive survey was held to 245 mothers taking care of children with ARFID. This research was conducted in 3 subdistricts and three community public health centres in Malang.  Data were collected by questionnaires of perceived seriousness and a managing eating disorder. Data were processed descriptively, using Pearson correlation and multiple linear regression (level of significant 0.05). Results: Factors in respect of motherly skill of managing eating disorder included the feeling of fear of children’s condition (p= 0.006), feeling of failure to contribute when children suffered from malnutrition (p= 0.010), serious condition (p= 0.017), and the whole-life changes (p= 0.002). The multiple-linear regression revealed that factors influenced motherly skill of managing eating disorder covered education (β = 1.089, p = 0.022), the number of children (β = -1.582, p = 0.025), and perceived seriousness (β = 0.097, p = 0.020). Conclusion: This current research had indicated that perceived seriousness was a significant factor to influencing mothers in making decisions for the sake of protection upon their children. Thus, we recommend that motherly belief is fostered in the event of health promotion.Keywords: Perceived seriousness, The skill of managing an eating disorder, ARFID.
Preparation, Characterization and Biological Activity Studies of Some Metal Complexes with New Schiff Base for Trimethoprim Ligand Nazar Munem Abdalsahib
Journal of Global Pharma Technology .
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A new ligand complexes have been synthesis from reaction of metal ions of MnII, CoII, NiII, CuII, ZnII, CdII and PdII with schiff base [(E)-1-((2-amino-5-(3, 4, 5-trimethoxybenzyl) pyrimidin-4-ylimino) methyl) naphthalen-2-ol [HL)]. The prepared [HL] was characterized by FT-IR, UV-Vis spectroscopy, 1H-13C-NMR spectra Mass spectra and melting point. The compounds were characterized by techniques UV-Vis and FT-IR spectral studies, micro analysis (C.H.N), determination of atomic absorption, chloride content, molar conductivity measurements, magnetic susceptibility and melting point. The ligand acts as a monobasic tridentate, coordinating through deprotonated phenolic O and azomethine N atoms. The compounds are neutral electrolytic in dimethylsulfoxide. The analytical and spectral data for these compounds indicated to (1:2) (metal: ligand) mole ratio. The metal content and magnetic moment suggest the square planar geometry for the palladium ion, but the other metal complexes show six-coordinate. Compounds were having been screened for their antimicrobial activities against various bacteria and fungi organisms using inhibition method.Keywords:  Preparation, Characterization, Azomethine, Inhibition method.
Antimicrobial Activity Test of Ginseng bugis (talinum paniculatum gaertn.) Leaves Ethanol Extract against Pseudomonas aeruginosa, Propionibacterium Acnes, Streptococcus Mutans and Candida Albicans Andi Emelda
Journal of Global Pharma Technology Volume 12 Issue 10 (2020) Oct. 2020
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Ginseng bugis (Talinum panicullatum Gaertn.) leaf is traditionally used in the treatment of diarrhea, ulcers, wounds and skin infections by the people of South Sulawesi province. The leaves contain chemical compounds such as saponins, alkaloids, tannins, flavonoids and triterpenes which can be a source of antioxidants and bactericidal. This study aims to determine the antimicrobial activity of ginseng bugis leaf extract against the microbes. The test microbes used were Pseudomonas aeruginosa, Propionibacterium acnes, Streptococcus mutans, and Candida albicans which has been matured. The antimicrobial activity test used agar well diffusion method with ginseng bugis leaf extract solution with a concentration variation of 0.1%; 0.5%; 1%; 2%; 4%; 8%; 16%; and 32%. The inhibition zone observations were carried out on bacteria incubated at 37oC for 24 hours and fungi incubated at 25oC for 72 hours. The results of the inhibition zone measurement showed that the higher the concentration of the test solution for the ethanol extract of ginseng bugis leaves, the greater the inhibition zone given. Based on the results, the ethanol extract of ginseng bugis leaves had antimicrobial activity at the minimum inhibitory concentration of 1% against Pseudomonas aeruginosa, Propionibacterium acne, Candida albicans and a minimum inhibitory concentration of 4% against Streptococcus mutans. Keywords: Antimicrobial, Ethanol Extract, Talinum panicullatum Gaertn.
