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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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The Effect of an E-Learning Design by Ruffini Model in Learning Passing and Lay Up Scoring Skills in Basketball for Female Students Hayder S. Mohseen
Journal of Global Pharma Technology .
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Abstract

The present study objectives to develop a pedagogical design in the Ruffini model for the correction of lay-up and the passing of basketball for female students. Learning the impact of the instructional design in the Ruffini model teaches you how to shoot the lay-up and the passing of the basketball for female students. The researcher used the experimental approach of two equal pretest and other measurement sets to fit the nature of the research problem and objectives. Researchers have used the experimental approach of two equal pretest and self-measurement sets to fit the nature of the research problem and objectives. The sample of research (30) was in the experimental group and the same as in the officer, and educational modules were prepared according to the instructional design of the Ruffini model for the skills examined and the main experience was applied to female students for 8 weeks with two educational units per week and with a time of capacity (90) Minutes for one educational unit. The design of the Ruffini model has contributed to the training of the passing and correction of the ladders of the first stage students in the experimental group. One of the most important findings of the researchers is that the design of the Ruffini model has contributed to the learning of the passing and correction of the foot ladders of the first stage students in the experimental group.Keywords: E-learning designs, Ruffini model, Shoot lay-up, the passing and basketball.
Compensatory and Adaptive Features of the Cerebellum under Stress Alexey Rozhentsev
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The paper discusses the results of the study of compensatory and adaptive changes in rat cerebellar tissues under stress. As a stress factor, the experiment simulated (hypobaric) hypoxia. Since hypoxia remains one of the central issues in the modern medical science, it is directly or indirectly related to human diseases of various etiologies. To identify the features of compensatory and adaptive changes in the rat cerebellum under the action of hypoxia, we conducted comprehensive histological and histochemical studies. At the early stages of hypoxia, changes in the cerebellar tissue could be found, that were characterized by a significant increase in the volume of intracellular structures. With a prolonged hypoxia, a decrease in the volume of intracellular structures was observed which, in turn, entailed a decrease in total glycosaminoglycans and a change in the ratio of sulfated and non-sulfated glycosaminoglycans. In addition, we noted cerebellar neuron migration into the molecular layer.  The experiment revealed that hypoxia has a significant effect on the intensity of metabolic processes in cells, with the generation of intermediate metabolic products leading to a change in pH.Keywords: Hypoxia, Cerebellum, Rats, Compensatory and adaptive changes, Glycosaminoglycans.
The Relationship between Blood Pressure with P-Selectin in Indonesian Hypertension Patients R. Mustarichie
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Objective: The involvement of vascular inflammation is shown in the initiation and development of hypertension. P-selectin plays an important role in the inflammatory response through the initiation of leukocyte adhesion in platelets and endothelial cells. The purpose of this research was to determine the relationship between blood pressure and P-selectin in Indonesian hypertensive patients. Methods: The cross-sectional design study was conducted in 56 patients with hypertension, aged 40 to 60 years, blood pressure and serum P-selectin (sP-selectin) concentration measured. sP-selectin was determined by a colorimetric ELISA sandwich. Interpretation of the relationship between blood pressure components and sP-selectin concentration was carried out by statistical analysis. Results: It was found that sP-selectin level did not correlate significantly with systolic blood pressure (r = 0.078; P = 0.568), diastolic blood pressure (r = -0.014; P = 0.921), mean arterial pressure (r = 0.062; P = 0.648), and pulse pressure (r = 0.062; P = 0.648). Conclusion: Our results concluded that the increase in blood pressure components was not significantly associated with an increase in circulating sP-selectin concentration in hypertensive patients. Thus, there was no significant correlation between blood pressure and P-selectin in hypertensive patients. The tendency of positive results indicated an inflammatory involvement in hypertension.Keywords: Blood pressure, P-selectin, hypertension, Vascular inflammation adhesion, ELISA.
Anaerobic Threshold is Significantly Enhanced by High Intensity Interval Training (HIIT) in Balinese Athletic Students Indira Vidiari Juhanna
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Introduction: Anaerobic threshold is a physiological point when lactate production begins to exceed the lactate spent via oxidation process resulting in increasing amount of lactate in the circulation. It is an important aspect of sports physiology and several methods have been developed to enhance it. However, little study had conducted to evaluate the effectiveness of high intensity interval training (HIIT) in enhancing the anaerobic threshold. Method: A quasi experimental study with pre test and post test group design was conducted at Ngurah Rai Sports Building Square from January to February 2017. The subjects were randomly divided into two groups in which the first group received HIIT and the second one was the Steady State Training group performed for 2 minutes of sprint and 2 minutes of jogging for 6 weeks. Results: 24 male students were enrolled in this study with mean age 13.92±1.165 years for the first group (HIIT) and 14±1.128 years old in the second one (SST). The anaerobic threshold was significantly after the intervention (HIIT [before vs after]: 178.17±2.368 vs 197.83±3.460; SST: 177.17±1.586 vs 185.25±1.288; p: <0.05). The value difference (after-before) comparison between both groups also proved to be significantly different (HIIT vs SST: 19.67± 2.309 vs 8.08 ± 1.311; p<0.05). Conclusion: Both HIIT and SST were proved to significantly enhance the anaerobic threshold in male highschool students. However, HIIT had significantly higher enhancement compared to SST.Keywords: Anaerobic threshold, Steady State Training, lactate, high intensity interval training.
Relationship between HCMV and Diabetic Mellitus Type 2 of Elderly Patients in Al-Najaf Governorate Elham Jawad Kadhum
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The sudden rise mellitus (DM2) and related complications go along with increasing evidence of clinically major age and gender differences. The aim of current study was to study the relationship between the virus and diabetes mellitus type2 through detection of human cytomegalovirus (HCMV) infection in DM2 patients in Najaf governorate by detection of human cytomegalovirus DNA in blood samples by using of PCR technique. Blood samples were collected from 93 diabetic patients randomly. Regarding PCR technique, the study showed that among 93 diabetic patients gave positive results in 39 patients(42%); In contrast, in control group PCR positive result was only 4.4% (4 out of 90) with significant differences . This study concluded that the higher prevalence of HCMV DNA in DM2 patients comparing with normal individuals, which means that patients with DM2 were at high risk for HCMV infections.Keywords: HCMV, DM2, PCR.
Phytoremediation Mechanisms of Lead (Pb) Metal Contaminated Soils of some location in Baghdad City Huda Farooq Zaki
Journal of Global Pharma Technology .
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Mechanisms phytoremediation of Lead metal from contaminated soil are a little time consuming because metals cannot degrade, therefore effective cleanup requires  to reduce or remove toxicity, use of plants to remove, detoxify or immobilize environmental contaminants in a growth matrix in soil  through the natural, biological, chemical or physical activities or processes of some location in Baghdad city , the current study was conducted to determine the effects of soil pollution on the elements and the plant absorption of pollutants and their effect on the population in parks, In the city of Baghdad, where ten areas were identified (5 areas by Karkh - 5 areas of the Rusafa side with control), pH and soil tissue were measured and element concentrations (pb) through the average results of plants that have been obtained there is a relationship between plants with a difference from one to other depending on the ability to absorb Lead and content in three dominate plants species, Consecutively: Cynodon dactylon> Eucalyptus camaldulensis> Dodonea viscosa,( 0.033, 0.032. 0.018) Respectively. Lead compounds can be dissolved in water which may result in introduction to soil and thus transfer to food chain. Many industrial activities such as mining, processing minerals and chemical industries, increase non-essential metal concentration in the water tables in the surrounding regions of their manufacturing plants.  
Feasibility and Applicability of Solar Disinfection (SODIS) for Point-of-use Water Treatment in Bandar Abbas, South of Iran Leila Rezaei
Journal of Global Pharma Technology .
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Abstract

