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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Anorexia in Childhood Ekaterina Zenia
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Over the past three decades, there has been a tendency to shift anorexia nervosa towards a younger age. It is necessary to identify a possible relationship between mental illness and the presence of anorexia. The purpose of the study is to comparatively examine the clinical, gastroenterological and psychopathological features of the development of anorexia nervosa in children with diagnosed mental disorders (autism, childhood schizophrenia). In 2008-2018, at the base of the Moscow Scientific Center for Mental Health and the Children's Psychiatric Clinic No. 6 (Russian Federation), 167 patients were selected, divided into two groups according to the diagnosis. The first included 90 children with a diagnosis of autism, the second - 77 children with a diagnosis of childhood schizophrenia. Children were observed from 3 months of age until they reach 10 years of age. At 8 years old, the children underwent gastroenterological examination. The frequency of occurrence of deviations in eating behavior was recorded. Used abdominal ultrasound, as well as esophagogastroduodenoscopy. In the group of children with autism aged 8-10 years, the total number of eating disorders is gradually decreasing, 2-2.5 times less than 1-3 years (p = 0.001). The incidence rate of anorexia was 70%. Also recorded a decrease in the frequency of occurrence of violations. At 1-3 years on average, the frequency of occurrence of eating disorders was at the level of one third of cases. At the age of 8-10 years, this indicator decreased by 6-15 times (p = 0.001). In the second group, children with schizophrenia, the manifestation of eating disorders occurs later, at 4-6 months of life. By 1-3 years, the frequency of occurrence of deceleration of chewing and swallowing increases 2 times (p = 0.05). At 8-10 years, these eating disorders develop into persistent phobias. Anorexia is recorded in 90% of cases. At 1-3 years of age, eating behavior changes: bulimia and vomitomania appear. The consequence of this is a decrease in body weight. Despite the fact that at the age of 8-10 years in the second group, many disorders are 2-4 times less likely (p = 0.001) than at 1-3 years, some (bulimia) can remain with the same frequency. Esophagitis and reflux in the esophagus are 3–7 times more likely to occur compared to cardia and erosion (p = 0.05 and p = 0.001). Gastroduodenitis and reflux were most often diagnosed in the stomach, 2 times more often than gastritis (p = 0.05), 6 times more often than erosion (p = 0.001), 10 times more than mucosal proliferation. Damage was found to occur to the gastrointestinal tract in children with anorexia nervosa in almost all of its departments. A group of patients with autism has a high percentage of anorexia (70%), with a predominance of eating disorders such as active or passive refusal to eat. In the group of patients with schizophrenia, anorexia is more common (90%), but eating disorders, edible substances, vomitomania, bulimia dominated among eating disorders. Gastroenterological examination revealed a number of diseases of the gastrointestinal tract, among which esophagitis (37%), gastroduodenitis (41%) and reflux (47%) predominated. The revealed age-related features of the development of eating disorders will allow establishing the disease in time and taking measures to cure it.Keywords: Anorexia nervosa, Autism, Schizophrenia, Bulimia, Womitomania, Eating disorders.
Analysis of National Lists of Essential Medicines in Ukraine and the Who Model List of Essential Medicines in the Dynamics of the Year Hanna Panfilova
Journal of Global Pharma Technology Volume 10 Issue 12.
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The article contains results of dynamic of changes of National lists of Essential medicines in Ukraine during 2001-2017 and the WHO Model list of essential medicines (1977-2017). During a long period of time the WHO International concept of model list of essential medicines was considered to have a complicated dynamic of changes of medicines. In 1977 as compared to 2017, the number of medicines increased twice. Maximum increase (455 drugs) was observed in 2011 and minimum (204 drugs) – as in 1977. The fluctuation of chain increase of the number of medicines, which were included in the WHO Model list of essential medicines from –8,0% (2013) to +22,0% (1979). In the last edition (2017) the WHO Model list of essential medicines was changed significantly, which meet up-to-date requirements of practical medicines development, and the requirements of the society as to the efficiency of medical and pharmaceutical aid. A significant fluctuations of qualitative indicators of the WHO National list of Essential medicines in Ukraine (from 215 to 780 drugs) allow us to state about the absence of a systematic approach and a relevant policy to the implementation of the WHO International concept of Essential medicines in our country to practical health protection and pharmacy. Thus, in 2008 the number of medicines included in the WHO National list of Essential medicines had 780 names, which exceeded the number of medicines of existing edition of the WHO 15th Model list of essential medicines by 1,8. We proved that the last edition (2017) of the National list of Essential medicines, which was confirmed in Ukraine based on the government program “Available medicines”, meets international requirements.Keywords: National Drug Policy, National list of Essential Medicines of Ukraine, Model list of Еessential medicines, рarmaceutical market of Ukraine, Ukraine, World Health Organization.
