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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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The Difference in Immunoglobulin M Anti-Phenolic Glycolipid-1 Antibody Levels in Leprosy Patient, Household Contacts, and Control Ramona Dumasari Lubis
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background: Leprosy is a disease caused by M. leprae infection, may affect the peripheral nervous system, skin and other tissues. Until recently, leprosy is still a health problem in Indonesia. Phenolic Glycolipid-1 (PGL-1) is a stable and unique component of M. leprae, and an antibody examination against this antigen may play a role in assisting early detection of subclinical stage leprosy (SSL) and treatment monitoring. Objective: This study aims to define the level of IgM anti-PGL-1 antibody in leprosy patients, household contacts and controls and their serology status  Methods: The examination of IgM anti-PGL-1 antibody was carried out on 52 leprosy patients, 95 people household contacts and 95 healthy controls. The data from subjects were then analyzed and tested using Kruskal-Wallis statistical test and a p-value <0.001 was obtained. Results: It was obtained that the levels of IgM anti-PGL-1 antibody significantly differed between leprosy, household contact and control groups (p<0.05). Most of the leprosy patients had seropositive status, contrary to dominant seronegative that was found in household contacts and control groups. In subgroup analysis, the IgM titer level did not significantly differ between household contacts and control groups (p=0.122). Conclusion: the IgM anti-PGL-1 antibody differed between leprosy and household contacts and control. IgM antibody titer may also depict a person's exposure status to M. leprae bacilli.Keywords: M. leprae, Leprosy, IGM anti-PGL-1 antibody, Household contacts.
Adsorption and Photocatalytic Degradation of Crystal Violet Dye by using Cadmium Sulfide in Aqueous Solutions Aseel M. Aljeboree
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Chemical methods were used to synthesized cadmium sulfide thin films in a mixed phase which testing for wastewater treatment through the photocatalytic degradation. Specific region of light (UV) was used to remove the organic pollutant which commonly destroy the environmental such Crystal violet dye forming what we could it wastewaters. The testing solutions were degraded under visible-light irradiation using the CdS thin films. Structural studies of the CdS photocatalyst refer to the hexagonal and cubic phases with good crystallinity and uniformly and homogenous distributed over all the sites of support with less agglomerations.  The morphology analysis mostly shown induces porosity, which mostly enhance intercalating dyes. The optical band-gap energy of sample within film was 2.35 eV, which explained the high photcatalytic behavior in the degradation of the non-biodegradable Crystal violet dye. As accepted the semiconductor/ UV-light were succeed to declaration of day which shows good acceptable results. The surprised was the efficiency of degradation or deceleration was rises very high as compare with the same conditions of reaction in room temperature in addition to increases with raises of concentration from 0.5 to 4 g/L. Keywords: Cadmium sulfide, Photcatalytic degradation, Adsorption, Crystal Violet dye.   
Synthesis, Antioxidant, and Preliminary Antitumor Activities of New Curcumin Analogues Yasser Fakri Mustafa
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Curcumin is a molecule gifted from nature to improve human health by its multiple biological activities. However, the application of curcumin in therapeutics is limited mainly due to its poor aqueous solubility, insignificant chemical stability, and low cellular uptake. To address some of these drawbacks, eight analogues of curcumin were synthesized starting from simple molecules. Characterization of the chemical structures of these analogues was documented by interpretation of their IR, 1H-NMR, and 13C-NMR spectra. Biological activities of the synthesized analogues were studied by comparing their activities with those of curcumin. This biological assessment included examining the antioxidant capacity via DPPH and hydroxyl radical scavenging activity tests, and screening the preliminary antitumor activity against MCF-7 and HeLa cancer cell lines by MTT test. Depending on the resulted data, it was found that these analogues have the comparable biological activities but with better stability and water solubility in comparison with curcumin. It is postulated that such analogues may be useful clues to improve the therapeutic applications of curcumin.Keywords: Curcumin, Synthesis, Analogues, Antioxidant, Antitumor.
Effects of Different Doses of Aspartame on Some Biochemical Parameters of Kidney Rats Marwa Amer Ali
Journal of Global Pharma Technology .
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Abstract