Today, drinking water supplies for most of the developing countries which mainly includes the remote villages are at stake. Therefore, using of low-cost and available methods, for the treatment of surface water for drinking in the areas without safe water system or emergency conditions was approved by international healthcare organizations. Solar disinfection technology (SODIS), is one of the most important technologies. In this study, the effect of UV-A radiation of sunlight in surface water disinfection in Bandar Abbas was studied. In a cross-sectional study, the samples have been exposed to sunlight for 1 to 7 hours in two types of PET and glass containers. Using of HPC method was measured number of remaining bacteria in the samples. Then, by using a statistical analysis, the relationship between reduce of microbial load and turbidity, contact time, weather conditions and type of containers was investigated. The results showed that removal efficiency of bacteria increased by increasing contact time from 1h to 7h. Also there was a direct and inverse relationship respectively between environmental temperature and turbidity with disinfection efficiency. Also results showed that in glass containers was observed more microbial load reduction. Noticed to significant impact of turbidity on SODIS, it is recommended, a filtration step performed prior to disinfection to reduce water turbidity. Based on the findings, the use of SODIS as a simple and practicable method is recommended to guarantee the drinking water safety.Keywords: Solar disinfection, SODIS, poInt-of-use, Water treatment, Bandar Abbas.
Correlation between Aryl Hydrocarbon Receptor with Hepatic and Renal Function Tests in Fuel Filling Station Workers Muthana S. Mashkour
Journal of Global Pharma Technology .
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Abstract

