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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Molecular Detection of Lysinibacillus Fusiformis Isolated from Milk Samples of Cow in Iraq Aseel Mohammed Hamzah
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Raw milk  infected by bacteria can start from exceptional resources: air, milking devices, feed, soil, dangs and hays.The strategies of  nourishing and lodging cows may impact the germs pleasant of milk. Bacterial contaminants can cause infection, or deterioration of drain and its auxiliary items and the destructive impacts on the grade and security of dairy items as a result of oxygen consuming spore-forming bacteria got from crude drain were characterized by isolation of Lysinibacillus fusiformis from 90 milk samples of cow at 21.6l%, the bacteria were identified by routein bacteriological methods and Molecular distinguishing proof of the confines was carried out by 16S rRNA sequencing and the bacterial confines were taxonomically classified as Lysinibacillus fusiformis. The groupings were stored in NCBI GenBank with the accession number KY038703, KF916675. and KF916675.1 with identity of 100%, 96 and 99% respectively. Keywords: Raw milk, Lysinibacillus fusiformis, 16S rRNA PCR sequencing.
Types and Determinants of Congenital Anomalies among Newborns in Bint Al-Huda Teaching Hospital in Thi-Qar Governorate at 2015-2017 Ghada Mansoor Abood Al-Asadi
Journal of Global Pharma Technology .
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Abstract

Background: Congenital anomalies are a major cause of neonatal and infant death, and disability around the world. The prevalence of congenital malformations differs widely between countries. Objectives: To determine the types of congenital anomalies among neonates and to identify the possible risk factors associated with congenital anomalies. Patients and Methods: A case-control study was carried out during 3years period (from the 1st of January 2015 to the 15th of December 2017). One hundred seventy-two neonates with congenital anomalies admitted to neonatal intensive care unit in Bint Al-Huda Teaching Hospital were involved in the study as a case group. A total of 305 neonates without congenital anomalies were randomly selected from neonates admitted to the same hospital for reasons other than congenital anomalies and including in the study as a control group.   Results: Neural tube defects are the predominant type of congenital anomalies (31.9%), followed by congenital heart diseases (14.5%), cleft lip and palate (6.9%), and upper and lower limbs deformity (5.9%). Both genders equally distributed among patient and control group p-value>0.05.The higher percentages of multiple congenital anomalies were detected among low birth weight neonates (30.6%), premature neonates (24.5%), neonates of mothers with advance age (> 35 years) (33.3%), grand multiparas (27.8%), and women with pregestational diabetes (37.5%).There is a significant positive association of low birth weight and premature neonates, young maternal age, chronic maternal illness, father occupation, and family history with the congenital anomalies, p-value < 0.05. Mother and Father Age, and prematurity were independent risk factors for congenital anomalies (OR 8.470, 17.367, 6.606, respectively). There is a highly significant association between congenital malformations with periconceptional folic acid intake, p-value <0.001, (OR 5.746). Conclusion: The commonest congenital anomalies are neural tube defects, followed by congenital heart diseases, cleft lip and palate, and upper and lower limbs deformity. There is a positive association of low birth weight, chronic maternal illness, father occupation, and family history with the congenital anomalies. Parental age and prematurity were independent risk factors for congenital anomalies. Periconceptional folicacidin take protect against congenital malformations.Keywords: Types, Risk factor, congenital anomalies.