Interaction Model Parents-Adolescents in Adolescents are Risk Addiction of Drugs Ah. Yusuf
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Background: One of problems in adolescents is risk of addiction to drugs that negative behavior disturbs the society. Adolescent had more spending time with friends in school and other places that have risk to addiction too Purpose: The aim of this study is analyzed interaction model of parents-adolescents in risk addiction of drugs based on King’s Goal Attainment theory. Method: This study was used cross-sectional design. 124 parents and adolescents from Senior High School through probability sampling that is simple random sampling. Questionnaire data were taken by parents’ (transactional factor, perception, judgment, and action), adolescents’ (transactional factor, perception, judgment, and actions), and parents-adolescents ’reaction, and parent-adolescents’ disclosure. Analysis method was used Partial Least Square (PLS). Results: Parents’ transactional factor influenced on parents’ perception (t=2,074), parents' perceptions influenced parent's judgment (t=2,697), parent’s judgment influenced parent’s action (t=2,396), parent’s action influenced parents-adolescents’ reaction (t=2.774), adolescents’ transactional factor not influenced adolescents’ perception (t=0,594), adolescents’ perception influenced adolescents’ judgment (t=5,744), adolescents’ judgment influenced adolescents’ action (t=2,118), adolescents’ action influenced parents-adolescents’ reaction (t=2.831), parents-adolescents’ reaction influenced parents’-adolecents’ interaction (t=3.048), parents’-adolescents’ interaction influenced parents’-adolescents’ disclosure (t=8,062). Conclusion: Many factors are being adolescent to risk addiction of drugs and can control with interaction models. Using interaction model of parents-adolescents so that practitioner can improve adolescent’s health promotion activities in community.Keywords: Adolescent, Parent, Risk addiction, Interaction.
Molecular Docking of The Potential Compound from Cocoa Shells (Theobroma cacao L.) Against Androgen Receptor as Anti-Alopecia Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

The determination of the components of the cocoa shells compounds that have anti-alopecia activity have not been reported, so the molecular docking approach is a very effective alternative before further testing is carried out. This study aimed to determine the potential compound components against androgen receptor targets as anti-alopecia drugs. Molecular docking used ChemDraw Ultra 12.0, Chem3D Pro 12.0, Biovia Discovery Studio 2016 Client®, and Autodock Tools 4.2, as well as to determine the pharmacokinetic properties and toxicity of drug ingredients with Pre-ADMET. It was found that that the components of the cocoa peel compound had the potential to act as anti-alopecia drugs, namely chlorogenic acid, epicatechin, and catechins with the value of the free energy binding (ΔG) and the inhibition constant (Ki) respectively (-7.87 kcal/mol; 1.70 µM)> (-6.48 kcal/mol; 17.65 µM)> (-6.36 kcal/mol; 21.91 µM) with the crucial amino acid residue formed was GLN 858. The pharmacokinetics (plasma protein binding) of epicatechin and catechin were excellent compared to chlorogenic acid and minoxidil because it could penetrate the plasma membrane when interacting. While the toxicity test, the components of chlorogenic acid, epicatechin, and catechin compounds were mutagenic, and only chlorogenic acid was carcinogenic. The study concluded chlorogenic acid, epicatechin, and catechin compounds from the cocoa shells were promising candidates for anti-alopecia drugs to be developed further targeting androgen receptors. It was consistent with the molecular docking results, which showed that ΔG and Ki's values were excellent compared to minoxidil. The pre-ADMET results also showed that the epicatechin and catechin compounds components could penetrate the plasma membrane when given topically compared to minoxidil. Keywords: Alopecia, Cocoa shells, Theobroma cacao, Molecular docking, Androgen receptor.
