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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Synthesis of New Five-Membered Hetrocyclic Compounds from 2-Furfuryl Mercaptan Derivative and Evaluation of their Biological Activity Luma S. Ahamed
Journal of Global Pharma Technology .
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Abstract

Sixteen compounds were synthesized from 2- furfuryl mercaptan as starting material which was reacted with ethyl chloroacetate to produce 2-furfuryl mercaptan ester derivative. The later was reacted  with hydrazine hydrate to  produce hydrazide derivative(2)which was introduced in different synthetic methods by using either cyclization reactions or  using  different reagents to produce biheterocyclic  systems(3-16).Keyword: Five-membered heterocycles, 2-furfuryl mercaptan, Biological activity.
Incidence of Lesions of Organs and Systems in Iron Deficiency Anemia in Children and Its Predictive Significance in the Development of Diseases of Internal Organs Albert Giliazev
Journal of Global Pharma Technology Volume 11 Issue 6.
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This article deals with the study of the incidence of somatic pathology in children with iron deficiency anemia. It is shown that children with anemia more often have respiratory pathology, and less often - endocrine diseases. Somatic pathology is almost equally diagnosed in boys and girls and predominates in young children. The authors established the importance of iron deficiency anemia in the development of diseases of internal organs, determining the time of formation and nature of the disease, as well as increasing the risk of involvement of a number of organs and systems in the pathological process.     Keywords: Iron deficiency anemia, children.
Synthesis and Characterization of New Heterocyclic Compounds and Studying the Biological Activity Wisam Khalifa Jassim
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

New series of some of synthesized compounds derived of the compound (2- (5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-yl-substituted benzalidine .The starting material was prepared by the reaction of 3,5-dinitro benzoic acid with thiosemicarbazide in presence of POCl3. The derivatives of Schiff bases were prepared by reaction of 2-amino -5-(3,5dinitro phenyl) 1, 3, 4-thiadiazole with appropriate aldehydes (m-nitro, p-N, N-dimethylamino, p-bromo, o-hydroxy, p-hydroxy) benzaldehydes. These Schiff base were synthesized in order to prepare more important compounds which are the quinazolines and oxazepins. These compounds were synthesized from the reaction of Schiff bases (2- 6) with o-amino benzoic acid (anthranilic acid) and phthalic anhydride respectively. The structures of the new compounds were characterized by FT-IR, 1H-NMR spectroscopy besides the melting points and other properties. The biological activity (antibacterial activity) in-vitro are investigated for the derivatives at prepared concentration (1*10-3 M) and showed inhibition ability against growth of the two types of pathogenic bacteria: [Staphylococcus aurous.] as gram positive and [Escherichia coli] as gram negative and showed inhibition ability against bacteria. The most of these compounds are effective against both types of bacteria in varying degree, with high activity for quinazolines and oxazepines. Keywords: Quinazolines, Oxazepines, Biological activity of 1, 3, 4-thiadiazole, Schiff base.
The Effectiveness of Different Teaching Methods According to the Kolb Theory in Performance Accuracy of Some Basic Skills and Neuralgic Inhibition in Tennis Aqeel Yahya Hashim Abdulaziz
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In an attempt to use modern techniques in learning skills and believing that there is a need to re-examine the method used and provide the potential for the student to obtain information from them to ensure the process of education and to change the methods that are widespread based on memorization and conservation and literal application and replace them with modern methods to ensure the development of thinking and creativity capabilities of teachers and students And to benefit from modern information and techniques ,And experimenting through the effectiveness of different teaching methods in accordance with the patterns of the theory of the circle Kolb in the performance of the accuracy of some basic skills in tennis. The aim of the research was to identify the classification of students according to the Kolb theory and the different teaching methods suitable for each classification, and to identify the best groups that were used according to Kolb's theory of performing some basic skills in tennis .The researchers hypothesized that the use of various teaching methods according to "Kolb theory is positively effective in learning some basic skills in tennis .he fields of research were the human field: students of the Department of Physical Education and Sports Sciences - Faculty of Education for Girls - University of Kufa, class III / for the academic year (2016-2017) .The period field from 1/11/2016until 1/8/2017, and the spatial field ,in the internal gymnasium of the department of Physical Education and Sports Sciences - Faculty of Education for Girls - University of Kufa .The researchers used the experimental method in the two groups (experimental) method. On this basis, the researchers selected the sample of the students from the third stage of the Department of Physical Education and Sports Sciences / Faculty of Education for Girls / University of Kufa with (25) .After excluding (7) female students from the original society for their participation in the exploratory experiment, the sample was selected by 18 female students in the simple random way ,Which was divided into two experimental groups according to the classification form of the theory of Kolb, which classified the sample to the practical and theoretical and according to the qualifications of each student, the first experimental group (the practical) (10) students and applied the method of solving problems in teaching basic skills in tennis ,And the second experimental group (theorists) (8) students. The method of mental training in teaching was applied to the basic skills of the tennis game. The special units were prepared for each group after presentation to the experts and the preparation of the tools for experimental procedures such as computer use ,video clips and strips educational, rackets and tennis balls, and form evaluating the performance of accuracy, was applied (8) educational units on the two sets of research experimental, by one unit for each week, as it has been implementing the teaching style of solving problems with the first experimental group (practically) and the style of mental training with the second experimental group (theorists), and the conclusions obtained between the results of tribal tests and dimensionality and there is a significant moral differences and in the interest posteriori tests and both sets, and either posteriori tests results were the absence of significant differences between the two groups differences The pilot, and the researchers recommended that the need to use Kolb's theory circle in teaching.