Synthesis and Characterization of the Ligand (S, S'-Bis (Benzo [d] Oxazol-2-yl) 2, 2'-((Methylenebis (4, 1 Phenylene)) Bis (Azanediyl)) Diethanethioate (BMPAE) and it's Complexes with Some Transition Metals Ions Tariq Hussein Mgheer
Journal of Global Pharma Technology .
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Abstract

This study involved synthesis of ligand (S,S'-bis (benzo[d]oxazol-2-yl) 2,2'-((methylenebis(4,1-phenylene))bis(azanediyl))diethanethioate(BMPAE)by reaction in two steps. The first involved reaction between 2-Mercaptobenzoxazole with chloroacetyl chloride to get S-benzo[d]oxazol-2-yl 2-chloroethanethioate(compound-1).The second step reaction (compound-1) with 4,4'-Methylenedianiline to form S,S'-bis(benzo[d]oxazol-2-yl)2,2'-((methylenebis(4,1phenylene))bis(azanediyl))diethanethioate (BMPAE) .This ligand was characterized by melting point, FTIR,1H NMR , 13C-NMR  and elemental analysis. New chelating complexes were prepared from reaction ligand (BMPAE) with transition metal salts of Co (II), Cu (II), Cd (II), Ag (I), and Hg (II).The structures of these complexes were identified by FT-IR and UV-Vis spectra molar conductivity, melting points, elemental analysis, atomic absorption and magnetic susceptibility measurements. The FTIR spectra clearly show new bands, which were not found in ligand spectrum, while many other bands observed changes in shape, position and in intensity which are explained by the coordination with metal ions. All complexes showed tetrahedral geometry structures except Co (II), Cu (II) complexes are octahedral.Keywords: Heterocyclic, 2-Mercaptobenzoxazole, Benzoxazole complexes, Transition metal complexes.
Technical Variables Affecting to the Production of Dried Herb Tea from Callisia Fragrans Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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C. fragrans is a herbaceous plant with small white fragrant flowers and waxy leaves. C. fragrans leaves contain biologically active components such as flavonoids, neutral glycol-and phospholipids and fatty-acids.The aim of this work was to evaluate the effect of blanching, drying and preservation on the free radical scavenging activity and total phenolic content of dried Callisia fragrans. By examining on different variables of the blanching, drying; the highest phenolic and antioxidant activity inside the dried Callisia fragrans could be achieved by blanching within 10 seconds, at 95oC in the presence of citric acid 4%; size of Callisia fragrans 2.0 cm; drying at 50oC by heat pump dryer until the final moisture content 6.5%. The dried Callisia fragrans may be stable for 12 months in PET/AL/PE bag at 25oC without any deterioration. The study was of great importance to generate information about the blanching and drying process in preserving herb quality and bioactivity by avoiding the degradation of metabolites.Keywords: Callisia Fragrans, Blanching, Citric acid, Drying, Phenolic, antioxidant.
Application of H-Point Standard Addition Method in Kinetic-Spectrophotometric Determination of Phenylephrine in Nasal Drops and Tetracycline in Capsule Faeza H. Zankanah
Journal of Global Pharma Technology Volume 11 Issue 05.
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A new simultaneous spectrophotometric-kinetic method was developed to determine phenylephrine (PHEN) and tetracycline (TETR) via H-point standard addition method (HPSAM). The proposed procedures rely on the measurements of the difference in the rate of charge-transfer (CT) reaction between each of PHEN and TETR as electron donors with p-Bromanil (p-Br) as an electron acceptor. Different experimental factors which affect the extent of the complex formation were investigated by monitoring the value of absorbance at 446 nm. Time pair of 50 -100 sec was selected and employed, among different examined pairs since it results in the highest accuracy for HPSAM-plot. Linear calibration graphs in the concentration ranges of 10.0-40.0 and 10.0–50.0 mg/L were obtained for PHEN and TETR, respectively and the proposed method was applied successfully in the determination of PHEN and TETR in their pure form and in commercial formulations.Keywords: Spectrophotometry, Kinetic H-point standard addition method, Phenylephrine, Tetracycline, Simultaneous analysis.

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