Articles
<![CDATA[PENINGKATAN LAJU PELARUTAN TRIMETOPRIM MELALUI METODE KO-KRISTALISASI DENGAN NIKOTINAMIDA ]]>
<![CDATA[Zaini, Erizal]]>;
<![CDATA[Halim, Auzal]]>;
<![CDATA[Soewandhi, Sundani N.]]>;
<![CDATA[Setyawan, Dwi]]>
<![CDATA[ JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 4 (2011) ]]>
Publisher : <![CDATA[Indonesian Research Gateway ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
<![CDATA[Co-crystallization of trimethoprim with nicotinamide had been done using solvent (methanol as a solvent) and melted technique. Kofler’s hot contact methode was used to identify the solid state interaction between these two components. The solid phase was characterized by microscopic, powder X-ray diffraction, thermal DTA and FT-IR spectroscopy analysis. Dissolution rate profile was performed by paddle methode (Type II USP), distilled water as a medium. Solid state interaction between trimethoprim and nicotinamide show a formation of conglomerate (simple eutectic) at eutectical point 125 0C. Dissolution rate of co-crystallization product of trimethoprim and nicotinamide increase significantly compare to physical mixture and intact trimethoprim. ABSTRAK Telah dilakukan ko-kristalisasi trimetoprim dengan bahan tambahan nikotinamida dengan metode pelarutan (menggunakan pelarut metanol) dan peleburan. Metode kontak panas Kofler digunakan untuk identifikasi awal pembentukan interaksi antar kedua komponen. Padatan hasil ko-kristalisasi dikarakterisasi dengan analisis mikroskopik, difraksi sinar-X, termal DTA dan spektrofotometer FT-IR. Uji laju pelarutan dilakukan dengan metode dayung (tipe II USP) dengan medium air. Hasil interaksi menunjukkan pembentukan konglomerat (eutektikal) antara kedua fase kristalin dalam keadaan padat, dengan titik eutektik pada temperatur 125 0C. Laju pelarutan trimetoprim hasil ko-kristalisasi meningkat secara signifikan dibandingkan dengan campuran fisika dan senyawa tunggal trimetprim.]]>
<![CDATA[PENINGKATAN LAJU PELARUTAN TRIMETOPRIM MELALUI METODE KO-KRISTALISASI DENGAN NIKOTINAMIDA ]]>
<![CDATA[Zaini, Erizal]]>;
<![CDATA[Halim, Auzal]]>;
<![CDATA[Soewandhi, Sundani N.]]>;
<![CDATA[Setyawan, Dwi]]>
<![CDATA[ Jurnal Farmasi Indonesia Vol 5, No 4 (2011) ]]>
Publisher : <![CDATA[Jurnal Farmasi Indonesia ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.35617/jfi.v5i4.57
<![CDATA[Co-crystallization of trimethoprim with nicotinamide had been done using solvent (methanol as a solvent) and melted technique. Koflerâ??s hot contact methode was used to identify the solid state interaction between these two components. The solid phase was characterized by microscopic, powder X-ray diffraction, thermal DTA and FT-IR spectroscopy analysis. Dissolution rate profile was performed by paddle methode (Type II USP), distilled water as a medium. Solid state interaction between trimethoprim and nicotinamide show a formation of conglomerate (simple eutectic) at eutectical point 125 0C. Dissolution rate of co-crystallization product of trimethoprim and nicotinamide increase significantly compare to physical mixture and intact trimethoprim. ABSTRAK Telah dilakukan ko-kristalisasi trimetoprim dengan bahan tambahan nikotinamida dengan metode pelarutan (menggunakan pelarut metanol) dan peleburan. Metode kontak panas Kofler digunakan untuk identifikasi awal pembentukan interaksi antar kedua komponen. Padatan hasil ko-kristalisasi dikarakterisasi dengan analisis mikroskopik, difraksi sinar-X, termal DTA dan spektrofotometer FT-IR. Uji laju pelarutan dilakukan dengan metode dayung (tipe II USP) dengan medium air. Hasil interaksi menunjukkan pembentukan konglomerat (eutektikal) antara kedua fase kristalin dalam keadaan padat, dengan titik eutektik pada temperatur 125 0C. Laju pelarutan trimetoprim hasil ko-kristalisasi meningkat secara signifikan dibandingkan dengan campuran fisika dan senyawa tunggal trimetprim.]]>
<![CDATA[PHYSICAL CHARACTERIZATION OF IBUPROFEN-STEARIC ACID BINARY MIXTURE DUE TO COMPRESSION FORCE ]]>
<![CDATA[Setyawan, Dwi]]>;
<![CDATA[Isadiartuti, Dewi]]>;
<![CDATA[Betari, Sita Desti]]>;
<![CDATA[Paramita, Diajeng Putri]]>
<![CDATA[ Indonesian Journal of Pharmacy Vol 27 No 1, 2016 ]]>
Publisher : <![CDATA[Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (865.652 KB)
|
DOI: 10.14499/indonesianjpharm27iss1pp28