Concordance and Validity of Urinalysis Using Sysmex UX-2000, Cobas U411 and Manual Microscopic Examination Anak Agung Wiradewi Lestari
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Objective: Urinalysis is important in screening, diagnosing, and monitoring the progress of certain diseases. However, the procedure takes time to finish, special skill, and lack of standardization in certain labs. This study evaluates the concordance between manual microscopic examination results to Sysmex UX-2000, and urinalysis chemical results between Sysmex UX-2000 and Cobas U411 (Roche Diagnostic), and the validity of urine sediment results between Sysmex UX-2000 and manual microscopic examination.  Methods: Eighty urine samples were analyzed using Sysmex UX-2000, Cobas u411, and manual microscopic examination. Concordance level was measured using kappa coefficient. Then we calculated the validity of Sysmex UX-2000 in sediment tests to manual microscopic examination. Results: Chemical urinalysis of Sysmex UX-2000 possesses good and very good concordance level to Cobas u411 (*weighted κ 0.65-0.91). Urine sediment tests of Sysmes UX-2000 possesses good concordance to manual microscopic examination (**weighted κ 0.76-0.77), with 86-100% sensitivity and 73-78% specificity. Conclusion: Sysmex UX-2000 has good concordance level to Cobas u411 for chemical tests urinalysis, and also good concordance and validity between Sysmex UX-2000 to microscopic examination for erythrocyte and leucocyte sediment tests.Keywords: Analytical System, Renal Diseases, Quality Assurance and Control.
Genotyping of Human Cytomegalo Virus Envelop Glycoprotein B in Iraqi Immunocopromised and immunosupresser Patients Raghad Harbi Mahdi Al-Azzawi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Envelope glycoprotein B is a surface protein of CMV which plays an important role in the pathogenesis of the virus, polymorphism in the gB gene may interfere with transmission of infection. This study was aimed to investigate the HCMV glycoprotein B genotypes in immunosupressed and immunocompromised Iraqi patients. A total of 362 Iraqi patients were collected from immunosupressed (pregnant women and infants) and immunocompromised (renal transplant and malignancies patients) that have been tested for the presence of acute infection of HCMV, during the period from November 2014 to February 2015. While another 20 individuals with negative serum IgM/IgG were included as negative control. The blood samples were positive for CMV-IgM and both IgM /IgG by ELISA and ELFA were found to be present in 85 (23.48 %) out of 362 blood samples. Five PCR confirmed isolates were chosen randomly for DNA sequences and similarity. Searches were carried out with the Basic Local Alignment Search Tool (BLAST) in National Center of Biotechnology Information (NCBI). The data showed that the glycoprotein B type 2 was the most common genotypes among the studied immunocoprimised and immunosupressed Iraqi patients. The nucleotide sequences of the glycoprotein B UL55 region from HCMV in this study have been deposited in the Gen Bank sequence database of HCMV under the following accession numbers: M17209.1, KP745721.1 and X17403.1.
The Exploratory Orientations of the Brain and Correlated with the Performance of Some Tennis Skills for Students Rawaa Allawi Kadhim
Journal of Global Pharma Technology .
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The exploratory orientation of the brain is an important self-motivation. The importance of this motivation is attributed to its obvious impact on the learning process because it enables learners to learn more about themselves, their abilities and their learning environment and to support them in persevering in the search for knowledge. The researchers noted the lack of interest by students motivated by the exploratory directions of the brain and the desire to keep pace with the wide changes in different areas of learning and knowledge and the relationship of that motivation results in their skilled performance, So deliberately researchers to study the trends of exploratory brain students and its relationship to the results of the performance of some skills in the game of tennis. The aim of the research was to identify the exploratory orientations of the brain and the technical performance of the sample of the students of the third stage of the morning study in the Faculty of Physical Education and Sports Sciences at Babylon University for the academic year 2016-2017. The researchers used the descriptive approach in their methods of surveying and correlative studies to suit the nature of the problem. The research community identified the students of the third stage of the morning study in the Faculty of Physical Education and Sports Sciences at Babel University for the academic year 2016-2017 (96), while the sample size (50) (52,083) were randomly selected by lottery. To achieve the objectives of the research, the researchers used the measure of the exploratory directions of the brain designed by the researcher (Maha Hadi Hussein) and the equivalent of (30) paragraphs, as well as the use of technical performance tests for tennis skills covered by the research and concluded the following: There is a significant correlation between the exploratory attitudes of the brain in the research sample of the students and their performance of some of the technical skills in the game of tennis.Keywords: Exploratory orientations, Brain and tennis skills.