The Effect of Entonox on the Apgar Scores of Infants Born to Mothers Requesting Painless Deliveries at Motahari Hospital in Jahrom City: A Double-Blind Clinical Trial Hasan Zabetian
Journal of Global Pharma Technology .
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Abstract

Introduction A vaginal delivery is one of the hard pains during a woman’s life. Therefore, different training methods or interventions have been employed in developed countries to encourage women to use Entonox for painless and safe deliveries. This study was conducted to investigate the effect of Entonox on the Apgar scores of infants born to mothers requesting painless deliveries at Motahari Hospital in Jahrom City. Method: In this double-blind clinical trial, the random sampling method was in Motahari Hospital in Jahrom City. The research sample included all of the parturient women requesting a vaginal delivery under the supervision of a gynecologist. The subjects were divided randomly into the experimental group (39 individuals receiving Entonox) and the control group (41 individuals). The descriptive statistics and the nonparametric Mann-Whitney test were used to analyze data in SPSS 18.Results The average ages of the experimental group (receiving Entonox) and the control group (non-receiving Entonox) were 25-26 years. The majority of parturient women had one child. In experimental group, the most prevalent complications of Entonox were xerostomia (13; 39.4%) and somnolence (10; 30.3%). The results of the Mann-Whitney test indicated that there was not a statistically significant difference between the two groups in terms of the Apgar scores of the newborn babies (p-value>0.05). Moreover, the vital signs of patients (systolic and diastolic blood pressures, heartbeat, and SpO2) did not show any significant differences in the experimental group receiving Entonox over time (1-5) (p-value>0.05).Conclusion use of Entonox was a safe method ,fewer complications for parturient women and her infant during delivery in comparison with other methods. Moreover, the analgesic efficacy of this gas is considerable.Keywords: Entonox, Parturient women, Apgar scores, Infants, Anesthesia.
Biomedical and Psychosocial Treatments in Pediatrics Khudhair Khalaf Shallal
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Over the past 20 years our talents about evidence-based psychological interventions for pediatric chronic pain has dramatically increased. Overall, the evidence between assist about psychological interventions because pediatric persistent discipline is strong, demonstrating fantastic psychological and behavioral effects because a range over youngsters along a thoroughness over judgment conditions. However, wide range get admission to according to tremendous psychologically-based judgment administration treatments remains a challenge for deep kids anybody go through with pain. Increasing get admission to in accordance with care then lowering chronic biomedical biases to that amount break prosperity over psychological purposes are an interior center of attention over contemporary judgment treatment interventions. Additionally, so the variety regarding evidence-based redress increase, tailoring redress according to a toddler or family’s precise wishes is increasingly more possible. This thesis intention (1) discuss the theoretical frameworks namely nicely as the particular psychological advantage yet techniques so presently preserve story as like effective retailers over change; (2) criticism and shorten tendencies within the development concerning well-researched outpatient interventions above the previous public years; yet (3) discuss after instructions for intervention lookup over pediatric chronic pain.Keywords: Chronic pain, Pediatric, Psychological intervention, Parent, Child, Evidence-based, Empirically supported.
Synthesis, Characterization and Study of the Biological Activity of New Metal Complexes of Ligand[2-(3-benzoylthioureido)-3-(-4-hydroxyphenyl) Propanoic Acid (BHP) Enass Jasim Waheed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

In this paper, series of new complexes of Manganese(II), Cobalt(II), Nickel (II) Cupper(II) Zinc(II), Cadmium(II) and Mercury (II) are prepared from the new ligand  [2-(3-benzoylthioureido)-3-(-4-hydroxyphenyl) propanoic acid (BHP) derived from tyrosine and benzoylisothiocyanate .Chemical structures are obtained from their 1 H, 13CNMR spectra (for BHP), elemental microanalyses, molar conductance, FTIR, UV–Vis, magnetic susceptibility in addition to TGA/DTG and DSC analysis, the suggested geometry for all complexes was tetrahedral. The biological activity of BHP and its complexes has been extensively studied against two bacterial species Staphylococcus aurous (G+) and Escherichia coli (G-) by agar-well diffusion technique, where Mn(II), Co(II), Ni (II)  complexes showed greater biological activity compared to ligand. Keywords: Tyrosine, Metal complexes, Biological activity.