<![CDATA[Aim of this research is to determine physical characteristic of ibuprofen-stearic acid due to compression force. Binary mixture of ibuprofen-stearic acid with weight ratio of 4:6, 5:5, and 6:4 was compressed under various compression force using hydraulic press with 13mm diameter flat punch.Identification of solid state interaction between these two components was performed by Hot Stage Microscopy (HSM). Physical characterization has been studied byDifferential Thermal Analysis (DTA), X-ray Powder Diffraction (XRPD), Scanning Electron Microscopy (SEM), and (Fourier Transform Infrared (FT-IR) spectroscopy. According to hardness measurement, 4:6 weight ratio has the highest tensile strength on 170.6N/cm2 under 19.93kN compression force. Interaction identification by HSM showed single blank line that indicates eutectic formation. Thermal analysis of DTA also revealed eutectic formation upon compression whichthe endotermic peak of ratio of 4:6has the lowest melting temperature of 53.2°C. X-ray diffraction of three peaksgenerally showed that peak intensity decreases as compression force increases, but at particular point it begins to increase again. Sintering phenomenon at the surface of compressed tablet was observed from SEM analysis. FT-IR study confirms the formation of simple eutectic. Key words: ibuprofen, stearic acid, binary mixture, compression force, physical characterization]]>
<![CDATA[Pengaruh Penggunaan Medial Arch Support Terhadap Pengurangan Derajat Nyeri, Keseimbangan Statis Dan Activity Of Daily Living Pada Penderita Plantar Faciitis ]]>
<![CDATA[Dwi Setyawan]]>;
<![CDATA[Bhisma Murti]]>;
<![CDATA[Hermanu Joebagio]]>
<![CDATA[ Jurnal Keterapian Fisik Vol 1 No 2 (2016): JURNAL KETERAPIAN FISIK ]]>
Publisher : <![CDATA[Poltekkes Kemenkes Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (165.594 KB)
|
DOI: 10.37341/jkf.v1i2.90
<![CDATA[Abstract: Plantar Facitis, Medial Arch Support, Degree Of Pain, Static Balance, Activity Of Daily Living. The case of plantar factis still a lot going on and the handling of the case there are a variety of ways including the use of tools such as the medial arch support, ultrasound therapy, medication, and surgery. The purpose of this study was to analyze the effect of the medial arch support to a reduction in the degree of pain, static balance and activity of daily living in patients with plantar faciitis. This research is kind of Randomized Control Trial (RCT) In this draft, dividing the subjects into two groups. Number of research subjects are 30 subjects were divided into two groups, one group as an experimental group treated medial arch support and one more group as a control group treated with ultrasound (US). Data collection technique used documentation study and observation. Data were analyzed using multiple linear regression analysis and statistical significance of the variables were tested by t test with the results shown by the p value. Significant influence use of medial arch support to the reduction of the degree of pain, static balance and activity of daily living in patients with plantar faciitis. It was demonstrated with p <0.001.]]>
<![CDATA[Identification of Physical Interaction in Binary Systems of Acyclovir – Succinic Acid ]]>
<![CDATA[Agnes Nuniek Winanta]]>;
<![CDATA[Dwi Setyawan]]>;
<![CDATA[Siswandono Siswandono]]>
<![CDATA[ JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (94.891 KB)
|
DOI: 10.20473/jfiki.v3i12016.27-31
<![CDATA[Background: Acyclovir, a guanosine analogue antiviral drug with low solubility of water. Due to its poor solubility and permeability, causes low oral bioavailability. Objective: The aim of this research is to investigate the physical interaction in binary systems acyclovir-succinic acid (AS). Methods: The msystem was prepared by solvent evaporation method. Results: Thermogram Differential Scanning Calorimetry showed endothermic peaks at 172.68oC (ethanol) and 171.84oC (methanol). The Powder X-Ray Diffraction (PXRD) pattern of AS was different from pure component and physical mixtures. Furthermore, physical characterization showed the binary system of AS have unique crystal habit by polarization microscope. Conclusion: New crystalline phase is formed from the interaction between acyclovir and succinic acid by solvent evaporation method using ethanol and methanol. ]]>
<![CDATA[Analysis of Solid-State Interactions of Ketoprofen-Coformer Binary Mixtures by DSC and Hot Stage Microscopy ]]>
<![CDATA[Yudi Wicaksono]]>;
<![CDATA[Dwi Setyawan]]>;
<![CDATA[Siswandono Siswandono]]>
<![CDATA[ Molekul Vol 15, No 2 (2020) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (534.945 KB)
|
DOI: 10.20884/1.jm.2020.15.2.638