Antimicrobial Properties of Snail Slime (Achatina Fulica) on the Growth of Actinobacilus Actinomycetemcomitans Bacteria Causing Periodontitis I Gusti Agung Ayu Putu Swastini
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

                                             Aim: The purpose of this study was to calculate the inhibition zones of the growth of A. actinomycetemcomitans by snail slime at concentrations of 12.5%, 25%, 50%, 100%. Methods: The study was an experimental randomized posttest-only control group design. This research was conducted in the oral biology laboratory of the Faculty of Dentistry, Airlangga University, Surabaya Indonesia. Variables in this study snail slime were made with concentrations of 12.5%, 25%, 50% and 100%. Take germ stock with osse, then plant on BHI broth media, then incubate 37C for 24 hours. Plant germs on BHI media so that with the swab technique to evenly spread on the surface, then contact the paper disc that has been given each concentration of 12,%, 25%, 50%, 100%, with tweezers on the surface as much as 10 micromillimeters, then incubate 37C for 2x 24 hours, eight repetitions are carried out. Results: The mean diameter of the inhibitory zone snail slime on the growth of A. actinomycetemcomitans bacteria in the treatment groups had significant differences p<0.05. The mean inhibition zone between controls and LB treatment group (LB 12.5%, 25%, 50%, 100%), were statistically different (p<0.05).In contrast with LB 12.5% (p>0.05) which significant difference with the control group. Conclusion: The concentration of 100% snail slime has the highest inhibitory power, against the growth of the A. actinomycetemcomitans bacteria, The 12.5% concentration snail slime showed no antibacterial activity against the growth A. actinomycetemcomitans.Keywords: Snail slime, Actinobacilus actinomycetemcomitans bacteria, Inhibition zone diameter.
Synthesis and Preliminary Antibacterial Activities of New 2, 3-Disubstituted-1, 3-Oxazepane-4, 7-Diones of Benzothiazole Zeid Hassan Abood
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

2-aminobenzothiazole 1 was converted to analogues diazonium salt which reacted with alkaline solution of 2-hydroxybenzaldehyde to yield azo-benzothiazole derivative 2 bearing aldehyde group. The resulting aldehyde 2 was then condensed with some aromatic amines including (4-nitroaniline, 3-nitroaniline, 4-aminophenol, 4-methoxyaniline, 4-bromoaniline, 4-chloroaniline and 2, 4-dichloroaniline) using microwave irradiation technique in absolute ethanol to produce seven imine derivatives of benzothiazole 3a-g, respectively. Treatment of the resulting imines 3a-g with succinic anhydride using microwave irradiation in dry benzene afforded seven new 1, 3-oxazepane-4, 7-diones 4a-g bearing the benzothiazole moiety, respectively. Preliminary in vitro antibacterial activity of the target compounds were investigated using two types of bacteria, Staphylococcus aurous (Gram-positive) and Escherichia coli (Gram-negative). The results indicated that all oxazepane compounds exhibited better activity to gentamycin against Gram-positive bacteria. On the other hand, the oxazepane compounds (4a, 4e and 4g) showed greater activity against Gram-negative bacteria when compared with that of the control drug.Keywords: Benzothiazoles; Oxazepanes; Imines; Azo; Antibacterial activity.
Impact of IL1, IL6, IL8, IL17 and TGF Gene Polymorphisms in Bladder Cancer Patients Hamsa Ahmed Jasim
Journal of Global Pharma Technology .
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Abstract

Bladder cancer is one of the most common cancers worldwide and the most frequent malignancy of the urinary tract recently, several single nucleotide polymorphisms (SNPs) have been identified in cytokine gene sequences, particularly within the promoter region of these genes, and have been shown to be associated with the development of bladder cancer. The present study investigates the association of IL1, IL6, IL8, IL17 and TGF polymorphisms with the incidence of bladder cancer. Blood samples were collected from 50 histologically confirmed adult patients with bladder cancer and 28 apparently healthy individuals. DNA was extracted from each blood sample, and the genes were amplified using polymerase chain reaction (PCR) with gene-specific primers target. Systemic IL1β, IL6, IL8, IL17 and TGFβ, concentration was assessed in serum samples from each participant by enzyme-linked immunosorbent assay (ELISA). A appositive association between The allele T of the SNP rs 16944 of IL 1 gene (P=0.005, OR=4.263, 95%CI=1.566-11.603) and the allele G of the SNP rs 1800469 of TGF β gene (OR=0.19, 95% CI=0.035-1.02) were found. These data indicate an etiological role of IL-1β and TGF gene polymorphism in bladder cancer.Keywords: Single nucleotide polymorphism (SNPs), Interleukin, TGF, bladder cancer.
