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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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The Effectiveness of Intervention of Treatment Based on Acceptance-Commtment Therapy with drug control on the Rate of Parent, s Acceptance of Autistic Children and Their Denial-Defense Mechanism Maryam Khorasani Dehshotoran
Journal of Global Pharma Technology .
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Abstract

The purpose of this study was to measure the efficiency of intervention of treatment based on acceptance-commitment therapy (ACT) with drug control on the rate of parent,s acceptance of autistic children and their denial defense mechanism. The present study consisted of pre-test and post test with control group. The subjects of this study were comprised of Atypical Children Centers in Esfahan in the first three months in 1394. Based on convenient sampling, 40 women, having at least one autistic child, were selected. The instruments of the study were Defense Styles Questionnaire (DSQ) and Acceptance and Action Questionnaire-2 (AAQ-2) and also Ways of Coping Questionnaire (WOCQ). Participants were randomly classified in to control and experimental groups. Also Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Automatic Thoughts Questionnaire(ATQ) were used for mental health assessment in depression-anxiety domain of participants. The experimental group had 8 training sessions, each 90 minutes, and participants were exposed to commitment acceptance therapy. Defense Styles, Acceptance and Action and Ways of Coping Questionnaire were applied again for two groups. The results of the study illustrate that maximal and minimal average number of coping strategy was for avoidant/ escap. And the dominant defense mode in mother’s experimental group was with regard to undeveloped mode. The result of covariance analysis revealed that acceptability of mothers being under the treatment of commitment- acceptance therapy significantly increased (p=0.032<0.05). Whereas there were on significant differences between the scores of mothers experiencing commitment domain in both groups (p=0.147>0.05). Based on the findings, it can be conclude that commitment acceptance therapy had positive effects on the increase of the level of mothers acceptance having auutistic children and with regard to the decrease of eruptional/denial fact in parents, it increased the improvement of the adaptation and family relationship.Keywords: autism, Denial defense machanism, Acceptance commitment therapy.
Development and Evaluation of Felbamate Loaded Solid Lipid Nanoparticles Ramanuj Prasad Samal
Journal of Global Pharma Technology Volume 12 Issue 01 (2020) Jan. 2020
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Abstract

Solid lipid nanoparticles (SLN’s) or lipid nano particles is typically sphere-shaped, with an average diameter of 1nm to 1000nm.  They are alternative carrier systems to tradition colloidal carriers, such as, emulsions, liposomes, and polymeric micro and nanoparticles. The main aim of the current research work is to prepare and optimize the Felbamate loaded solid lipid nanoparticles using by placket and burman design of experiments. SLN’s were prepared by microemulsion technique. Based on preliminary experiments and on literature, the influence of independent variable parameters selected were lipid (X1), surfactant (X2), and co-surfactant concentration(X3),aqueous phase volume(X4),magnetic stirrer rate (X5), probe sonication duration (X6), volume of beaker used for sonication (X7), volume of cold aqueous phase (X8) on the dependent variable such as average particle size (Y1) was studies. Other parameters, i.e., magnetic stirrer rate and probe sonication duration were not having a significant impact on particle size and their levels were kept constant for all the experiments. Magnetic stirrer rate has an impact on particle size and was included in the design. It was concluded from the study that the composition prepared with lipid concentration of 50 mg, surfactant concentration of 75 mg, Co-surfactant concentration of 0.75 ml, aqueous phase volume of 5 ml, magnetic stirring speed of 400 rpm, probe sonication duration 30 minutess, volume of beaker used for sonication 500 ml and volume of cold aqueous phase 30 ml has shown the smallest particle size of 165 nm
The Role of Servant Leadership Components on the Organizational Effectiveness in Zabol University Mohammad Ghasemi
Journal of Global Pharma Technology .
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Abstract

Servant leadership with the impact on the Organizational effectiveness is one of the factors that affect the efficiency and effectiveness, which are considered the most important goals of an organization and it should be taken a step to be strengthened. So, the aim of this research is explaining the impact of servant leadership components on the Organizational effectiveness of staffs of Zabol University. Since the purpose of this research is explaining the impact of the servant leadership components on the Organizational effectiveness of staffs. In terms of goal is applied research, based on the descriptive nature, that is kind of correlation and in terms of procedure is quantitative. The statistical population of this research consists of all staffs of the Zabol University, which are 305 individuals. To determine the sample size by using the method of Morgan table, 169 individuals have chosen and the method of sampling for this study is simple random. In this research, in order to collect theoretical basics and background, it has been used the library studies and articles and academic journals. As well as collecting statistical data in order to test the hypothesis of the research, it has been used field method and questionnaire, that their validity and reliability have been approved. In this study, after gathering the questionnaires, the data file will be formed in SPSS software and according to the number of variables and the type of study as well as the relationships between variables were by using the tables of frequency, diversity indices of bar graphs, the histogram used both descriptive and inferential statistics. In the level of inferential statistics has been used linear regression test and step by step to show the impact of the servant leadership and its components on the Organizational effectiveness of the staffs. The findings of the research showed that the servant leadership and its components of the productivity of staffs of Medical Science University have a significant impact.Keywords: servant leadership, productivity, staffs, Medical Science University
Comparative Histological Study of Teat in Jenubi Cow and Her Crossbreed Karim H. Al-Derawi
Journal of Global Pharma Technology .
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Abstract