<![CDATA[Ketoprofen is a non-steroidal anti-inflammatory drug with poor water solubility, so the absorption is less than optimal. One method to improve the solubility of ketoprofen is through the formation of multicomponent solid forms. The success of the formation of the multicomponent solid forms is strongly influenced by interactions between components in their solids. In this study, the analysis of the interactions in solid form of ketoprofen-coformers was carried out using the differential scanning calorimetry (DSC) and hot stage microscopy (HSM) with adipic acid and isonicotinamide as coformers. From the experimental results, the mixtures of ketoprofen-adipic acid show a solid-liquid phase diagram that indicates a simple eutectic system with eutectic points on the molar fraction of ketoprofen 0.9 and temperature at 92.9 °C. The ketoprofen-isonicotinamide mixtures have a eutectic system with the peritectic point. The solid-liquid phase diagram has indicated that the ketoprofen-adipic acid in eutectic composition forms a miscible liquid phase without interaction in its solid form, whereas the ketoprofen-isonicotinamide forms a miscible liquid phase accompanied by interaction with the excess component. The results of the HSM analysis showed the same phenomenon as the result of the DSC experiment and have confirmed with the FTIR analysis]]>
<![CDATA[Optimasi Tablet Levofloksasin yang Mengandung Bahan Pengikat PVP K-30 dan Disintegran Vivasol ]]>
<![CDATA[Dina Ayu Fatmawati]]>;
<![CDATA[Bambang Widjaja]]>;
<![CDATA[Dwi Setyawan]]>
<![CDATA[ Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017 ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Andalas ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (1096.029 KB)
|
DOI: 10.29208/jsfk.2017.4.1.155
<![CDATA[The aim of this research was to get optimal formula of levofloxacin tablet prepared with variation of PVP K-30 as binder and vivasol as disintegrant. The making of levofloxacin tablets was done by wet granulation. Tablet was prepared with various levels of PVP K-30 and disintegrant vivasol, compressed using a hydraulic press with 12 mm punch diameter, for 3 seconds. Physical quality (hardness, friability, and disintegration time) and dissolution rate of tablet was evaluated. The optimization of the formula was done by factorial design of 22 factorial experiments with 2 factors (PVP K-30 and vivasol) and 2 levels (2% and 4%). Optimization results showed that elevated levels of PVP K-30 increased tablet hardness, reduced friability of tablet, decreased disintegrating time, and increased dissolution rate of levofloxacin tablets. Meanwhile, elevated levels of vivasol increased the hardness of tablets, decreased the disintegrating time of tablets, decreased the dissolution rate of levofloxacin tablets, but did not affect the friability of tablets. In conclusion, the optimal tablet that meet the specifications of physical quality (hardness, friability, and disintegrating time) and dissolution rate was made by 2.4 to 3.7% of PVP K-30 and 2.0 to 3.2% vivasol as shown in the feasible area of design space.]]>
<![CDATA[Penghambatan Interaksi Eutektik Akibat Energi Kompresi dengan Penambahan Pati Jagung ]]>
<![CDATA[Dwi Setyawan]]>;
<![CDATA[Noorma Rosita]]>;
<![CDATA[Diajeng Putri Paramita]]>;
<![CDATA[Dicky Pratama]]>
<![CDATA[ Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018 ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Andalas ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (606.989 KB)
|
DOI: 10.25077/jsfk.5.1.17-22.2018
<![CDATA[This research has been carried out to study inhibition of eutectic interaction which occurs on compressed binary mixture of ibuprofen-stearic acid by addition of corn starch. Corn starch was mixed into binary mixture of 40:60 (% b/b) ibuprofen-stearic acid with composition 10, 20, and 30% (w/w) and then compressed into tablet form. The physical characterization was conducted using tensile strength test, differential thermal analysis (DTA), powder X-ray diffraction (PXRD), Fourier transform infrared (FT-IR), and scanning electron microscope (SEM). According to tensile strength test, the value was reduced upon addition of 10 and 20% corn starch compared to the compressed binary mixture. Addition 20% corn starch to compressed binary mixture shifted the eutectic diffraction peaks with a decline in intensity during PXRD study. Thermal analysis of compressed binary mixture-20% corn starch exhibited an increase in eutectic point, and FT-IR spectrum was observed no difference compared to the compressed binary mixture. SEM analysis indicated that 20% corn starch addition was able to inhibit sintering phenomena by dispersed on particle’s surfaces. Physical characterizations result in the conclusion that corn starch can inhibit the eutectic interaction between ibuprofen and stearic acid upon compression]]>