This study aims to determine the effect of aspartame on the biochemical parameter, and its influence on the kidney tissues in rats. Thirty adult male rats and 30 adult female rats, with age of 60-65 day are used in this study, almost on an average live weight between (165-200) gm. The experiment concentrates on the daily dose, where the animals are randomly divided into four groups, each group contains 15 animals (five males & ten females), three experiment groups treated and control group. The first group treatment A gavage with concentrated aspartame of (250 mg / kg/ per day), the second group treatment B gavage with concentrated aspartame (500mg/kg/per day) and the third group treatment C dosage of (1000mg/ kg/ per day), while the control group dosed with 1ml physiologic solution daily. All the groups had their daily dosages orally for 90 days, and the study continued from 29 October 2017- 26 January 2018. After the end of experiment , blood sample was collected for estimate this serum of urea ,uric acid  and creatinine .The results of this study showed that there is non- significant differences (P> 0.05)  in urea concentration between control group and group A,B and C.  Also there is non-significant differences (p>0.05) between treatment groups .The result showed there is a significant differences (p<0.01)in creatinine concentration in group A in comparison with control group .But group B showed non- significant differences (p>0.05) in creatinine concentration compared with control group .while group C has a significant increase (p<0.05) in creatinine concentration in compared with control increase (p<0.05) in creatinine concentration in compared with control group. When the treatment groups the results showed that the group A high significant difference (p<0.01) when compared with B group .whereas non -significant differences (p>0.05) between A and C groups. Also there is non- significant differences (p>0.05) between B and C groups. In uric acid showed non- significant differences (p>0.05) compared with group A and control group, Also there is a non-significant decreased (P>0.05) compared with the B group and control group. While showed in the C group has a high significantly differences (p<0.01) compared with the control group .when compared the treatment groups the results showed there is non- significant differences (p>0.05) between group A and B, C groups .Also there is non- significant differences (p>0.05) between B group and C.Keywords: Aspartame and effect on kidney.
Dietary Diversity among Children Aged 12-23 Months in Urban Area Eka Mishbahatul Marah Has; Nursalam .; Yuni Sufyanti Arief
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

This study aimed to describe the dietary diversity among 12-23 months old children living in an urban area. A cross-sectional survey which involved 146 mothers who had children aged 12-23 months, living in Surabaya City, East Java, was conducted. Mother's, child's, household's characteristics, and child's dietary diversity were collected by using a questionnaire. Then, the frequency distribution and percentage analysis were performed. The result showed that most children (96.6%) met the minimum dietary diversity as recommended by WHO. The food groups which mainly consumed were vitamin A-rich fruits and vegetables (100%) and grains, roots, and tubers (96.6%). In reverse, the food groups which less consumed were other fruits and vegetables, and legumes and nuts. Integrated health promotion is needed to ensure low socioeconomic status household who lived in the urban area met the appropriate infant and young child feeding practice. Keywords: Dietary diversity; Children aged 12-23 months; Urban area.
Effect of Mindfulness-Based Therapy with Control Drug on Cognitive Distortions of Addicted Adolescents in Isfahan Mohsen Saeid Manesh
Journal of Global Pharma Technology .
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Abstract

The purpose of this study was to investigate the effectiveness of mindfulness-based therapy on cognitive disorders in addicted adolescents in Isfahan city. The target population of all addicted teenagers is leaving the city of Isfahan in 1396. Sampling method was available from available centers in Isfahan province to the center of addiction treatment of rubbish in Isfahan province. After random sampling, 30 adolescent addicts who had entry criteria were randomly assigned into two experimental and control groups. After performing a pretest in two groups, the experimental group received cognitive therapy based on mind-awareness during 8 sessions of 90 minutes (once a week). During this period, the control group was on the waiting list. Then, both groups were measured in post-test and follow up. For information gathering, Abdollahzadeh and Salar Cognitive Distortion Questionnaire (2010), Tangji Self-Control Questionnaire-Form 36 (2004) was used. Data were analyzed using repeated measures ANOVA. The results of this study showed that Mindfulness-based therapy was effective on cognitive distortions and this effect continued throughout the follow-up period of one month. Based on the results of this study, Mindfulness-based therapy was effective in cognitive disturbances of addicted adolescents (p <0.05).Keywords: Mindfulness, Cognitive distortions, Self-control.
Combination of Chitosan and Lemongrass (Cymbopogon citratus) Essential Oil as Edible Coating to Cantaloupe (Cucumis melo L) Quality and Shelf Life during Storage Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Cantaloupe (Cucumis melo L.) is an important source of bioactive compounds, which are considered to be health beneficial. Chitosan and its derivatives have a wide range of applications, for example thickening, film formation, metal binding and antimicrobial activity. Lemongrass (Cymbopogon citratus) contains various phytoconstituents such as flavonoids and phenolic compounds, terpenoids and essential oils, which may be responsible for the different biological activities. The objective of this study was to evaluate the combination of chitosan with lemongrass essential oil as edible coating to improve the quality and extend the shelf life of Cantaloupe (Cucumis melo L.) during storage. Cantaloupe fruits were coated in different formulas of chitosan: lemongrass essential oil (0.15%: 0.15%, 0.20%: 0.1%, 0.25%: 0.05%, respectively). The uncoated fruits were used as control samples. Then, cantaloupe fruits were preserved at ambient temperature (28°C) and cool storage (4°C). The effectiveness of edible coating in cantaloupe fruit quality and shelf life was evaluated by estimating weight loss, firmness, total soluble solids, total acidity, ascorbic acid, carotenoid content, microbial proliferation (total bacterial, yeast and mold) and sensory acceptability at beginning and during 16 days of storage. The results obtained showed that 0.20%: 0.1% (chitosan: lemongrass essential oil) as edible coating could reduced weight loss; maintained firmness, total soluble solids, total acidity, ascorbic acid and sensory score; delayed the change in cartenoid content and microbial proliferation. The coated fruits had a shelf life of 16 days (4oC) or 12 days (28oC) under storage.Keywords: Cantaloupe, Chitosan, lemongrass essential oil, Coating, Shelf life.
Effect of Giving A Combination of ROM and Mirror Therapy to Increase The Muscle Strength of the Upper Limb Dedi Irawandi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background:One of the problems in stroke patients is a decrease in muscle strength due to hemiparesis which affects the client's self-acceptance. The study aims is to determine the effectiveness of  combination mirror therapy and ROM on upper limb muscle strength and self-acceptance stage in stroke clients with hemiparesis.Materials and Methods:Quasi experimental research with pre-post control group design was done on 36 respondents with consecutive sampling technique, for 3 months in the stroke room. Upper limb muscle strength was measured using a Medical Research Council scale, while the self-acceptance stage used a self-acceptance stage questionnaire based on the Kubler Ross adaptation stage. Data were analyzed using wilcoxon and Mann-Witney test with p value <0,05.Results: Wilcoxon test known p value <0.05 for muscle strength and self-acceptance stage both in the treatment group and in the control group. The result of analysis of muscle strength difference between treatment group and control is known p value = 0.000, while for self-acceptance stage known p value <0,05 for denial, anger, bargaining and depression, At acceptance stage known p value 0,05. This analysis shows that there is a significant difference in muscle strength and self-acceptance at the denial, anger, bargaining and depression stages after being given a combination of mirror and ROM therapy with stroke clients given ROM therapy alone.Conclusion: Combination of mirror therapy with ROM can be used as nursing intervention in the hospital, especially on ischemic stroke clients with hemiparesis to increase muscle strength and self-acceptance of client
Occupational Performance and its Correlation with Some of Anthropometric Variables for Sports Supervisors in the Directorates of Youth and Sports Sawsan Hadoud Obeid Shaileh
Journal of Global Pharma Technology .
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Abstract