For histological comparative study of the teat, Samples of about 1 cm3 were collected from different parts of teat immediately after slaughter of Jenubi cow and her Friesians crossbreed in Misan government. There are histological similarities in the main structures of the teat found between them. The epithelium of teat canal is thicker in teat of crossbreed cow than the epithelium of teat canal of Jenubi cow. Furstenberg’s Rosette ,is composed of about 10-12 of folds of double layered epithelium in a rose flower like pattern, while in the teat of  crossbreed cow the numbers of the fold decrease to about 7-9 folds .Epithelium thickness of  teat canal is particularly increased for Holsteins Crossbreed cow  compared with Jenubi cow.Keywords: Histology, Teat, Jenubi Cow.
Determination of the Genotoxic Potential of Annatto Seed by Single Cell Gel Electrophoresis in Layer- Hen Bushra M.W. Al-Obaidi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The aimed of this study is to investigation the toxicity of annatto seeds added to the diet of layer hens for different level. A total of 240 Lohmann hens 67 week of ages for 12 weeks were distributed randomized blocks into four treatments (60 hens) with three replicates 20 hens of each. The following treatments were applied: T1- control feed on based die; T2- feed on Annatto seed at 75gm/100kg, T3- feed on Annatto seed at 150gm/100kg, T4- feed on Annatto seed at 225gm/100gm. In the end of study blood samples were collected from 9 birds from each group from the wing vein in a test tube with coagulant for cytogenetic parameters. The result demonstrated that 2nd group recorded maximum significant (p≤0.05) differences compared to other nourished  groups in all comet assay parameters(%DNA in head, Tail  length,% DNA in tail, Tail moment and Olive tail moment) then followed by T3 regressed maximum significant (p≤0.05) differences of comet length. T1, T4 recorded a significant (p≤ 0.05) decrement in comet assay parameter respectively compared with other studied groups. The addition of Annatto seed at 225gm / 100kg  to the diet of layer hens has an adverse effect on blood lymphocyte and cases highly damage of DNA, while added at level 75gm/kg(T2) and 150 gm/kg(T3)which protect lymphocyte from damage  as shown in comet assay parameters.Keywords: Annatto seed, Single Cell Gel Electrophoresis (comet assay), Layer.
The Effect of the Methods of Distributed and Intensive Exercise in Terms of Mental Logic in Learning Some of the Basic Skills of Futsal Yasin Ali Khalaf
Journal of Global Pharma Technology .
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The research aims to study the effect of using the distributed and intensive exercise in terms of mental logic in learning some basic skills of futsal, and to compare the effect of the use of the distributed and intensive exercise in the sense of mental reasoning in the remote tests in learning some basic skills of futsal. The researcher used the experimental method to suit the nature of the research. The research society was chosen deliberately by the students of the second stage in the Faculty of Physical Education - University of Sulaymaniyah for the academic year 2016-2017 (32) students, where the percentage of the sample (75%) of the community of origin, 24 students were divided into two experimental groups with 12 students per group. Eight students were excluded from the pilot experiment. By the draw, the first experimental group was chosen to implement the distributed method while the second group performed the intensive method. The results of the tests were statistically treated and the researcher concluded that the experimental groups achieved progress using the methods of the distributed and intensive training in the sense of mental reasoning to learn some basic skills of futsal halls, and the results showed that the superiority of the first experimental group T-used style exercise distributor on the second experimental group that used the style of intensive exercise in their results dimensionality.Keywords: Methods, Distributed and intensive exercise, Mental logic and futsal.
Antibacterial Evaluation of Gradient Extracts of Adiantum latifolium Lam. Towards Pathogenic Cutaneous Bacteria Toji Thomas
Journal of Global Pharma Technology Volume. 9 Issue 6
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Abstract

