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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Degradation High Concentration of Eosin Yellowish Dye in Heterogeneous Catalyst Solution Ihab Abbas Taher
Journal of Global Pharma Technology .
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Abstract

Eosin yellowish was intended to be degraded by the use of photo catalysis process which is proposed to be mediated by ZnO and irradiated under visible light. Effects of variant swayful factors were studied for instance dosage of catalyst, concentration of dye and the incipient pH. A huge number of intermediates which yielded from photo degradation were disunited, identified, and distinguished via ultra performance to gain a well concept about the photo degradation of eosin yellowish dye assisted by ZnO and the mechanistic details related to this process which depends upon irradiation with visible light of low watt. As a photo catalyst, ZnO was depended in the current paper to perform the degradation process of eosin yellowish dye under UV light via a slurry reactor. Depending upon varying concentrations of catalyst and initial dye as (0.3 – 1.5 g/l) and (20 – 120 mg/l) respectively, different parameters optimum values were gained videlicet concentration of catalyst, initial substrate concentration that affects the eosin yellowish dye degradation rate and the type of catalyst. The diminishing of substrates and colour as concomitant with the diminution of total content of organic carbon was monitored.          Keywords:  Heterogeneous reaction; Eosin yellowish dye; Degradation dyes
The Effect of Moringa oleifera Extract as Candidate Prebiotic to Increase the Growth of Lactobacillus acidophilus and Lactobacillus plantarum Probiotics Widya Paramita Lokapirnasari
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Objectives: The potential of probiotics can be increased by adding prebiotics, which are substances that cannot be digested, but can be used by probiotics to increase their growth. Prebiotics generally consist of oligosaccharides. Moringa oleifera has potential as a prebiotic candidate. This study aims to prove the use of Moringa oleifera (M. oleifera) extract as a prebiotic candidate to increase the growth of Lactobacillus acidophilus (L. acidophilus) and Lactobacillus plantarum (L. plantarum) probiotics. Methods: This study consisted of 4 treatments and each treatment was repeated 5 times. The treatments consisted of: P0: 0% Moringa oleifera extract, P1: 0.1% Moringa oleifera extract (v/v), P2: 0.2% M. oleifera extract (v/v), P3: 0.3% M. oleifera extracts (v/v). The probiotic concentration is 1.5x108CFU/ml. Results: The results showed that there was a significant difference (p
Clinical Aspects of Tetanus in Bali, Indonesia mahadewa gde bagus tjokorda
Journal of Global Pharma Technology .
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Tetanus is well known for its significant effects to human body. It may cause neurological deficit, systemic symptoms, and mortality in worse cases. The aim of this study was to describe comprehensive clinical aspects of tetanus in Sanglah Hospital. Tetanus prevalence in Sanglah Hospital, from June 2014 - December 2015, were 29 cases. The majority of age was less than 60 years old, predominantly were male patients. All of tetanus cases were classified as moderate-severe general tetanus. We recommended DAKAR classification in order to determine prognosis of tetanus. Most prevalent symptoms were trismus, rigidity and muscle spasm. All patients were hospitalized in isolation ward. There were tendencies to use more than one kind of antibiotics. Metronidazole and cephalosporin were the most frequently used as they were recommended by other researchers. This research showed critical period of treatment for general tetanus were on 6-7 days of admission. Mortality rate of tetanus cases in Sanglah Hospital were 27.6%. Factors that associated with mortality were incubation periods, aspiration pneumonia, sepsis, high fever and opistotonus.Keywords: Tetanus, Prevalence, Symptoms, Treatment, Mortality.
Effect of Ethanol Extracts of Mustard Green (Brassica rapa L.) on Streptozotocin Induced Rats Sri Wahjuni
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Objective: This experimental study was conducted to evaluate the effect of the mustard green extract on blood glucose and the pancreas histopathological feature. Methods: Five groups of rats divided into the control group that received standard food (P0) and streptozotocin-induced group (P1, P2, P4, and P4). P1 (positive control group) was given glibenclamide; P2, P3, and P4 (treatment group) were given mustard green ethanol extract at a dose of 0.5; 2.0; and 5.0 mg/kg body weight/day respectively. The separation of ethanol extract of mustard green was carried out by  LC-MS/MS. One way ANOVA and Post hoc test was conducted to evaluate the mean difference of the blood glucose. Results: Post hoc test showed significant result for P0 vs P3 (p<0.001), P0 vs P4 (p=0.001), P1 vs P2 (p=0.048), P2 vs P3 (p=0.001). Comparison between P1 and treatment group was found a similar effect on blood glucose between P1 vs P3 (p=0.048) and P1 vs P4 (p=0.830). Histological studies showed the administration of ethanol extract of mustard green showed a restorative effect. Conclusion: Administration of ethanol extract of mustard green decrease the level of blood glucose and might be a usable treatment for hyperglycemia.Keywords: Mustard green (Brassica rapa L.), Streptozotocin, Hyperglycemic effects.