<![CDATA[Pengaruh Komponen Hidrofobik Elastis terhadap Karakteristik Fisik dan Laju Disolusi Tablet Eritromisin Stearat ]]>
<![CDATA[Diajeng Putri Paramita]]>;
<![CDATA[Dwi Setyawan]]>
<![CDATA[ Jurnal Sains Farmasi & Klinis Vol 6, No 3 (2019): J Sains Farm Klin 6(3), Desember 2019 ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Andalas ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (386.151 KB)
|
DOI: 10.25077/jsfk.6.3.220-227.2019
<![CDATA[Eritromisin stearat (ERS) telah diketahui menunjukkan fenomena sintering ketika dikempa dan ini berpotensi menyebabkan masalah pada kualitas sediaan mengingat ERS umum dipasarkan sebagai tablet. Pembuatan campuran biner ERS dengan parasetamol (PRS) dan asam mefenamat (ASM) dilakukan untuk menelaah pengaruh karakter hidrofobik elastis kedua senyawa tersebut terhadap sintering dari ERS. Karakterisasi fisik tablet campuran biner meliputi uji kekuatan mekanis, difraksi sinar-X serbuk (DSXS), scanning electron microscope (SEM), differential thermal analysis (DTA), spektrofotometri inframerah, dan terakhir dilakukan uji disolusi. Keberadaan PRS dan ASM meningkatkan nilai kekuatan tarik tablet ERS dan ASM memberikan peningkatan yang lebih tinggi. Superimposisi pola difraksi ERS dengan PRS maupun ASM teramati dari difraktogram sinar-X campuran biner. Fotomikrograf SEM memperlihatkan batas-batas antarpartikel pada permukaan dan patahan tablet campuran biner yang lebih jelas terlihat pada tablet ERS-ASM. Spektra inframerah dan termogram DTA tidak menunjukkan adanya puncak baru akibat interaksi pada sampel campuran biner, hanya teramati transformasi polimorfik dari PRS. Tablet campuran biner ERS-PRS dan ERS-ASM menghasilkan profil disolusi lebih baik dari pada tablet ERS. Berdasarkan hasil karakterisasi tersebut di atas dapat disimpulkan bahwa kemampuan PRS dan ASM dalam mencegah fenomena sintering dari ERS tidak melibatkan adanya interaksi dan dapat memengaruhi profil disolusinya.]]>
<![CDATA[Comparison Of The Function Of Neutrophil Cells Oxidative Burst Among Various Group Ages ]]>
<![CDATA[Dwi Setyawan]]>;
<![CDATA[Gatot Sugiarto]]>;
<![CDATA[Novira Widajanti]]>
<![CDATA[ Current Internal Medicine Research and Practice Surabaya Journal Vol. 1 No. 1 (2020): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE JOURNAL SURABAYA ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.20473/cimrj.v1i1.17091
<![CDATA[Background: In old ages there is a change in the immune system along with the aging process called the term immunosenescence. Neutrophil cells play an important role in natural immunity because they are the first immune cells to be deployed in the body's defenses.Objective: To prove that there is a difference in the function of neutrophil cell oxidative burst in older age group compared with the younger age group as well as the tendency of decreased oxidative burst function of neutrophil cells with increasing age.Method: This is a cross-sectional observational analytic study involving 48 healthy subjects. The subjects were divided into 3 age groups: young age (18-40 years old), middle age (41-59 years old), and old age ≥60 years old). Each of them were examined for the function of neutrophil cells oxidative burst. The data were then analyzed using one-way ANOVA test. The result was considered significant if p<0.05.Results: The obtained mean age 59.26±8.03 years old. The mean age for young age group was 28.75±6.66 years old. The mean of middle age group was 50.19±5.46 years old. The mean age of old group was 66.38±3.83 years old. The mean of netrofil oxidative burst cell function was 96.83±2.7% with mean of young age being 98.57±0.98%, middle age 97.71±1.64%, and old age 94.20±3.56%. One way ANOVA comparison analysis showed a significant difference with p = 0.000 (significant when p <0.05). The result of Rank Spearman test showed significant result with r=-0.590 (p=0.000).Conclusion: There are differences in the function of neutrophil cells oxidative burst between young and old age groups. There is a negative trend between the age group and the function of neutrophil cell oxidative burst. The increase of age causes decrease in the function of neutrophil cells oxidative burst.]]>