The study aimed to identify the relationship between the professional performance of the supervisors who are specialists in physical education and sports sciences with some anthropometric measurements in the directorates of youth and sports. The study also assumed that there is a statistical relation between the professional performance and some anthropometric variables in the sports supervisor in the youth and sports directorates. The descriptive approach was used in the style of correlative relationships to suit the nature of the research procedures. The sample was divided according to the age groups into two groups, ranging between 25-35 years and a second group ranging in age from 35-45 years. After the tests and measurements, Data and processed statistically to reach the results on which the following conclusions were reached:There is a significant correlation between the body mass index of overweight people with the variable length, while there is no relationship between BMI and the other variables investigated.There is a significant correlation between the variable height and weight for people with overweight.There is a significant correlation between the body mass index with the variable length and the variable occupational performance of people with normal weight.There is no correlation between the BMI and other variables investigated for people with normal weight.Keywords: Occupational performance, Anthropometric variables, Sports supervisors and youth.
Positive Thinking and Affirmative behavior and their Correlation with the Psychological Flow of Students of the Faculty of Physical Education and Sports Sciences Yasmin Hamid Majid Al Bayati
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The study objectives to:To identify positive thinking, affirmative behavior and psychological flow among students of the Faculty of Physical Education and Sports sciences at the University of Babylon.To learn about the relationship between positive thinking, affirmative behavior and the psychological flow of students at the Faculty of Physical Education and Sports sciences at the University of Babylon.Researchers used the survey methodology to identify these variables, and in the relational relationship method to identify the relationship between them, the research community included the first-stage students at the Faculty of Physical Education and Sports Sciences of Babylon University for the 2017-2018 school year, which number (130) students, Thirty students from the research community were selected (25 students per college) (23.07%) The measurements were then applied for the purpose of the relations, and the appropriate statistical methods were used in the processing of the data, as the authors used the statistical pouch (SPSS).In the light of the results of the present research, and of the interpretations that have been followed, we can draw some conclusions, the most important of which are the following:First-stage students at the Faculty of Physical Education and sports sciences have positive thinking, affirmative behavior and good psychological flow.There is a strong correlation between both positive thinking and affirmative behavior on the one hand and psychological flow on the other.In the light of the findings and conclusions of the research, the current research has reached the most important recommendations, as follows:To pay attention to the psychological aspects of the students of the Faculty of Physical Education and sports sciences, in particular positive thinking and affirmative behavior, because of their direct relationship with the psychological flow;Conducting studies similar to psychological variables to determine their relationship with the basic skills of the various sporting events for students.The need to provide specific lectures to students during educational and teaching units by a psychologist and a psychologist.Keywords: Positive thinking, Affirmative behavior, Psychological flow and Sports Sciences.

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