The Effect of Hypoxic Control Mask Exercises on Some Physiological Indicators in Terms of the Sport Technology for Young Players in Volleyball Suhad Qasem Al-Moussawi
Journal of Global Pharma Technology .
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The objectives of the study was to prepare exercises using the hypoxic mask in volleyball, to identify the effect of exercises using the hypoxic control mask in some physiological indicators in terms of the sports technology of young players in volleyball, the experimental method was used in experimental design of two experimental groups with tight control in both the tribal and remote tests on a sample of (12) young players from the volleyball industry club in the sports season (2018), were deliberately selected. The sample was randomly divided into two experimental groups of equal number. The dependent variables were determined by physiological indicators (time of the anaerobic threshold, frequency of breathing during the voltage, peak oxygen during the voltage), Adopting the technology of sport by testing the physical effort with a device system (Fitmatepro), these exercises were implemented at the beginning of the main section of the training unit at a rate of (3) training modules for a period of (8) training weeks. This indicates the number of training units (24) training units. The training exercises are similar to the volleyball skill and height control. (2000-3000) meters in increments and not more than (20) minutes from the main section of the training module, so as not to constitute harm or risk to the safety of young players, and the results were processed by the system (SPSS), and concluded the researchers that training with the hypoxic mask helps young players volleyball To develop the threshold And increase the peak oxygen, and the number of times the breath during the effort, which is a training tool that can help trainers to compensate for training in the highlands or training in different circumstances, and the young players in the volleyball who train them outperform others who train without them when developing these indicators.Keywords: Hypoxic mask, Exercises, Physiological indicators and sport technology.
Utilizing Bioidentical Hormone as Efficacious and Safe Hormone Jopy Wikana
Journal of Global Pharma Technology Volume 11 Issue 6.
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Background: The relative safety and efficacy of bioidentical hormone compared with synthetic version of hormone replacement therapy (HRT) is still the subject of debate. Some data suggest that bioidentical hormones have opposite physiological effects to synthetic hormones, which associated with lower risk of breast cancer and cardiovascular events. Nevertheless, there is still little evidence to support claims that bioidentical hormones are safer and more effective. Methods: Published papers were identified from PLOS, PubMed/MEDLINE, ProQuest, ScienceDirect, Google Scholar, and Elsevier (SCOPUS) databases, written in English, and fully accessible by reviewers, for studies enrolled postmenopausal women using bioidentical hormones vs. synthetic hormones as HRT. Results: A hundred and eighteen of 341 citations were reviewed. The results of this study found the disparities between bioidentical and synthetic hormones with respect to safety and efficacy. Bioidentical hormones have demonstrated effectiveness in addressing menopausal symptoms. Clinical data has indicated that bioidentical hormone, especially progesterone is associated with a diminished risk for breast cancer and cardiovascular disease, compared with commonly used synthetic versions. Conclusions: The use of bioidentical hormone therapy is well tolerated, provides symptom relief and can address the safer and more efficacious forms of HRT with respect to the lower risk for breast cancer and cardiovascular disease. Thus, bioidentical hormones remain the preferred method of HRT.Keywords: Progesterone, Estradiol, Synthetic progestins, Breast cancer, Cardiovascular disease,
The Effect of Assertiveness Training Skill on Feelings of Happiness and Mental Health of Students in Iran Bahram Gheitarani
Journal of Global Pharma Technology .
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Background and objective Assertiveness is one skill that it can change interpersonal relations and cause happiness. Hence, the aim of present study is the effect of assertiveness training skill on feelings of happiness and mental health of students. Methods and materials the method in this study is empirical method with control group. Statistical population in this study consists of all male high school students of Radar City by 2016. Among those students identified with low assertiveness by their teachers and those with low scores in Mental Health Questionnaire, 30 students were selected randomly and were placed in two experimental and control groups. The experimental group received sessions of assertiveness training and control group was remained in waiting list. Both groups fulfilled Happiness Questionnaire and General Health Questionnaire (GHQ) before and after intervention. Data analysis was done using analysis of covariance (MANCOVA) using SPSS-22.Results The results showed that there is significant difference statistically between two groups in terms of amount of happiness and mental health after training assertiveness training (p<0.01). Conclusion Training assertiveness skill can enhance happiness and mental health of students.Keywords: Assertiveness methods, Happiness, Mental health.