Objective: The study focused to analyse antibacterial evaluation of gradient extracts of Adiantum latifolium, a healing pteridophyte towards bacteria involved in cutaneous infections. Methods: Whole plant of Adiantum latifolium was analyzed for its antibacterial nature and phytochemical components in different solvents extracts of accelerating polarity. Disc diffusion method was used to analyse antibacterial activity. Preliminary phytochemical evaluation was done using various spraying reagents. Minimum inhibitory concentration as well as minimum bactericidal concentration was determined towards Pseudomonas aeruginosa. Results: The plant primarily exhibited antibacterial activity in ethanol extract. Maximum intensity of activity was noticed towards Pseudomonas aeruginosa, a resistant strain towards amoxicillin and chloramphenicol. Petroleum ether and water extracts could not show any antibacterial activity towards the tested organisms. Flavonoids and phenols were found in different extracts. Occurrence of flavonoid and phenol in ethanol extract of the plant can be an explanation for its antibacterial activity. Ethanol extract of the plant showed minimum inhibitory concentration as 18.75mg/ml and minimum bactericidal concentration as 37.5mg/ml towards Pseudomonas aerogenosa. Conclusion: Adiantum latifolium showed antibacterial activity in ethanol extract especially towards   Pseudomonas aeruginosa. Adiantum latifolium; Antibacterial activity; Phytochemical; Pteridophytes.
An Update of Male Contraception: A Review of Cellular Perspective Silvia W Lestari
Journal of Global Pharma Technology Volume 11 Issue 01.
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Introduction: Similar to the world, Indonesia also undergoes a population explosion. One solution to overcome this population problem is to conduct contraception. Although woman contraception is widely used, still the role of man is needed. There are a few methods in male contraception, but all is still not proven optimally. Therefore, it is intend to understand more about the cellular mechanism of male contraception.  Methods: A computerized finding process of database in Pub med which related to the key words was performed for obtaining data. After that, the most update and relevant articles were reviewed and selected. Results: The results are mainly revealing the regimens that are administered in male hormonal contraception and substances that are used in immunocontraception. Furthermore, this reviews also reveales the cellular mechanism of both types of male contraception. In male hormonal contraception, the mechanism was depends on negative feedback in hypothalamic-pituitary-gonadal axis by regimens to impair the spermatogenesis into severe-oligozoospermia or azoospermia. In addition, immunocontraception was based on ‘vaccination’ concept in which antibodies recognize proteins in the spermatozoa as "non-self” thus spermatozoa may be destroyed. Conclusion: It is necessary to understand the cellular mechanism, thus the development of male contraception increases.  Further researches should be conducted to confirm the cellular mechanisms.Keywords: Male hormonal contraception, Testosterone, Progestin, Negative feedback, Immunocontraception, Sperm antigen.
Effect of MnCl2 Additive on Optical and Dispersion Parameters of Poly methyl Methacrylate Films Nadir Fadhil Habubi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

PMMA films with various content of MnCl2 additive (1, 3%) are prepared by casting method. Amorphous films of PMMA-Mn are examined using X-ray diffraction (XRD). UV-Visible spectrophotometer is used to record the transmittance spectra, which decreased with the increasing of MnCl2. Energy gap value decreased from 3.91 eV for PMMA to 3.39 eV for film with 3% additive of MnCl2, while the Urbach energy are increased from 555 meV to 741 meV for the same additives. Dispersion parameters are determined using Wemple and DiDomenico model. The Ed, Eo, and So increased with the increasing of MnCl2 additive, while n (0), λo, and M-1, M-3 are decreased.Keywords: PMMA, Dispersion parameters, Composite, Optical properties.
Prevalence of Stunting among 10-Year Old Children in Indonesia Taqwin Taqwin
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Children are characterized as healthy when they grow and develop adequately. This is determined through age-appropriate ideal height and weight measurements. This study aimed to quantify the prevalence of stunting among 10-year old children. This observational study had a cross-sectional design. This descriptive research was conducted from October to November 2019 using a total sample of 392 children obtained through the multistage proportional sampling to select participants from the student in 19 first elementary school in the study area. The anthropometric measurements of height were taken using a microtoice. The measurement results were compared with the World Health Organization (WHO) AntroPlus 2007 standards for 10-year old children. Height was measured using standard methods and height for age and the z-score was computed to assess stunting. The hypothesis test was done using ANOVA. The prevalence of stunting among 10-year old children in central Sulawesi, Indonesia is 24.7%. Poso's district has the highest percentage at around 35.9%, Donggala district is around 35.7%, Sigi district is around 16.5% and Palu City is around 12.5%. The highest mean for height was found in Palu City at 135,7 cm and the lowest was in Donggala district at 129,9cm. ANOVA showed a significant value of <0.001 with z-scores of -0.72, -1.63, -1.45 and -1.09 in Palu City, Donggala District, Poso and Sigi respectively. The prevalence of stunting in Central Sulawesi for children aged 10 years old is 24.7%. Donggala and Poso district have the highest prevalence of stunting. Some strategies need to be executed in order to improve the level of nutrition of elementary school children. This can be done by providing safe and hygienic school canteens, promoting healthy food diversity, encouraging more fish consumption and other healthy protein ingredients.Keywords: Children, South Sulawesi, stunting.

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