Vitamin D Receptor Gene Polymorphisms and Risk in Children with Recurrent Wheezy Chest among Babylon Province Naser Z. Al-Jourany
Journal of Global Pharma Technology .
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Abstract

Introduction: wheezing is continuous whistling happen from the chest in breathing; early childhood wheezing may develop later to asthma, this study aimed to make a genetic study to show the relationship between recurrence of wheezing, and polymorphism in vitamin D receptor. This has not been explored in Iraqi settings widely.  Aim: Present study investigated the association between VDR gene BsmI single nucleotide polymorphisms and recurrent wheeze in patients with a recurrent wheezy chest in Babylon children. Materials and Methods: Ninety patients with recurrent wheezy chest and ninety apparently healthy children as a control in Hilla City/Iraq were enrolled in this study. A questionnaire was used to obtain information. Estimation of VDR gene BsmI single nucleotide polymorphism was done using the PCR-RFLP method. Standard statistical tools were used, p-value <0.05 was considered to be statistically significant. And p-value <0.001 was considered to be statistically a highly significant SPSS software version 20.0 was used.  Results: The genotype and allele distribution of the VDR BsmI A/G SNP showed a significant difference between cases and controls with (p-value < 0.001).  Conclusion: The study concluded that BsmI gene polymorphism of vitamin D receptor associated with a recurrent wheezy chest in children beyond 5 years in Babylon province. Moreover, this study, conclude some risk factors that related to recurrent wheezing that the male gender is more affected and the children who breastfeed for less than six months is more vulnerable for wheezing and the family history of allergic rhinitis and maternal asthma also play role in patient wheezing.Keywords: Recurrent wheezing, Vitamin D receptor, SNPs, Babylon province. 
Effect of Pregelatinization on Suweg Tuber Starch (Amorphophallus Paeonifolius) as Tablet Crusher Dwi Setyawan
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Background: Disintegrant tablet from starch is more often used to crush the tablet that has been swallowed. However, the material of this starch is tablet crusher which very weak. In contrast to the suweg starch (Amorphophallus paeonifolius) which has undergone pregelatinization where the content of amylose and amylopectin and the water absorption capacity that is high enough so that it can crush the tablet quickly. The aim of this study was to determine the influence of pregelatinization towards elephant foot yam (Amorpophallus paeonifolius) starch as disintegrant against tablet physical quality profile of the Paracetamol tablet. Method: The research was carried out by making suweg natural starch which then it made a suspension in the water with a concentration of 20% and heated to the temperature of 60 ± 5 0C and 70 ± 5 0C within 15 minutes. After the suweg pregelatin starch has been made, then a paracetamol tablet and a qualitative examination also made which includes the determination of the paracetamol infrared spectrum, the examination of moisture content, the testing with iodine, the testing with optical microscopy, X-ray diffraction analysis, the starch thermal analysis with DTA, and the examination of swelling power which then compared to each tablet formula made by the wet granulation method. after that, it was continued with the examination of the granule quality, including the examination of moisture content, the examination of granule particle size and number of fines, the examination of flow velocity and rest angle of the granule. Moreover, it was carried out an evaluation of the paracetamol tablet physical quality in the form of hardness test, friability test, and disintegration time test. The data obtained was further analyzed by One Way ANOVA. Result: Tablet formula with pregelatinization of suweg natural starch can reduce the hardness, increased the tablet disintegration time, and made no difference in friability compared to the formulas containing natural suweg tuber starch and SSG. The result of increased disintegration time was then compared with the result of the swelling power test, but did not indicate a correlation both of them. The different of disintegration was not showed a correlation with values of swelling power. Keywords: Suweg Tuber Starch, Starch Pregelatinization, Pregelatinized Starch Tablet.