Effect of Adding Different Concentrations of the Mint oil Mentha spicata L. to the Ration on Some Blood Traits of Broiler Chicks Ross 308 Nihad Abdul-Lateef Ali
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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This study was conducted at poultry farm of Animal Resources Dept., College of Agriculture, and University of AL-Qasim Green to investigate the effect of adding different concentrations of the Mint oil Menthaspicata L. to the ration on some blood traits of broiler chicks Ross 308. Use the 144 broiler chicks Ross 308 day-old were randomly assigned to four treatments by 3 replicates per treatment (12 chicks per replicate). The treatments were as follows: The first treatment (control) without adding mint oil to the ration. Adding mint oil at a concentration of 600 mg / kg basal feed (second treatment). While third treatment had mint oil at a concentration of 800 mg / kg feed. Adding mint oil at a concentration of 1000 mg / kg feed (fourth treatment). The study included the following characteristics: red blood cell counts, white blood cell counts, hematocrit, hemoglobin concentration and differential leucocyte count. The results indicated that the addition of mint oil at a concentration of 600 ، 800 and 1000 mg / kg feed to broiler ration led to a significant improvement in white blood cell counts of broiler chick’s ، and addition of 1000 mg Mint oil / kg of significantly improved the lymphocytes cell compared to the first treatment (control) and the second treatment. Keywords: Mint oil, Broiler chicks, Blood parameters.
Effect of Valsartan on Echo Cardio Graphic Fraction Shortening, Troponin I, Malondialdehyde in Trastuzumab Treated Females with Breast Cancer Maysaa Ali Abdul Khaleq
Journal of Global Pharma Technology .
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Background: Trastuzumab therapy is highly effective in HER2 positive breast cancer patients, but it is complicated by cardio toxicity. Objective: To elucidate the possible effects of valsartan medication on echocardiographic fraction shortening, serum troponin I and serum malondialdehyde in trastuzumab treated patients with HER2 positive breast cancer. Patients and Methods: A total of twenty six female patients with HER2 positive breast cancer were enrolled in this study. The patients were randomized into two groups, thirteen patients in each group. Group I included patients who received trastuzumab medication for 8 cycles with 21 days apart. Group II included patients who treated with trastuzumab medication with valsartan 40 mg, orally, once daily dose for 8 cycles. Echocardiography was used to measure fraction shortening at zero time, 4th and 8th cycles in both groups Serum troponin I and malondialdehyde were measured at zero time, 2nd, 4th, 6th and 8th cycles in both groups. Results: Treatment with trastuzumab medication caused a significant reduction in echocardiographic fraction shortening at an only 8th cycle in comparison to baseline level readings (P < 0.05). Combined trastuzumab plus valsartan medications caused a significant increment in echocardiographic fraction shortening in comparison with that of trastuzumab medication group (P < 0.05). Regarding serum troponin I and malondialdehyde, trastuzumab medication caused a significant increment in both these markers compared with those baseline readings (P < 0.05). Combined trastuzumab plus valsartan caused significant reduction in troponin I and malondialdehyde in comparison with that of trastuzumab medication group (P < 0.05). Conclusion: Valsartan causes significant increase in echocardiographic fraction shortening level and cause significant reduction in serum troponin I and malondialdehyde in trastuzumab treated patients.Keywords: Valsartan, Trastuzumab, Cardiotoxicity, Fraction shortening, Troponin I, MDA.
Copper (II) and Silver (I) Complexes with bis Schiff Base Ligand: Synthesis, Spectral Characterization and Thermal Studies Ahmed Razzaq Ibrahim
Journal of Global Pharma Technology .
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Metal complexes of the bis Schiff base (BSAA) ligand, synthesized via condensation 4-amino antipyrine with 4-(4-dimethylamino) benzalidene amino) benzaldehyde which has synthesized from condensation p-amino benzaldehyde and p-dimethyl amino benzaldehyde, are synthesized from nitrate salts of Cu(II) and Ag(I) with ligand in ethanol. The metal complexes and ligand are characterized o86n the basis of elemental analyses, melting point, molar conductance, UV –Vissible , FTIR and thermo gravimetric analysis. The molar conductance data revel that the metal chelates of the ligand with Cu (II) and Ag (I) are electrolytes. From the suggest that the concent sites were proven to be through oxygen of the ring and Nitrogen of the azomethine group.Keywords: 4-aminoantipyrine, copper, Silver, TGA

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