Comparison of the effects of ethanol extract with aqueous extract of purple sweet potato tuber in expression of SOD-2, SOD-3, and eNOS on human vascular endothelial cells exposed by H2O2 in-Vitro I Made Jawi; I G K Arijana; I Wayan Putu Sutirta Yasa; AAN Subawa
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Aqueous extract of purple sweet potato tubers have antioxidant potential in animal and human vascular endothelial, through increased expression of superoxide dismutase. This study aims to prove the comparison between ethanol extract and aqueous extract of purple sweet potato tubers increasing the expression of superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in human vascular endothelium. This study was an experimental study of the vascular endothelial cells which underwent oxidative stress in vitro, which is protected by ethanol extract or aqueous extract of purple sweet potato tuber at various concentrations. Observation of the superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in endothelial cells is done using the method immunohistochemistry with monoclonal antibodies. The results showed an increase in superoxide dismutase - 2, superoxide dismutase -3, and endothelial nitric oxide synthase was significantly (p < 0.05) in endothelium protected by ethanol extract or water extract of purple sweet potato tubers. The ethanol extract only showed its effect at concentration of 1.5625 µg/ml for superoxide dismutase -2 and superoxide dismutase -3. The effect of aqueous extract were at a concentration of 1.5625–3.125µg/ml. From these results it can be concluded that the ethanol extract or aqueous extract of purple sweet potato tubers can protect endothelial cells from oxidative stress through increased expression of superoxide dismutase -2 and superoxide dismutase -3. The ethanol extract requires much lower concentrations to show its effect compared with aqueous extracts. Keywords: Aqueous extract or ethanol  extract of purple sweet potato, Superoxide dismutase, Human umbilical vein endothelial cells.
Child Protection and Development of Child Abuse Pediatrics Hamdiyah Abdul Ameer, Kadhim Al-Dahhan
Journal of Global Pharma Technology Volume 11 Issue 01.
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The history about teenagers reflects toddler misbehavior the development on medication as much a walk of life is influenced through social actions up to expectation engage together with poverty, economic exploitation, or infant abuse. When docs began in imitation of specialize between childcare, bold cases born in accordance with the awareness to that amount youth have been affected via special scientific issues and ailments so had been angry through bad conditions, abuse, yet neglect. They hold promoted pediatric pedophilia or toddler misbehavior in accordance with advocate because their needs in courts and communities. Using the records of medical practitioner then distinguished cases, the objectives about this treatise are: (1) in imitation of re-discover the establishment concerning pediatrics of the surroundings as served as much an instruction for its development; (2) in imitation of highlight our promptly appreciation concerning medical issues encirclement child abuse, Increasing the medical ponder able regarding children; yet (3) exploring the development on pediatric misuse between the mild of outstanding medical doctors perform large contributions in accordance with baby protection. The schedules exhibit shortly interplay between communal problems, reported cases, personal or government agencies, and the improvement concerning pediatrics. The essay concludes with feasible training according to stay discovered then greater questions as regards it interaction of toddler safety structures and toddler improvement.Keywords: Child Abuse and Neglect, Child Protection, Abuse Pediatrics
The Role of Cowmilk’s Colostrum as the Source of Passive Immunity and Growth Factor for Improving the Haematological Status and Titre of Antibody against Hog Cholera in Pre-Weaning Piglets Ida Bagus Komang Ardana
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Background: pre-weaning piglets often suffer from anemia, and infected with the bacteria so as growth slows even death. Aim: The purpose of this study was to determine the effect of cow colostrum administration on hematology profile and anti-body titers as an immunomodulatory effect to prevent germ infection. Methods: Seventy two piglets were divided in 4 groups in this research. Group who were not given bovine colostrum as a control, group who were given cow colostrum dose of 3 ml per animal, groups of piglet given bovine colostrum dose of 6 ml per animal, and a group of bovine colostrum piglet given a dose of 9 ml per animal. At the age of 7 days vaccinated against Hog Cholera and repeated at 14 days. Besides, at the period of 20 days all the piglets to have blood drawn and then accommodated in a vacuum tube which already contains anticoagulant (EDTA) for examination hematological profile is checked with Automated Manual VET ABC Blood Counter, made in Germany. Finally at the age of 30 days all piglet blood drawn and then accommodated in the tube for examination Hog Cholera antibody titer by ELISA. The data were analyzed with statistical test. Result: The results showed bovine colostrum supplementation at a dose of 1-5 days of age piglet 3-9 ml/piglet can raise the profile hematology and Hog cholera antibody titer. Conclusion: Addition of cowmilk’s colostrum in pre-weaning for the first five days of life could improve both the hematological profile and immunomodulatory set.Keywords: Piglet, Bovine colostrum, Hematology.

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