The exposures to gasoline and gas oil, for a long time, in the gas stations through inhalation of vapors during refueling are generally hazardous. Gasoline consists of different types of aliphatic hydrocarbons and aryl compounds. Aryl hydrocarbon receptor (AHR) is a receptor involved in the regulation of biological responses to planar aromatic hydrocarbons. The aim of the present study is to compare the serum AHR level in the fuel station workers (FSW) with the non-workers as a control group. The other aim is to find out a possible correlation between AHR with liver and kidney function tests. Sixty male FSW and 30 controls, from ten fuel stations at Al-Najaf City-Iraq, were participated in the present study. The AHR levels were measured using ELISA technique. Other parameters (urea, creatinine, total serum bilirubin (TSB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and albumin) were measured spectrophotometrically by using ready for use kits. Serum concentration of AHR, ALT, AST and Creatinine in FSW group revealed a significant increase (p<0.001) as compared with the control group. No significant difference was noticed in other parameters. There were significant increase in AST (p=0.002) and ALT (p<0.001) in exposure ≥12yrswith exposure <12yrs in FWS. Smoking has no significant correlation with other parameters. Correlation study indicated a correlation between AHR and Age. No correlation noticed between AHR and any measured parameters in FWS.  It can be concluded that, AHR estimation is important in FSW in order to monitor the health of liver and kidney in those workers.Keywords: Aryl Hydrocarbon Receptor, Liver, Kidney, Fuel Filling Workers.
All Optical UWB-DWDM for Medical Applications Based on Optical Phase Conjugation Technique Ali Hayder Abdul Kareem
Journal of Global Pharma Technology .
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Abstract

In this paper, optical phase conjugation (OPC) devices are used along the optical link as a new method for improving the performance of wireless medical communications using all optical UWB signal. A 50 GHz spaced two-channel dense wavelength division multiplexing (DWDM) communication system is considered using 360 km single mode fiber (SMF) link with two pumps. Simulation results are compared with the case of without using compensation technique showing better performance in terms of achievable Q-factor, BER performance, and the total length of transmission link.Keywords: All optical UWB, DWDM technique, Optical Phase Conjugation (OPC), Wireless medical communication.
Potential of Astaxanthin from Asian Tiger Shrimp (Penaeus Monodon) Shell Extract as an Antibacterial and Ant Inflamatory Sukmawati .
Journal of Global Pharma Technology Volume 11 Issue 04.
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Asian tiger shrimp (Penaeus monodon) shell is an industrial waste which becomes one of the sources of carotenoids in the form of astaxanthin (3.3’-dihydroxy-β, β′-carotene-4.4′-dione) which has a very potential biological activity because it can work on target molecules. Astaxanthin in Asian tiger shrimp shell is well known to be lipophilic, being insoluble in water but soluble in organic solvents, one of which acetonitrile. The characteristics of astaxanthin were obtained through qualitative and quantitative analyses using FTIR (Fourier Transform Infra-Red) and HPLC (High Performance Liquid Chromatography). Furthermore, antibacterial and anti-inflammatory activities had been tested. Based on the research results done on the inhibition of Asian tiger shrimp (Penaeus monodon ) shell extract on the 5th growth of the test bacteria, the tiger shrimp shell extract had antibacterial activity on Eschericia coli., Streptococcus mutans, Pseudomans auriginosa, Salmonella typhi, Staphylococcus aureus which was characterized by the presence of clear zone / inhibition zone / Oligodynamic zone which showed the effect of tiger shrimp shell extract in killing and inhibiting the growth of test bacteria. Besides, An anti-inflammatory testing through extracting chemical components with acetonitrile solvent with several concentrations showed that the anti-inflammatory activity with a concentration of 1000 ppm with % stability on erythrocyte membrane obtained 60.516%, indicating that the higher the concentration used, the better was the anti-inflammatory effect.Keywords: Astaxanthin, Asian tiger shrimp, Antibacterial, Anti-inflammatory.

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