Correction of the Tooth Alignment In Case of the Popov-Godon Phenomenon Using A Dental Implant With Immediate Loading (Clinical Case) DilanyanK. Mamikon
Journal of Global Pharma Technology .
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This paper describes a clinical example with immediate loading on the dental implant with a temporary (cobalt-chromium alloy crown) that was mounted in the area of the secondary edentulism of tooth 24 with the Popov-Godon phenomenon of its antagonist – tooth 34 – with vertical malalignment and tilt towards the tongue. This pathology is part of the second form and second subgroup thereof. Treatment started with the mounting of a dental implant in the area of the secondary edentulism of tooth 24 with immediate loading on the dental implant, with a view to correcting the impaction of the antagonist tooth 34 into its usual alignment in a continuous dental arch. This work was done in clinical conditions. The patient was examined once every fortnight after the fixation of the temporary pontic. Spot X-ray of the dental implant and tooth 34 was conducted. The work lasted four months. Over the course of the work, all structures were produced once.Keywords: Tooth Alignment, Popov-Godon Phenomenon, Dento-Alveolar Malalignment, Dental Implant, Dental Arches.
Pathological Risk Factors in Retinoblastoma Patients Underwent Enucleation I Wayan Eka Sutyawan
Journal of Global Pharma Technology Volume 11 Issue 01.
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Objective: Retinoblastoma is a malignancy that originates from primitive retinal cells and is usually found in children under 4-5 years of age. Retinoblastoma is the second largest cause of death among other malignancies in developing countries. The purpose of this study was to determine the characteristics and pathological risk factors of enucleated retinoblastoma Patients and Methods: This is a descriptive study with a cross-sectional study design conducted retrospectively by evaluating data from the patient's medical record. A total of 18 subjects were enrolled in this study. Characteristics observed were sex, age, and laterality.  Data was compiled and calculated by Microsoft Excel 2017 software. All calculations and presentations were conducted in descriptive manner. Results: Unilateral retinoblastoma cases (77.2%) were found more often in this study. Leucochoria was the most often presenting symptoms (61.1%), followed by propotosis, strabismus, and cellulitis. Out of 18 subjects, 72.2% subjects had intraocular retinoblastoma. The most common PRF finding in this study was optic nerve invasion (44.4%), followed by choroid invasion, and scleral invasion. While 11.1 % of the subjects had no PRF findings. Conclusion: Invasion to the optic nerve was the most common pathological risk factors found in enucleated retinoblastoma. Other PRFs include choroid invasion and sclera invasion. PRFs may become a sign that determines the progressivity of retinoblastoma, and it can also determine further decisions regarding the prevention of recurrence and possible adjuvant therapy in retinoblastoma patients.Keywords: Pathological risk factor, Retinoblastoma, Enucleation.
The Use of Methanolic Extract of Annona Muricata Linn Leaves as an Effective Anti-Hyperglycemia on Mice Anak Agung Wiradewi Lestari
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Background: Extracts from various morphological parts of soursop leaf (Annona muricata Linn/Annonaceae) are widely used in many parts of the world for the management, control, and treatment of a human diseases, including diabetes mellitus (DM).  This study investigates possible anti-hyperglycemia effects of methanolic extract of Annona muricata Linn in mice experimental paradigms of DM.Materials and Methods: The mice used were divided into three experimental groups. Group A served as ‘control’ animals and received sodium citrate buffer solution in quantities equivalent to the administered volumes of methanolic extract of Annona muricata Linn. Diabetes mellitus was induced in Groups B and C by intraperitoneal injections of streptozotocin (STZ, 80 mg/kg body weight). Group C were additionally treated with methanolic extract of Annona muricata Linn (100 mg/kg body weight, PO) for two weeks.Results: A statistically significant lower blood glucose level was found in Group C compared to Group B in sixth (215.14±78.37 vs 319.57±135.92 mg/dL) and seventh week (158.57±24.23 vs 238.85±51.35 mg/dL) of observation.Conclusion: Daily dose of 100 mg/kg body weight methanolic extract of Annona muricata Linn administration lowers blood glucose compared to those who did not receive in mice.

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