Measuring the Amount of AFM1 in Milk in Isfahan Province Iraj Javadi
Journal of Global Pharma Technology .
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A Flatoxin (AF) is a toxic metabolite produced by fungi of Aspergillus flavus, Aspergillus Parasiticus and Aspergillus Nomius. Among them, AFB1 is the most toxic and potent agent. AFM1 and AFB1 are metabolites primarily produced by AFB2 and AFM2 which are found mostly in milk and meat from animals have been fed by AF-contaminated foods. Given the risks of AF for men and also due to the high consumption of milk and dairy products, the aim of this project is to examine the contamination of the food by measuring the toxin in milk in Isfahan province and compare it with international standards as well as take steps to reduce and prevent the contamination. In this study, a number of raw milk samples from a milk station, Shahreza dairy store, Isfahan diary and Pegah Milk factory of Isfahan were collected to measure AFM1. To measure AF in milk, AFM1 was extracted with chloroform and column chromatography on a silica gel 60 G with anhydrous sodium sulfate were used for purification. AFM1 was detected and measured using two methods; 1- TLC with silica stationary phase and mobile phase chloroform - acetone - isopropanol in a ratio of (87 + 3 + 10), 2- using C18 reverse-phase HPLC with columns and methanol - acetonitrile  water mobile phase in ratios (15:22:63) and UV detector at 350 nm. The results showed that 20% of the total samples collected from Shahreza milk station is contaminated with AFM1. Also, in 25% of samples taken from Shahreza dairy store, AFM1 was detected. The average amount of AFM1 in samples collected from Shahreza milk station and Shahreza dairy store was obtained 1.9 ± 0.26 and 2.9 ± 0. 59 ppb, respectively. In all the samples that the toxin has been detected in them, AFM1 was much higher than the limit set.  However, in the samples prepared from Najaf Abad, Tiran and Karvan and Shahin Shahr, AFM1 was below the acceptable level. According to results, high content of AFM1 in the raw milk is worrying and more attention should be paid to control and monitor the milk production and consumption.Keywords: Aflatoxin, Raw milk, Isfahan province.
Seasonal Variation, Antibiotic Resistance of Some Sewage Bacteria from Hamdan Waste Water Treatment Plant in Basrah City-Iraq Maytham A. Al-Hamdani
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Seasonal variation and antibiotic resistance pattern of some sewage bacteria have been studied during the period of at Hamdan wastewater treatment plant in basrah city-Iraq. The results obtained revealed that there is a seasonal variation in the number of bacteria studied. The bacterial taxa in the present study found to resist several antibiotics. The isolated bacteria are multidrug resistant bacteria.  Higher percentage of antibiotic resistance was recorded for bacteria from raw sewage that decreased during the subsequent treatments. Sewage bacteria showed different antibiotic resistance patterns. The effluents to Shatt al-Basrah still contain multidrug resistant bacteria that cause a big health problem through dissemination of multidrug resistant bacteria to the area around.
A Training Program to Develop the Endurance Strength and Effect of the Enzyme Sgot and the Level of Some Performance Some of the Complex Skills in the Basketball for Youth Hasan Saleh Mahdi Al-Okbi
Journal of Global Pharma Technology .
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The objective of the research is to prepare a training program to develop the endurance of the strength, as well as to know the effect of this program on the enzyme SGOT and the level of performance of some skills in the basketball youth. The study sample consisted of (12) players, selected from the total community of (14) players, has been excluded (2) player for the purpose of conducting the exploratory experiment, and the experimental method was used to suit the nature of the research procedures. After the tests were carried out and the application of the training program was carried out the post-test to obtain the results through which the most important conclusions were reached. The researchers concluded that there was a significant effect of the training curriculum in the development of strength endurance of the muscles of the arms, increased rates of SGOT enzyme, and the emergence of a significant development in the level of performance of offensive youth composite basketball skills.Keywords: Endurance strength, Enzyme (SGOT), Complex offensive skills and basketball.

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